Abstract: Microparticle and nanoparticles comprised of a polymer and of a lipid-polymer conjugate (lipopolymer) are described. The particles can include a therapeutic or diagnostic agent and/or a ligand attached to the lipopolymer. Compositions comprising the particles and methods of treatment using the particles are also described.

Abstract: An anchor to hold getter materials in place within a micromechanical device package substrate. First and second cavity faces define an anchor cavity and mechanically retain a getter away from a region holding the micromechanical device. The getter anchor may be formed in a substrate comprised of at least three layers. The layers form a cavity in the substrate with a wide bottom portion—formed in the middle layer and a relatively narrower top portion—formed by the top layer. The narrow portion helps to retain the getter in the cavity by creating a mechanical lock on the wide portion of getter in the bottom of the cavity.

Abstract: The present invention provides methods and apparatus for separating and/or analyzing fluids of interest. According to principles of the present invention, fluid analysis is accomplished with microfluidic devices and may be reported in real-time or near real-time in a subterranean environment. In addition or alternative to oilfield applications, the principles of the present invention contemplate separation in a laboratory or other environment for biological sample separation and analytical chemistry applications. The present invention is capable of separating liquid-liquid mixtures or emulsions in a microfluidic device without fouling.

Abstract: A microfluidic system for performing fluid analysis is described having: (a) a submersible housing having a fluid analysis means and a power supply to provide power to said system; and (b) a substrate for receiving a fluid sample, having embedded therein a fluid sample inlet, a reagent inlet, a fluid sample outlet, and a mixing region in fluid communication with the fluid sample inlet, the reagent inlet, and the fluid sample outlet, and wherein the substrate includes a fluid drive means for moving the fluid sample through the substrate, and wherein the substrate interconnects with the housing. At least a portion of the fluid analysis means may be embedded in the substrate.

Abstract: By using electron beam lithography, chemically assisted ion beam etching, and electroplating, high aspect ratio magnetic columns, 60 nm-170 nm in diameter, which are embedded in an aluminum-gallium-oxide/gallium-arsenide (Al0.9Ga0.1)203/GaAs heterostructured substrate, are fabricated. Storage of data in electroplated Ni columns is realized in the form of tracks 0.5 &mgr;m and 0.25 &mgr;m in the down-track direction, and 1 &mgr;m in the cross-track direction, corresponding to areal densities of 1.3 and 2.6 Gbits/in2 respectively. The fabrication of patterned media samples, using dry etching and oxidation of AlGaAs, and electrodeposition of Ni into GaAs substrate is realized.

Abstract: One embodiment provides an anchor to hold getter materials in place within a micromechanical device package substrate, said anchor comprising: a first cavity face; and a second cavity face. The cavity faces define an anchor cavity and mechanically retain a getter away from a region holding the micromechanical device. Another embodiment provides an anchor to hold a getter in place within a micromechanical device package. The anchor comprises: a package substrate; and a member attached to the package substrate, the member shaped to provide mechanical retention of the getter material formed over said member. Another embodiment provides a micromechanical device package comprising: a package substrate; a package lid enclosing a package cavity; a micromechanical device in the package cavity; and a getter anchor in the package cavity. Other embodiments provide methods of packaging and forming packages having a getter anchor. One getter anchor is formed in a substrate 906 comprised of at least three layers.