Abstract: The present invention relates to a novel pharmaceutical combination comprising an ILDR2 antagonist according to any of the aforementioned claims, plus one or more other therapeutically active compounds, and to novel specific ILDR2 antagonists.

Abstract: A first voltage source produces a first voltage such as an AC voltage. Further, a first electrode of a hydrogen generation system conveys the first voltage. The first voltage conveyed over the first electrode generates low-temperature plasma extending between the first electrode and the mass of material. Presence of the low-temperature plasma releases gas from the mass of material.

Abstract: A parking meter detects an object in proximity, based on a change in a proximity measurement at the meter, activates a directional sensor in response to detecting the object, receives sensor data at a meter processor from the directional sensor, wherein the received sensor data indicates a predetermined direction to the detected object relative to the meter. The parking meter determines a presence of the object, or lack thereof, in the predetermined direction based on the sensor data, and upon a positive determination of the presence of the object, stores an indication of the presence of the object along with a time of the positive determination.

Abstract: A meter apparatus and method of operating a removable meter apparatus are described. The meter apparatus includes a tag associated with unique tag identification information and configured to be permanently affixed to a location housing at a unique physical location, and includes a removable meter unit configured to mate with the location housing and receive the tag identification from the tag and report the tag identification to a data manager configured to associate an identifier of the removable meter unit with the tag identification and unique physical location, and associate configuration information for the physical location with the removable meter unit and the tag identification. The unique physical location can comprise a single-space parking location.

Abstract: The present invention is directed to combination treatments with anti-PVRIG antibodies and anti-PD-1 antibodies, in particular nivolumab, using stable liquid pharmaceutical formulations thereof.

Abstract: A downhole flow control device is described having a flow control valve and a sensor communication with the flow control valve. The sensor measures a downstream process parameter and the flow control valve is configured to control the fluid flow through the valve to achieve a target downstream process parameter value in response to the measured downstream process parameter. A control system for controlling the downhole flow control device and a method for controlling the downhole flow device are also provided.

Abstract: The present invention is directed to anti-PVRIG antibodies and stable liquid pharmaceutical formulations thereof.

Abstract: A parking meter detects an object in proximity, based on a change in a proximity measurement at the meter, activates a directional sensor in response to detecting the object, receives sensor data at a meter processor from the directional sensor, wherein the received sensor data indicates a predetermined direction to the detected object relative to the meter. The parking meter determines a presence of the object, or lack thereof, in the predetermined direction based on the sensor data, and upon a positive determination of the presence of the object, stores an indication of the presence of the object along with a time of the positive determination.

Abstract: The present invention relates to an anti-ILDR2 antibody, a fragment or derivative thereof, a modified antibody format, or an antibody mimetic for use in combination with a PD-1 antagonist in the treatment of cancer. Other aspects of the present invention relate to a combination comprising an anti-ILDR2 antibody and a PD-1 antagonist and the use of such combination as a medicament, as well as methods of treatment or prophylaxis of a cancer in a subject, comprising administering to said subject a therapeutically effective amount of the antibodies as described herein. Further, the present invention relates to a kit comprising anti-ILDR2 antibodies and PD-1 antagonists and optionally one or more further pharmaceutical agents.

Abstract: A packaged filtration mask can include a filtration mask packaged in a container in a vacuum or a partial vacuum. The container can be a tearable container, at least a portion of which can include a laminate of a first part and a second part. A resistance to tearing of the second part can be different than a resistance to tearing of the first part.

Abstract: A power source system including a plurality of cells. The power source system uses electrical charge or current generated by a reaction in at least one of the cells to provide at least one operating material to at least one other of the cells. Optionally, the power source system uses the electrical charge generated by the reaction in the at least one of the cells to provide the at least one operating material to the at least one other of the cells only when the state of charge of the at least one of the cells is equal to or below a threshold or when the use of the cell is equal to or above a threshold. Optionally, in an initial or non-operational state, one or more or each of the cells is dry or without the at least one operating material and the power source system is configured to selectively switch at least one of the plurality of cells from the non-operational state to an operational state by providing the at least one operating material to the at least one cell.

Abstract: A packaged filtration mask comprising a filtration mask packaged in a container in a vacuum or a partial vacuum, wherein the packaged filtration mask comprises an indicator configured to indicate the presence of a vacuum or a partial vacuum in the container, or configured to indicate the lack of a vacuum or a partial vacuum in the container.

Abstract: Provided herein are intermediate frame systems and methods, comprising one or more arrays of channels on upper and/or lower edges of the intermediate frame wherein the channels are configured to provide a spatially uniform flow of electrolyte through the plane of the intermediate frame.

Abstract: Devices and meters comprising: a housing configured to mount to a pole supporting an existing meter, the housing defining an interior; a sensor within the interior of the housing, the sensor configured to collect environmental information pertaining to the local external environment of the existing meter; a wireless radio within the interior of the housing, the wireless radio configured to transmit the environmental information to the existing meter or to a remote server in communication with the existing meter; a power unit within the interior of the housing, the power unit supplying power to the sensor and the wireless radio.

Abstract: Lean-burn engines are important due to their ability to reduce emissions, increase fuel efficiency, and mitigate engine knock. Embodiments of a spark plug with a nanostructured electrode extend the lean flammability limit of natural gas. A nano-/micro-morphology modification is applied on a surface of the spark plug electrode to increase its surface roughness. Measurements indicate that the lean flammability limit of spark-ignited methane can be lowered by modulating the surface roughness of the spark plug electrode with nanostructures.

Abstract: An apparatus for controlling water production in a wellbore comprises a body in the form of a base pipe, the base pipe having an axial flow passage in the form of axial throughbore and a lateral flow passage in the form of radial port. A shroud is disposed around the base pipe and forms a housing of the apparatus. In use, the apparatus forms part of a completion string for location in the wellbore, the apparatus configured to direct production fluid into a production conduit for recovery to surface, perform a quantitative measurement of water content within the production fluid, and vary the fluid flow in the fluid flow path based on the quantitative measurement of water content within the production fluid to maintain water production at or below a predetermined threshold.

Abstract: A substrate (e.g., metal or non-metal sheet) can have multiple textures on a surface of the substrate. The various textures can be impressed or applied on the surface of the substrate by passing the substrate between multiple pairs of work rolls that each include at least one textured work roll for transferring a texture of the work roll onto the surface of the substrate. The pairs of work rolls apply the various textures on the surface of the substrate while maintaining a thickness of the substrate (e.g., with substantially no reduction in a thickness of the substrate). A single pass of the substrate between the pairs of work rolls can allow various different textures, patterns, or features to be applied to the surface of the substrate while the thickness of the substrate remains substantially constant.

Abstract: Devices and meters comprising: a housing configured to mount to a pole supporting an existing meter, the housing defining an interior; a sensor within the interior of the housing, the sensor configured to collect environmental information pertaining to the local external environment of the existing meter; a wireless radio within the interior of the housing, the wireless radio configured to transmit the environmental information to the existing meter or to a remote server in communication with the existing meter; a power unit within the interior of the housing, the power unit supplying power to the sensor and the wireless radio.

Abstract: A power supply unit for supplying power to a device has a rechargeable, main battery; a charging arrangement for charging the main battery; a non-rechargeable back-up battery; load terminals for connection to a load; and a control unit for controlling supply of power to the load primarily from the main battery and secondarily from the back-up battery. The device is, in particular, a single bay, stand alone parking meter. In the event that the main battery runs low, the control unit is configured to supply power to the load from both the main battery and the back-up battery or only from the back-up battery. The back-up battery is easily replaceable, and the power supply unit has a bay, with connectors for receiving the back-up battery. The main battery is charged from solar panels. A communication device is provided to communicate status messages wirelessly to a control system.

Abstract: An applicator system for extrusive dispensing of work material from a flexible pre-charged portion of a cartridge unit is provided. The system comprises a body portion having an actuator and a housing coupled thereto. The housing includes a cartridge bay and an arresting member displaceably coupled thereto. The cartridge bay is configured to receive the cartridge unit and defines at least one containment compartment for receiving the pre-charged cartridge. The arresting member is displaceable between open and closed configurations for releasably retaining the cartridge unit. The actuator, coupled to the housing in communication with the cartridge bay, includes a drive member engaging the pre-charged cartridge within the containment compartment. The body includes a handle and an activation member coupled thereto.