Abstract: A method of inhibiting anaphylaxis includes administering to a subject a composition comprising a first antibody, or fragment thereof, that binds to an allergen and a second antibody, or fragment thereof, that binds to the allergen, wherein the first antibody and the second antibody are from selected, epitope bins for an allergen that show the highest relative efficacy.

Abstract: The technology described herein relates, at least in part, to compositions comprising and methods for isolating and enriching natural IgM-producing phagocytic B (NIMPAB) cells and methods of producing IgM antibodies using such cells, as well as uses of the antibodies produced by the methods for the prevention and treatment of diseases wherein immunotherapy with such natural IgM antibodies and their derivatives can be useful.

Abstract: The technology described herein relates, at least in part, to compositions comprising and methods for isolating and enriching natural IgM-producing phagocytic B (NIMPAB) cells and methods of producing IgM antibodies using such cells, as well as uses of the antibodies produced by the methods for the prevention and treatment of diseases wherein immunotherapy with such natural IgM antibodies and their derivatives can be useful.

Abstract: Illustrative embodiments of the present invention are directed to devices and methods for ion generation. One such device includes a substrate. The substrate is disposed within a housing that is configured to contain a gas. The substrate includes an interior surface that at least partially defines an interior volume. The substrate also includes a number of channels with walls. Nano-tips are disposed on the walls of the channels.

Abstract: Illustrative embodiments of the present invention are directed to devices and methods for ion generation. One such device includes a substrate. The substrate is disposed within a housing that is configured to contain a gas. The substrate includes an interior surface that at least partially defines an interior volume. The substrate also includes a number of channels with walls. Nano-tips are disposed on the walls of the channels.

Abstract: The present invention relates to the fabrication and use of microbubbles. In some embodiments, the invention provides for the fabrication and use of polymerized shell lipid microbubbles (PSMs). The microbubbles of the invention can be used, for example, for diagnosis and treatment of a condition.

Abstract: Methods and devices relating to a radiation detector comprising of a gas chamber having a cathode plate and a substrate separated by a gap. An array of nano-tips deposited on the substrate that forms an anode structure for electron charge collection. An external power source in communication with the cathode plate and the substrate, wherein the external power source is capable of generating a plurality of regions and each region includes an electric field near each nano-tip of the array of the nano-tips that results in initiating a radiation induced controlled discharge of electrons and ions from at least one gas or at least one gas mixture. Finally, the plurality of regions include multiple generated electric fields near tips of the array of nano-tips such as CNTs, that communicatively create a conductive path between the cathode plate and the substrate, the radiation detector is capable of determining at least one radiation property.

Abstract: A fluid separation method for performing fluid analysis of an unfiltered fluid. The fluid separation method includes providing a structure with a fluid analyzer and a power supply. Using a substrate for receiving a fluid flow stream of a multiphase mixture through a fluid sample inlet, wherein the substrate interconnects with the structure. Providing a membrane disposed across the fluid sample inlet for separating a fluid of interest from the multiphase mixture, wherein the fluid flow stream of the multiphase mixture has a shear rate that prevents a fouling of the membrane. Finally, the fluid separation method includes the substrate having fabricated channels, such that the fabricated channels are arranged substantially tangent to the fluid stream downstream of the porous membrane.

Abstract: Methods and devices relating to a radiation detector comprising of a gas chamber having a cathode plate and a substrate separated by a gap. An array of nano-tips deposited on the substrate that forms an anode structure for electron charge collection. An external power source in communication with the cathode plate and the substrate, wherein the external power source is capable of generating a plurality of regions and each region includes an electric field near each nano-tip of the array of the nano-tips that results in initiating a radiation induced controlled discharge of electrons and ions from at least one gas or at least one gas mixture. Finally, the plurality of regions include multiple generated electric fields near tips of the array of nano-tips such as CNTs, that communicatively create a conductive path between the cathode plate and the substrate, the radiation detector is capable of determining at least one radiation property.

Abstract: A carbon nanostructured micro-fabricated gas chromatography column which is particularly well-suited to the surface well-site and/or the downhole analysis of natural gas in oilfield or gasfield applications (but which may also be used in non-oilfield or non-gasfield situations) is described. This micro-fabricated column integrates a micro-structured substrate such as a silicon substrate with carbon nanotubes as an active nanostructured material in a micro-channel. Benefits of the present invention include enhanced separation of alkanes and isomers, particularly below hexane (i.e., below C6), as well as the separation of carbon dioxide, hydrogen sulfide, and water and other substances present in natural gas. The chromatography column of the present invention is in one embodiment a part of an entire gas chromatograph system that in its simplest form also comprises an injector and a detector. Preferably the injector, separation column, and detector are all micro-fabricated on a substrate.

Abstract: A microfluidic system for performing fluid analysis is described having: (a) a submersible housing having a fluid analysis means and a power supply to provide power to said system; and (b) a substrate for receiving a fluid sample, having embedded therein a fluid sample inlet, a reagent inlet, a fluid sample outlet, and a mixing region in fluid communication with the fluid sample inlet, the reagent inlet, and the fluid sample outlet, and wherein the substrate includes a fluid drive means for moving the fluid sample through the substrate, and wherein the substrate interconnects with the housing. At least a portion of the fluid analysis means may be embedded in the substrate.

Abstract: The present invention provides methods and apparatus for separating and/or analyzing fluids of interest. According to principles of the present invention, fluid analysis is accomplished with microfluidic devices and may be reported in real-time or near real-time in a subterranean environment. In addition or alternative to oilfield applications, the principles of the present invention contemplate separation in a laboratory or other environment for biological sample separation and analytical chemistry applications. The present invention is capable of separating liquid-liquid mixtures or emulsions in a microfluidic device without fouling.

Abstract: A betatron structure having a donut-shaped vacuum chamber, wherein the vacuum chamber is made up of two or more pieces bonded together; an injector positioned within the vacuum chamber; and two or more magnets positioned to the outside of the vacuum chamber. A method of manufacturing a betatron structure, including: (a) fabricating two or more pieces; (b) positioning an injector on one of the two or more pieces; and (c) bonding the two or more pieces such that when bonded, the substrates form a hollow donut-shaped chamber.

Abstract: A fluid separation method for performing fluid analysis of an unfiltered fluid. The fluid separation method includes providing a structure with a fluid analyzer and a power supply. Using a substrate for receiving a fluid flow stream of a multiphase mixture through a fluid sample inlet, wherein the substrate interconnects with the structure. Providing a membrane disposed across the fluid sample inlet for separating a fluid of interest from the multiphase mixture, wherein the fluid flow stream of the multiphase mixture has a shear rate that prevents a fouling of the membrane. Finally, the fluid separation method includes the substrate having fabricated channels, such that the fabricated channels are arranged substantially tangent to the fluid stream downstream of the porous membrane.

Abstract: The present invention provides methods and apparatus for separating and/or analyzing fluids of interest. According to principles of the present invention, fluid analysis is accomplished with microfluidic devices and may be reported in real-time or near real-time in a subterranean environment. In addition or alternative to oilfield applications, the principles of the present invention contemplate separation in a laboratory or other environment for biological sample separation and analytical chemistry applications. The present invention is capable of separating liquid-liquid mixtures or emulsions in a microfluidic device without fouling.

Abstract: The present invention provides methods and apparatus for separating and/or analyzing fluids of interest. According to principles of the present invention, fluid analysis is accomplished with microfluidic devices and may be reported in real-time or near real-time in a subterranean environment. In addition or alternative to oilfield applications, the principles of the present invention contemplate separation in a laboratory or other environment for biological sample separation and analytical chemistry applications. The present invention is capable of separating liquid-liquid mixtures or emulsions in a microfluidic device without fouling.

Abstract: An athletic ball carrier has a strap assembly that is able to open and close to retain balls. A first set of straps may be interconnected at a connection point. The connection point may be opposed from an intersection area. A transverse strap is secured to the first set of straps. A draw string can be adjustably secured to the first set of straps to “close” the strap assembly to hold balls of varying shapes and sizes.

Abstract: A betatron structure having a donut-shaped vacuum chamber, wherein the vacuum chamber is made up of two or more pieces bonded together; an injector positioned within the vacuum chamber; and two or more magnets positioned to the outside of the vacuum chamber. A method of manufacturing a betatron structure, including: (a) fabricating two or more pieces; (b) positioning an injector on one of the two or more pieces; and (c) bonding the two or more pieces such that when bonded, the substrates form a hollow donut-shaped chamber.