Abstract: The present invention provides for a disinfecting radiation base with a germicidal bulb for providing disinfecting radiation to a storage case for an ophthalmic lens, such as a contact lens. The disinfecting radiation base provides disinfecting radiation for disinfecting a contact lens. The disinfecting radiation base may also include a processor and digital memory for automated functions associated with the base.

Abstract: Apoptosis is generally believed to be a process that requires several hours, in contrast to non-programmed forms of cell death that can occur in minutes. Our findings challenge the time-consuming nature of apoptosis. We describe herein the discovery and characterization of a small molecule, named Raptinal, which initiates intrinsic pathway caspase-dependent apoptosis within minutes, in multiple different cell lines. Comparison to a mechanistically diverse panel of apoptotic stimuli reveals Raptinal-induced apoptosis proceeds with unparalleled speed. The rapid phenotype enabled identification of the critical roles of mitochondrial voltage-dependent anion channel function, mitochondrial membrane potential/coupled respiration, and mitochondrial complex I, III and IV function for apoptosis induction. Use of Raptinal in whole organisms demonstrates its utility to study apoptosis in vivo for a variety of applications.

Abstract: The present invention discloses methods and apparatus for forming a Viewing Set of Ophthalmic Lenses for Three-dimensional Perception of stereoscopic media and includes the resulting Viewing Set devices. The Viewing Sets include a left Ophthalmic Lens and a right Ophthalmic Lens, wherein each Ophthalmic Lens includes a translation filter that, when combined, allow for Three-dimensional Perception. The present invention also includes embodiments where the translation filters are included in an encapsulated Rigid Insert or Media Insert, wherein the Media Insert includes a variable optic zone.

Abstract: Apoptosis is generally believed to be a process that requires several hours, in contrast to non-programmed forms of cell death that can occur in minutes. Our findings challenge the time-consuming nature of apoptosis. We describe herein the discovery and characterization of a small molecule, named Raptinal, which initiates intrinsic pathway caspase-dependent apoptosis within minutes, in multiple different cell lines. Comparison to a mechanistically diverse panel of apoptotic stimuli reveals Raptinal-induced apoptosis proceeds with unparalleled speed. The rapid phenotype enabled identification of the critical roles of mitochondrial voltage-dependent anion channel function, mitochondrial membrane potential/coupled respiration, and mitochondrial complex I, III and IV function for apoptosis induction. Use of Raptinal in whole organisms demonstrates its utility to study apoptosis in vivo for a variety of applications.

Abstract: Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.

Abstract: The present invention discloses methods and apparatus for forming a Viewing Set of Ophthalmic Lenses for Three-dimensional Perception of stereoscopic media and includes the resulting Viewing Set devices. The Viewing Sets include a left Ophthalmic Lens and a right Ophthalmic Lens, wherein each Ophthalmic Lens includes a translation filter that, when combined, allow for Three-dimensional Perception. The present invention also includes embodiments where the translation filters are included in an encapsulated Rigid Insert or Media Insert, wherein the Media Insert includes a variable optic zone.

Abstract: Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.

Abstract: The present invention describes methods for creating single-piece or multi-piece Rigid Inserts that may be included in an Ophthalmic Lenses or may comprise the Ophthalmic Lens, wherein the Rigid Insert may be formed through the processing of thin sheet material by thermoforming. Single piece annular Rigid Inserts may perform the function of providing a template for printed patterns to be included in Ophthalmic Lenses. Single piece full Rigid Inserts may perform the function of polarizing light or filtering light based on the properties of materials used to form the insert. Multi-piece Rigid Inserts may incorporate activation and energization elements. The present invention also includes apparatus for implementing such methods, as well as Ophthalmic Lenses and inserts formed with the Rigid Insert pieces that have been thermoformed.

Abstract: The present invention provides for a disinfecting radiation base with a germicidal bulb for providing disinfecting radiation to a storage case for an ophthalmic lens, such as a contact lens. The disinfecting radiation base provides disinfecting radiation for disinfecting a contact lens. The disinfecting radiation base may also include a processor and digital memory for automated functions associated with the base.

Abstract: The present invention provides for a disinfecting radiation base for working in conjunction with a storage case for an ophthalmic lens. The disinfecting radiation base provides disinfecting radiation for disinfecting an ophthalmic lens. The disinfecting radiation base may also include a processor and digital memory for automated functions associated with the base.

Abstract: The present invention, as described above and as further defined by the claims below, provides methods for creating an Ophthalmic Lens with Stabilizing Features and a Rigid Insert, where the Stabilizing Features may orient the Ophthalmic Lens when placed on an eye. In some embodiment, the Stabilizing Features may be included as a unique Reactive Monomer Mixture with separate properties than the encapsulating RMM. Other embodiments may include Stabilizing Features comprising separate insert pieces. In alternate embodiments, the Rigid Insert may include the Stabilizing Features, such as, for example, through thermoforming techniques.

Abstract: The present invention provides for a disinfecting radiation base with a radiation source for providing disinfecting radiation to a storage case for an ophthalmic lens, such as a contact lens. The disinfecting radiation base includes a diffusing material is molded into a shape or geometry that is capable of providing disinfecting radiation to all regions of the lens being disinfected in uniform intensity and contrast. The disinfecting radiation base may also include a processor and digital memory for automated functions associated with the base.

Abstract: The presented invention describes the development of a measuring method based on the degradation of various chromophores/fluorophores that can be used as quantitative method to elucidate the UV dose within a liquid or as a qualitative visual color-changing chemical indicator of UV sterilization is described.

Abstract: This invention discloses methods and apparatus for forming Ophthalmic Lenses with Stabilizing Features, and more specifically, Ophthalmic Lenses that include an encapsulated Insert Device.

Abstract: The present invention relates to methods, apparatus, and devices associated with an ophthalmic lens system wherein the lenses may communicate with multiple external devices. More particularly, the present invention relates to an ophthalmic lens system that may communicate with a secondary and a tertiary device, wherein the wireless communication with the secondary and the tertiary electronic external devices may reduce power, communication, and processing requirements within the ophthalmic lenses and may broaden the range of possible functionalities of the ophthalmic lens system.

Abstract: The present invention discloses an Ophthalmic Lens device with a programmable Media Insert. In some embodiments, a Media Insert may be programmable to allow for further customization of the energized Ophthalmic Lens. The programming may occur after the electrical components have been encapsulated in the programmable Media Insert. In some embodiments, the Media Insert may be programmed prior to or during the manufacturing process. Alternatively, the Media Insert may be programmable after manufacturing process, such as, for example, through use of a wireless programming apparatus or device. In some such embodiments, the programming device may comprise an overlay, wherein the overlay may program the Media Insert when placed in proximity to the Media Insert.

Abstract: The present invention discloses an apparatus for programming an energizable Ophthalmic Lens with a programmable Media Insert. In some embodiments, a Media Insert may be programmable to allow for further customization of the energized Ophthalmic Lens. The programming may occur after the electrical components have been encapsulated in the programmable Media Insert. In some embodiments, the apparatus may wirelessly program the Media Insert after the Ophthalmic Lens has been fully assembled. Alternatively, the apparatus may indirectly program the Media Insert by wirelessly programming an overlay. The overlay may subsequently program the Media Insert when placed in proximity to the Media Insert, wherein the placing completes the assembly of the Ophthalmic Lens.

Abstract: The present invention describes single-piece or multi-piece Rigid Inserts that may be included in an Ophthalmic Lenses or may comprise the Ophthalmic Lens, wherein the Rigid Insert may be formed through the processing of thin sheet material by thermoforming. Single piece annular Rigid Inserts may perform the function of providing a template for printed patterns to be included in Ophthalmic Lenses. Single piece full Rigid Inserts may perform the function of polarizing light or filtering light based on the properties of materials used to form the insert. Multi-piece Rigid Inserts may include activation and energization elements. The present invention also includes methods and apparatus for forming the Rigid Inserts.

Abstract: This invention discloses methods and apparatus for forming Ophthalmic Lenses with Stabilizing Features, and more specifically, Ophthalmic Lenses that include an encapsulated Insert Device.

Abstract: The present invention provides for a disinfecting radiation base for working in conjunction with a storage case for an ophthalmic lens. The disinfecting radiation base provides disinfecting radiation for disinfecting a surface of the storage case. The disinfecting radiation base may also include a processor and digital memory for automated functions associated with the base.