Abstract: In general, the present disclosure describes inventory management systems and methods which track all inventory of items within a retail supply chain. A computerized system aggregates inventory movement events to produce a common source of truth for the location and disposition of items within a supply chain. Order events and inventory events are received from multiple data sources. Additionally, a current inventory level for each item at each location within the supply chain is provided according to the data source. The computerized system normalizes the information in the event messages before it is stored in the centralized inventory database. The inventory information in the database can be accessed by multiple consumers through an API to obtain the most up-to-date information about the disposition and location of an item.

Abstract: A method of monitoring the temperature of a solid state switch in an aircraft solid state power controller. The method includes: measuring an electric current (I) flowing through the solid state switch; calculating, based on the measured electric current (I), an introduced electric power (Pel) that is introduced into the solid state switch within the predefined time period (?t); calculating an increase in temperature (?T) of the solid state switch that is caused by the introduced electric power (Pel); calculating an actual temperature (Tact) of the solid state switch by adding the calculated increase in temperature (?T) to an ambient temperature (Tamb); and comparing the calculated actual temperature (Tact) with a predefined temperature threshold (Tth) and determining an overheat condition if the calculated actual temperature (Tact) exceeds the predefined temperature threshold (Tth).

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Systems and methods for generating a data aggregator interactive graphical user interface. An interactive graphical user interface (GUI) includes a selectable symbol region, a query region and a data results region. The selectable symbol region displays predefined symbols. The query region displays user input fields for generating queries. The system receives user input associated with the user input fields of the query region to form a filter set. The data results region is automatically updated responsive to the user input, to display one or more data values from among one or more databases associated with the filter set. The system receives a subscription request to save the filter set as a user-customized query. A custom symbol is created responsive to the subscription request that is associated with the filter set. The the selectable symbol region is updated to display the custom symbol together with the predefined symbols.

Abstract: A method of audio signal processing comprising Hybrid Expansive Frequency Compression (hEFC) via a digital signal processor, wherein the method includes: classifying an audio signal input, wherein the audio signal input includes frication high-frequency speech energy, into two or more speech sound classes followed by selecting a form of input-dependent frequency remapping function; and performing hEFC including, re-coding of one or more input frequencies of the speech sound via the input-dependent frequency remapping function to generate an audio output signal, wherein the output signal is a representation of the audio signal input having a lower sound frequency.

Abstract: Described herein are methods of treating, preventing, or reducing dendritic spine density loss in a subject, the method comprising administering a compound selected from: metformin, pentosan polysulfate, amlexanox, leflunomide, prasterone, glutathione disulfide, pazopanib, bosutinib, dabrafenib, baricitinib, or a pharmaceutically acceptable salt, prodrug, or derivative thereof; or any combination thereof; or compositions described herein.

Abstract: One aspect of the present application relates to a pharmaceutical composition comprising a sulfated glycosaminoglycan having an average molecular weight ranging from 3,000 to 15,000 Daltons, a skin penetrating agent, where the skin penetrating agent promotes transdermal penetration of the sulfated glycosaminoglycan when applied to intact skin surfaces, and a pharmaceutical carrier for topical application, where the pharmaceutical carrier is mixed with the sulfated glycosaminoglycan and the skin penetrating agent. This composition is useful in carrying out a method of treating a subject for pain, joint stiffness, soft tissue injury, connective tissue disorders, and/or muscle soreness.

Abstract: A ladder rack system may have a slide with a support flange and a spanning flange. The system may also have a ladder support member adapted to selectively receive a portion of the support flange therein. The system may also have a pivot bracket pivotally connected to the ladder support member. The pivot bracket may be adapted to selectively move the ladder support member.

Abstract: A cutting assembly in which an inner tube is rotatably disposed within an outer tube and defines as aspiration path. The inner tube may include segments, and the segments may define a flexible region associated with a bend of the outer tube. The outer tube may define irrigation channels, and further define irrigation apertures positioned proximal to a cutting window or distal to the flexible region. The irrigation channels fluidly separate the aspiration lumen from an irrigation path so as to prevent ingress of irrigation fluid into the aspiration lumen through slots defined by the segments. An inner jacket may be coaxially disposed within the inner tube and configured to provide a seal between the aspiration path and the irrigation path. A distal end of the inner jacket may be disposed in a counterbore, and the proximal end of the inner jacket may be proximal to the inner tube.

Abstract: An electromechanical biasing member for moving a closure panel between an open and a closed position relative to a motor vehicle body is provided. The electromechanical biasing member includes a housing having an inner cavity for housing an electric motor having a motor shaft and a rotary output member rotatable relative to the housing. An extension member within the housing and engageable with the rotary output member moves the closure panel between the open and closed positions in response to driving the electric motor. Also provided is a control unit positioned within the inner cavity and configured to drive the electric motor, the control unit including at least one controller board juxtaposed to the electric motor, and a plurality of control components mounted to the at least one controller board and configured to supply a drive signal to the electric motor and receive signals representative of operation of the electric motor.

Abstract: Management and maintenance of tools. Tool parameters are measured. The measured values are scored according to an index. In some examples, indexed scores can be aggregated. The indexed and/or aggregated scores can be used to quickly check status of tools and identify for which tools maintenance or remediation may be required. A dashboard interface can be provided for navigating among tools or systems based on their indexed scores. Maintenance and/or remediation measures for one or more tools can then be implemented as needed.

Abstract: Systems and methods for aggregating data. The system is configured to receive metadata from an interactive graphical user interface (GUI) of a user device, aggregate field values from the data stored on one or more databases based on the received metadata and generate filter instructions based on the received metadata. The system is further configured to transmit the aggregated field values and the filter instructions to the user device, receive a user-customized filter set and subscription request for a synthetic symbol associated with the user-customized filter set from the user device, and create the synthetic symbol responsive to the subscription request. Moreover, the system aggregates one or more data values from the data stored on the databases associated with the created synthetic symbol and generates instructions to display the data values on the interactive GUI in accordance with the user-customized filter set associated with the created synthetic symbol.

Abstract: Provided are methods and compositions, including assays, probes and primers for identifying Brassica plants that are resistant to clubroot disease. Also provided are breeding methods for introducing a clubroot resistance phenotype into Brassica plants and/or their progeny.

Abstract: This application relates to a building energy analysis and management system for measurement and verification of building performance. The system can analyze, optimize, manage, maintain, trouble shoot, and/or modify building systems, such as HVAC systems, in connection with the building energy usage. Measurements may be gathered for one or more HVAC units coupled to pressure independent valves, and sent to one or more Surge Panels that pass data to remote analysis servers, which can receive other system or external data. The analysis servers compare measurements to predicted values and can standardize the predicted values to account for external conditions. The comparison can result in difference values used to generate probable causes and optimization recommendations. The system outputs reports or other data display using a graphical user interface that can be adjusted for an anticipated user.

Abstract: Systems and methods are provided for automatically marking locations within a radiograph of one or more dental pathologies, anatomies, anomalies or other conditions determined by automated image analysis of the radiograph by a number of different machine learning models. Image annotation data may be generated based at least in part on obtained results associated with output of the multiple machine learning models, where the image annotation data indicates at least one location in the radiograph and an associated dental pathology, restoration, anatomy or anomaly detected at the at least one location by at least one of the machine learning models. A number of different pathologies may be identified and their locations marked within a single radiograph image.

Abstract: An electrode material for a lithium ion secondary battery and method of forming the same, the electrode material including composite particles, each composite particle including: a primary particle including an electrochemically active material; and an envelope disposed on the surface of the primary particle. The envelope includes turbostratic carbon having a Raman spectrum having: a D band having a peak intensity (ID) at wave number between 1330 cm-1 and 1360 cm-1; a G band having a peak intensity (IG) at wave number between 1530 cm-1 and 1580 cm-1; and a 2D band having a peak intensity (I2D) at wave number between 2650 cm-1 and 2750 cm-1. In one embodiment, a ratio of ID/IG ranges from greater than zero to about 1.1, and a ratio of I2D/IG ranges from about 0.4 to about 2.

Abstract: Various embodiments of apparatuses and methods for multi-cast, multiple unicast, and unicast distribution of messages with time synchronized delivery are described. In some embodiments, the disclosed system and methods include a reference timekeeper providing a reference clock to one or more host computing devices. The one or more host computing devices host compute instances, and also contain respective isolated timing hardware outside the control of the compute instances. The isolated timing hardware of the one or more host computing devices then receive respective packets, and obtain the same time to deliver the respective packets. Each isolated timing hardware provides either the packet, or information to access the packet, to its respective destination compute instance subsequent to determining that the same specified time to deliver the packet has occurred. Thus, the respective packets are delivered near simultaneously to the one or more destination compute instances.

Abstract: Magnetically-assisted mechanical gear systems and other power transmission systems, and related methods of operation and assembly, are disclosed herein. In an example embodiment, such a system includes a driving gear, a driven gear, and a first magnetomotive force (MMF) source that generates a magnetic flux. A first portion of the flux is communicated between at least one driving gear teeth and at least one driven gear teeth so that one or more magnetic forces are exerted between the gears. When the first rotational movement of the driving gear alternates from being in the first rotational direction to being in a third rotational direction opposite the first rotational direction, then the driven gear is driven by the one or more magnetic forces so that the second rotational movement also alternates, and a first amount of backlash movement between the driving and driven gears is avoided or reduced.

Abstract: In general, the present disclosure describes inventory management systems and methods which track all inventory of items within a retail supply chain. A computerized system aggregates inventory movement events to produce a common source of truth for the location and disposition of items within a supply chain. Order events and inventory events are received from multiple data sources. Additionally, a current inventory level for each item at each location within the supply chain is provided according to the data source. The computerized system normalizes the information in the event messages before it is stored in the centralized inventory database. The inventory information in the database can be accessed by multiple consumers through an API to obtain the most up-to-date information about the disposition and location of an item.

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to improve the health, nutrition, and growth performance. The present disclosure further relates to methods of modulating the microbial species present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level or function of microbial species.