Patents by Inventor John Lister-James

John Lister-James has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cross-linking protein compositions having two or more identical binding sites
    Patent number: 5185433
    Abstract: The present invention provides cross-linked protein compositions consisting of two or more units of a target-specific protein joined by binding sulfhydryl groups on the target-specific protein units to a sulfhydryl-selective cross-linking agent and a method of making the compositions. These cross-linked protein compositions combine an increase in binding affinity due to the presence of multiple identical binding sites and stability to reduction conditions.
    Type: Grant
    Filed: April 9, 1990
    Date of Patent: February 9, 1993
    Assignee: Centocor, Inc.
    Inventors: Richard T. Dean, John Lister-James, Raymond H. Boutin
  • Proteins modified with positively charged carriers and compositions prepared therefrom
    Patent number: 5162505
    Abstract: Protein conjugates comprising a protein covalently linked to at least one positively charged agent, so that the protein conjugate has an overall net positive charge in aqueous conditions at physiological pH are disclosed. The positively charged agents comprise polymers of three or more subunits selected from the group consisting of amino acids containing positively charged side chains and alkylamines. These protein conjugates have decreased blood clearance rates compared to conjugates which do not have the positively charged agents. The protein conjugates may further comprise diagnostic or therapeutic radionuclides bound to the protein or the positively charged agent through bifunctional coupling agents.
    Type: Grant
    Filed: September 19, 1989
    Date of Patent: November 10, 1992
    Assignee: Centocor
    Inventors: Richard T. Dean, Raymond H. Boutin, John Lister-James
  • Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands
    Patent number: 4746505
    Abstract: A bisamide-bisthiol ligand containing fatty acid substituted thiol useful for producing Tc-labelled radiodiagnostic imaging agents is described. The ligand forms a complex with the radionuclide .sup.99m Tc suitable for administration as a radiopharmaceutical to obtain images of the heart for diagnosis of myocardial disfunction.
    Type: Grant
    Filed: April 26, 1985
    Date of Patent: May 24, 1988
    Assignees: President and Fellows of Harvard College, Children's Medical Center Corp., Massachusetts Institute of Technology
    Inventors: Alun G. Jones, John Lister-James, Alan Davison
  • Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
    Patent number: 4673562
    Abstract: A radiodiagnostic bisamido-bisthio ligand useful for producing Tc-labelled radiodiagnostic renal agents is described. The ligand forms a complex with the radionuclide .sup.99m Tc suitable for administration as a radiopharmaceutical to obtain images of the kidney for diagnosis of kidney disfunction.
    Type: Grant
    Filed: August 19, 1983
    Date of Patent: June 16, 1987
    Assignees: The Children's Medical Center Corporation, Massachusetts Institute of Technology
    Inventors: Alan Davison, David Brenner, John Lister-James, Alun G. Jones