Patents by Inventor Jun Inoue
Jun Inoue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20130053374Abstract: The present invention provides an ophthalmic composition comprising a hyperbranched polyester. The ophthalmic compositions may also comprise carbonic anhydrase inhibitors, wherein the hyperbranched polyester increases the aqueous solubility of the carbonic anhydrase inhibitor, and increases corneal permeation of the active agent. The ophthalmic compositions may also comprise non-ionic surfactants, such as PEG, Polysorbate, HPMC or HEC, and beta-blockers, such as Carteolol, Levobunolol, Betaxolol, Metipranolol, Timolol or Propranolol. The concentration of the hyperbranched polyester in the ophthalmic formulation should be less than or equal to 4% (w/v) in order to avoid any cytotoxic effects on human corneal cells and thus the eye irritation.Type: ApplicationFiled: May 4, 2011Publication date: February 28, 2013Inventors: Jun Inoue, Tapan Shah
-
Publication number: 20130046002Abstract: To provide a triazole compound which has remarkably excellent pesticidal activities.Type: ApplicationFiled: May 27, 2011Publication date: February 21, 2013Applicants: Ihara Chemical Industry Co., Ltd., Kumai Chemical Industry Co., Ltd.Inventors: Keiji Toriyabe, Jun Inoue, Masaaki Komatsu
-
Patent number: 8343302Abstract: There is disclosed a method for preparing a honeycomb segment joined body in which a plurality of honeycomb segments are arranged in directions parallel to a first flat surface and a second flat surface of an installation reference jig to install the honeycomb segments in predetermined positions via a paste-like joining material on the installation reference jig by use of the installation reference jig having the first flat surface and the second flat surface forming a right angle therebetween, and then the joining material is dried and cured to join the plurality of honeycomb segments together. In the preparation method, in at least a part of a process of successively installing the plurality of honeycomb segments in the predetermined positions, when a new honeycomb segment is installed, at least a part of the installed honeycomb segments is pressurized and held in the predetermined positions so that the already installed honeycomb segments are not displaced.Type: GrantFiled: November 20, 2008Date of Patent: January 1, 2013Assignee: NGK Insulators, Ltd.Inventors: Akifumi Nishio, Takao Tani, Jun Inoue
-
Patent number: 8317171Abstract: A bicycle suspension including a stroke adjustment unit, a suspension damper, and a damper adjustment unit. The stroke adjustment unit is configured to adjust a stroke of the bicycle suspension, which is configured to expand and contract within the stroke. The suspension damper is configured to apply damping force to the bicycle suspension, and the damper adjustment unit is configured to adjust the damping force applied by the suspension damper in accordance with the stroke adjusted by the stroke adjustment unit.Type: GrantFiled: April 11, 2008Date of Patent: November 27, 2012Assignee: Shimano Inc.Inventor: Jun Inoue
-
Publication number: 20120270910Abstract: Provision of an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, and a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like. A preparation containing [3-[2-[4-isopropyl-2-(4-trifluoroethyl)phenyl-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazol-6-yl]oxyacetic acid, [4-[3-[2-(4-trifluoromethyl)phenyl-4-isopropyl-5-thiazolyl]propionyl]-2-methylphenoxy]acetic acid or [4-[3-[2-(2-hydroxy-4-chlorophenyl)-5-isopropyl-4-oxazolyl]propionyl]-2-methylphenoxy]acetic acid, or a pharmacologically acceptable salt thereof as an active ingredient is used as an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, as well as a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.Type: ApplicationFiled: May 20, 2008Publication date: October 25, 2012Applicants: SENJU PHARMACEUTICAL CO., LTD., NIPPON CHEMIPHAR CO., LTD.Inventors: Yoshikuni NAKAMURA, Ikuko HANANO, Jun INOUE
-
Patent number: 8256787Abstract: An adjustable bicycle suspension system includes a first stroke adjustment unit and a second stroke adjustment unit. The first stroke adjustment unit is configured to adjust a stroke of a suspension by changing a position of the suspension at a first position or a second position. The second stroke adjustment unit is configured to change the position of the suspension at the second position independently from the first position.Type: GrantFiled: October 8, 2009Date of Patent: September 4, 2012Assignee: Shimano Inc.Inventors: Jun Inoue, Toyoto Shirai
-
Publication number: 20120220612Abstract: An object of the present invention is to provide an agent for promoting proliferation of a meibomian gland epithelial cell and a corneal epithelial cell, as well as provide an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye. There are provided an agent for promoting proliferation of a meibomian gland epithelial cell or a corneal epithelial cell, containing a PPAR? or ? agonist as an active ingredient, as well as an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye, containing a PPAR? or ? agonist as an active ingredient.Type: ApplicationFiled: February 28, 2012Publication date: August 30, 2012Inventors: Yoshikuni NAKAMURA, Ikuko Hanano, Jun Inoue
-
Patent number: 8216785Abstract: The present invention is intended to provide a means for judging the malignancy of neuroblastoma and the progress of spontaneous regression thereof. The present invention provides a method for detecting cancer which comprises detecting activation or inactivation of the lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) gene and amplification of the MYCN gene in a specimens to evaluate the malignancy of the specimens and the progress of spontaneous regression.Type: GrantFiled: September 28, 2009Date of Patent: July 10, 2012Assignees: Fujifilm Corporation, National University Corporation Tokyo Medical and Dental UniversityInventors: Johji Inazawa, Issei Imoto, Jun Inoue
-
Patent number: 8211450Abstract: The present invention provides an ophthalmic composition comprising a hyperbranched polymer. The ophthalmic compositions may also comprise carbonic anhydrase inhibitors, wherein the hyperbranched polymer increases the aqueous solubility of the carbonic anhydrase inhibitor, and increases corneal permeation of the active agent. The ophthalmic compositions may also comprise non-ionic surfactants, such as polysorbate, hydroxypropyl methyl cellulose or hydroxyethyl cellulose, and beta-blockers, such as carteolol, levobunolol, betaxolol, metipranolol, timolol or propranolol.Type: GrantFiled: May 5, 2010Date of Patent: July 3, 2012Assignee: Senju USA, Inc.Inventors: Jun Inoue, Tapan Shah
-
Patent number: 8174689Abstract: According to an apparatus for inspecting defects of a honeycomb structure that is provided with a current plate and an air current formation means (air source and a header tube), fine defects or defects taking place in the vicinity of an outer periphery of the honeycomb structure can be detected with high sensitivity.Type: GrantFiled: March 13, 2009Date of Patent: May 8, 2012Assignee: NGK Insulators, Ltd.Inventors: Takayoshi Akao, Hiroyuki Shindo, Jun Inoue, Keita Oikawa
-
Patent number: 8148389Abstract: An object of the present invention is to provide an agent for promoting proliferation of a meibomian gland epithelial cell and a corneal epithelial cell, as well as provide an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye. There are provided an agent for promoting proliferation of a meibomian gland epithelial cell or a corneal epithelial cell, containing a PPAR? or ? agonist as an active ingredient, as well as an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye, containing a PPAR? or ? agonist as an active ingredient.Type: GrantFiled: November 27, 2006Date of Patent: April 3, 2012Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Yoshikuni Nakamura, Ikuko Hanano, Jun Inoue
-
Publication number: 20120049614Abstract: A bicycle wheel securing structure includes a bicycle fork, an adapter and a holding member. The bicycle fork has two axle support portions that are spaced apart for receiving a bicycle hub therebetween. The adapter is disposed in an adapter receiving bore in one of the axle support portions. The adapter includes a threaded axle mounting opening. The holding member is operatively coupled between the adapter and the one of the axle support portions with the adapter. The holding member prevents both rotational movement of the adapter with respect to the bicycle fork and axial movement of the adapter with respect to the bicycle fork along an axis of the axle mounting opening when the holding member is in a retaining position. The adapter is rotatable within the adapter receiving bore without moving axially with respect to the bicycle fork when the holding member is in a releasing position.Type: ApplicationFiled: November 7, 2011Publication date: March 1, 2012Applicant: Shimano Inc.Inventors: Jun INOUE, Takanori KANEHISA
-
Publication number: 20120049613Abstract: A bicycle wheel securing structure includes a bicycle fork, an adapter and a holding member. The bicycle fork has two axle support portions that are spaced apart for receiving a bicycle hub therebetween. The adapter is disposed in an adapter receiving bore in one of the axle support portions. The adapter includes a threaded axle mounting opening. The holding member is operatively coupled between the adapter and the one of the axle support portions with the adapter. The holding member prevents both rotational movement of the adapter with respect to the bicycle fork and axial movement of the adapter with respect to the bicycle fork along an axis of the axle mounting opening when the holding member is in a retaining position. The adapter is rotatable within the adapter receiving bore without moving axially with respect to the bicycle fork when the holding member is in a releasing position.Type: ApplicationFiled: November 7, 2011Publication date: March 1, 2012Applicant: Shimano Inc.Inventors: Jun INOUE, Takanori KANEHISA
-
Publication number: 20110275617Abstract: The present invention provides an ophthalmic composition comprising a hyperbranched polymer. The ophthalmic compositions may also comprise carbonic anhydrase inhibitors, wherein the hyperbranched polymer increases the aqueous solubility of the carbonic anhydrase inhibitor, and increases corneal permeation of the active agent. The ophthalmic compositions may also comprise non-ionic surfactants, such as polysorbate, hydroxypropyl methyl cellulose or hydroxyethyl cellulose, and beta-blockers, such as carteolol, levobunolol, betaxolol, metipranolol, timolol or propranolol.Type: ApplicationFiled: May 5, 2010Publication date: November 10, 2011Inventors: Jun INOUE, Tapan Shah
-
Patent number: 8052225Abstract: A bicycle wheel securing structure includes a bicycle fork, an adapter and a holding member. The bicycle fork has two axle support portions that are spaced apart for receiving a bicycle hub therebetween. The adapter is disposed in an adapter receiving bore in one of the axle support portions. The adapter includes a threaded axle mounting opening. The holding member is operatively coupled between the adapter and the one of the axle support portions with the adapter. The holding member prevents both rotational movement of the adapter with respect to the bicycle fork and axial movement of the adapter with respect to the bicycle fork along an axis of the axle mounting opening when the holding member is in a retaining position. The adapter is rotatable within the adapter receiving bore without moving axially with respect to the bicycle fork when the holding member is in a releasing position.Type: GrantFiled: December 15, 2010Date of Patent: November 8, 2011Assignee: Shimano Inc.Inventors: Jun Inoue, Takanori Kanehisa
-
Patent number: 8042881Abstract: A bicycle wheel securing structure includes a bicycle fork, an adapter and a holding member. The bicycle fork has two axle support portions that are spaced apart for receiving a bicycle hub therebetween. The adapter is disposed in an adapter receiving bore in one of the axle support portions. The adapter includes a threaded axle mounting opening. The holding member is operatively coupled between the adapter and the one of the axle support portions with the adapter. The holding member prevents both rotational movement of the adapter with respect to the bicycle fork and axial movement of the adapter with respect to the bicycle fork along an axis of the axle mounting opening when the holding member is in a retaining position. The adapter is rotatable within the adapter receiving bore without moving axially with respect to the bicycle fork when the holding member is in a releasing position.Type: GrantFiled: November 11, 2008Date of Patent: October 25, 2011Assignee: Shimano Inc.Inventors: Jun Inoue, Takanori Kanehisa
-
Publication number: 20110178299Abstract: The present invention aims at providing an optically active difluoromethanesulfonanilide derivative exhibiting an excellent herbicidal activity at a low dose. An optically active (R)-2?-(4,6-dimethoxy-pyrimidin-2-yl)hydroxymethyl-1,1-difluoromethanesulfonanilide derivative is represented by the formula (I) (in the formula, R1 is a hydrogen atom, a C1-C4 alkyl group or a C1-C4 alkoxy C1-C4 alkyl group). and this difluoromethanesulfonanilide derivative is produced by subjecting to optical resolution a racemate of 2?-(4,6-dimethoxypyrimidin-2-yl)hydroxymethyl-1,1-difluoromethanesul-fonanilide derivative.Type: ApplicationFiled: June 10, 2009Publication date: July 21, 2011Applicants: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.Inventors: Jun Inoue, Hiroshi Kawasaki, Sohei Asakura
-
Patent number: 7956072Abstract: The amide compound of the formula (I) [each symbol is as defined in the description] has a promoting action on neuritogenesis of trigeminal nerve cells, and the compound is useful as a corneal neuritogenesis promoter, an agent for recovering corneal sensitivity by promotion of corneal neuritogenesis, and an agent for treating dry eye.Type: GrantFiled: November 3, 2008Date of Patent: June 7, 2011Assignees: Senju Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma CorporationInventors: Yoshiko Takayama, Yoshikuni Nakamura, Jun Inoue, Mitsuyoshi Azuma
-
Publication number: 20110084464Abstract: An adjustable bicycle suspension system includes a first stroke adjustment unit and a second stroke adjustment unit. The first stroke adjustment unit is configured to adjust a stroke of a suspension by changing a position of the suspension at a first position or a second position. The second stroke adjustment unit is configured to change the position of the suspension at the second position independently from the first position.Type: ApplicationFiled: October 8, 2009Publication date: April 14, 2011Applicant: Shimano Inc.Inventors: Jun INOUE, Toyoto Shirai
-
Publication number: 20110079984Abstract: A bicycle wheel securing structure includes a bicycle fork, an adapter and a holding member. The bicycle fork has two axle support portions that are spaced apart for receiving a bicycle hub therebetween. The adapter is disposed in an adapter receiving bore in one of the axle support portions. The adapter includes a threaded axle mounting opening. The holding member is operatively coupled between the adapter and the one of the axle support portions with the adapter. The holding member prevents both rotational movement of the adapter with respect to the bicycle fork and axial movement of the adapter with respect to the bicycle fork along an axis of the axle mounting opening when the holding member is in a retaining position. The adapter is rotatable within the adapter receiving bore without moving axially with respect to the bicycle fork when the holding member is in a releasing position.Type: ApplicationFiled: December 15, 2010Publication date: April 7, 2011Applicant: SHIMANO INC.Inventors: Jun INOUE, Takanori KANEHISA