Abstract: A seal arrangement includes a body having a face seal, and a flexible arm extending from the body. The arm includes a contact seal. A flapper valve, includes a housing, a flapper and a flapper seat. The flapper seat includes a body having a face seal positioned to make sealing contact with the flapper in selected flapper positions A method for sealing a flapper valve includes closing a flapper toward a seat and making a seal, by deflecting a flexible arm of the flapper seat that supports a contact seal. A borehole system including a borehole in a subsurface formation, a string in the borehole, and a seal arrangement disposed within or as a part of the string.

Abstract: Provided herein are methods for increasing bone mineral density, treating osteoporosis and the like, that include administration of abaloparatide in combination with denosumab.

Abstract: An industrial safety zone configuration system leverages a digital twin of an industrial automation system to assist in configuring safety sensors for accurate monitoring of a desired detection zone. The system renders a graphical representation of the automation system based on the digital twin and allows a user to define a desired detection zone to be monitored as a three-dimensional volume within the virtual industrial environment. Users can define the locations and orientations of respective safety sensors as sensor objects that can be added to the graphical representation. Each sensor object has a set of object attributes representing configuration settings available on the corresponding physical sensor. The system can identify sensor configuration settings that will yield an estimated detection zone that closely conforms to the defined detection zone, and generate sensor configuration data based on these settings that can be used to configure the physical safety sensors.

Abstract: A system for determining access for a hypercube includes an interface configured to receive a request for access from a user to data in a location in a hypercube; receive a tree structure with subcubes of the hypercube arranged in a hierarchical structure; and receive a user permission list, wherein an element of the user permission list comprises a permission, a root node, and a set of pruned nodes. The system also includes a processor configured to determine a user permission associated with the data in the location of the hypercube using the user permission list; and provide an indication of the user permission.

Abstract: An industrial safety zone configuration system leverages a digital twin of an industrial automation system to assist in configuring safety sensors for accurate monitoring of a desired detection zone. The system renders a graphical representation of the automation system based on the digital twin and allows a user to define a desired detection zone to be monitored as a three-dimensional volume within the virtual industrial environment. Users can define the locations and orientations of respective safety sensors as sensor objects that can be added to the graphical representation. Each sensor object has a set of object attributes representing configuration settings available on the corresponding physical sensor. The system can identify sensor configuration settings that will yield an estimated detection zone that closely conforms to the defined detection zone, and generate sensor configuration data based on these settings that can be used to configure the physical safety sensors.

Abstract: A display cover can include a rectangular body having opposing outer and inner surfaces and an edge that connects the outer and inner surfaces. A central region, widthwise edge regions, and lengthwise edge regions can each define a portion of the outer and inner surfaces, and the edge regions each can extend from the central region to define a portion of the edge. The central region can be planar such that a plane lies between the outer and inner surfaces throughout the central region. Each of the widthwise edge regions can curve away from the central region such that a line that is tangent to the outer surface at the edge region is substantially perpendicular to the plane of the central region. The body's average thickness can be less than or equal to 0.5 mm, and the body can comprise at least a majority, by weight, of a polymeric material.

Abstract: An industrial safety zone configuration system leverages a digital twin of an industrial automation system to assist in configuring safety sensors for accurate monitoring of a desired detection zone. The system renders a graphical representation of the automation system based on the digital twin and allows a user to define a desired detection zone to be monitored as a three-dimensional volume within the virtual industrial environment. Users can define the locations and orientations of respective safety sensors as sensor objects that can be added to the graphical representation. Each sensor object has a set of object attributes representing configuration settings available on the corresponding physical sensor. The system can identify sensor configuration settings that will yield an estimated detection zone that closely conforms to the defined detection zone, and generate sensor configuration data based on these settings that can be used to configure the physical safety sensors.

Abstract: This invention provides compositions and methods for restoring proper folding and function of Cystic Fibrosis Transmembrane Conductance Regulator mutant with in-flame-deletion of phenylalanine 508 (AF508 CFTR). The invention also provides methods for identifying novel agents capable of restoring proper folding and function of ?P508 CFTR. The invention additionally provides methods for treating cystic fibrosis.

Abstract: An approach for providing compression of a database table that uses a compiled table algorithm (CTA) that provides leverage. Data within any given column in adjacent rows is often the same as or closely related to its neighbors. Rather than storing data in each column of each row as a specific integer, floating point, or character data value, a field reconstruction instruction is stored that when executed by a decompression engine can reconstruct the data value. The field reconstruction instruction may be bit granular and may depend upon past history given that the data compression engine may preserve state as row data is streamed off a storage device.

Abstract: A barrier has an expandable width barrier having opposing first and second ends. A locking arm is pivotably coupled to the expandable width barrier at the first end and slidably coupled to the expandable width barrier at the second end. The locking arm may be an adjustable-length construction. The pivoting of the locking arm causes the barrier to move between locked and unlocked states. When the locking arm is pivoted to lock the barrier, it causes the barrier to linearly expand a supplemental amount and fits the barrier to opposing sides of a passageway opening.

Abstract: A gate has an expandable barrier and a horizontal rail located at a top of the barrier. A post may be coupled to the barrier and may have a portion extending above the horizontal rail. A lock is movably coupled to the post above the rail to provide for the locking and unlocking of the gate.

Abstract: A barrier has an expandable width barrier having opposing first and second ends. A locking arm is pivotably coupled to the expandable width barrier at the first end and slidably coupled to the expandable width barrier at the second end. The locking arm may be an adjustable-length construction. The pivoting of the locking arm causes the barrier to move between locked and unlocked states. When the locking arm is pivoted to lock the barrier, it causes the barrier to linearly expand a supplemental amount and fits the barrier to opposing sides of a passageway opening.

Abstract: The invention relates to C9orf46 homolog, a novel murine membrane protein, and its orthologs in human, mouse and all other species, termed Plg-RKT, or analogs, thereof and the isolation method. The function of this molecule is to bind to plasminogen, plasminogen fragments such as angiostatin1 and other plasminongen fragments having angiostatic activity, tissue plasminogen activator and Lipoprotein(a). Plasminogen receptors function to modulate cell surface proteolysis and physiological and pathophysiological processes requiring cell migration, including, but not limited to, cell migration during inflammation, tissue remodeling, wound healing, tumor cell invasion and metastasis, skeletal myogenesis, neurite outgrowth. Plasminogen receptors also modulate apoptosis and cell death.

Abstract: The present invention describes a formulation comprising: (A) at least one surfactant; and (B) an anti-microbial composition that comprises (i) an anti-microbial agent with surfactant properties; (ii) a hydrophobic material and (iii) a polar solvent.

Abstract: A barrier has an expandable width barrier having opposing first and second ends. A locking arm is pivotably coupled to the expandable width barrier at the first end and slidably coupled to the expandable width barrier at the second end. The locking arm may be an adjustable-length construction. The pivoting of the locking arm causes the barrier to move between locked and unlocked states. When the locking arm is pivoted to lock the barrier, it causes the barrier to linearly expand a supplemental amount and fits the barrier to opposing sides of a passageway opening.

Abstract: A thermoplastic composition is prepared by melt blending a poly(arylene ether) and an other resin, where the poly(arylene ether) has a particular molecular weight distribution. The thermoplastic composition exhibits significantly increased melt flow compared to compositions containing poly(arylene ether)s with similar intrinsic viscosities but different molecular weight distributions. The increased melt flow facilitates preparation of the thermoplastic composition and subsequent article fabrication procedures.

Abstract: The invention relates to C9orf46 homolog, a novel murine membrane protein, and its orthologs in human, mouse and all other species, termed Plg-RKT, or analogs, thereof and the isolation method. The function of this molecule is to bind to plasminogen, plasminogen fragments such as angiostatin 1 and other plasminongen fragments having angiostatic activity, tissue plasminogen activator and Lipoprotein(a). Plasminogen receptors function to modulate cell surface proteolysis and physiological and pathophysiological processes requiring cell migration, including, but not limited to, cell migration during inflammation, tissue remodeling, wound healing, tumor cell invasion and metastasis, skeletal myogenesis, neurite outgrowth. Plasminogen receptors also modulate apoptosis and cell death.

Abstract: The invention relates to C9orf46 homolog, a novel murine membrane protein, and its orthologs in human, mouse and all other species, termed Plg-RKT, or analogs, thereof and the isolation method. The function of this molecule is to bind to plasminogen, plasminogen fragments such as angiostatin1 and other plasminongen fragments having angiostatic activity, tissue plasminogen activator and Lipoprotein(a). Plasminogen receptors function to modulate cell surface proteolysis and physiological and pathophysiological processes requiring cell migration, including, but not limited to, cell migration during inflammation, tissue remodeling, wound healing, tumor cell invasion and metastasis, skeletal myogenesis, neurite outgrowth. Plasminogen receptors also modulate apoptosis and cell death.

Abstract: A gate has an expandable barrier and a horizontal rail located at a top of the barrier. A post may be coupled to the barrier and may have a portion extending above the horizontal rail. A lock is movably coupled to the post above the rail to provide for the locking and unlocking of the gate.

Abstract: A barrier has an expandable width barrier having opposing first and second ends. A locking arm is pivotably coupled to the expandable width barrier at the first end and slidably coupled to the expandable width barrier at the second end. The locking arm may be an adjustable-length construction. The pivoting of the locking arm causes the barrier to move between locked and unlocked states. When the locking arm is pivoted to lock the barrier, it causes the barrier to linearly expand a supplemental amount and fits the barrier to opposing sides of a passageway opening.