Patents by Inventor Karel J. Lambert
Karel J. Lambert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7030155Abstract: A method of making an emulsion of tocopherol incorporating a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various routes, is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated ?-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of ?-tocopherol.Type: GrantFiled: May 17, 2002Date of Patent: April 18, 2006Assignee: Sonus Pharmaceuticals, Inc.Inventors: Karel J. Lambert, Panayiotis P. Constantinides, Alexander K. Tustian, Steven C. Quay
-
Patent number: 6982282Abstract: An emulsion of ?-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans via various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated ?-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of ?-tocopherol.Type: GrantFiled: May 17, 2002Date of Patent: January 3, 2006Assignee: Sonus Pharmaceuticals, Inc.Inventors: Karel J. Lambert, Panayiotis P. Constantinides, Steven C. Quay
-
Publication number: 20040202712Abstract: An emulsion of &agr;-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans various routes is disclosed. Also included in the emulsion is PEGylated vitamin E PEGylated &agr;-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of &agr;-tocopherol.Type: ApplicationFiled: April 28, 2004Publication date: October 14, 2004Applicant: Sonus Pharmaceuticals, Inc.Inventors: Karel J. Lambert, Panayiotis P. Constantinides, Steven C. Quay
-
Patent number: 6727280Abstract: The present invention provides methods for administering a taxane composition for the treatment of cancer. In one aspect, the compositions are not diluted prior to administration. Some embodiments provide methods for administering a taxane as a bolus injection or an intravenous infusion in less than about 30 minutes. In other aspects, the invention provides methods for administering a taxane to provide high concentrations of the taxane in blood or in tumors. Another aspect provides methods for administering a taxane to provide anti-tumor activities against solid tumors. In some embodiments, the methods provide anti-tumor activities against tumors that were resistant to conventional taxane administration methods. In some embodiments, the methods provide anti-tumor activities against colorectal tumors.Type: GrantFiled: July 1, 2002Date of Patent: April 27, 2004Assignee: Sonus Pharmaceuticals, Inc.Inventors: Nagesh Palepu, Dean Kessler, Alexander K. Tustian, Steven C. Quay, Panayiotis P. Constantinides, Karel J. Lambert
-
Publication number: 20040053993Abstract: Tocol-based compositions of charged amphiphilic and water soluble pharmaceutically active compounds or their charged precursors are prepared by forming a tocol-soluble ion pair with an oppositely charged ion-pair forming compound capable of forming a tocol-soluble ion-pair with the active compound.Type: ApplicationFiled: January 25, 2002Publication date: March 18, 2004Applicant: Sonus Pharmaceuticals, Inc.Inventors: Panayiotis P. Constantinides, Karel J. Lambert, Alexander K. Tustian, Andrew M. Nienstedt
-
Patent number: 6667048Abstract: An emulsion of &agr;-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated &agr;-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of &agr;-tocopherol.Type: GrantFiled: July 27, 1999Date of Patent: December 23, 2003Assignee: Sonus Pharmaceuticals, Inc.Inventors: Karel J. Lambert, Panayiotis P. Constantinides, Steven C. Quay
-
Patent number: 6660286Abstract: An emulsion of tocopherol incorporating a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated &agr;-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of &agr;-tocopherol.Type: GrantFiled: May 24, 1999Date of Patent: December 9, 2003Assignee: Sonus Pharmaceuticals, Inc.Inventors: Karel J. Lambert, Panayiotis P. Constantinides, Alexander K. Tustian, Steven C. Quay
-
Publication number: 20030170279Abstract: An emulsion of &agr;-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated &agr;-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of &agr;-tocopherol.Type: ApplicationFiled: November 19, 2002Publication date: September 11, 2003Applicant: Sonus Pharmaceuticals, Inc.Inventors: Karel J. Lambert, Panayiotis P. Constantinides, Steven C. Quay
-
Publication number: 20030147959Abstract: An emulsion of &agr;-tocopherol, stabilized by b ocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated &agr;-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of &agr;-tocopherol.Type: ApplicationFiled: November 19, 2002Publication date: August 7, 2003Applicant: Sonus Pharmaceuticals, Inc.Inventors: Karel J. Lambert, Panayiotis P. Constantinides, Steven C. Quay
-
Publication number: 20030109575Abstract: An emulsion of tocopherol incorporating a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated &agr;-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of &agr;-tocopherol.Type: ApplicationFiled: June 28, 2002Publication date: June 12, 2003Applicant: Sonus Pharmaceuticals, Inc.Inventors: Karel J. Lambert, Alexander K. Tustian, Steven C. Quay
-
Publication number: 20030105156Abstract: The present invention provides methods for administering a taxane composition for the treatment of cancer. In one aspect, the compositions are not diluted prior to administration. Some embodiments provide methods for administering a taxane as a bolus injection or an intravenous infusion in less than about 30 minutes. In other aspects, the invention provides methods for administering a taxane to provide high concentrations of the taxane in blood or in tumors. Another aspect provides methods for administering a taxane to provide anti-tumor activities against solid tumors. In some embodiments, the methods provide anti-tumor activities against tumors that were resistant to conventional taxane administration methods. In some embodiments, the methods provide anti-tumor activities against colorectal tumors.Type: ApplicationFiled: July 1, 2002Publication date: June 5, 2003Inventors: Nagesh Palepu, Dean Kessler, Alexander K. Tustian, Steven C. Quay, Panayiotis P. Constantinides, Karel J. Lambert
-
Publication number: 20030104015Abstract: An emulsion of &agr;-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated &agr;-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of &agr;-tocopherol.Type: ApplicationFiled: May 17, 2002Publication date: June 5, 2003Applicant: Sonus Pharmaceuticals, Inc.Inventors: Karel J. Lambert, Panayiotis P. Constantinides, Steven C. Quay
-
Publication number: 20030087954Abstract: The present invention provides methods for administering a taxane composition for the treatment of cancer. In one aspect, the compositions are not diluted prior to administration. Some embodiments provide methods for administering a taxane as a bolus injection or an intravenous infusion in less than about 30 minutes. In other aspects, the invention provides methods for administering a taxane to provide high concentrations of the taxane in blood or in tumors. Another aspect provides methods for administering a taxane to provide anti-tumor activities against solid tumors. In some embodiments, the methods provide anti-tumor activities against tumors that were resistant to conventional taxane administration methods. In some embodiments, the methods provide anti-tumor activities against colorectal tumors, bladder carcinoma, or gastrointestinal tumors.Type: ApplicationFiled: September 13, 2002Publication date: May 8, 2003Applicant: Sonus Pharmaceuticals, Inc.Inventors: Nagesh Palepu, Dean Kessler, Alexander K. Tustian, Steven C. Quay, Panayiotis P. Constantinides, Karel J. Lambert
-
Publication number: 20030087953Abstract: The present invention provides methods for administering a taxane composition for the treatment of cancer. In one aspect, the compositions are not diluted prior to administration. Some embodiments provide methods for administering a taxane as a bolus injection or an intravenous infusion in less than about 30 minutes. In other aspects, the invention provides methods for administering a taxane to provide high concentrations of the taxane in blood or in tumors. Another aspect provides methods for administering a taxane to provide anti-tumor activities against solid tumors. In some embodiments, the methods provide anti-tumor activities against tumors that were resistant to conventional taxane administration methods. In some embodiments, the methods provide anti-tumor activities against colorectal tumors.Type: ApplicationFiled: July 1, 2002Publication date: May 8, 2003Inventors: Nagesh Palepu, Dean Kessler, Alexander K. Tustian, Steven C. Quay, Panayiotis P. Constantinides, Karel J. Lambert
-
Publication number: 20030065024Abstract: A method of making an emulsion of tocopherol incorporating a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated &agr;-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of &agr;-tocopherol.Type: ApplicationFiled: May 17, 2002Publication date: April 3, 2003Applicant: Sonus Pharmaceuticals, Inc.Inventors: Karel J. Lambert, Panayiotis P. Constantinides, Alexander K. Tustian, Steven C. Quay
-
Publication number: 20030027858Abstract: An emulsion of &agr;-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated &agr;-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of &agr;-tocopherol.Type: ApplicationFiled: May 17, 2002Publication date: February 6, 2003Applicant: Sonus Pharmaceuticals, Inc.Inventors: Karel J. Lambert, Panayiotis P. Constantinides, Steven C. Quay
-
Patent number: 6479540Abstract: Tocol-based compositions of charged amphiphilic and water soluble pharmaceutically active compounds or their charged precursors are prepared by forming a tocol-soluble ion pair with an oppositely charged ion-pair forming compound capable of forming a tocol-soluble ion-pair with the active compound. Also disclosed are novel compounds tocopherolsuccinate-aspartate and tocopherolsuccinate-glutamate, which are useful as ion-pair forming compounds.Type: GrantFiled: September 27, 2000Date of Patent: November 12, 2002Assignee: Sonus Pharmaceuticals, Inc.Inventors: Panayiotis P. Constantinides, Karel J. Lambert, Alexander K. Tustian, Andrew M. Nienstedt
-
Patent number: 6458373Abstract: An emulsion of &agr;-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated &agr;-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of &agr;-tocopherol.Type: GrantFiled: January 5, 1998Date of Patent: October 1, 2002Assignee: Sonus Pharmaceuticals, Inc.Inventors: Karel J. Lambert, Panayiotis P. Constantinides, Steven C. Quay
-
Patent number: 5855865Abstract: Elastic protein microspheres, filled with water insoluble gases, have been produced by ultrasound and mechanical cavitation without the present of oxygen. The microspheres are highly echogenic. The microspheres exhibit greatly enhanced static pressure stability, up to 40 psig. The microspheres are resistant to coalescence and to expansion due to differential gas diffusion. The microspheres are resistant to collapse when suspended in a gas-depleted aqueous solution.Type: GrantFiled: July 2, 1997Date of Patent: January 5, 1999Assignee: Molecular Biosystems, Inc.Inventors: Karel J. Lambert, Sheila Benay Podell, Edward G. Jablonski, Carl Hulle, Kenneth Hamilton, Rolf Lohrmann
-
Patent number: 5606973Abstract: Ultrasonic imaging agents comprising an aqueous suspension of negatively buoyant aspherical microdroplets composed of a biocompatible liquid core encapsulated by a shell of amphiphilic biocompatible material are prepared by milling a mixture of a solution of the shell material and vaporized liquid and cooling the milled mixture to below the boiling point of the liquid.Type: GrantFiled: June 7, 1995Date of Patent: March 4, 1997Assignee: Molecular biosystems, Inc.Inventors: Karel J. Lambert, Edward G. Jablonski