Patents by Inventor Joseph J. Hlavka

Joseph J. Hlavka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Platinum complexes of amines with novel dibasic acids
    Patent number: 4866092
    Abstract: Novel organic compounds of the formula ##STR1## where R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl(C.sub.1 -C.sub.6); or R.sub.1 and R.sub.2 taken together are selected from the group consisting of ##STR2## where n is an integer 3-6, ##STR3## where m is an integer 3-6, and ##STR4## and L is selected from the group consisting of --O--, --CH.sub.2 --, ##STR5## and >NR.sub.3 where R.sub.3 is alkyl(C.sub.1 -C.sub.6) or --CH.sub.2 CH.sub.2 OH, which have antineoplastic activity, compositions containing the compounds and methods of using the compounds to treat tumors in mammals.
    Type: Grant
    Filed: March 27, 1987
    Date of Patent: September 12, 1989
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Ralph G. Child, Joseph J. Hlavka, Yang-I Lin
  • Synthesis of cisplatin analogs
    Patent number: 4808730
    Abstract: This disclosure sets forth a novel process for producing cisplatin analogs which possess antitumor activity.
    Type: Grant
    Filed: June 23, 1987
    Date of Patent: February 28, 1989
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • (2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes
    Patent number: 4760157
    Abstract: Novel organic-platinum compounds selected from those of the formulae: ##STR1## wherein L and L' are selected from the group consisting of halide, nitrate, sulfate and a monobasic carboxylate such as acetate or hydroxy acetate or L and L' taken together are a dibasic carboxylate selected from the group consisting of ##STR2## oxalic acid, methylmalonic acid, succinic acid and tartronic acid, or L and L' taken together are a tribasic carboxylate selected from the group consisting of ##STR3## taken together is ascorbic acid and X is selected from the group consisting of halogen and hydroxy.
    Type: Grant
    Filed: January 31, 1986
    Date of Patent: July 26, 1988
    Assignee: American Cyanamid Company
    Inventors: Ralph G. Child, Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • Heterocyclic-1,2-diamine platinum complexes
    Patent number: 4716157
    Abstract: This disclosure describes platinum complexes of heterocyclic-1,2-diamines which possess the property of inhibiting the growth of tumors in mammals.
    Type: Grant
    Filed: March 20, 1986
    Date of Patent: December 29, 1987
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Ralph G. Child, Joseph J. Hlavka, Yang-I Lin
  • Platinum complexes of diamino-dideoxy sugars and di- or tricarboxylic acids
    Patent number: 4703115
    Abstract: Platinum complexes and Di- or Tricarboxylic acids which is then reacted with the appropriate di- or tricarboxylic acid in aqueous medium.
    Type: Grant
    Filed: December 17, 1984
    Date of Patent: October 27, 1987
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Ralph G. Child, Panayota Bitha, Yang-i Lin
  • Platinum complexes of amines with dibasic acids
    Patent number: 4675336
    Abstract: Novel organic compounds of the formula ##STR1## Where R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl(C.sub.1 -C.sub.6); or R.sub.1 and R.sub.2 taken together are selected from the group consisting of ##STR2## where n is an integer 3-6, ##STR3## where m is an integer 3-6, and ##STR4## and L is selected from the group consisting of --O--, --CH.sub.2 --, ##STR5## where R.sub.3 is alkyl(C.sub.1 -C.sub.6) or --CH.sub.2 CH.sub.2 OH, which have antineoplastic activity, compositions containing the compounds and method of using the compounds to treat tumors in mammals.
    Type: Grant
    Filed: June 26, 1985
    Date of Patent: June 23, 1987
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Ralph G. Child, Joseph J. Hlavka, Yang-I Lin
  • Hydroxylated 1,2-diaminocyclohexane platinum complexes
    Patent number: 4670458
    Abstract: This disclosure describes platinum complexes of 3.beta., 4.alpha.-diamino-1.alpha.,2.alpha.-cyclohexanediol which possess the property of inhibiting the growth of tumors in mammals.
    Type: Grant
    Filed: January 31, 1986
    Date of Patent: June 2, 1987
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Yang-I Lin, Panayota Bitha
  • Platinum complexes of aliphatic tricarboxylic acids
    Patent number: 4665210
    Abstract: Platinum complexes of aliphatic tricarboxylic acids useful for inducing regression and/or palliation of cancer diseases in mammals.
    Type: Grant
    Filed: October 28, 1985
    Date of Patent: May 12, 1987
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Ralph G. Child, Joseph J. Hlavka, Yang-I Lin
  • Platinum complexes of polyhydroxylated alkylamines and 2-polyhydroxylated alkyl-1,2-diaminoethanes
    Patent number: 4587331
    Abstract: Platinum complexes of polyhydroxylated alkylamines and 2-polyhydroxylated alkyl-1,2-diaminoethanes useful for inducing regression and/or palliation of cancer diseases in mammals.
    Type: Grant
    Filed: December 17, 1984
    Date of Patent: May 6, 1986
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Ralph G. Child, Panayota Bitha, Yang I. Lin
  • 2,3-Diamino-substituted-4(3H)-pyrimidinones and platinum chelates
    Patent number: 4577018
    Abstract: Platinum chelates of 2,3-diamino-substituted-4(3H)-pyrimidinones which are useful as antitumor agents.
    Type: Grant
    Filed: August 22, 1983
    Date of Patent: March 18, 1986
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Panayota Bitha, Yang-i Lin
  • Platinum chelates of 2-hydrazino-azoles
    Patent number: 4550169
    Abstract: This disclosure describes platinum chelates of 2-hydrazino-1-aza (or 1,3-diaza,1-oxa-3-aza or 1-thia-3-aza)-1-cyclo-alkenes which possess activity as antitumor agents.
    Type: Grant
    Filed: November 21, 1983
    Date of Patent: October 29, 1985
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Panayota Bitha, Yang-I Lin
  • Platinum chelates of 3-amino-substituted-[1,2,4]triazolo[1,5-a]-pyrimidin-7(3H)-ones
    Patent number: 4546181
    Abstract: Platinum chelates of 3-amino-substituted-[1,2,4]-triazolo[1,5-a]pyrimidin-7(3H)-ones which are antitumor agents.
    Type: Grant
    Filed: August 22, 1983
    Date of Patent: October 8, 1985
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Panayota Bitha, Yang-i Lin
  • Platinum complexes of antitumor agents
    Patent number: 4544759
    Abstract: The compounds are the class of substituted hydrazine carboximidamides which are useful for inducing the regression and/or palliation of leukemia and related cancers in mammals when administered in amounts of from about one mg. to about 1.2 gm. per square meter of body surface area per day.
    Type: Grant
    Filed: July 29, 1983
    Date of Patent: October 1, 1985
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Panayota Bitha, Yang-i Lin
  • Alkylated derivatives of antibacterial agents cis-BM123.gamma..sub.1 and cis-BM123.gamma..sub.2
    Patent number: 4154925
    Abstract: This disclosure describes a novel series of potent antibacterial agents designated alkylated-cis-BM123.gamma..sub.1 and alkylated-cis-MB123.gamma..sub.2 produced by a novel photolytic process whereby alkylated-trans-BM123.gamma..sub.1 and alkylated-trans-BM123.gamma..sub.2 are transformed to their corresponding cis-isomers. The new antibacterial agents are active against a variety of microorganisms and thus are useful in inhibiting the growth of such bacteria wherever they may be found.
    Type: Grant
    Filed: January 19, 1977
    Date of Patent: May 15, 1979
    Assignee: American Cyanamid Company
    Inventor: Joseph J. Hlavka
  • Alkylated derivatives of antibiotic BM123.gamma.
    Patent number: 4123607
    Abstract: This disclosure describes a novel series of potent antibacterial agents derived by reductive alkylation of antibiotic BM123.gamma. with certain classes of aldehydes and ketones.
    Type: Grant
    Filed: May 31, 1977
    Date of Patent: October 31, 1978
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Panayota Bitha