Patents by Inventor John J. Leonard
John J. Leonard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11654934Abstract: A system and method for generating a predicted vehicle trajectory includes a generative adversarial network configured to receive a trajectory vector of a target vehicle and generate a set of latent state vectors using the received trajectory vector and an artificial neural network. The latent state vectors each comprise a high-level sub-vector, ZH. The GAN enforces ZH to be correlated to an annotation coding representing semantic categories of vehicle trajectories. The GAN selects a subset, from the set of latent state vectors, using farthest point sampling and generates a predicted vehicle trajectory based on the selected subset of latent state vectors.Type: GrantFiled: November 25, 2020Date of Patent: May 23, 2023Assignees: TOYOTA RESEARCH INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Xin Huang, Stephen G. McGill, Jonathan A. DeCastro, Brian C. Williams, Luke S. Fletcher, John J. Leonard, Guy Rosman
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Publication number: 20230085422Abstract: A method for task-informed planning by a behavior planning system of a vehicle includes observing a previous trajectory of an agent within a distance from the vehicle. The method also includes predicting, by the behavior planning system, a set of potential trajectories for the agent and/or the vehicle based on observing the previous trajectory. The method further includes selecting, by the behavior planning system, a potential action from a set of potential actions associated with a task to be performed by the vehicle, each potential action being associated with a utility value based on the respective potential action and the set of potential trajectories, the selected potential action being associated with a highest utility value of respective utility values associated with the set of potential actions. The method still further includes controlling the vehicle to perform an action associated with the potential action selected by the behavior planning system.Type: ApplicationFiled: July 22, 2022Publication date: March 16, 2023Applicants: TOYOTA RESEARCH INSTITUTE, INC., TOYOTA JIDOSHA KABUSHIKI KAISHA, MASSACHUSETTS INSTITUE OF TECHNOLOGYInventors: Xin HUANG, Guy ROSMAN, Ashkan Mohammadzadeh JASOUR, Stephen G. McGILL, JR., John J. LEONARD, Brian C. WILLIAMS
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Patent number: 11475720Abstract: An embodiment takes the form of a vehicle that generates a data collection configuration for one or more vehicle sensors of a vehicle based on an estimated information gain to a neural network were the vehicle to provision the neural network with notional sensor data, and based on a vehicle resource consumption by the vehicle were the vehicle to provision the neural network with the notional sensor data. The notional sensor data comprises sensor data that would be collected from a given sensor among the vehicle sensors according to a respective sensor configuration of the given sensor. The vehicle collects sensor data from the vehicle sensors according to the generated data collection configuration.Type: GrantFiled: March 31, 2020Date of Patent: October 18, 2022Assignee: TOYOTA RESEARCH INSTITUTE, INC.Inventors: Stephen G. McGill, Guy Rosman, Luke S. Fletcher, John J. Leonard, Simon Stent
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Publication number: 20220280646Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.Type: ApplicationFiled: February 14, 2022Publication date: September 8, 2022Applicant: DURECT CORPORATIONInventors: Jeremy C. WRIGHT, Wilma TAMRAZ, John J. LEONARD, John W. GIBSON, Keith E. BRANHAM, Stefania SJOBECK, Brooks Boyd, Christopher M. RUBINO
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Publication number: 20220265830Abstract: The present disclosure provides long-acting formulations and vehicles, methods of making the same and methods of using the same.Type: ApplicationFiled: July 17, 2020Publication date: August 25, 2022Applicant: DURECT CORPORATIONInventors: Susan AUTIO, Keith Edward BRANHAM, James A. FILICE, John W. GIBSON, John J. LEONARD, James MATRIANO, Whitney MORO, Michael SEKAR, Chelsea Alexandra SNYDER, Robert G. STRICKLEY, Raju SUBRAMANIAN, Felix THEEUWES, Monica TIJERINA, Jeremy C. WRIGHT, Su II YUM, Faye XU
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Publication number: 20220257619Abstract: The present disclosure provides long-acting formulations of tenofovir alafenamide, methods of making the same and methods of using the same.Type: ApplicationFiled: July 17, 2020Publication date: August 18, 2022Inventors: Susan Autio, Keith Edward Branham, James A. Filice, John W. Gibson, John J. Leonard, James Matriano, Whitney Moro, Michael Sekar, Chelsea Alexandra Snyder, Robert G. Strickley, Raju Subramanian, Felix Theeuwes, Monica Tijerina, Jeremy C. Wright, Su Il Yum, Faye Xu
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Patent number: 11285217Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.Type: GrantFiled: June 1, 2020Date of Patent: March 29, 2022Assignee: Durect CorporationInventors: Jeremy C. Wright, Wilma Tamraz, John J. Leonard, John W. Gibson, Keith E. Branham, Stefania Sjobeck, Brooks Boyd, Christopher M. Rubino
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Publication number: 20210304524Abstract: An embodiment takes the form of a vehicle that generates a data collection configuration for one or more vehicle sensors of a vehicle based on an estimated information gain to a neural network were the vehicle to provision the neural network with notional sensor data, and based on a vehicle resource consumption by the vehicle were the vehicle to provision the neural network with the notional sensor data. The notional sensor data comprises sensor data that would be collected from a given sensor among the vehicle sensors according to a respective sensor configuration of the given sensor. The vehicle collects sensor data from the vehicle sensors according to the generated data collection configuration.Type: ApplicationFiled: March 31, 2020Publication date: September 30, 2021Applicant: Toyota Research Institute, Inc.Inventors: Stephen G. McGill, Guy Rosman, Luke S. Fletcher, John J. Leonard, Simon Stent
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Patent number: 11079758Abstract: A method of collecting data regarding the operation of a vehicle that includes receiving sensor data regarding one or more objects or events in a surrounding environment using one or more vehicle sensors, classifying, by one or more processors, the one or more detected objects or events, generating one or more vehicle inquiries based on the classification of the one or more detected objects or events, presenting one or more vehicle inquiries, and receiving user feedback to the one or more vehicle inquiries.Type: GrantFiled: January 12, 2018Date of Patent: August 3, 2021Assignee: TOYOTA RESEARCH INSTITUTE, INC.Inventors: John J. Leonard, Simon A. I. Stent, Luke S. Fletcher, Stephen G. McGill
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Publication number: 20210163038Abstract: A system and method for generating a predicted vehicle trajectory includes a generative adversarial network configured to receive a trajectory vector of a target vehicle and generate a set of latent state vectors using the received trajectory vector and an artificial neural network. The latent state vectors each comprise a high-level sub-vector, ZH. The GAN enforces ZH to be correlated to an annotation coding representing semantic categories of vehicle trajectories. The GAN selects a subset, from the set of latent state vectors, using farthest point sampling and generates a predicted vehicle trajectory based on the selected subset of latent state vectors.Type: ApplicationFiled: November 25, 2020Publication date: June 3, 2021Applicants: Toyota Research Institute, Inc., Massachusetts Institute of TechnologyInventors: Xin Huang, Stephen G. McGill, Jonathan A. DeCastro, Brian C. Williams, Luke S. Fletcher, John J. Leonard, Guy Rosman
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Publication number: 20210015924Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic- acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.Type: ApplicationFiled: June 1, 2020Publication date: January 21, 2021Applicant: DURECT CORPORATIONInventors: Jeremy C. WRIGHT, Wilma TAMRAZ, John J. LEONARD, John W. GIBSON, Keith E. BRANHAM, Stefania SJOBECK, Brooks Boyd, Christopher M. RUBINO
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Patent number: 10752249Abstract: Vehicle systems and methods for assisting a driver making a turn at an intersection are disclosed. In one embodiment, a vehicle includes a plurality of sensors configured to output a plurality of operational signals, one or more processors, and one or more non-transitory memory modules communicatively coupled to the one or more processors. The processors store machine-readable instructions that, when executed, cause the one or more processors to receive a signal indicating a driver of the vehicle is attempting to make a turn at an intersection. The processors are further caused to access a behavioral profile that is representative of the intersection. The processors are also caused to develop a perception as well as a risk associated with the intersection based on the plurality of operational signals from the plurality of sensors and the behavioral profile of the intersection. The processors are further caused to calculate at least one maneuver.Type: GrantFiled: March 14, 2018Date of Patent: August 25, 2020Assignee: TOYOTA RESEARCH INSTITUTE, INC.Inventors: John J. Leonard, Stephen G. McGill, Luke S. Fletcher
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Publication number: 20200085829Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed.Type: ApplicationFiled: August 19, 2019Publication date: March 19, 2020Applicant: DURECT CORPORATIONInventors: Jeremy C. WRIGHT, Wilma TAMRAZ, John J. LEONARD, John W. GIBSON, Keith E. BRANHAM, Stefania SJOBECK, Brooks BOYD, Christopher M. RUBINO
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Publication number: 20190283756Abstract: Vehicle systems and methods for assisting a driver making a turn at an intersection are disclosed. In one embodiment, a vehicle includes a plurality of sensors configured to output a plurality of operational signals, one or more processors, and one or more non-transitory memory modules communicatively coupled to the one or more processors. The processors store machine-readable instructions that, when executed, cause the one or more processors to receive a signal indicating a driver of the vehicle is attempting to make a turn at an intersection. The processors are further caused to access a behavioral profile that is representative of the intersection. The processors are also caused to develop a perception as well as a risk associated with the intersection based on the plurality of operational signals from the plurality of sensors and the behavioral profile of the intersection. The processors are further caused to calculate at least one maneuver.Type: ApplicationFiled: March 14, 2018Publication date: September 19, 2019Applicant: Toyota Research Institute, Inc.Inventors: John J. Leonard, Stephen G. McGill, Luke S. Fletcher
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Publication number: 20190255179Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.Type: ApplicationFiled: January 17, 2019Publication date: August 22, 2019Applicant: DURECT CORPORATIONInventors: Jeremy C. WRIGHT, Wilma TAMRAZ, John J. LEONARD, John W. GIBSON, Keith E. BRANHAM, Stefania SJOBECK, Brooks Boyd, Christopher M. RUBINO
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Publication number: 20190220010Abstract: A method of collecting data regarding the operation of a vehicle that includes receiving sensor data regarding one or more objects or events in a surrounding environment using one or more vehicle sensors, classifying, by one or more processors, the one or more detected objects or events, generating one or more vehicle inquiries based on the classification of the one or more detected objects or events, presenting one or more vehicle inquiries, and receiving user feedback to the one or more vehicle inquiries.Type: ApplicationFiled: January 12, 2018Publication date: July 18, 2019Applicant: Toyota Research Institute, Inc.Inventors: John J. Leonard, Simon A.I. Stent, Luke S. Fletcher, Stephen G. McGill
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Patent number: 10226532Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.Type: GrantFiled: July 18, 2017Date of Patent: March 12, 2019Assignee: DURECT CORPORATIONInventors: Jeremy C. Wright, Wilma Tamraz, John J. Leonard, John W. Gibson, Keith E. Branham, Stefania Sjobeck, Brooks Boyd, Christopher M. Rubino
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Publication number: 20180140605Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed.Type: ApplicationFiled: January 16, 2018Publication date: May 24, 2018Applicant: DURECT CORPORATIONInventors: Jeremy C. WRIGHT, Wilma TAMRAZ, John J. LEONARD, John W. GIBSON, Keith E. BRANHAM, Stefania SJOBECK, Brooks BOYD, Christopher M. RUBINO
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Publication number: 20180036412Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.Type: ApplicationFiled: July 18, 2017Publication date: February 8, 2018Applicant: DURECT CORPORATIONInventors: Jeremy C. WRIGHT, Wilma TAMRAZ, John J. LEONARD, John W. GIBSON, Keith E. BRANHAM, Stefania SJOBECK, Brooks Boyd, Christopher M. RUBINO
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Patent number: 9737605Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.Type: GrantFiled: March 11, 2014Date of Patent: August 22, 2017Assignee: DURECT CORPORATIONInventors: Jeremy C. Wright, Wilma Tamraz, John J. Leonard, John W. Gibson, Keith E. Branham, Stefania Sjobeck, Brooks Boyd, Christopher M. Rubino