Abstract: A solid pharmaceutical composition is provided that includes a core, an inner coating, and an outer coating. The core includes tiopronin as an active agent. Further, the inner coating, which includes a cellulose-based polymer, surrounds the core, and the outer coating, which includes an enteric polymer, surrounds the inner coating. As a result of the specific components of the solid pharmaceutical composition, the solid pharmaceutical composition exhibits a fed state Cmax of tiopronin that is at least 70% of a 12-hour fasted state Cmax of tiopronin after oral administration of the solid pharmaceutical composition when administered as a 300 milligram dose. As such, it is possible for the solid pharmaceutical composition to be administered orally with or without food (e.g., in a fed or fasted state) while still achieving a desired maximum plasma concentration of the tiopronin in a delayed release formulation.

Abstract: The present disclosure is directed to a medical instrument. The medical instrument may include a delivery device and a retraction mechanism including a target tissue anchor and a first stabilizing anchor, wherein the target tissue anchor attaches to target tissue and connects to the delivery device.

Abstract: A system for detecting contamination in a two-phase immersion cooling system based on current leakage between two combs on a printed circuit board. A first comb is opposite a second comb, wherein each finger of the first comb is positioned between two adjacent fingers on the second comb. The combs are positioned near a heat source in the liquid portion of the fluid. As the fluid boils, contaminants are distilled out of the fluid. Acidic contaminants deposited on either comb may cause metal migration to occur, resulting in bridging between two combs. A current sensor may detect the current leakage and send a signal to allow the information handling system, the fluid, or the cooling system to be serviced before damage occurs to the information handling system.

Abstract: A system for detecting residue in a two-phase immersion cooling system based on contact resistance. A structure is formed to represent a type of connection between a component and a connector. The structure is positioned near a heat source in the two phase fluid in its liquid state. As the fluid boils, residues are deposited on the structure. An increase in the current resistance across the structure may indicate the presence of a residue or corrosion caused by the residue. Structures may be formed using materials that are similar to existing connections in the information handling system. A heating element may generate more heat than existing components such that the system detects the presence of contaminants with sufficient time to allow less expensive and less intensive corrective measures.

Abstract: A two-phase cooling apparatus for an information handling system, including a container holding dielectric fluid, the dielectric fluid having a vapor-fluid boundary within the container, the container further containing a printed circuit board (PCB) including computing components, with the dielectric fluid surrounding the PCB and the computing components, the dielectric fluid decreasing a temperature of the PCB by removing heat from the PCB in the form of vaporization; a pump positioned within the container, the pump capturing a portion of vapor of the dielectric fluid, at the vapor-fluid boundary, that results from the vaporization of the dielectric fluid; and a diffuser positioned within the container and coupled to the pump to introduce the captured vapor into the dielectric fluid.

Abstract: A system for detecting contamination in a two-phase immersion cooling system based on current leakage between two combs on a printed circuit board. A first comb is opposite a second comb, wherein each finger of the first comb is positioned between two adjacent fingers on the second comb. The combs are positioned near a heat source in the liquid portion of the fluid. As the fluid boils, contaminants are distilled out of the fluid. Acidic contaminants deposited on either comb may cause metal migration to occur, resulting in bridging between two combs. A current sensor may detect the current leakage and send a signal to allow the information handling system, the fluid, or the cooling system to be serviced before damage occurs to the information handling system.

Abstract: A system for detecting residue in a two-phase immersion cooling system based on changes in the intensity of energy reflected off a reflective surface. An energy source is positioned at an incident angle relative to a reflective surface and an intensity sensor is positioned at a target reflected energy angle relative to the reflective surface, wherein the intensity sensor detects light or other energy reflected off the reflective surface. If residues are deposited on the reflective surface, the reflectivity of the residue will change the reflected energy angle or otherwise change the amount of energy reflected toward the sensor. A heating element may generate more heat than existing components such that the system detects the presence of residues with sufficient time to allow less expensive and less intensive corrective measures.

Abstract: A system for detecting residue in a two-phase immersion cooling system based on contact resistance. A structure is formed to represent a type of connection between a component and a connector. The structure is positioned near a heat source in the two phase fluid in its liquid state. As the fluid boils, residues are deposited on the structure. An increase in the current resistance across the structure may indicate the presence of a residue or corrosion caused by the residue. Structures may be formed using materials that are similar to existing connections in the information handling system. A heating element may generate more heat than existing components such that the system detects the presence of contaminants with sufficient time to allow less expensive and less intensive corrective measures.

Abstract: Provided herein are systems and methods of collecting a biological sample. Samples may be collected using a sample collection apparatus. The sample collection apparatus may be used to store samples for shipping. The sample collection apparatus may be used to store samples for later analysis. The sample collection apparatus may comprise a membrane having one or more test regions for detecting one or more target analytes within the sample. The sample collection apparatus may comprise a membrane having one or more test regions for quantifying one or more target analytes within the sample.

Abstract: A system for detecting residue in a two-phase immersion cooling system based on changes in the intensity of energy reflected off a reflective surface. An energy source is positioned at an incident angle relative to a reflective surface and an intensity sensor is positioned at a target reflected energy angle relative to the reflective surface, wherein the intensity sensor detects light or other energy reflected off the reflective surface. If residues are deposited on the reflective surface, the reflectivity of the residue will change the reflected energy angle or otherwise change the amount of energy reflected toward the sensor. A heating element may generate more heat than existing components such that the system detects the presence of residues with sufficient time to allow less expensive and less intensive corrective measures.

Abstract: A biosensor inserter is configured to insert a biosensor. The biosensor inserter includes a push member including a receiver, a contact member translatable relative to the push member, and a trocar holder having a sheath configured to receive a trocar assembly including a trocar therein. The trocar holder is configured to be insertable into, and removable from, the receiver. Thus, an amount of medical waste can be minimized by discarding only the removable trocar holder and trocar assembly after use. System and method embodiments are provided.

Abstract: A continuous analyte monitor wearable device. The wearable device includes a primary portion comprising at least a sensor assembly comprising a biosensor, and a secondary portion comprising a pocket configured to receive a transmitter unit and a sealable opening to the pocket, the sealable opening containing an adhesive on edges thereof; and a backing member provided over the adhesive wherein removing the backing member exposes the adhesive to seal the sealable opening and encapsulate the transmitter unit. Biosensor inserters and method of using the biosensor inserter are also provided.

Abstract: The present disclosure is directed to a medical instrument. The medical instrument may include a delivery device and a retraction mechanism including a target tissue anchor and a first stabilizing anchor, wherein the target tissue anchor attaches to target tissue and connects to the delivery device.

Abstract: A single-insertion, multiple sampling biopsy device for insertion into a host includes an outer cutting cannula that has an inner lumen, a cutting distal end, and a proximal sample receiving port. The device includes a stylet extending at least partially within the inner lumen of the outer cutting cannula and along a longitudinal axis of the outer cutting cannula. A sheath extends at least partially within the inner lumen of the outer cutting cannula. A stylet tip is attached to a stylet rail. Each of the sheath and the stylet rail extends along the longitudinal axis. The stylet tip extends in the distal direction beyond the distal end of the outer cutting cannula. A drive unit is configured to translate each of the cutting cannula, the sheath, and the stylet relative to the stylet tip in proximal and distal directions. The stylet rail remains stationary relative to the drive unit.

Abstract: A medical device en-vivo positional determination system using a plurality of ultrasonic transducers for the time-of-flight (TOF) determination of absolute linear and angular positional information of the tool bit tip for the purposes of more accurate hand-held drilling, cutting, etc. on the work piece using digital code modulation schemes and digital signal processing (DSP) to provide a real-time display of the 3-linear position and 2-angular orientation of the tool bit (drill, scalpel).

Abstract: A chassis includes a first computing component; a second computing component; and an air mover that generates an airflow in the chassis used to thermally manage the first computing component and the second computing component. The chassis also includes an airflow control component that modifies a first portion of the airflow proximate to the first computing component based on a corrosion rate of the first computing component without modifying a second portion of the airflow proximate to the second computing component.

Abstract: A computing device of an information handling system includes an environmental control component and a chassis environmental manager. The chassis environmental manager obtains a temperature of an environment proximate to a component of the information handling system; obtains a humidity level of the proximate environment; obtains, based on the temperature and the humidity level, a corrosion rate of the component; makes a determination that the corrosion rate indicates a premature failure of the component based on a service life of the component; and in response to the determination: obtains an environmental control modification that mitigates the premature failure; and updates an operation of the environmental control component based on the environmental control modification.

Abstract: An information handling system includes a computing device, the information handling system includes a computing component of the computing device that is housed in a chassis; and a heating component that increases a temperature of a portion of an airflow when the heating component is in an active state, the portion of the airflow thermally manages the computing component by reducing a temperature of the computing component. The airflow is received by the chassis via an air receiving exchange, and exhausted by the chassis via an air expelling exchange.

Abstract: An information handling system includes a computing component that is sensitive to corrosion; and a chassis in which the computing component is disposed. The chassis receives an airflow used to thermally manage the computing component, and expels the airflow after thermally managing the computing component. The information handling system also includes an environmental control component that reduces a condensation formation propensity of a portion of the airflow that traverses the chassis proximate to the computing component.

Abstract: An information handling system includes a computing device, a computing component of the computing device that is housed in a chassis, and a chilled air filter that reduces a humidity level of a portion of an airflow when the chilled air filter is in an active state. The portion of the airflow thermally manages the computing component. The airflow is received by the chassis via an air receiving exchange and exhausted by the chassis via an air expelling exchange.