Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

Abstract: A method includes obtaining an under-display camera (UDC) image captured using a camera located under a display. The method also includes processing, using at least one processing device of an electronic device, the UDC image based on a machine learning model to restore the UDC image. The method further includes displaying or storing the restored image corresponding to the UDC image. The machine learning model is trained using (i) a ground truth image and (ii) a synthetic image generated using the ground truth image and a point spread function that is based on an optical transmission model of the display.

Abstract: A method includes identifying, using at least one processing device of an electronic device, a spatially-variant point spread function associated with an under-display camera. The spatially-variant point spread function is based on an optical transmission model and a layout of a display associated with the under-display camera. The method also includes generating, using the at least one processing device, a ground truth image. The method further includes performing, using the at least one processing device, a convolution of the ground truth image based on the spatially-variant point spread function in order to generate a synthetic sensor image. The synthetic sensor image represents a simulated image captured by the under-display camera. In addition, the method includes providing, using the at least one processing device, the synthetic sensor image and the ground truth image as an image pair to train a machine learning model to perform under-display camera point spread function inversion.

Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: Dynamic campaign optimization systems and methods may be used to continuously test many alternative campaign configurations while allowing all configurations, including configurations formerly identified as successful and unsuccessful, to be re-tested in order to identify successful configurations that may previously have been identified as unsuccessful.

Abstract: An inverted exercise cycling assembly allows a user to exercise their lower body while lying with a back to a ground surface. The assembly includes a support assembly configured for positioning upon a ground surface. A post is coupled to the support assembly. A cycling frame is coupled to the post. A flywheel is rotatably coupled to the cycling frame. A pair of pedals is coupled to the cycling frame and mechanically coupled to the flywheel such that rotation of the pedals rotates the flywheel. A rear axle is coupled to the cycling frame and extends between the pedals. The rear axle is operationally coupled to the pedals wherein the pedals urge the rear axle to rotate. A front axle is coupled to the cycling frame and extends through the flywheel. The front axle is operationally coupled to the pedals wherein the pedals urge the front axle to rotate.

Abstract: A system includes a computer and an attached database. The database stores inflation, unemployment, budget deficit, and gross domestic product (GDP) data for a variety of time periods for at least one country. The computer determines standard deviations, over a first time period, of an unemployment rate, a ratio of budget deficit to GDP, a GDP rate, and absolute value of an inflation rate. The computer also determines weights for each of the unemployment rate, the ratio of budget deficit to GDP, the GDP rate, and the absolute value of the inflation rate according to the ratio of the average of the standard deviations to the unemployment rate, the ratio of budget deficit to GDP, the GDP rate, and the absolute value of the inflation rate. The computer determines an economic health score for at least a second time period, the second time period being shorter than the first time period.

Abstract: An STOL aircraft structure has a variable-attitude, variable-area wing in addition to a traditional airfoil. The variable wing has an angle of attack that varies from 0° to a predetermined angle far in excess of the stall angle. The variable wing area can be adjusted from 0% to 100% by a roller furling arrangement. The aircraft structure operates during takeoff by deploying the variable wing with an attitude exceeding the stall angle, applying thrust to the aircraft so that the variable wing generates reaction lift and the aircraft attains a predetermined altitude, and stowing the variable wing so that the traditional airfoil is the primary lifting surface. Those steps are reversed for landing.

Abstract: A digitizing tablet (190) for use in handwriting analysis is described. The tablet includes a digitizing layer (1920) translating pressure from a stylus (1930) into digital information, a display layer (1910) for providing visible output that corresponds to a student's use of the stylus (1930) on the tablet, and an overlay layer (1900) for protecting the display layer (1910) and providing an electro-mechanical mechanism for erasing the displayed contents.

Abstract: An STOL aircraft structure has a variable-attitude, variable-area wing in addition to a traditional airfoil. The variable wing has an angle of attack that varies from 0° to a predetermined angle far in excess of the stall angle. The variable wing area can be adjusted from 0% to 100% by a roller furling arrangement. The aircraft structure operates during takeoff by deploying the variable wing with an attitude exceeding the stall angle, applying thrust to the aircraft so that the variable wing generates reaction lift and the aircraft attains a predetermined altitude, and stowing the variable wing so that the traditional airfoil is the primary lifting surface. Those steps are reversed for landing.

Abstract: An STOL aircraft structure has a variable-attitude, variable-area wing in addition to a traditional airfoil. The variable wing has an angle of attack that varies from 0° to a predetermined angle far in excess of the stall angle. The variable wing area can be adjusted from 0% to 100% by a roller furling arrangement. The aircraft structure operates during takeoff by deploying the variable wing with an attitude exceeding the stall angle, applying thrust to the aircraft so that the variable wing generates reaction lift and the aircraft attains a predetermined altitude, and stowing the variable wing so that the traditional airfoil is the primary lifting surface. Those steps are reversed for landing.

Abstract: A digitizing tablet (190) for use in handwriting analysis is described. The tablet includes a digitizing layer (1920) for translating pressure from a stylus (1930) into digital information, a display layer (1910) for providing visible output that corresponds to a student's use of the stylus (1930) on the tablet, and an overlay layer (1900) for protecting the display layer (1910) and providing an electro-mechanical mechanism for erasing the displayed contents.

Abstract: An apparatus for generating video signals from a photographic image previously recorded on film (a cine-video system) which includes a film transport mechanism for advancing or rewinding the film in order to position a film frame at a film gate for projection, an image projector which detects when a film frame is positioned at the film gate and projects an illuminated image of that frame, a video pickup system which receives the image and generates a video signal which represents it, and an output circuit which produces a resultant output video signal. A window generating capability provides for optional enhancement of the video signal within a user-selectable range of video signal values. One or more cursors may be superimposed on the video image, and measurements to determine the distance between two such cursors may be performed.

Abstract: A process for forming T-shaped metal contacts on a dielectric substrate. The process includes deposition of first and second photoresist layers onto a substrate; individually overall electron beam exposure of both layers; with subsequent imagewise UV exposure and development of both layers to form hollow cavities in the layers. By concentrating the electron beam radiation on the mid-point in the thickness of each photoresist layer, the radiation is distributed throughout each layer, resulting in solubility properties which lead to the formation of hollow cavities of a certain desired shape. In one embodiment of the invention, three-dimensional structures are formed in the photoresist layers by filling the hollow cavities with metal. Subsequent removal of unwanted portions of the photoresist layers produces a dielectric substrate having T-shaped metal contacts on its surface.

Abstract: An educational method and system for executing the method, to improve the efficiency of individual learning by monitoring the student's progress and pacing the course material to the student's ability to comprehend and learn. This method and system also reduces the teachers's administrative and paperwork burden. Interactive multimedia technology is combined with unique courseware development to provide a flexible teaching tool and student monitoring system.

Abstract: An educational method and system for executing the method, to improve the efficiency of individual learning by monitoring the student's progress and pacing the course material to the student's ability to comprehend and learn. This method and system also reduces the teachers's administrative and paperwork burden. Interactive multimedia technology is combined with unique courseware development to provide a flexible teaching tool and student monitoring system.

Abstract: Film transport apparatus for a cine-video system in which video signals are produced from film that is driven between supply and take-up reels. The film, which may be wound in A or B configuration on each reel, is threaded automatically about a film drive mechanism which transports the film from the supply reel, through a film gate to the take-up reel. Tensioning apparatus imparts tension to the film at the entry and exit of the film gate which, during the threading operation, causes the respective reels to rotate before film actually is transported therebetween. The direction in which each reel rotates to unwind film therefrom when tension is imparted serves to identify whether the film is wound in A or B configuration. Advantageously, a programmable processor controls the film transport speed in response to a user-actuated knob; and this same processor serves to detect when the film approaches its end on the supply or take-up reel.

Abstract: Apparatus for selectively generating video signals representing photographic images previously recorded in a film on a photographic film-type medium includes an image pickup device which produces video signals in response to a light image of the projected photographic image, a window generating device which generates a window having a range of video signal values in response to a user input, a processor which suppresses the produced video signals having values outside the generated window, and an enhancer which enhances the produced video signals having values within the generated window.

Abstract: Film transport apparatus for a cine-video system in which video signals are produced from film that is driven between supply and take-up reels. The film, which may be wound in A or B configuration on each reel, is threaded automatically about a film drive mechanism which transports the film from the supply reel, through a film gate to the take-up reel. Tensioning apparatus imparts tension to the film at the entry and exit of the film gate which, during the threading operation, causes the respective reels to rotate before film actually is transported therebetween. The direction in which each reel rotates to unwind film therefrom when tension is imparted serves to identify whether the film is wound in A or B configuration. Advantageously, a programmable processor controls the film transport speed in response to a user-actuated knob; and this same processor serves to detect when the film approaches its end on the supply or take-up reel.