Patents by Inventor Julian Adams

Julian Adams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Analogs of Benzoquinone-Containing Ansamycins and Methods of Use Thereof
    Publication number: 20090062250
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Application
    Filed: August 27, 2008
    Publication date: March 5, 2009
    Inventors: Julian Adams, Yun Gao, Asimina T. Georges Evangelinos, Louis Grenier, Roger H. Pak, James R. Porter, James L. Wright
  • CYCLOPAMINE ANALOGUES AND METHODS OF USE THEREOF
    Publication number: 20080269272
    Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
    Type: Application
    Filed: July 10, 2008
    Publication date: October 30, 2008
    Inventors: Julian Adams, Alfredo C. Castro, Michael A. Foley, Somarajan Nair Janardanan Nair, Marta Nevalainen, James R. Porter, Martin R. Tremblay
  • Cyclopamine analogues and methods of use thereof
    Patent number: 7407967
    Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: August 5, 2008
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Julian Adams, Alfredo C. Castro, Michael A. Foley, Somarajan Nair Janardanan Nair, Marta Nevalainen, James R. Porter, Martin R. Tremblay
  • Boronic ester and acid compounds, synthesis and uses
    Publication number: 20080132678
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Application
    Filed: January 2, 2008
    Publication date: June 5, 2008
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross L. Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Analogs of benzoquinone-containing ansamycins and methods of use thereof
    Patent number: 7375217
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: May 20, 2008
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yun Gao, Asimina T. Georges Evangelinos, Louis Grenier, Roger H. Pak, James R. Porter, James L. Wright
  • Analogs of benzoquinone-containing ansamycins and methods of use thereof
    Patent number: 7361647
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: April 22, 2008
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yun Gao, Asimina T. Georges Evangelinos, Louis Grenier, Roger H. Pak, James R. Porter, James L. Wright
  • Substituted ?-carbolines
    Patent number: 7348336
    Abstract: The subject matter of the present invention is directed to novel substituted ?-carbolines, and specifically compounds of the formula I, which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of I?B kinase is involved.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: March 25, 2008
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Olaf Ritzeler, Alfredo Castro, Louis Grenier, Francois Soucy, Wayne W. Hancock, Hormoz Mazdiyasni, Vito Palombella, Julian Adams
  • Boronic ester and acid compounds, synthesis and uses
    Publication number: 20070282100
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Application
    Filed: December 20, 2006
    Publication date: December 6, 2007
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Analogs of benzoquinone-containing ansamycins and methods of use thereof
    Patent number: 7282493
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: October 16, 2007
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yun Gao, Asimina T. Georges Evangelinos, Louis Grenier, Roger H. Pak, James R. Porter, James L. Wright
  • CYCLOPAMINE ANALOGUES AND METHODS OF USE THEREOF
    Publication number: 20070191410
    Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
    Type: Application
    Filed: April 18, 2007
    Publication date: August 16, 2007
    Inventors: Julian ADAMS, Alfredo CASTRO, Michael FOLEY, Somarajan JANARDANAN NAIR, Marta NEVALAINEN, James PORTER, Martin TREMBLAY
  • Cyclopamine analogues and methods of use thereof
    Patent number: 7230004
    Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: June 12, 2007
    Assignee: Infinity Discovery, Inc.
    Inventors: Julian Adams, Alfredo C. Castro, Michael A. Foley, Somarajan Nair Janardanan Nair, Marta Nevalainen, James R. Porter, Martin R. Tremblay
  • Boronic ester and acid compounds, synthesis and uses
    Patent number: 7119080
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: October 10, 2006
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross L. Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Formulation of boronic acid compounds
    Patent number: 7109323
    Abstract: The invention relates to the formulation of pharmaceutical compounds. More particularly, the invention provides stable, pharmaceutically acceptable compositions prepared from boronic acid compounds and methods for preparing the compositions. The invention also provides novel boronate ester compounds. The invention further provides boronic acid anhydride compounds useful in the methods of the invention.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: September 19, 2006
    Assignees: The United States of America as represented by the Department of Health and Human Services, Millennium Pharmaceutical, Inc.
    Inventors: Louis Plamondon, Louis Grenier, Julian Adams, Shanker Lal Gupta
  • Substituted beta carbolines
    Publication number: 20060166978
    Abstract: The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I, which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of I?B kinase is involved.
    Type: Application
    Filed: March 28, 2006
    Publication date: July 27, 2006
    Inventors: Olaf Ritzeler, Alfredo Castro, Louis Grenier, Francois Soucy, Wayne Hancock, Hormoz Mazdiyasni, Vito Palombella, Julian Adams
  • Boronic ester and acid compounds, synthesis and uses
    Publication number: 20060122390
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Application
    Filed: October 17, 2005
    Publication date: June 8, 2006
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Substituted beta-carbolines
    Patent number: 7026331
    Abstract: The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I, which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of I?B kinase is involved.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: April 11, 2006
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Olaf Ritzeler, Alfredo Castro, Louis Grenier, Francois Soucy, Wayne W. Hancock, Hormoz Mazdiyasni, Vito Palombella, Julian Adams
  • Cyclopamine analogues and methods of use thereof
    Publication number: 20060074030
    Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
    Type: Application
    Filed: August 26, 2005
    Publication date: April 6, 2006
    Inventors: Julian Adams, Alfredo Castro, Michael Foley, Somarajan Janardanan Nair, Marta Nevalainen, James Porter, Martin Tremblay
  • Analogs of benzoquinone-containing ansamycins and methods of use thereof
    Publication number: 20060019941
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Application
    Filed: July 13, 2005
    Publication date: January 26, 2006
    Applicant: Infinity Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yun Gao, Asimina Evangelinos, Louis Grenier, Roger Pak, James Porter, James Wright
  • Analogs of benzoquinone-containing ansamycins and methods of use thereof
    Publication number: 20060019939
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Application
    Filed: April 13, 2005
    Publication date: January 26, 2006
    Inventors: Julian Adams, Yun Gao, Asimina Evangelinos, Louis Grenier, Roger Pak, James Porter, James Wright
  • Analogs of benzoquinone-containing ansamycins and methods of use thereof
    Publication number: 20060014731
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Application
    Filed: April 14, 2005
    Publication date: January 19, 2006
    Inventors: Julian Adams, Yun Gao, Asimina Georges Evangelinos, Louis Grenier, Roger Pak, James Porter, James Wright