Patents by Inventor Joseph A. Gross
Joseph A. Gross has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6157858Abstract: The invention is directed to a device for delivering a pharmaceutically active compound or cosmetic substance to a subject comprises a flexible substrate sheet attached to an electronic controller. The controller is provided with a pair of electrical contacts on the underside thereof and is adhered to the sheet by means of a pair of strips of electrically conductive adhesive. The underside of the sheet is printed in two halves with electrically conductive ink to provide a pair of electrodes separated by an insulating barrier. A protuberance extends from each electrode and is folded onto the top of the sheet such that the contacts of the controller are adhered in electrical connection with the protuberances and thus also with the electrodes. The use of an adhesive to connect a controller in electrical communication with the electrodes enables an extremely simple construction of delivery device to be achieved.Type: GrantFiled: December 23, 1997Date of Patent: December 5, 2000Assignee: Elan Pharma International LimitedInventors: Joseph Gross, Zvi Nitzan
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Patent number: 6099504Abstract: A syringe (10) comprises a barrel (11) containing an internal cylindrical body (12) containing a liquid (14) and communicating with a delivery needle (15). The needle (15) is covered before use by a removable sheath (16), and after the sheath (16) is removed, the needle (15) is concealed by a displaceable sleeve (20). In use the sleeve (20) is pressed against the skin by applying pressure while holding the barrel (11). The sleeve (20) is thereby retracted into the barrel (11) allowing the needle (15) to penetrate the skin. The movement of the sleeve (20) also activates a gas generator (17) which expels the liquid (14) from the needle (15). When delivery is complete and the syringe (10) is taken from the skin, a coil spring (22) moves the sleeve (20) back to the starting position again concealing the needle (15). The coil spring (22) is torsionally biased before use and causes a rotational movement of the sleeve (20) relative to the barrel (11) when the sleeve (20) moves into and out of the barrel (11).Type: GrantFiled: October 21, 1998Date of Patent: August 8, 2000Assignee: Elan Corporation, plcInventors: Joseph Gross, Gilad Lavi, Izrail Tsals
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Patent number: 6078842Abstract: An improved electrode and iontophoretic device and method where the electrode exhibits varied resistance. The electrode is made of a conductive material and applied to a flexible substrate. The variation in resistance can be achieved by varying the thickness of the electrode across its length or by varying the conductivity of the material across the area of the electrode or a combination of both. A pair of such electrodes may be used with a power source in electrical relation thereto and applied over a layer of agent to the skin to deliver the agent into the skin iontophoretically. The pair of electrodes may be shaped so as to cover a portion of the face, hands, feet or other body parts to iontophoretically apply particular agents to those areas.Type: GrantFiled: December 23, 1997Date of Patent: June 20, 2000Assignee: Elan Corporation, plcInventors: Joseph Gross, Zvi Nitzan, Izrail Tsals
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Patent number: 5997501Abstract: An intradermal drug delivery device comprises a housing (301a, 301b) having a drug reservoir (312) therewithin and a gas generation chamber (313) separated from the reservoir (312) by a displaceable membrane (311). A microprocessor-controlled electrolytic cell (316a, 316b, 319) provides gas to expand the gas generation chamber (313) and thereby contract the reservoir (312). A hollow needle (310), communicating at an inner end thereof with the reservoir (312), extends from a lower surface (308) of the housing (301) such that contraction of the reservoir (312) forces drug to escape therefrom via the needle (310). The device permits delivery of drugs of relatively large molecular weights at slow controllable rates. A displaceable protective cover (303) is mounted in means (307) allowing movement of the cover (303) between extended and retracted positions (305, 306). The cover (303) has an adhesive lower surface (309) for attachment to the skin of a subject.Type: GrantFiled: August 19, 1996Date of Patent: December 7, 1999Assignee: Elan Corporation, plcInventors: Joseph Gross, John Gerard Kelly
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Patent number: 5991655Abstract: An iontophoretic drug delivery device comprising a flexible reservoir sandwiched between a flexible printed circuit board and a pair of flexible electrodes. A rigid top cover is mounted on a spine on the reservoir by means of snap-fit connections. The rigid cover protects the device from damage while the flexible reservoir, circuit board and electrodes can conform to the skin of a subject. The configuration of the flexible elements allows the manufacturing process to be simplified considerably, resulting in a less expensive device with ease of fabrication.Type: GrantFiled: February 26, 1998Date of Patent: November 23, 1999Assignee: Drug Delivery Systems, Inc.Inventors: Joseph Gross, Gilad Lavi
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Patent number: 5925030Abstract: Oral drug delivery device having a housing with walls of water permeable material and having at least two chambers separated by a displaceable membrane. The first chamber receives drug and has an orifice through which the drug is expelled under pressure. The second chamber contains at least one of two spaced apart electrodes forming part of an electric circuit which is closed by the ingress of an aqueous ionic solution into the second chamber. When current flows through the circuit, gas is generated and acts on the displaceable membrane to compress the first chamber and expel the active ingredient through the orifice for progressive delivery to the gastrointestinal tract.Type: GrantFiled: September 29, 1997Date of Patent: July 20, 1999Assignee: Elan Corporation, plcInventors: Joseph Gross, John Gerard Kelly
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Patent number: 5871125Abstract: A liquid delivery pumping device for the delivery of liquids enterally or parenterally comprises a housing including a gas generating chamber, wherein a gas is generated intermittently when two reactants, such as the components of an effervescent couple, are caused to react, a pumping chamber for a reciprocating pumping unit operable by the gas and to which chamber the gas is conveyed once generated, the pumping unit forming part of a mechanism which receives and regulates the liquid to be delivered in response to the reciprocation of the pumping unit, and means for controlling the gas pressure within the pumping chamber to enable controlled reciprocation of the pumping unit. The device provides precisely controlled rates of liquid delivery to a patient irrespective of the viscosity of the liquid to be delivered.Type: GrantFiled: September 5, 1996Date of Patent: February 16, 1999Assignee: Elan Medical Technologies LimitedInventor: Joseph Gross
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Patent number: 5858001Abstract: A liquid drug delivery device is adapted to be adhered to the skin of a subject by a base member defining a skin-contacting surface having an adhesive coating. A columnar cartridge serves as reservoir for the drug and is incorporated in a housing which is connected to the base member such that in use the longitudinal axis of the cartridge is disposed substantially parallel to the skin-contacting surface. A delivery needle communicating in use with the interior of the cartridge penetrates the skin of the subject when the housing snaps downward relative to the base member. This action also causes the actuation of a citric acid/sodium bicarbonate gas generator which generates a gas to move a piston within the cartridge, compressing the drug compartment. This compression causes a stopper to be penetrated by a conduit in communication with the delivery needle, allowing the drug to be ejected from the compartment through the needle and into the subcutaneous tissue of the subject.Type: GrantFiled: December 10, 1996Date of Patent: January 12, 1999Assignee: Elan Medical Technologies LimitedInventors: Izrail Tsals, Joseph Gross, Gilad Lavi
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Patent number: 5848991Abstract: An intradermal drug delivery device for delivering a liquid drug to a subject via the subject's skin includes a housing having a lower surface provided with an adhesive coating for adhering the housing to the subject's skin. An expansible-contractible chamber within the housing defines a reservoir which is expanded upon being filled with the drug and contracted to dispense the drug. A hollow needle extends through the lower surface of the housing and has an inner end which communicates with the reservoir and an outer end which projects outwardly of the housing a short distance to penetrate through the epidermis and into the dermis of the subject's skin when the housing is adhered thereto. The device permits delivery of drugs of relatively large molecular size and at slow rates which can be precisely controlled.Type: GrantFiled: April 25, 1997Date of Patent: December 15, 1998Assignee: Elan Medical Technologies Limited Athlone, Co.Inventors: Joseph Gross, John Gerard Kelly
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Patent number: 5820622Abstract: A liquid delivery device comprising a housing having a lower surface for application to the skin of a subject and having a reservoir and a gas generation chamber therein separated by a displaceable membrane. Gas generated by an electrolytic cell under the control of a microprocessor causes the gas generation chamber to expand and the reservoir to contract, thereby discharging a liquid drug, such as insulin, from the reservoir via a hollow delivery needle extending from the lower surface. The delivery needle and a sensor needle both extend from the lower surface a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin. The sensor needle has an enzymatic coating for the detection of an analyte, such as glucose in the subject's plasma. The delivery needle is made of platinum-iridium, and a current passes between the needles and a potentiostat circuit according to the amount of glucose detected.Type: GrantFiled: December 18, 1996Date of Patent: October 13, 1998Assignee: Elan Medical Technologies LimitedInventors: Joseph Gross, John Gerard Kelly
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Patent number: 5814020Abstract: A medicament delivery device has a reservoir within a housing and means for driving medicament from the reservoir. The device is provided with a filling mechanism upon which a medicament container sealed by a penetrable stopper is mounted. The mechanism comprises an internal bore which accommodates an internal rod from which a needle projects. Needle is hollow and is in communication with the reservoir. In order to fill the reservoir, the container is pressed into the bore, causing the needle to pierce the stopper, the stopper abutting against the rod and acting as a piston to drive medicament from the container as the container is pushed into the bore and moves relative to the stopper. Thus, the reservoir can be filled with the sterile medicament which is stable when stored in the container, and the filling is easily accomplished without the use of a syringe. A further advantageous feature is provided by a delivery needle which is mounted on the periphery of the lower surface of the housing.Type: GrantFiled: September 6, 1996Date of Patent: September 29, 1998Assignee: Elan Medical Technlogies LimitedInventor: Joseph Gross
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Patent number: 5807375Abstract: A liquid delivery device comprising a housing having a lower surface for application to the skin of a subject and having a reservoir and a gas generation chamber therein separated by a displaceable membrane. Gas generated by an electrolytic cell under the control of a microprocessor causes the gas generation chamber to expand and the reservoir to contract, thereby discharging a liquid drug, such as insulin, from the reservoir via a hollow delivery needle extending from the lower surface. The delivery needle and a sensor needle both extend from the lower surface a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin. The sensor needle has an enzymatic coating for the detection of an analyte, such as glucose in the subject's plasma. The delivery needle is made of platinum-iridium, and a current passes between the needles and a potentiostat circuit according to the amount of glucose detected.Type: GrantFiled: November 2, 1995Date of Patent: September 15, 1998Assignee: Elan Medical Technologies LimitedInventors: Joseph Gross, John Gerard Kelly
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Patent number: 5800420Abstract: A liquid delivery device comprising a housing having a lower surface for application to the skin of a subject and having a reservoir and a gas generation chamber therein separated by a displaceable membrane. Gas generated by an electrolytic cell under the control of a microprocessor causes the gas generation chamber to expand and the reservoir to contract, thereby discharging a liquid drug, such as insulin, from the reservoir via a hollow delivery needle extending from the lower surface. The delivery needle and a sensor needle both extend from the lower surface a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin. The sensor needle has an enzymatic coating for the detection of an analyte, such as glucose in the subject's plasma. The delivery needle is made of platinum-iridium, and a current passes between the needles and a potentiostat circuit according to the amount of glucose detected.Type: GrantFiled: December 19, 1996Date of Patent: September 1, 1998Assignee: Elan Medical Technologies LimitedInventors: Joseph Gross, John Gerard Kelly
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Patent number: 5799663Abstract: A nicotine oral delivery device, which includes a hollow housing (10) and a hollow mouthpiece (14) which may be detachable connected to the housing (10) or may form with the housing a single piece. The mouthpiece includes a nicotine-containing material (16), in the form of a gel, on one or more of the outer surfaces of the mouthpiece. The housing (10) may also include flavoring (20), such as menthol. The nicotine-containing material (16) may be located as a layer on the mouthpiece (14), or in holes in the mouthpiece or under a permeable membrane (18) covering a portion of the mouthpiece (14). Where the mouthpiece and housing are separate pieces, the mouthpiece may be disposable while the housing reusable.Type: GrantFiled: December 23, 1996Date of Patent: September 1, 1998Assignee: Elan Medical Technologies LimitedInventors: Joseph Gross, John Gerard Kelly
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Patent number: 5704520Abstract: A liquid material dispenser, for use, for example, in dispensing liquid medicine over an extended period of time, which includes a housing (10) enclosing a reservoir (12) for storing the liquid to be dispensed and having an outlet (14) through which the liquid is dispensed, and a connecting passageway (16) between the reservoir and the outlet. Located in the passageway is a diaphragm (18), one side of which defines a pumping chamber (20) and the other side of which defines a pressure control chamber (22). The diaphragm (18) is cyclically displaceable through a pumping stroke for pumping liquid through the outlet (14) and a drawing stroke for drawing liquid from the reservoir (12). Also located in the passageway (16) are a pair of valves (30, 33) which serve, during the drawing stroke, to cause the diaphragm (18) to draw liquid from the reservoir (12) into the pumping chamber (20), and during the pumping stroke, to cause the diaphragm (18) to pump liquid from the pumping chamber (20) through the outlet (14).Type: GrantFiled: March 27, 1996Date of Patent: January 6, 1998Assignee: Elan Medical Technologies, LimitedInventor: Joseph Gross
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Patent number: 5527288Abstract: An intradermal drug delivery device for delivering a liquid drug to a subject via the subject's skin includes a housing having a lower surface provided with an adhesive coating for adhering the housing to the subject's skin. An expansible-contractible chamber within the housing defines a reservoir which is expanded upon being filled with the drug and contracted to dispense the drug. A hollow needle extends through the lower surface of the housing and has an inner end which communicates with the reservoir and an outer end which projects outwardly of the housing a short distance to penetrate through the epidermis and into the dermis of the subject's skin when the housing is adhered thereto. The device permits delivery of drugs of relatively large molecular size and at slow rates which can be precisely controlled.Type: GrantFiled: January 18, 1994Date of Patent: June 18, 1996Assignee: Elan Medical Technologies LimitedInventors: Joseph Gross, John G. Kelly
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Patent number: 5475557Abstract: Apparatus for providing an electrical system with protection against electrical shock in the event of a ground fault. The electrical system supplies power from a central mains inlet to at least one local electrical device. The central mains inlet includes a central ground fault detector and interrupter actuatable upon detection of a first predetermined level of current imbalance to interrupt the central mains inlet. A local ground fault detector is associated with the at least one local electrical device and is actuatable upon detecting a current imbalance of a second predetermined level which is lower than the first predetermined level. Controls are effective upon actuation of the local ground fault interrupter to actuate the central ground fault detector to cause it to interrupt the central mains inlet.Type: GrantFiled: July 30, 1991Date of Patent: December 12, 1995Assignee: Solar Wide Industrial Ltd.Inventors: Dov Larom, Joseph Gross, Zohar Avrahami, Ram Shalvi
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Patent number: D404366Type: GrantFiled: February 10, 1998Date of Patent: January 19, 1999Assignee: Elan Medical Technologies LimitedInventors: Joseph Gross, Gilad Lavi, Zvi Nitzan
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Patent number: D404482Type: GrantFiled: May 1, 1998Date of Patent: January 19, 1999Assignee: Elan Medical Technologies LimitedInventors: Yael Falk, Joseph Gross, Mario Rozanowich
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Patent number: D405524Type: GrantFiled: May 1, 1998Date of Patent: February 9, 1999Assignee: Elan Medical Technologies LimitedInventors: Yael Falk, Joseph Gross