Patents by Inventor John Lister-James
John Lister-James has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5888474Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to specific binding peptides, methods and kits for making such peptides, and methods for using such peptides labeled with technetium-99m via a radiolabel-binding moiety covalently linked to the peptide to image thrombus sites in a mammalian body.Type: GrantFiled: June 7, 1995Date of Patent: March 30, 1999Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James
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Patent number: 5879658Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to specific binding peptides, methods and kits for making such peptides, and methods for using such peptides labeled with technetium-99m via a radiolabel-binding moiety covalently linked to the peptide to image thrombus sites in a mammalian body.Type: GrantFiled: June 7, 1995Date of Patent: March 9, 1999Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James
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Patent number: 5871711Abstract: This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somatostatin, and embodiments of such peptides labeled with technetium-99m (Tc-99m), as well as methods and kits for making, radiolabeling and using such peptides to image sites in a mammalian body. The invention also relates to peptide derivatives and analogues of somatostatin labeled with rhenium-186 (.sup.186 Re) and rhenium-188 (.sup.188 Re), and methods and kits for making, radiolabeling and using such peptides therapeutically in a mammalian body.Type: GrantFiled: January 13, 1995Date of Patent: February 16, 1999Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James
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Patent number: 5849260Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to specific binding peptides, methods and kits for making such peptides, and methods for using such peptides labeled with technetium-99m via a radiolabel-binding moiety covalently linked to the peptide to image thrombus sites in a mammalian body.Type: GrantFiled: July 11, 1994Date of Patent: December 15, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James
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Patent number: 5849261Abstract: This invention relates to radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic and radiotherapeutic agents. Specifically, the invention relates to VIP receptor binding peptides, derivatives and analogues of VIP, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to VIP receptor binding peptide derivatives and analogues of VIP radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention also specifically relates to VIP receptor binding peptide derivatives and analogues of VIP radiolabeled with cytotoxic radioisotopes such as rhenium-186 (.sup.186 Re) and rhenium-188 (.sup.188 Re) for use as radiotherapeutic agents.Type: GrantFiled: March 31, 1995Date of Patent: December 15, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Daniel A. Pearson, John Lister-James, Edgar R. Civitello
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Patent number: 5843401Abstract: This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somatostatin, and embodiments of such peptides labeled with technetium-99m (Tc-99m), as well as methods and kits for making, radiolabeling and using such peptides to image sites in a mammalian body. The invention also relates to peptide derivatives and analogues of somatostatin labeled with rhemium-186 (.sup.186 Re) and rhenium-188 (.sup.188 Re), and methods and kits for making, radiolabeling and using such peptides therapeutically in a mammalian body.Type: GrantFiled: June 6, 1995Date of Patent: December 1, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James
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Patent number: 5833942Abstract: This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somatostatin, and embodiments of such peptides labeled with technetium-99m (Tc-99m), as well as methods and kits for making, radiolabeling and using such peptides to image sites in a mammalian body. The invention also relates to peptide derivatives and analogues of somatostatin labeled with rhemium-186 (.sup.186 Re) and rhenium-188 (.sup.188 Re), and methods and kits for making, radiolabeling and using such peptides therapeutically in a mammalian body.Type: GrantFiled: June 6, 1995Date of Patent: November 10, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James
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Patent number: 5830856Abstract: This invention relates to radiolabeled scintigraphic imaging agents, and methods and reagents for producing such agents. Specifically, the invention relates to specific binding compounds, including peptides, that bind to a platelet receptor that is the platelet GPIIb/IIIa receptor, methods and kits for making such compounds, and methods for using such compounds labeled with technetium-99m via a covalently-linked radiolabel-binding moiety to image thrombi in a mammalian body.Type: GrantFiled: June 3, 1994Date of Patent: November 3, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James, Edgar R. Civitello, William McBride
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Patent number: 5820845Abstract: This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somatostatin, and embodiments of such peptides labeled with technetium-99m (Tc-99m), as well as methods and kits for making, radiolabeling and using such peptides to image sites in a mammalian body. The invention also relates to peptide derivatives and analogues of somatostatin labeled with rhemium-186 (.sup.186 Re) and rhenium-188 (.sup.188 Re), and methods and kits for making, radiolabeling and using such peptides therapeutically in a mammalian body.Type: GrantFiled: June 6, 1995Date of Patent: October 13, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James
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Patent number: 5814298Abstract: This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somatostatin, and embodiments of such peptides labeled with technetium-99m (Tc-99m), as well as methods and kits for making, radiolabeling and using such peptides to image sites in a mammalian body. The invention also relates to peptide derivatives and analogues of somatostatin labeled with rhemium-186 (.sup.186 Re) and rhenium-188 (.sup.188 Re), and methods and kits for making, radiolabeling and using such peptides therapeutically in a mammalian body.Type: GrantFiled: June 6, 1995Date of Patent: September 29, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James
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Patent number: 5780007Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.Type: GrantFiled: June 6, 1995Date of Patent: July 14, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5776428Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.Type: GrantFiled: June 6, 1995Date of Patent: July 7, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5736122Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to specific binding peptides, methods and kits for making such peptides, and methods for using such peptides labeled with technetium-99m via a radiolabel-binding moiety covalently linked to the peptide to image thrombus sites in a mammalian body.Type: GrantFiled: June 7, 1995Date of Patent: April 7, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James
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Patent number: 5720934Abstract: This invention relates to radiolabel binding moieties for producing radiolabeled peptides and methods for making such peptides. Specifically, the invention relates to picolinic acid or picolinamine containing radiolabel binding moieties, peptides radiolabeled therewith and methods of making and using both the radiolabel binding moieties and peptides radiolabeled therewith.Type: GrantFiled: June 6, 1995Date of Patent: February 24, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5716596Abstract: This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somatostatin, and embodiments of such peptides labeled with technetium-99m (Tc-99m), as well as methods and kits for making, radiolabeling and using such peptides to image sites in a mammalian body. The invention also relates to peptide derivatives and analogues of somatostatin labeled with rhemium-186 (.sup.186 Re ) and rhenium-188 (.sup.188 Re ), and methods and kits for making, radiolabeling and using such peptides therapeutically in a mammalian body.Type: GrantFiled: June 23, 1992Date of Patent: February 10, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James
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Patent number: 5648471Abstract: A one vial method for labeling a sulfhydryl containing antibody or antibody fragment with technetium-99m is disclosed. The method comprises contacting an antibody mixture comprised of a sulfhydryl containing antibody or antibody fragment and a reducing agent with technetium-99m in an oxidized state. In a preferred embodiment, the antibody mixture further contains a water soluble ligand. A one vial kit for labeling a sulfhydryl containing antibody or antibody fragment with technetium-99m is also disclosed.Type: GrantFiled: March 7, 1991Date of Patent: July 15, 1997Assignee: Centocor, Inc.Inventors: Scott Buttram, Richard T. Dean, John Lister-James, Koon Yan Pak
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Patent number: 5645815Abstract: This invention relates to radiolabeled scintigraphic imaging agents, and methods and reagents for producing such agents. Specifically, the invention relates to specific binding compounds, including peptides, that bind to a platelet receptor that is the platelet GPIIb/IIIa receptor, methods and kits for making such compounds, and methods for using such compounds labeled with technetium-99m via a covalently-linked radiolabel-binding moiety to image thrombi in a mammalian body.Type: GrantFiled: May 12, 1995Date of Patent: July 8, 1997Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James, Edgar R. Civitello
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Patent number: 5508020Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via Tc-99m binding moieties. In particular, the peptide reagents of the invention are covalently linked to a polyvalent linker moiety, so that the polyvalent linker moiety is covalently linked to a multiplicity of the specific-binding peptides, and the Tc-99m binding moieties are covalently linked to a plurality of the specific-binding peptides, the polyvalent linker moiety, or to both the specific-binding peptides and the polyvalent linker moiety.Type: GrantFiled: June 5, 1992Date of Patent: April 16, 1996Assignee: Diatech, Inc.Inventors: Richard T. Dean, John Lister-James
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Patent number: 5405597Abstract: The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention specifically provides somatostatin, somatostatin derivatives, somatostatin analogues or peptides that bind to the somatostatin receptor and contain at least 2 cysteine residues that form a disulfide or wherein the disulfide is reduced to the sulfhydryl form that are labeled with technetium-99m and that can be targeted to specific sites within a mammalian body for imaging.Type: GrantFiled: November 17, 1992Date of Patent: April 11, 1995Assignee: Diatech, Inc.Inventors: Richard T. Dean, John Lister-James, Scott Buttram
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Patent number: 5225180Abstract: The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention specifically provides somatostatin, somatostatin derivatives, somatostatin analogues or peptides that bind to the somatostatin receptor and contain at least 2 cysteine residues that form a disulfide or wherein the disulfide is reduced to the sulfhydryl form that are directly labeled with technetium-99m and that can be targeted to specific sites within a mammalian body for imaging.Type: GrantFiled: September 10, 1991Date of Patent: July 6, 1993Assignee: Diatech, Inc.Inventors: Richard T. Dean, John Lister-James, Scott Buttram