Patents by Inventor Julian Adams

Julian Adams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Boronic ester and acid compounds, synthesis and uses
    Patent number: 6297217
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Grant
    Filed: January 25, 2000
    Date of Patent: October 2, 2001
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Boronic ester and acid compounds, synthesis and uses
    Patent number: 6083903
    Abstract: Disclosed herein are boronic ester and acid compounds, their synthesis and uses. More specifically, disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain boronic ester and acid compounds.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: July 4, 2000
    Assignee: LeukoSite, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Boronic ester and acid compounds, synthesis and uses
    Patent number: 6066730
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Grant
    Filed: May 26, 1998
    Date of Patent: May 23, 2000
    Assignee: ProScript, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Boronic ester and acid compounds
    Patent number: 5780454
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Grant
    Filed: October 27, 1995
    Date of Patent: July 14, 1998
    Assignee: ProScript, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Method for the preparation of 3-amino-2-chloro-4-methylpyridines
    Patent number: 5668287
    Abstract: A process for the preparation of a 3-amino-2-chloro-4-alkylpyridine of the formula: ##STR1## wherein R is alkyl of from one to three carbon atoms, an intermediate in the preparation of certain 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine compounds useful in the prevention and treatment of HIV infection.
    Type: Grant
    Filed: August 14, 1995
    Date of Patent: September 16, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl G. Grozinger, Karl D. Hargrave, Julian Adams
  • Antiherpes pentapeptides
    Patent number: 5648337
    Abstract: Disclosed herein are pentapeptide derivatives of the formula (SEQ ID NO: 24) XNR.sup.1 --CH(R.sup.2)--C(O)--NH--CH(R.sup.3 --C(O)--NR.sup.4 --CH(CH.sub.2 Y)--CO--NH--CH[CR.sup.5 (R.sup.6)--COOH]--C(W)--NH--CH(R.sup.7)--Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R.sup.1 is alkyl or phenylalkyl, R.sup.2, R.sup.3 and R.sup.7 are selected from the side chains of amino acid or derived amino acid residues, R.sup.4, R.sup.5, and R.sup.6 are hydrogen or lower alkyl, W is oxo or thioxo, Y is carboxy, carbamyl or 5-1H-tetrazolyl and Z is carboxy or 5-1H-tetrazolyl. The derivatives are useful for treating herpes infections.
    Type: Grant
    Filed: July 13, 1993
    Date of Patent: July 15, 1997
    Assignee: Bio-Mega/Boehringer Ingelheim Research Inc.
    Inventors: Julian Adams, Pierre Louis Beaulieu, Pierre Lavallee, Raymond Plante, Sumanas Rakhit
  • 5,11-dihyro-6H-dipyrido[3,2-B:2',3'-e][1,3]diazepines and their use in the prevention or treatment of HIV infection
    Patent number: 5620974
    Abstract: Disclosed are novel 5,11-dihydro-6H-dipyrido[3,2-b; 2',3'-e][1,4]diazepines. These are useful in the prevention or treatment of HIV infection.
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: April 15, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, John R. Proudfoot, Julian Adams, Karl G. Grozinger, Gunther Schmidt, deceased, Wolfhard Engel, Gunther Trummlitz, Wolfgang Eberlein
  • Pyridobenzo- and pyridiothieno-diazepines useful for the treatment of HIV infection
    Patent number: 5602113
    Abstract: Disclosed are novel pyrido[2,3,-b][1,5]benzodiazepines. These compounds are useful in the treatment of AIDS, ARC and related disorders associated with HIV infection.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: February 11, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, Ernest Cullen, John R. Proudfoot, Karl G. Grozinger, Kollol Pal, Julian Adams
  • Pyridobenzo-and pyridiothieno-diazepines useful for the treatment of HIV infection
    Patent number: 5593979
    Abstract: Disclosed are novel pyrido[2,3-b][1,4]benzodiazepines. These compounds are useful in the treatment of AIDS, ARC and related disorders associated with HIV infection.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: January 14, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, Ernest Cullen, John R. Proudfoot, Karl G. Grozinger, Kollol Pal, Julian Adams
  • Pyrrolidine derivatives inhibitors of leukotriene biosynthesis
    Patent number: 5594008
    Abstract: 2-(1-pyrrolidino)-benzoxazoles of general formula ##STR1## are disclosed which are inhibitors of leukotriene biosynthesis.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: January 14, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Kollol Pal, Mark Behnke, Julian Adams
  • Method for the preparation of 5,11-dihydro-6h-dipyrido [3,2-b:2',3'-e][1,4]diazepines
    Patent number: 5571912
    Abstract: This invention relates to a novel method for preparing certain dipyrido-diazepines.
    Type: Grant
    Filed: August 14, 1995
    Date of Patent: November 5, 1996
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl G. Grozinger, Karl D. Hargrave, Julian Adams
  • Leukotriene biosynthesis inhibitors
    Patent number: 5552421
    Abstract: Various substituted benzoxazoles and benzothiazoles, are described and disclosed, which are potent inhibitors of leukotriene synthesis in warm-blooded animals.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: September 3, 1996
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Edward S. Lazer, Julian Adams, Clara K. Miao, Peter Farina
  • Dipyrido[3,2-B:2 ',3'-E][1,4]Diaqzepines and their use in the treatment of HIV infection
    Patent number: 5550117
    Abstract: Disclosed are novel dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the treatment of HIV-1 infection.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: August 27, 1996
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, Ernest Cullen, John R. Proudfoot, Karl G. Grozinger, Kollol Pal, Julian Adams
  • Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain
    Patent number: 5502036
    Abstract: Disclosed herein are pentapeptide derivatives of the formula X--NR.sup.1 --CH(R.sup.2)--C(W)--NH--CR.sup.3 (R.sup.4)--C(W.sup.2)--NR.sup.5 --CH CH.sub.2 C(O)--Y!--C(W.sup.3)--NH--CR.sup.6 -- CR.sup.7 (R.sup.8)--COOH!--C(W.sup.4)--NH--CR.sup.9 (R.sup.10)--Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R.sup.1 is hydrogen, alkyl or phenylalkyl, R.sup.2, R.sup.4 and R.sup.10 are selected from amino acid or derived amino acid residues, R.sup.3, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are hydrogen or alkyl or R.sup.7 and R.sup.8 are joined to form a cycloalkyl, W.sup.1, W.sup.2, W.sup.3 and W.sup.4 are oxo or thioxo, Y is, for example, an alkoxy or a mono or disubstituted amino, and Z is a terminal group, for example, COOH or CH.sub.2 OH. The derivatives are useful for treating herpes infections.
    Type: Grant
    Filed: March 9, 1994
    Date of Patent: March 26, 1996
    Assignee: BioMega Boehringer Ingelheim Research Inc.
    Inventors: Julian Adams, Pierre L. Beaulieu, Robert De/ ziel, John DiMaio, Louis Grenier, Pierre Lavalle/ e, Neil Moss
  • 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
    Patent number: 5366972
    Abstract: Disclosed are novel 5,11-dihydro-6H-dipyrido[3,2-b; 2',3'-e][1,4]diazepines. These are useful in the prevention or treatment of HIV infection.
    Type: Grant
    Filed: July 13, 1993
    Date of Patent: November 22, 1994
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, John R. Proudfoot, Julian Adams, Karl G. Grozinger, Gunther Schmidt, deceased, Wolfhard Engel, Gunther Trummlitz, Wolfgang Eberlein
  • Leukotriene biosynthesis inhibitors
    Patent number: 5296486
    Abstract: Various substituted benzoxazoles, benzothiazoles, oxazolopyridines and thiazolopyridines are described and disclosed, compounds that are potent inhibitors of leukotriene synthesis in warm-blooded animals.
    Type: Grant
    Filed: September 4, 1992
    Date of Patent: March 22, 1994
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Edward S. Lazer, Julian Adams, Clara K. Miao, Peter Farina
  • Cyclic peptides for treating herpes infections
    Patent number: 5258493
    Abstract: Disclosed herein are cyclic peptide derivatives of the formula ##STR1## wherein A is absent or the tripeptide radical Thr.rarw.Gly.rarw.Ala, R.sup.1 is benzyl or benzyl monosubstituted at position 4 of the aromatic ring with halo, hydroxy, lower alkyl or lower alkoxy, R.sup.2 and R.sup.4 each independently is hydrogen or lower alkyl, R.sup.3 is lower alkyl or lower alkyl monosubstituted with a hydroxy, R.sup.5 is lower alkyl, Y is oxo or thioxo and Z is hydroxy or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 each independently is hydrogen or lower alkyl. The derivatives are useful for treating herpes infections.
    Type: Grant
    Filed: March 16, 1992
    Date of Patent: November 2, 1993
    Assignee: Bio-Mega/Boehringer Ingelheim Research Inc.
    Inventors: Julian Adams, John DiMaio, Raymond Plante
  • Method for preparing 3-amino-2-chloro-4-alkylpyridines
    Patent number: 5200522
    Abstract: A process for the preparation of a 3-amino-2-chloro-4-alkylpyridine of the formula: ##STR1## wherein R is alkyl of from one to three carbon atoms, an intermediate in the preparation of certain 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine compounds useful in the prevention and treatment of HIV infection.
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: April 6, 1993
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl G. Grozinger, Karl D. Hargrave, Julian Adams
  • Cyclic peptides for treating herpes infections
    Patent number: 5149778
    Abstract: Disclosed herein are cyclic peptide derivatives of the formula ##STR1## wherein A is absent or the tripeptide radical Thr.rarw.Gly.rarw.Ala, R.sup.1 is benzyl or benzyl monosubstituted at position 4 of the aromatic ring with halo, hydroxy, lower alkyl or lower alkoxy, R.sup.2 and R.sup.4 each independently is hydrogen or lower alkyl, R.sup.3 is lower alkyl or lower alkyl monosubstituted with a hydroxy, R.sup.5 is lower alkyl, Y is oxo or thioxo and Z is hydroxy or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 each independently is hydrogen or lower alkyl. The derivatives are useful for treating herpes infections.
    Type: Grant
    Filed: July 3, 1990
    Date of Patent: September 22, 1992
    Assignee: Bio-Mega, Inc.
    Inventors: Julian Adams, John DiMaio, Raymond Plante
  • 4,7-benzofurandione derivatives
    Patent number: 4968821
    Abstract: 4,7-Benzofurandione derivatives of Formula I, pharmaceutical compositions, and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents. Also disclosed are novel intermediates useful for the preparation of the 4,7-benzofurandiones of this invention.
    Type: Grant
    Filed: July 11, 1988
    Date of Patent: November 6, 1990
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Julian Adams, Yvan Guindon, Patrice C. Belanger, Michel L. Belley, Joshua Rokach