Abstract: The present invention relates to pyrrolopyrimidine compounds according to Formula I and their use in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases. In a particular aspect, the present compounds are ASK inhibitors, particularly ASK1 inhibitors. The present invention also provides methods for the production of a compound of the invention, pharmaceutical compositions comprising a compound of the invention, the use of the compounds in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases.

Abstract: The present invention relates to novel compounds of formula (I) and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and in the treatment of cancer.

Abstract: The present invention relates to a sugar paste substrate with a reduced sugar content comprising fondant, fructooligosaccharides (oligofructose or oligofructan) and starch. The paste can be used in standard sugar paste substrate processes, for example to produce printed decorations.

Abstract: The invention relates to a restraint device, in particular for a motor vehicle, for reducing an abrupt sideward movement of an occupant in the case of an impact with an airbag which is inflatable by means of a gas generator when an accident situation occurs. It is provided that the airbag has at least one side chamber and one shoulder chamber which are connected together, wherein in the inflated state of the airbag the side chamber and the shoulder chamber form different main extension planes which run at an angle to one another. An anchoring strap is fastened at one end to the shoulder chamber and at the other end to the vehicle seat. The shoulder chamber comprises two regions which transition into one another and which together form a reverse U-shape, the base thereof in the inflated state of the shoulder chamber forming the upper end thereof.

Abstract: A method of controlling the brake system of a vehicle. The method includes receiving one or more electrical signals each indicative of a value of a respective vehicle-related parameter. The method further includes detecting that the vehicle is traveling across a slope based on the value(s) of one or more of the vehicle-related parameters. The method still further includes automatically modifying the amount of brake torque being applied to at least certain of the wheels of the vehicle in response to the detection of the vehicle traveling across a slope by increasing the amount of brake torque being applied to one or more wheels on one side of the vehicle, and decreasing the amount of brake torque being applied to one or more wheels on the other side of the vehicle.

Abstract: A method of controlling the braking of a vehicle descending a slope. The method includes receiving one or more electrical signals each indicative of a value of a respective vehicle-related parameter. The method further includes detecting that the vehicle is descending a slope based on the value(s) of one or more of the vehicle-related parameters. The method still further includes automatically modifying an amount of brake torque being applied to at least certain of the wheels of the vehicle in response to the detection of the vehicle descending a slope by increasing the amount of brake torque being applied to one or more trailing wheels of the vehicle, and decreasing the amount of brake torque being applied to one or more leading wheels of the vehicle.

Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

Abstract: A method of managing the deceleration of a vehicle. The method comprises receiving a brake command and determining an actual rate of deceleration of the vehicle. The method further comprises monitoring the speed of the vehicle as the vehicle decelerates in response to the brake command. The method still further comprises modifying the amount of brake torque being applied to one or more wheels of the vehicle when the vehicle speed reaches a predetermined threshold, by first decreasing the amount of brake torque being applied and then subsequently increasing the amount of brake torque being applied to bring the vehicle to a standstill. A system for implementing the methodology is also provided.

Abstract: A traction control system for a motor vehicle includes a controller configured to initiate a traction control intervention at one or more vehicle wheels. The controller is configured to inhibit the traction control intervention in dependence on a reduced wheel load condition in said one or more wheels. The reduced wheel load condition is identified based on at least one of a signal indicative of vehicle pitch and a signal indicative of vehicle heave.

Abstract: A motor vehicle controller configured to reduce net drive torque applied to one or more driving wheels of a first axle of a driveline when an amount of slip of a driving wheel of the first axle exceeds a first predetermined threshold value. The controller controls torque applied to wheels of a second axle and determines when the vehicle is operating in a split-mu condition in which slip of a driving wheel on one side of each of the two axles exceeds that of a driving wheel on an opposite side of the axles by more than a predetermined amount. The controller performs a split-mu mitigation operation by reducing net torque applied to a driving wheel of the axle that is experiencing the greater slip when an amount of slip of that driving wheel exceeds a second predetermined threshold value less than the first predetermined threshold value.

Abstract: The present invention relates to novel compounds of formula (I) and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and in the treatment of cancer.

Abstract: The invention relates to novel compounds of formula I which are inhibitors of deubiquitylating enzymes (DUBs) and/or desumoylating enzymes. In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 7 or ubiquitin specific peptidase 7 (USP7). The invention further relates to methods for the preparation of these compounds and to their use in the treatment of cancer.

Abstract: Disclosed herein are flame resistant composite mats. The composite mat contains a fiber, fire resistant additive, and a binder. The mats are useful in the production of flame resistant sandwich constructions.

Abstract: In some embodiments, an apparatus includes a protective cover configured to attach to a wireless device having an exterior surface. The surface includes a first portion and a second portion mutually exclusive from the first portion. The second portion of the surface is associated with at least a portion of an antenna of the wireless device that performs proximity sensing for the wireless device. The protective cover is configured to cover the first portion of the surface when the protective cover is attached to the wireless device. The protective cover is configured to not cover the second portion of the surface when the protective cover is attached to the wireless device. As a result, the proximity sensing and/or the power transmitted by the antenna are not affected by the protective cover when the protective cover is attached to the wireless device and when the wireless device is operational.

Abstract: Embodiments of the present invention provide a motor vehicle controller comprising a computing device, the controller being configured to command a first releasable torque transmitting device of a drive-line to switch between a released condition in which a first releasable torque transmitting device substantially prevents transmission of torque from an input to an output portion thereof, and an engaged condition in which a releasable torque transmitting device allows torque transmission from an input portion to an output portion thereof. The controller may be configured to receive information indicative of: a speed of wheels of a first axle; a speed of wheels of a second axle; and a terrain over which a vehicle is driving.

Abstract: A method of managing the deceleration of a vehicle. The method comprises receiving a brake command and determining an actual rate of deceleration of the vehicle. The method further comprises monitoring the speed of the vehicle as the vehicle decelerates in response to the brake command. The method still further comprises modifying the amount of brake torque being applied to one or more wheels of the vehicle when the vehicle speed reaches a predetermined threshold, by first decreasing the amount of brake torque being applied and then subsequently increasing the amount of brake torque being applied to bring the vehicle to a standstill. A system for implementing the methodology is also provided.

Abstract: A method of automatically controlling the speed of a vehicle as the vehicle traverses a water obstacle. The method includes the step of detecting that the vehicle has entered a water obstacle. The method further includes the step of determining a depth of the water proximate the vehicle based on readings or information received from, for example, one or more sensors or other components of the vehicle. And when the depth of the water exceeds a predetermined depth, the method still further includes the step of automatically reducing the speed of the vehicle such that a bow wave created in the water by the vehicle propagates ahead of the vehicle and in an intended direction of travel of the vehicle. A system for implementing the methodology is also provided.

Abstract: Embodiments of the present invention provide a control system for a motor vehicle comprising: means for detecting a side-slope condition in which a vehicle is traversing a side-slope; and means for controlling an amount of torque applied to one or more wheels to induce a turning moment on a vehicle, the system being configured to cause a turning moment to be induced in a direction opposing side-slip of a trailing axle in a down-slope direction relative to a leading axle.

Abstract: The invention provides compounds of formula I, wherein: R1 represents a cyclic group selected from phenyl, heteroaryl1, heterocyclyl1 and C3-6 cycloalkyl; wherein each cyclic group is optionally substituted with from 1 to 3 substituents selected from halo, C1-6 alkyl optionally substituted with 1-3 halogen atoms, phenyl, C1-6 alkoxy optionally substituted with 1-3 halogen atoms, cyano, heteroaryl1a and heterocyclyl1a; and wherein each cyclic group is optionally fused to a benzene ring or a 5- or 6-membered heteroaromatic or heterocyclic ring each containing from 1 to 3 heteroatoms (selected from N, O and S); and when the group is substituted the substitution may occur anywhere on the optionally fused ring system as a whole; and wherein heterocyclyl1 and heterocyclyl1a may additionally be substituted with ?O; X represents a bond or C1-6 alkylene (which may be straight or branched); R2 represents H or C1-6 alkyl; R3 represents H or C1-6 alkyl; Y represents a bond or C1-6 alkylene (which may be straight

Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.