Abstract: A method for producing a honeycomb structure for fine particle collection filters, the honeycomb structure including a plurality of porous honeycomb structure segments. The method includes joining each of the porous honeycomb segments via a joining material layers by applying a joining material between joining surfaces of each of the porous honeycomb structure segments, through a nozzle portion of a joining material applicator. The nozzle portion of the joining material applicator includes: a joining material introduction port; a joining material discharge space; and a joining material flow path having a bent portion, through which the joining material passes from the joining material introduction port to the joining material discharge space. The joining material flow path of the nozzle portion includes a buffer space configured such that a flow path cross section gradually expands toward the joining material discharge space on a downstream side of the bent portion.

Abstract: A monitoring control system includes: at least one transmission monitoring control subsystem; and at least one distribution monitoring control subsystem. The transmission monitoring control subsystem and the distribution monitoring control subsystem respectively include an operation procedure creation unit that creates an operation procedure that defines a procedure of an operation for a facility installed in an electric power system, and an operation unit that, in a case an on-site operation that cannot be remotely performed on the facility is included in the operation procedure, transmits, to an on-site terminal associated with the on-site operation, a start confirmation instruction to confirm whether or not the on-site operation can be started and the operation procedure for the on-site operation. The monitoring control system performs monitoring control of the power transmission system and the power distribution system based on the operation procedure.

Abstract: A monitoring system includes a monitoring control device, an image information providing device, and a client control device. The monitoring control device monitors infrastructure facilities and transmits statuses of the infrastructure facilities acquired on the basis of information input from a sensor to the image information providing device. The image information providing device generates original image information on the basis of the infrastructure facility statuses received from the monitoring control device. The client control device is connected to a display device and an operation device, receives information for designating a partial area of an entire image capable of being generated from the original image information from the operation device, transmits the received information to the image information providing device, and displays an image based on information received from the image information providing device on the display device.

Abstract: The present inventors have found microRNAs which are strongly associated with stabilization of NRF2 in tumors, and an object of the present invention is to provide means for utilizing such miRNAs for the diagnosis and treatment of cancer. The inventors conducted screening of 470 microRNAs in a microRNA library by use of HeLa cells. As a result, 8 miRNAs each exhibiting a large decrease in miRNA activity as compared with a control miRNA, and 8 miRNAs each exhibiting a large increase in miRNA activity as compared with a control miRNA, were identified. The inventors have found that the NRF2 activation in the living body, in particular tumor cells, can be detected by use of the thus-identified miRNAs, whereby malignancy of a tumor, or the like can be differentiated. The inventors have also found that a nucleic acid including a miRNA sequence associated with reduction in the aforementioned ARE activity can be used as a cancer therapeutic agent.

Abstract: An acoustic device includes a member which divides an ear canal of a user and an external space when being attached to an ear or the ear canal of the user, a memory that stores instructions, and a processor that executes the instructions. The instructions cause the processor to perform, acquiring a sound signal indicating a sound, applying a filter processing to the acquired sound signal, the filter processing being changed in accordance with a predetermined condition, and radiating the sound indicated by the sound signal applied with the filter processing to the ear canal.

Abstract: The present inventors have found microRNAs which are strongly associated with stabilization of NRF2 in tumors, and an object of the present invention is to provide means for utilizing such miRNAs for the diagnosis and treatment of cancer. The inventors conducted screening of 470 microRNAs in a microRNA library by use of HeLa cells. As a result, 8 miRNAs each exhibiting a large decrease in miRNA activity as compared with a control miRNA, and 8 miRNAs each exhibiting a large increase in miRNA activity as compared with a control miRNA, were identified. The inventors have found that the NRF2 activation in the living body, in particular tumor cells, can be detected by use of the thus-identified miRNAs, whereby malignancy of a tumor, or the like can be differentiated. The inventors have also found that a nucleic acid including a miRNA sequence associated with reduction in the aforementioned ARE activity can be used as a cancer therapeutic agent.

Abstract: An outer periphery coating method of honeycomb structure has coating steps where the honeycomb structure including a ring-like bulge portion is rotated; a coating member is brought into contact with a side surface of the honeycomb structure by pressing a side edge portion of a spatula via a rubber sheet, the coating member including the plate-like spatula in which a specific cut portion is formed in the one side edge portion and the side edge portion provided with the cut portion is an inclined surface inclined on a coating surface side, and the rubber sheet in which a cut is formed so that an end surface of the end portion is parallel to a back surface of the spatula when the end portion is bent along the side edge portion of the spatula; and a slurry coating material is supplied to the side surface of the honeycomb structure.

Abstract: A preparation containing [3-[2-[4-isopropyl-2-(4-trifluoromethyl)phenyl-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazol-6-yl]oxyacetic acid, [4-[3-[2-(4-trifluoromethyl)phenyl-4-isopropyl-5-thiazolyl]propionyl]-2-methylphenoxy]acetic acid or [4-[3-[2-(2-hydroxy-4-chlorophenyl)-5-isopropyl-4-oxazolyl]propionyl]-2-methylphenoxy]acetic acid, or a pharmacologically acceptable salt thereof as an active ingredient is used as an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, as well as a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.

Abstract: The present inventors have found microRNAs which are strongly associated with stabilization of NRF2 in tumors, and an object of the present invention is to provide means for utilizing such miRNAs for the diagnosis and treatment of cancer. The inventors conducted screening of 470 microRNAs in a microRNA library by use of HeLa cells. As a result, 8 miRNAs each exhibiting a large decrease in miRNA activity as compared with a control miRNA, and 8 miRNAs each exhibiting a large increase in miRNA activity as compared with a control miRNA, were identified. The inventors have found that the NRF2 activation in the living body, in particular tumor cells, can be detected by use of the thus-identified miRNAs, whereby malignancy of a tumor, or the like can be differentiated. The inventors have also found that a nucleic acid including a miRNA sequence associated with reduction in the aforementioned ARE activity can be used as a cancer therapeutic agent.

Abstract: A speed ratio control device for an automatic transmission of a vehicle calculate a minimum engine rotation speed based on a travel load, and sets a target speed ratio such that the engine rotation speed does not fall below the minimum engine rotation speed. If the travel load of the vehicle is equal to or greater than a predetermined value, a higher value is used for the minimum engine rotation speed compared to a case when the travel load of the vehicle is smaller than the predetermined value. Re-acceleration performance of the vehicle under a high travel load as in a case when the vehicle travels uphill while towing another vehicle is thereby improved.

Abstract: An object of the present invention is to provide an agent for promoting proliferation of a meibomian gland epithelial cell and a corneal epithelial cell, as well as provide an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye. There are provided an agent for promoting proliferation of a meibomian gland epithelial cell or a corneal epithelial cell, containing a PPAR? or ? agonist as an active ingredient, as well as an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye, containing a PPAR? or ? agonist as an active ingredient.

Abstract: A front subframe structure for an automotive vehicle comprises: a pair of right and left side members each provided with an arm support member for supporting a suspension arm is mounted; a cross member disposed between the left and right side members to couple together respective locations in the side members at each of which the arm support member is provided; and an oblique member extending from central portion of the cross member, in each of right and left directions of the vehicle and obliquely rearwardly and outwardly in the vehicle width direction, wherein each of the side members has a rear end joined to a rear portion of a respective one of the oblique members, and wherein the rear portion of the oblique member is provided with a tunnel-lower-frame coupling portion couplable to a tunnel lower frame, and a floor frame attaching portion attachable to a floor frame.

Abstract: A speed ratio control device for an automatic transmission of a vehicle calculate a minimum engine rotation speed based on a travel load, and sets a target speed ratio such that the engine rotation speed does not fall below the minimum engine rotation speed. If the travel load of the vehicle is equal to or greater than a predetermined value, a higher value is used for the minimum engine rotation speed compared to a case when the travel load of the vehicle is smaller than the predetermined value. Re-acceleration performance of the vehicle under a high travel load as in a case when the vehicle travels uphill while towing another vehicle is thereby improved.

Abstract: Provision of an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, and a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like. A preparation containing [3-[2-[4-isopropyl-2-(4-trifluoromethyl)phenyl-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazol-6-yl]oxyacetic acid, [4-[3-[2-(4-trifluoromethyl)phenyl-4-isopropyl-5-thiazolyl]propionyl]-2-methylphenoxy]acetic acid or [4-[3-[2-(2-hydroxy-4-chlorophenyl)-5-isopropyl-4-oxazolyl]propionyl]-2-methylphenoxy]acetic acid, or a pharmacologically acceptable salt thereof as an active ingredient is used as an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, as well as a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.

Abstract: A front subframe structure for an automotive vehicle comprises: a pair of right and left side members each provided with an arm support member for supporting a suspension arm is mounted; a cross member disposed between the left and right side members to couple together respective locations in the side members at each of which the arm support member is provided; and an oblique member extending from central portion of the cross member, in each of right and left directions of the vehicle and obliquely rearwardly and outwardly in the vehicle width direction, wherein each of the side members has a rear end joined to a rear portion of a respective one of the oblique members, and wherein the rear portion of the oblique member is provided with a tunnel-lower-frame coupling portion couplable to a tunnel lower frame, and a floor frame attaching portion attachable to a floor frame.

Abstract: Provision of an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, and a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like. A preparation containing [3-[2-[4-isopropyl-2-(4-trifluoromethyl)phenyl-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazol-6-yl]oxyacetic acid, [4-[3-[2-(4-trifluoromethyl)phenyl-4-isopropyl-5-thiazolyl]propionyl]-2-methylphenoxy]acetic acid or [4-[3-[2-(2-hydroxy-4-chlorophenyl)-5-isopropyl-4-oxazolyl]propionyl]-2-methylphenoxy]acetic acid, or a pharmacologically acceptable salt thereof as an active ingredient is used as an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, as well as a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.

Abstract: To provide a triazole compound which has remarkably excellent pesticidal activities.

Abstract: An outer periphery coating method of honeycomb structure has coating steps where the honeycomb structure including a ring-like bulge portion is rotated; a coating member is brought into contact with a side surface of the honeycomb structure by pressing a side edge portion of a spatula via a rubber sheet, the coating member including the plate-like spatula in which a specific cut portion is formed in the one side edge portion and the side edge portion provided with the cut portion is an inclined surface inclined on a coating surface side, and the rubber sheet in which a cut is formed so that an end surface of the end portion is parallel to a back surface of the spatula when the end portion is bent along the side edge portion of the spatula; and a slurry coating material is supplied to the side surface of the honeycomb structure.

Abstract: A bicycle wheel securing structure includes a bicycle fork, an adapter and a holding member. The bicycle fork has two axle support portions that are spaced apart for receiving a bicycle hub therebetween. The adapter is disposed in an adapter receiving bore in one of the axle support portions. The adapter includes a threaded axle mounting opening. The holding member is operatively coupled between the adapter and the one of the axle support portions with the adapter. The holding member prevents both rotational movement of the adapter with respect to the bicycle fork and axial movement of the adapter with respect to the bicycle fork along an axis of the axle mounting opening when the holding member is in a retaining position. The adapter is rotatable within the adapter receiving bore without moving axially with respect to the bicycle fork when the holding member is in a releasing position.

Abstract: A bicycle wheel securing structure includes a bicycle fork, an adapter and a holding member. The bicycle fork has two axle support portions that are spaced apart for receiving a bicycle hub therebetween. The adapter is disposed in an adapter receiving bore in one of the axle support portions. The adapter includes a threaded axle mounting opening. The holding member is operatively coupled between the adapter and the one of the axle support portions with the adapter. The holding member prevents both rotational movement of the adapter with respect to the bicycle fork and axial movement of the adapter with respect to the bicycle fork along an axis of the axle mounting opening when the holding member is in a retaining position. The adapter is rotatable within the adapter receiving bore without moving axially with respect to the bicycle fork when the holding member is in a releasing position.