Abstract: An apparatus and/or method includes localization of a mobile device. The localization technique is calibrated by prompting the mobile device for a collection of static position images for an image-based localization service, sending static position images to the image-based localization service, receiving, for the static position images, a plurality of localization values from the image-based localization service, calculating a correction for the plurality of localization values, and providing a location for the mobile device based on the correction for the plurality of localization values.

Abstract: An attachable data system for tracking items includes a microprocessor; a power supply configured to supply power to the microprocessor; a memory communicatively connected to the microprocessor; a Bluetooth communications module; and an NFC module. The NFC module performs operations including establishing an NFC field with an NFC initiator device in response to receiving an NFC signal from the NFC initiator device via the NFC antenna; extracting identifying information from the NFC signal; and storing the identifying information in the NFC memory. The microprocessor is configured to perform microprocessor operations including accessing the identifying information stored in the NFC memory; and causing a transmission of the identifying information using the Bluetooth communications module.

Abstract: Methods are provided to separately isolate antigen-binding T cells and antigen-activated T cells derived from a starting population of peripheral blood mononuclear cells, and to identify overlapping T cell receptor clonotypes. Antigens include personal and shared neoantigens as well as cancer-testis antigens. The T cell receptor clonotypes can be further used to develop cancer treatment therapies.

Abstract: A method for identifying T-cells that are antigen-specific for at least one neoantigen that is likely to be presented by class II MHC alleles on surfaces of tumor cells of a subject. Peptide sequences of tumor neoantigens are obtained by sequencing the tumor cells of the subject. The peptide sequences are input into a machine-learned presentation model to generate presentation likelihoods for the tumor neoantigens, each presentation likelihood representing the likelihood that a neoantigen is presented by the class II MHC alleles on the surfaces of the tumor cells of the subject. A subset of the neoantigens is selected based on the presentation likelihoods. T-cells that are antigen-specific for at least one of the neoantigens in the subset are identified. These T-cells can be expanded for use in T-cell therapy. TCRs of these identified T-cells can also be sequenced and cloned into new T-cells for use in T-cell therapy.

Abstract: Machine learning based methods for planning, execution, and reporting of clinical trials, incorporating a patient burden index are disclosed. In one aspect, there is a method for determining a patient burden index. The method includes parsing a protocol for a clinical trial. The method further includes providing factor data for each of a plurality of patients. The method further includes calculating a patient burden index for each of the plurality of patients based on the parsed protocol and the provided factor data for each of the plurality of patients.

Abstract: A shelf system may have a shelf member, and a biasing bracket attached to the shelf member having a rear portion and a forward portion. The system may also have a biasing member having a first end connected to the rear portion of the biasing bracket and a second end connected to the shelf member. The forward portion of the biasing bracket may have a lower stop adapted to prevent the shelf member from extending below a horizontal orientation. And, a pivot bracket may be located behind the lower stop through which a pivot extends and into the biasing bracket to permit selective movement of the shelf member.

Abstract: A wedge tool includes an elongated body having a cavity disposed within its proximal portion, the body having two vertical sides intersecting two force-applying surfaces with a tapered, curved profile to define a blade at a distal end of the body. At least one a light emitter within the body emits light from the distal portion. A power source is disposed within the cavity for providing power to the light emitter.

Abstract: A flooring installation includes at least two floor supports separated from one another by a span distance, the floor supports each having lateral, vertical side walls between which an opening is defined. A bay is defined between the floor supports. A primary subfloor is supported atop and attached to one of the at least two floor supports, the primary subfloor including an overhanging portion overhanging a portion of the bay. A spanning brace is disposed between the at least two floor supports in the bay, the spanning brace engaging on opposing ends the lateral, vertical side walls of the floor supports, one end of the spanning brace extending beneath and spaced from the overhanging portion of the primary subfloor. A recessed subfloor panel is supported atop the spanning brace, the recessed subfloor panel being supported at a lower elevation than the overhanging portion of the adjacent, primary subfloor.

Abstract: A method to provide flexible access to an internal data of an regulated system, the method comprising receiving, by a data access component of the regulated system, a loadable configuration file defining a set of triggering events and a set of memory, determining the occurrence of a single triggering event, accessing at least a subset of memory that contain the internal data of the avionics system to retrieve data associated with the one or more memory of the set of memory, and outputting the retrieved data to a receiving component.

Abstract: A wearable data storage and transmission device and related systems that collect and store sensor data from sensors worn by a user. The device components can include a processor, battery, data storage media, NFC components, Bluetooth components, Wi-Fi components, and wired communications components. The device can remain powered down, powering up periodically to collect sensor data using low energy methods and/or in response to receiving a signal (e.g., NFC, power, Bluetooth, etc.) from an external device that causes the device to power up its components and make sensor data available to the external device. The collected sensor data may be encoded, compressed, stored, and/or exchanged in one or more structured records using various methods to improve the information storage capabilities of the device, including using the disclosed QR coding methods.

Abstract: A system includes a robot configured to load and/or unload from a location, such as a cargo carrier or building. The robot includes a base unit that has a transport system to move the base unit. A mast extends from the base unit, and the mast has a mast conveyor. An End of Arm Tool (EoAT) is coupled to the mast. The EoAT includes an EoAT conveyor configured to move a cargo item to and from the mast conveyor. A gripper mechanism is configured to move between a retracted position where the gripper mechanism is clear of the cargo item on the EoAT conveyor and an extended position where the gripper mechanism is able to grip the cargo item.

Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.

Abstract: Techniques of editing images using a digital image editing tool involve defining a local adjustment that includes, as separate masks, a spatial mask and a range mask. The spatial mask specifies a region of the image to be adjusted and the range mask specifies ranges of colors and tones to be adjusted independent of the region specified by the spatial mask. In applying these masks, when a user changes a setting in the digital image editing tool, the digital image editing tool weights the effect of the setting according to the values of the spatial mask and the range mask for each pixel of the image.

Abstract: A single stage clarifier mixing assembly includes a housing having a circular sidewall and a center axis, a mixing section in the housing, a clarifier section overlying and axially aligned with the mixing section along the center axis within the housing, an inlet delivering an inlet stream to the mixing section and an agitator. The agitator is adapted for mixing the inlet stream in the mixing chamber.

Abstract: Golf club heads (102) are releasably engaged with shafts (106) so that the club heads and shafts can be readily interchanged and/or so that the shaft position with respect to the club head can be readily changed. Assemblies for connecting the club head and shaft include: a shaft adapter (200), a hosel adapter (300), a hosel ring (500), a securing system (408) and a club head having an interior chamber. The club head and shaft may be changed by releasing the securing system and exchanging the original parts with different parts.

Abstract: A continuous solvent extract process is provided for concentrating rare earth elements from leachates generated from coal sources. The process involves solvent extraction which utilizes an organic extractant mixed into an organic solvent.

Abstract: Systems for producing nitrogen compounds that are configured for integration with an irrigation device. The systems generally include an absorber receiving a reactor-outlet stream comprising one or more oxidized nitrogen species, the absorber containing water to produce a nitrogen-compound stream comprising nitrates, nitrites, nitric acid, salts thereof, or a mixture thereof; and a system-outlet port configured to be fluidically coupled to an irrigation line, the system-outlet port in fluid communication with the absorber to receive at least a portion of the nitrogen-compound stream and provide the nitrogen-compound stream to the irrigation line.

Abstract: A wearable data storage and transmission device and related systems that collect and store sensor data from sensors worn by a user. The device components can include a processor, battery, data storage media, NFC components, Bluetooth components, Wi-Fi components, and wired communications components. The device can remain powered down, powering up periodically to collect sensor data using low energy methods and/or in response to receiving a signal (e.g., NFC, power, Bluetooth, etc.) from an external device that causes the device to power up its components and make sensor data available to the external device. The collected sensor data may be encoded, compressed, stored, and/or exchanged in one or more structured records using various methods to improve the information storage capabilities of the device, including using the disclosed QR coding methods.

Abstract: Systems and methods for producing nitrates, nitric acid, salts thereof, or a mixture thereof are disclosed. The systems may include a feed conduit configured for receiving a feed stream comprising molecular oxygen and molecular nitrogen; an inlet conduit configured for receiving an inlet stream; a plasma reactor fluidically coupled to the inlet conduit, the plasma reactor fluidically coupled to a reactor-outlet conduit configured for receiving the reactor-outlet stream, the plasma reactor configured to produce oxidized nitrogen species; and an absorber fluidically coupled to the reactor-outlet conduit, the absorber configured to receive the reactor outlet stream and to produce nitrates, nitrites, nitric acid, salts thereof, or a mixture thereof from the reactor outlet stream. A recycle conduit may be fluidically coupled to the absorber and the inlet conduit, wherein the recycle conduit is configured to receive the gas-phase stream from the absorber and provide the gas-phase stream to the inlet conduit.