Abstract: The present disclosure relates to amino acid sequences that are directed against (as defined herein) any of IL-17A, IL-17F and/or IL-17A/F including combinations thereof, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.

Abstract: Described herein is a coupling device, associated parts and a method of use thereof. In one aspect, a coupling device is described comprising a sleeve with an inner surface that encloses at least part of at least one elongated element to be coupled; and at least one deformation means fitted with interference between, and causing local deformation about, at least part of the inner surface of the sleeve and/or an adjacent outer surface of the at least one elongated element. A deformation means insertion tool, a coupling sleeve, a deformation means, and a method of coupling at least one element are also described. The described coupling device, associated parts and a method of use offer the ability to couple together different elements in a strong and/or ductile manner, coupling being tuneable as needed to suit the preferred application. The coupling described may overcome art issues associated with bulky size of coupling, in particular, radial protrusion.

Abstract: A system in a water body uses buoyant force of gaseous Hydrogen and Oxygen to generate electrical power with one or more turbines that includes power resulting from the buoyant force while transporting the Hydrogen or Oxygen to a higher elevation, without loss of electrons, for conversion to electricity at the higher elevation. Conversion of Hydrogen and Oxygen to water through a Hydrogen Fuel Cell or by burning at the higher elevation may generate additional steam power, hydropower, or purified water. Portable submersible modules may transport the system below or above the water to and from the base of a plumbing portion of the system. The amount of gaseous fuel energy available at the higher elevation is not detrimentally impacted by the generation of electricity by the turbine.

Abstract: A method for automatic systems devices rediscovery includes creating a hardware map of hardware components of a computing system at a time when each of the hardware components of the computing system is discoverable. The method includes determining discoverability of each hardware component in the hardware map at a point in time after creation of the hardware map, and in response to determining that a hardware component listed in the hardware map is not discoverable, initiating a reset of the hardware component.

Abstract: A turbine with an associated shaftless electric generator is disclosed. The generator includes a rotor and a stator; a mounting plate rotatable with the rotor and a void along a central axis of the rotor. A plurality of blades extend from the mounting plate. Adjustable bearings are interposed between the rotor and the stator, the adjustable bearings being configured to support the mounting plate and the plurality of blades. A threaded adjustor rod located in the void may be manipulated to adjust tension on the adjustable bearings.

Abstract: A system for modeling the evolution of a system over time using an advection-based process is provided. The system continuously evolves a probability density function (“PDF”) for a characteristic of a characteristic of the state of the system and its time-varying parameters. The PDF is evolved based on advection by solving an advection partial differential equation that is based on a system model of the system. The system model has time-varying parameters for modeling the characteristic of the state of the system. The system uses the continuously evolving PDF to make predictions about the characteristic of the state of the system.

Abstract: The present invention relates to antibodies and antigen binding fragments thereof which bind to the human CD70 protein with high affinity and display potent inhibition of tumour cell growth.

Abstract: Substituted N-phenylacetamide compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases.

Abstract: Described herein is a coupling device, associated parts and a method of use thereof. In one aspect, a coupling device is described comprising a sleeve with an inner surface that encloses at least part of at least one elongated element to be coupled; and at least one deformation means fitted with interference between, and causing local deformation about, at least part of the inner surface of the sleeve and/or an adjacent outer surface of the at least one elongated element. A deformation means insertion tool, a coupling sleeve, a deformation means, and a method of coupling at least one element are also described. The described coupling device, associated parts and a method of use offer the ability to couple together different elements in a strong and/or ductile manner, coupling being tuneable as needed to suit the preferred application. The coupling described may overcome art issues associated with bulky size of coupling, in particular, radial protrusion.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed for valve lever apparatus for use with fluid valves. An example apparatus includes a valve stem for a fluid valve, a pin removably coupled to an end of the valve stem to receive a valve lever to manually actuate the fluid valve, and a damping material to provide a damping effect between the valve stem and the valve lever.

Abstract: An authentication method and system for authenticating and registering a product which employs an authentication label and a registration label. An authentication label may provide an authentication code for determining a product identification at a remote server. A registration label may provide a registration code for verifying the product registration and/or registering the product. The authentication label and the registration label may be provided as a layered security element, the authentication label being a top layer and the registration label being a bottom layer of the layered security element.

Abstract: Pharmaceutical ophthalmic compositions are described, the compositions consisting essentially of a therapeutically effective quantity of an anti-bacterial agent (such as moxifloxacin), a therapeutically effective quantity of an anti-inflammatory agent (such as prednisolone), a combination of at least two solubilizing and suspending agents (of which one is a non-ionic polyoxyethlene-polyoxypropylene block copolymer), and a carrier. Methods for fabricating the compositions and using them are also described.

Abstract: A dispensing closure system includes an upper closure portion and a lower closure portion including an axial flow conduit and a vent conduit. The upper closure portion is axially movable relative to lower closure portion between shipping and dispensing positions. A seal is disposed on the lower closure portion over the flow and vent conduits. A peripheral spacing strip is removably secured to the upper closure portion and engages with either the lower closure or the outside of the container to prevent movement. A piercing probe includes piercing elements in alignment with the flow and vent conduits for piercing the seal. In the shipping position, the piercing elements are spaced from the seal. However, when the spacing strip is removed and the upper closure portion is axially moved to the dispensing position, the piercing elements pierce the seal to open the flow conduit and the vent conduit.

Abstract: A key fob for controlling operation of a motor vehicle includes a pushbutton that responds to being pushed by causing a signal to be transmitted to the motor vehicle. The signal requests that the motor vehicle perform a predetermined operation. The key fob includes a microphone detecting audible speech from a user and transmitting a signal based on the detected speech to an automatic speech recognition system such that the automatic speech recognition system can recognize in the signal a request that the motor vehicle perform the predetermined operation.

Abstract: A dynamically controlled cooling device for targeted cooling of a moving or stationary user includes a fan, which is rotationally mounted to a base, and a targeting device, which is in possession of the user. A first actuator is attached to the base and is operationally engaged to the fan to selectively rotate the fan. A control module is operationally engaged to the first actuator and the fan. The control module comprises a first receiver, which is Global Positioning System (GPS) enabled, and a second receiver. The targeting device comprises a third receiver, which is GPS enabled, and a transmitter. The first receiver and the third receiver receive coordinates of the fan and the user, respectively. The transmitter relays the coordinates of the user to the control module, whereupon the control module to actuates the fan and the first actuator to direct a stream of air onto the user.

Abstract: A surgical stapling instrument includes an anvil defining a plurality of staple forming pockets and a stapling head assembly configured to drive a plurality of staples against the staple forming pockets of the anvil. The stapling head assembly comprises a coupling member configured to actuate the anvil relative to the stapling head assembly, a firing assembly configured to drive the plurality of staples against the staple forming pockets of the anvil, and a deck member. The deck member includes a deck surface extending radially between an inner circular edge and an outer circular edge, and a plurality of staple openings extending through the deck surface. The plurality of staple openings define at least one cross shape.

Abstract: Water outlet fitting, e.g. tap or shower head, producing a combined flow of gas and water, and power connector therefor An apparatus produces bubbles of pure water from a flow emitter (11) comprising an annular water outlet (13) surrounding a gas outlet (12) and operating within a defined parameter space. One or more flow emitters may be incorporated into an emitter body (10) configured as a shower head or a tap. In another aspect, an apparatus produces bubbles of water from coaxial, gas and annular water flowpaths. In another aspect, a magnetic power connector is arranged to supply electrical energy to a shower head.

Abstract: Methods, systems and devices that allow independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods, systems and devices are particularly suitable for use with a mass spectrometer.

Abstract: An authentication system includes an authentication module and a user history database storing order information that includes, for each of multiple logins of the first user to a web property, at least one of: an indication of an order of hypertext transfer protocol (HTTP) headers that were previously received at the authentication module during the login, and an indication of an order of navigator object properties that were previously returned to the authentication module during the login. The authentication module is configured to: receive, from a web browser of a first entity attempting to log in to the web property, credentials of the first user; determine order information of the first entity's web browser; perform a comparison operation based on the order information of the first user and that of the first entity, and determine whether to allow the first entity to log in based on the comparison operation.

Abstract: A computer system includes memory storing computer-executable instructions and a processor configured to execute the computer-executable instructions. The computer-executable instructions include building a questions table including multiple first questions and multiple potential requirements to which the first questions correspond, respectively. The computer-executable instructions include adding, to the questions table, one or more second questions, each of which correspond to at least two requirements from among the potential requirements. The computer-executable instructions include adding, to the questions table, for each second question among the one or more second questions, the at least two requirements to which the second question corresponds. The computer-executable instructions include determining a question, from among the first questions and the second questions, that corresponds to a highest number of potential requirements, and displaying the determined question to a user.