Patents by Inventor Joseph J. Hlavka

Joseph J. Hlavka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tri-, tetra-, penta-, and polypeptides and their therapeutic use as an antidepressant agent
    Patent number: 5767083
    Abstract: The present invention discloses novel peptides utilized to treat patients suffering from depression. These novel peptides are modifications of the tripeptide hormone MIF, including modification of amino terminus residues, carboxyl terminus residues and internal residues, including addition and substitution of amino acid residues and modification of the peptide bonds and functional side groups of respective amino acid residues. The tri-, tetra-, penta-, peptides and polypeptides of the present invention may be utilized alone or in combination to treat patients suffering from depression.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: June 16, 1998
    Assignee: Innapharma, Inc.
    Inventors: Henry B. Abajian, John F. Noble, Joseph J. Hlavka
  • Tri-, tetra-, penta-, and polypeptides and their therapeutic use as an antidepressant agent
    Patent number: 5589460
    Abstract: The present invention discloses novel peptides utilized to treat patients suffering from depression. These novel peptides are modifications of the tripeptide hormone MIF, including modification of amino terminus residues, carboxyl terminus residues and internal residues, including addition and substitution of amino acid residues and modification of the peptide bonds and functional side groups of respective amino acid residues. The tri-, tetra-, penta-, and polypeptides of the present invention may be utilized alone or in combination to treat patients suffering from depression.
    Type: Grant
    Filed: May 4, 1994
    Date of Patent: December 31, 1996
    Assignee: Innapharma, Inc.
    Inventors: Henry B. Abajian, John F. Noble, Joseph J. Hlavka
  • 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
    Patent number: 5530117
    Abstract: The disclosure is drawn to novel 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds. These compounds are useful to treat infections caused by a wide spectrum of bacterial organisms, including those which are resistant to tetracycline.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: June 25, 1996
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Phaik-Eng Sum, Yakov Gluzman, Ving J. Lee, Adma A. Ross
  • Method for treating bacterial infection with novel 7-substituted-9-substituted amino 6-demethyl-6-deoxytetracyclines
    Patent number: 5529990
    Abstract: The disclosure is drawn to a method of using novel 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds to treat infections caused by a wide spectrum of bacterial organisms, including those which are resistant to tetracycline.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: June 25, 1996
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Phaik-Eng Sum, Yakov Gluzman, Ving J. Lee, Adma A. Ross
  • 7-(substituted)-8-(substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracyclines
    Patent number: 5512553
    Abstract: The invention provides compounds of formula ##STR1## wherein X, R and R.sup.1 are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: April 30, 1996
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • 7-(substituted-9-(substituted amino)-6-demethyl-6-deoxytetracyclines
    Patent number: 5495018
    Abstract: The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents.
    Type: Grant
    Filed: December 8, 1994
    Date of Patent: February 27, 1996
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
    Patent number: 5494903
    Abstract: The invention is drawn to 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds of the formula ##STR1## wherein R, X, R.sup.5 and R.sup.6 are defined in the specification. The compounds of the invention are useful as broad spectrum antibiotics.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: February 27, 1996
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Phaik-Eng Sum, Yakov Gluzman, Ving J. Lee, Adma A. Ross
  • Process for producing 7-(substituted)-8-(substituted-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
    Patent number: 5495032
    Abstract: The invention provides a process for the production of compounds of the formula: ##STR1## wherein, R, R.sup.3, R.sup.4, X and W are defined in the specification in which a compound of the following formula: ##STR2## is reacted with a nucleophile of the formula WH in an inert atmosphere in the presence of a polar-protic or a polar-aprotic solvent. The resulting compounds are useful as antibiotics.
    Type: Grant
    Filed: September 27, 1994
    Date of Patent: February 27, 1996
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • 7-(substituted)-8-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
    Patent number: 5457096
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4, X and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: October 10, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • 7-(substituted)-8-(substituted)-9-substituted amino)-6-demethyl-6-deoxytetracyclines
    Patent number: 5430162
    Abstract: The invention provides compounds of formula ##STR1## wherein X, R and R.sup.1 are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: March 21, 1994
    Date of Patent: July 4, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
    Patent number: 5420272
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4, X and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: August 13, 1992
    Date of Patent: May 30, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
    Patent number: 5401863
    Abstract: Novel 9-amino-7-(substituted amino)-6-demethyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also disclosed are intermediates and methods for making the novel compounds of the present invention.
    Type: Grant
    Filed: March 29, 1994
    Date of Patent: March 28, 1995
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Phaik-Eng Sum, Yakov Gluzman, Ving J. Lee
  • 7-(substituted)-8-(substituted)-9-[(substituted glycyl) amido]-6-demethyl-6-deoxytetracyclines
    Patent number: 5386041
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4, X and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: February 8, 1994
    Date of Patent: January 31, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
    Patent number: 5326759
    Abstract: Novel 9-amino-7-(substituted amino)-6-demethyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also disclosed are intermediates and methods for making the novel compounds of the present invention.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: July 5, 1994
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Phaik-Eng Sum, Yakov Gluzman, Ving J. Lee
  • 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
    Patent number: 5281628
    Abstract: 9-amino-7-(substituted amino)-6-demethyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also disclosed are intermediates and methods for making the novel compounds of the present invention.
    Type: Grant
    Filed: October 4, 1991
    Date of Patent: January 25, 1994
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Phaik-Eng Sum, Yakov Gluzman, Ving J. Lee
  • Synthesis of cisplatin analogs
    Patent number: 4996337
    Abstract: This disclosure sets forth a novel process for producing cisplatin analogs which possess antitumor activity.
    Type: Grant
    Filed: March 13, 1990
    Date of Patent: February 26, 1991
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • Synthesis of cisplatin analogs
    Patent number: 4937358
    Abstract: This disclosure sets forth a novel process for producing cisplatin analogs which possess antitumor activity.
    Type: Grant
    Filed: December 8, 1988
    Date of Patent: June 26, 1990
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • (2,2-bis(aminomethyl)-1,3-propranediol-N,N')platinum complexes
    Patent number: 4900756
    Abstract: Organic-platinum complexes useful as anti-cancer agents in the treatment of tumors sensitive to the subject compounds are described.
    Type: Grant
    Filed: July 15, 1988
    Date of Patent: February 13, 1990
    Assignee: American Cyanamid Company
    Inventors: Ralph G. Child, Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • (Gem-heterocyclodimethanamine-N,N')platinum complexes
    Patent number: 4880790
    Abstract: Organic platinum complexes active as anti-tumor agents in warm-blooded animals, and methods for synthesis of same, are described.
    Type: Grant
    Filed: January 31, 1986
    Date of Patent: November 14, 1989
    Assignee: American Cyanamid Company
    Inventors: Ralph G. Child, Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • Water soluble platinum complexes of novel malonate derivatives
    Patent number: 4870070
    Abstract: This disclosure describes water soluble platinum complexes of novel malonate derivatives which possess the property of inhibiting the growth of tumors in mammals.
    Type: Grant
    Filed: August 10, 1987
    Date of Patent: September 26, 1989
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Joseph J. Hlavka, Yang-I Lin