Patents by Inventor Joseph A. Gross
Joseph A. Gross has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20030236498Abstract: A drug delivery device having a housing containing a gas generator controlled by an electronic controller. The gas generator generates gas into a reciprocable chamber, whereby reciprocation of the chamber causes a lever to reciprocate a pawl, and this action causes a ratchet to The device may also be provided with manually control for delivering a bolus dose of drug when necessary.Type: ApplicationFiled: June 13, 2003Publication date: December 25, 2003Inventors: Joseph Gross, Izrail Tsals, Gilad Lavi, Gil Yigal, Ehoud Carmel
-
Patent number: 6645181Abstract: The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.Type: GrantFiled: November 12, 1999Date of Patent: November 11, 2003Assignee: Elan Pharma International LimitedInventors: Gilad Lavi, Gil Yigal, Izrail Tsals, Joseph Gross
-
Patent number: 6641565Abstract: The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.Type: GrantFiled: November 12, 1999Date of Patent: November 4, 2003Assignee: Elan Pharma International LimitedInventors: Gilad Lavi, Gil Yigal, Izrail Tsals, Joseph Gross
-
Patent number: 6595956Abstract: A drug delivery device having a housing containing a gas generator controlled by an electronic controller. The gas generator generates gas into a reciprocate chamber, whereby reciprocation of the chamber causes a lever to reciprocate a pawl, and this action causes a ratchet to The device may also be provided with manually control for delivering a bolus dose of drug when necessary.Type: GrantFiled: March 23, 1999Date of Patent: July 22, 2003Inventors: Joseph Gross, Izrail Tsals, Gilad Lavi, Gil Yigal, Ehoud Carmel
-
Patent number: 6585707Abstract: A system adapted to be disposed between a rigid or semi-rigid device and human skin for reliably attaching the device to the skin for an extended period of time. The system includes a skin-contacting surface for adhering to human skin, and an opposed surface for attachment to a rigid or semi-rigid device. The system is attached along its opposed surface to a portion of the total area of the adjacent surface of the device. When the device is subjected to external stress, the stress is transmitted through the area of attachment and distributed to the unattached area. This minimises stress on the skin and reduces the chance of detachment from the skin.Type: GrantFiled: May 20, 1999Date of Patent: July 1, 2003Assignee: Elan Pharma International LimitedInventors: Oz Cabiri, David Katz, Mario Rozanowich, Haim Danon, Joseph Gross, Izrail Tsals, Craig Brodeur, Robert Etheredge
-
Publication number: 20030023203Abstract: The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.Type: ApplicationFiled: September 23, 2002Publication date: January 30, 2003Applicant: Elan Pharma International LimitedInventors: Gilad Lavi, Gil Ygal, Israil Tsals, Joseph Gross
-
Patent number: 6500150Abstract: A drug delivery device having a base member defining a skin-contacting surface, a syringe serving as a reservoir for the drug, and means for expelling drug from the syringe. The syringe is connected to the base member such that the longitudinal axis of the syringe is substantially parallel to the skin surface. A delivery needle is in communication with the syringe. The needle has an angled bend which directs the tip of the needle substantially perpendicular to the skin-contacting surface. In use, the tip of the needle is adapted to penetrate the skin of the subject.Type: GrantFiled: June 23, 1998Date of Patent: December 31, 2002Assignee: Elan Pharma International LimitedInventors: Joseph Gross, Gilad Lavi, Izrail Tsals
-
Patent number: 6478771Abstract: The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.Type: GrantFiled: November 12, 1999Date of Patent: November 12, 2002Assignee: Elan Pharma International LimitedInventors: Gilad Lavi, Gil Yigal, Izrail Tsals, Joseph Gross
-
Publication number: 20020123719Abstract: The present invention related to a drug delivery device for mixing and delivering a drug by injection. The devices includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example, a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.Type: ApplicationFiled: February 7, 2002Publication date: September 5, 2002Applicant: ELAN PHARMA INTERNATIONAL LIMITEDInventors: Gilad Lavi, Gil Ygal, Izrail Tsals, Joseph Gross
-
Patent number: 6364865Abstract: The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle s used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.Type: GrantFiled: November 12, 1999Date of Patent: April 2, 2002Assignee: Elan Pharma International LimitedInventors: Gilad Lavi, Gil Yigal, Izrail Tsals, Joseph Gross
-
Patent number: 6346095Abstract: A needle (10) for the delivery of a liquid to a subject comprises a shaft (11) having an internal surface defining a longitudinally extending internal bore open at one end (15) to receive a liquid supply, the other end (16) being sharpened for penetration of the skin of the subject. A plurality of apertures (18) are provided, each in the form of a cut extending across the external surface of the side of the shaft (11) at a sufficient depth to establish communication with the bore. The external aperture area is approximately three times greater than the internal aperture area, thereby ensuring that the liquid is delivered to a large surface area of tissue to improve absorption and eliminate fluctuations in the delivery rate. The needle (10) can be mass-produced by aligning a batch of shafts alongside one another and running a grinder across the surfaces of the shafts to create the apertures (18) in the entire batch of needles simultaneously.Type: GrantFiled: February 6, 2001Date of Patent: February 12, 2002Assignee: Elan Corporation, plcInventors: Joseph Gross, Haim Danon
-
Publication number: 20020010423Abstract: A drug delivery device having a base member defining a skin-contacting surface, a syringe serving as a reservoir for the drug, and means for expelling drug from the syringe. The syringe is connected to the base member such that the longitudinal axis of the syringe is substantially parallel to the skin surface. A delivery needle is in communication with the syringe. The needle has an angled bend which directs the tip of the needle substantially perpendicular to the skin-contacting surface. In use, the tip of the needle is adapted to penetrate the skin of the subject.Type: ApplicationFiled: April 17, 2001Publication date: January 24, 2002Applicant: Elan Corporation plcInventors: Joseph Gross, Gilad Lavi, Izrail Tsals
-
Publication number: 20010056262Abstract: A system adapted to be disposed between a rigid or semi-rigid device and human skin for reliably attaching the device to the skin for an extended period of time. The system includes a skin-contacting surface for adhering to human skin, and an opposed surface for attachment to a rigid or semi-rigid device. The system is attached along its opposed surface to a portion of the total area of the adjacent surface of the device. When the device is subjected to external stress, the stress is transmitted through the area of attachment and distributed to the unattached area. This minimises stress on the skin and reduces the chance of detachment from the skin.Type: ApplicationFiled: May 20, 1999Publication date: December 27, 2001Inventors: OZ CABIRI, DAVID KATZ, MARIO ROZANOWICH, HAIM DANON, JOSEPH GROSS, IZRAIL TSALS, CRAIG BRODEUR, ROBERT ETHEREDGE
-
Patent number: 6312409Abstract: A device (10) for generating a pulsatile fluid drug flow comprises a housing (11) containing an expandable-contractible chamber (12) having an inlet (14) and an outlet (15), a valve (16) associated with the outlet (15) which is actuated by the expansion and contraction of the chamber (12), and means (13, 23) for biasing the chamber (12) to its contracted state. When the inlet (14) is connected to a pressurised fluid drug supply the chamber (12) is expanded by the drug, and this expansion of the chamber (12) actuates the valve (16) to open, thereby allowing release of the drug from the chamber (12), following which the chamber (12) contracts under the influence of the biasing means (13, 23), this contraction in turn actuating the valve (16) to close thereby allowing the chamber (12) to refill. By this mechanism, a constant supply of liquid, such as from an osmotic or elastomeric drug delivery pump, can be converted to a pulsatile flow, which may provide a more suitable delivery of certain drugs.Type: GrantFiled: September 7, 1999Date of Patent: November 6, 2001Assignee: Elan Corporation, PLCInventor: Joseph Gross
-
Publication number: 20010025168Abstract: A drug delivery device having a base member defining a skin-contacting surface, a syringe serving as a reservoir for the drug, and means for expelling drug from the syringe. The syringe is connected to the base member such that the longitudinal axis of the syringe is substantially parallel to the skin surface. A delivery needle is in communication with the syringe. The needle has an angled bend which directs the tip of the needle substantially perpendicular to the skin-contacting surface. In use, the tip of the needle is adapted to penetrate the skin of the subject.Type: ApplicationFiled: April 18, 2001Publication date: September 27, 2001Applicant: Elan Corporation plcInventors: Joseph Gross, Gilad Lavi, Izrail Tsals
-
Patent number: 6275717Abstract: A method of calibrating an analyte sensor in vivo, by providing a first predetermined stimulus to the sensor when the sensor is applied to a subject to produce a first sensor signal, measuring the first sensor signal, and determining a calibration function based on the first measured sensor signal resulting from the predetermined stimulus. The calibration function, when applied to further signals received from the sensor, can be used to provide a calibrated output.Type: GrantFiled: June 23, 1998Date of Patent: August 14, 2001Assignee: Elan Corporation, plcInventors: Joseph Gross, Meir Reingewirtz, Moshe George Katz
-
Publication number: 20010012926Abstract: A needle (10) for delivering a liquid to a subject comprises a shaft (11) having an internal surface defining a longitudinally extending internal bore having an open end (15) to receive a liquid supply, the other end (16) being sharpened for penetration of the subject's skin. A plurality of apertures (18) are provided, each being a cut extending across the external surface of the shaft side (11) at a sufficient depth to establish communication with the bore. The external aperture area is approximately three times greater than the internal aperture area, thereby ensuring that the liquid is delivered to a large surface area of tissue to improve absorption and eliminate fluctuations in delivery rate. The needle (10) can be mass-produced by aligning a batch of shafts alongside one another and running a grinder across the shafts' surfaces to create apertures (18) in the entire batch of needles simultaneously.Type: ApplicationFiled: February 6, 2001Publication date: August 9, 2001Applicant: Elan Medical TechnologiesInventors: Joseph Gross, Haim Danon
-
Patent number: 6261272Abstract: A needle (10) for the delivery of a liquid to a subject comprises a shaft (11) having an internal surface defining a longitudinally extending internal bore open at one end (15) to receive a liquid supply, the other end (16) being sharpened for penetration of the skin of the subject. A plurality of apertures (18) are provided, each in the form of a cut extending across the external surface of the side of the shaft (11) at a sufficient depth to establish communication with the bore. The external aperture area is approximately three times greater than the internal aperture area, thereby ensuring that the liquid is delivered to a large surface area of tissue to improve absorption and eliminate fluctuations in the delivery rate. The needle (10) can be mass-produced by aligning a batch of shafts alongside one another and running a grinder across the surfaces of the shafts to create the apertures (18) in the entire batch of needles simultaneously.Type: GrantFiled: June 1, 1999Date of Patent: July 17, 2001Assignee: Elan Corporation, plcInventors: Joseph Gross, Haim Danon
-
Patent number: D437930Type: GrantFiled: May 13, 1999Date of Patent: February 20, 2001Assignee: Elan Corporation, plcInventors: Joseph Gross, Gilad Lavi, Izrail Tsals, Gil Yigal
-
Patent number: D455207Type: GrantFiled: May 13, 1999Date of Patent: April 2, 2002Assignee: Elan Corporation, plcInventors: Joseph Gross, Gilad Lavi, Izrail Tsals, Gil Yigal