Patents by Inventor Jukka Tuunanen
Jukka Tuunanen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220412970Abstract: A target substance is collected from a composition by using magnetically responsive particles and a magnetic transfer probe. The composition may be prepared, e.g., by introducing magnetically responsive particles to a sample. The particles selectively bind to a target substance of the composition. The target substance and the particles are collected from the sample by using the magnetic transfer probe, which comprises a probe magnet. The probe magnet is a permanent magnet, which comprises a cylindrical portion and a convex bottom portion adjoining the cylindrical portion. The particle collection region of the magnetic transfer probe is at a low position, which allows collecting the particles from a small amount of the prepared composition.Type: ApplicationFiled: December 1, 2020Publication date: December 29, 2022Inventor: Jukka Tuunanen
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Publication number: 20220275447Abstract: The invention relates to a sample processing apparatus comprising a holder for a microtiter plate comprising a plurality of microwells, optical measurement unit for measuring optical responses of samples dosed to the microwells, and a computing unit configured to analyze the optical responses in order to detect dosing failures in said plurality of microwells, and if a dosing failure has been detected in one or more of the microwells, to communicate the existence of the dosing failure to a user of the apparatus through signaling means or to store data indicative of the dosing failure to data storage means for further use. In particular, the invention relates to detecting dosing failures in before, during and after a PCR process.Type: ApplicationFiled: October 11, 2021Publication date: September 1, 2022Applicant: Thermo Fisher Scientific Baltics UABInventors: Jukka Tuunanen, Jaako Kurkela, Katja Eklin
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Publication number: 20220120688Abstract: The optical reader for analyzing biological samples comprises a reading plane (3) for receiving a microplate (1), an illuminating arrangement (4) configured to illuminate samples in the wells (2) of the microplate (1), an imaging device (6) arranged to receive light from the microplate (1), a beam splitter (7), which is arranged to direct light from the illuminating arrangement (4) towards the reading plane (3) and to direct light received from the microplate (1) to the imaging device (6), and a lens system (8) arranged between the beam splitter (7) and the reading plane (3) to focus the light received from the illuminating arrangement (4) to a sample and to focus an image of the sample to the imaging device (6).Type: ApplicationFiled: January 31, 2020Publication date: April 21, 2022Inventors: Jukka TUUNANEN, Adyary FALLARERO, Pasi TOIVANEN
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Publication number: 20200308643Abstract: The invention relates to a sample processing apparatus comprising a holder for a microtiter plate comprising a plurality of microwells, optical measurement unit for measuring optical responses of samples dosed to the microwells, and a computing unit configured to analyze the optical responses in order to detect dosing failures in said plurality of microwells, and if a dosing failure has been detected in one or more of the microwells, to communicate the existence of the dosing failure to a user of the apparatus through signaling means or to store data indicative of the dosing failure to data storage means for further use. In particular, the invention relates to detecting dosing failures in before, during and after a PCR process.Type: ApplicationFiled: March 11, 2020Publication date: October 1, 2020Applicant: Thermo Fisher Scientific Baltics UABInventors: Jukka Tuunanen, Jaako Kurkela, Katja Eklin
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Patent number: 10677734Abstract: A method and an apparatus for optical measurement of a liquid sample placed in a sample well where the sample in the sample well is exposed to excitation light at first wavelength from an excitation light source, which excitation light generates a collection of singlet state oxygen molecules from donor molecules in the liquid sample, said singlet state oxygen molecules reacting with acceptor molecules in the liquid sample causing said acceptor molecules to emit chemiluminescence emission light at second wavelength, which second wavelength is shorter than said first wavelength, and where the emission light produced by the excitation light is measured with a detector, characterized in that the excitation light source is a LED.Type: GrantFiled: September 3, 2015Date of Patent: June 9, 2020Assignee: Thermo Fisher Scientific OyInventors: Jukka Tuunanen, Sauli Porttila, Matti Sairanen, Tuomo Von Lerber, Jorma Lampinen, Timo Karmeniemi
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Patent number: 10626461Abstract: The invention relates to a sample processing apparatus comprising a holder for a microtiter plate comprising a plurality of microwells, optical measurement unit for measuring optical responses of samples dosed to the microwells, and a computing unit configured to analyze the optical responses in order to detect dosing failures in said plurality of microwells, and if a dosing failure has been detected in one or more of the microwells, to communicate the existence of the dosing failure to a user of the apparatus through signaling means or to store data indicative of the dosing failure to data storage means for further use. In particular, the invention relates to detecting dosing failures in before, during and after a PCR process.Type: GrantFiled: May 25, 2018Date of Patent: April 21, 2020Assignee: Thermo Fisher Scientific Baltics UABInventors: Jukka Tuunanen, Jaako Kurkela, Katja Eklin
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Publication number: 20180355428Abstract: The invention relates to a sample processing apparatus comprising a holder for a microtiter plate comprising a plurality of microwells, optical measurement unit for measuring optical responses of samples dosed to the microwells, and a computing unit configured to analyze the optical responses in order to detect dosing failures in said plurality of microwells, and if a dosing failure has been detected in one or more of the microwells, to communicate the existence of the dosing failure to a user of the apparatus through signaling means or to store data indicative of the dosing failure to data storage means for further use. In particular, the invention relates to detecting dosing failures in before, during and after a PCR process.Type: ApplicationFiled: May 25, 2018Publication date: December 13, 2018Applicant: Thermo Fisher Scientific Baltics UABInventors: Jukka Tuunanen, Jaako Kurkela, Katja Eklin
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Patent number: 10006086Abstract: The invention relates to a sample processing apparatus comprising a holder for a microtiter plate comprising a plurality of microwells, optical measurement unit for measuring optical responses of samples dosed to the microwells, and a computing unit configured to analyze the optical responses in order to detect dosing failures in said plurality of microwells, and if a dosing failure has been detected in one or more of the microwells, to communicate the existence of the dosing failure to a user of the apparatus through signaling means or to store data indicative of the dosing failure to data storage means for further use. In particular, the invention relates to detecting dosing failures in before, during and after a PCR process.Type: GrantFiled: July 14, 2016Date of Patent: June 26, 2018Assignee: Thermo Fisher Scientific Baltics UABInventors: Jukka Tuunanen, Jaako Kurkela, Katja Eklin
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Publication number: 20170254756Abstract: A method and an apparatus for optical measurement of a liquid sample placed in a sample well where the sample in the sample well is exposed to excitation light at first wavelength from an excitation light source, which excitation light generates a collection of singlet state oxygen molecules from donor molecules in the liquid sample, said singlet state oxygen molecules reacting with acceptor molecules in the liquid sample causing said acceptor molecules to emit chemiluminescence emission light at second wavelength, which second wavelength is shorter than said first wavelength, and where the emission light produced by the excitation light is measured with a detector, characterized in that the excitation light source is a LED.Type: ApplicationFiled: September 3, 2015Publication date: September 7, 2017Inventors: Jukka Tuunanen, Sauli Porttila, Matti Sairanen, Tuomo Von Lerber, Jorma Lampinen, Timo Karmeniemi
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Patent number: 9568403Abstract: The invention concerns a method for processing magnetic particles, which selectively interact with a substance present in a liquid medium. The particles are collected with a probe (2) comprising a hollow shield (4) and a probe magnet (3) moveable up and down. The lower end of the probe with the collected particles is placed on a release location (7) of a plate (6), below which release location there is a release magnet (8). The surface of the release location is dry or has a liquid film or a drop on it. In accordance with the invention, very high concentration ratios can be achieved.Type: GrantFiled: February 22, 2012Date of Patent: February 14, 2017Assignee: THERMO FISHER SCIENTIFIC OYInventor: Jukka Tuunanen
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Publication number: 20170009291Abstract: The invention relates to a sample processing apparatus comprising a holder for a microtiter plate comprising a plurality of microwells, optical measurement unit for measuring optical responses of samples dosed to the microwells, and a computing unit configured to analyze the optical responses in order to detect dosing failures in said plurality of microwells, and if a dosing failure has been detected in one or more of the microwells, to communicate the existence of the dosing failure to a user of the apparatus through signaling means or to store data indicative of the dosing failure to data storage means for further use. In particular, the invention relates to detecting dosing failures in before, during and after a PCR process.Type: ApplicationFiled: July 14, 2016Publication date: January 12, 2017Applicant: Thermo Fisher Scientific Baltics UABInventors: Jukka Tuunanen, Jaako Kurkela, Katja Eklin
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Patent number: 9422604Abstract: The invention relates to a sample processing apparatus comprising a holder for a microtiter plate comprising a plurality of microwells, optical measurement unit for measuring optical responses of samples dosed to the microwells, and a computing unit configured to analyze the optical responses in order to detect dosing failures in said plurality of microwells, and if a dosing failure has been detected in one or more of the microwells, to communicate the existence of the dosing failure to a user of the apparatus through signaling means or to store data indicative of the dosing failure to data storage means for further use. In particular, the invention relates to detecting dosing failures in before, during and after a PCR process.Type: GrantFiled: April 1, 2011Date of Patent: August 23, 2016Assignee: Thermo Fisher Scientific Baltics UABInventors: Jukka Tuunanen, Jaakko Kurkela, Katja Eklin
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Publication number: 20140099658Abstract: The invention concerns a method for processing magnetic particles, which selectively interact with a substance present in a liquid medium. The particles are collected with a probe (2) comprising a hollow shield (4) and a probe magnet (3) moveable up and down. The lower end of the probe with the collected particles is placed on a release location (7) of a plate (6), below which release location there is a release magnet (8). The surface of the release location is dry or has a liquid film or a drop on it. In accordance with the invention, very high concentration ratios can be achieved.Type: ApplicationFiled: February 22, 2012Publication date: April 10, 2014Applicant: THERMO FISHER SCIENTIFIC OYInventor: Jukka Tuunanen
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Patent number: 8689982Abstract: The invention relates to a device (2) for separating magnetic particles comprising several substantially aligned magnets (3). Some of the magnets (3) are inversely oriented. This array reduces any magnetic interference with the collection area of an adjacent magnet.Type: GrantFiled: November 9, 2004Date of Patent: April 8, 2014Assignee: Thermo Fisher Scientific OyInventors: Timo Karmeniemi, Jukka Tuunanen
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Publication number: 20110251080Abstract: The invention relates to a sample processing apparatus comprising a holder for a microtiter plate comprising a plurality of microwells, optical measurement unit for measuring optical responses of samples dosed to the microwells, and a computing unit configured to analyze the optical responses in order to detect dosing failures in said plurality of microwells, and if a dosing failure has been detected in one or more of the microwells, to communicate the existence of the dosing failure to a user of the apparatus through signaling means or to store data indicative of the dosing failure to data storage means for further use. In particular, the invention relates to detecting dosing failures in before, during and after a PCR process.Type: ApplicationFiled: April 1, 2011Publication date: October 13, 2011Applicant: FINNZYMES OYInventors: Jukka TUUNANEN, Jaakko Kurkela, Katja Eklin
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Patent number: 7504641Abstract: A polarization fluorometer and a method for calibrating such a fluorometer. The fluorometer includes an excitation channel with an excitation polarizer for generating light polarized in a first plane or in a second plane to be conducted as a excitation light to a sample, an emission channel for conducting emission light from the sample, in which emission channel there is an emission polarization filter, an excitation detector, to which light polarized by the excitation polarizer can be conducted from the excitation channel, and a reference detector, to which light polarized by the excitation polarizer can be conducted from the excitation channel before being conducted to the sample or to the excitation detector. The reference detector can be calibrated by the excitation detector so that correction measurements can be carried out in real time during sample measurement. The fluorometer can be used especially for fluorescence spectra measurements.Type: GrantFiled: September 10, 2004Date of Patent: March 17, 2009Assignee: Thermo ElectronInventor: Jukka Tuunanen
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Publication number: 20080135741Abstract: The present invention relates to photometers wherein light signals on different wavelengths are directed to samples and a light scattered from or penetrated through the sample is measured with a photodetector. Method provides a required filtered light signal for a photometer (4). The method comprises providing a source of white light by a pulsed flash light source (7) and filtering the light signal for providing signals on different wavelengths by using multiple filters (6) arranged on a perimeter of a rotary filter disk (5). At least one filtered light signal is led to at least one photometer (4). The filter disk (5) Is rotated continuously for passing successive filters (6) over the path of light from the flash light source (7) to the photometer (4) and the flash light source (7) is triggered when a filter (6) providing the required wavelength of light is on the path of light from the flash light source (7) to the photometer (4).Type: ApplicationFiled: November 26, 2007Publication date: June 12, 2008Inventors: Jukka Tuunanen, Henrik Johansson, Ville Saarainen, Olli Myyrylainen
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Publication number: 20070221543Abstract: The invention relates to a device (2) for separating magnetic particles comprising several substantially aligned magnets (3). Some of the magnets (3) are inversely oriented. This array reduces any magnetic interference with the collection area of an adjacent magnet.Type: ApplicationFiled: November 9, 2004Publication date: September 27, 2007Applicant: THERMO ELECTRON OYInventors: Timo Karmeniemi, Jukka Tuunanen
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Publication number: 20070200073Abstract: A polarisation fluorometer and a method for calibrating such a fluorometer. The fluorometer includes an excitation channel with an excitation polariser for generating light polarised in a first plane or in a second plane to be conducted as a excitation light to a sample, an emission channel for conducting emission light from the sample, in which emission channel there is an emission polarisation filter, an excitation detector, to which light polarised by the excitation polariser can be conducted from the excitation channel, and a reference detector, to which light polarised by the excitation polariser can be conducted from the excitation channel before being conducted to the sample or to the excitation detector. The reference detector can be calibrated by the excitation detector so that correction measurements can be carried out in real time during sample measurement. The fluorometer can be used especially for fluorescence spectra measurements.Type: ApplicationFiled: September 10, 2004Publication date: August 30, 2007Applicant: THERMO ELECTRON OYInventor: Jukka Tuunanen
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Publication number: 20040218261Abstract: An apparatus for the conduction of light. The apparatus includes two concave refracting elements, such as spherical mirrors or concave gratings, such that a connecting line segment between centers of the elements forms with a main axis of a first element an angle of incidence in excess of zero, and with a main axis of a second element an angle of incidence equal in size but in a plane perpendicular to the plane defined by the connecting line segment and the main axis of the first element. Thus, astigmatism error can be corrected. The apparatus is applicable in optical analyzers for conduction of measuring light to or from a sample.Type: ApplicationFiled: June 15, 2004Publication date: November 4, 2004Inventor: Jukka Tuunanen