Abstract: The present invention describes the development of a measuring method based on the degradation of various chromophores/fluorophores that can be used as a quantitative method to elucidate the UV dose within a liquid or as a qualitative visual color-changing chemical indicator of UV sterilization is described.

Abstract: Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.

Abstract: The present invention for a storage case for an ophthalmic lens, wherein the storage case facilitates disinfecting of the ophthalmic lens with disinfecting radiation. Various embodiments may include an alignment device, such as a pedestal or a concave bowl to position the lens to receive disinfecting radiation. In addition, the case may include one or more disinfecting radiation windows for admitting disinfecting radiation into the storage case.

Abstract: The present invention provides for a programmable processor in a ophthalmic lens storage unit for contact lenses. The processor can be in logical connection with a plurality of sensors that can provide data and a digital storage for storing the data and using it via executable software for lens monitoring. In some embodiments, the processor is additionally operative via the executable software to correlate geo-social phenomena with the optical performance of a lens.

Abstract: The present invention provides for a programmable processor in a Ophthalmic Lens Storage Unit capable of storing and disinfecting ophthalmic lenses. A base unit and/or storage case can include sensors for providing data and a digital storage for storing the data and using it via executable software for lens monitoring and automated lens ordering. In some embodiments, the processor is additionally operative via the executable software to provide disinfecting radiation base radiation for disinfecting an ophthalmic lens.

Abstract: The present invention provides for a disinfecting radiation base with a radiation source for providing disinfecting radiation to a storage case for an ophthalmic lens, such as a contact lens. The disinfecting radiation base includes a diffusing material is molded into a shape or geometry that is capable of providing disinfecting radiation to all regions of the lens being disinfected in uniform intensity and contrast. The disinfecting radiation base may also include a processor and digital memory for automated functions associated with the base.

Abstract: The present invention provides for a disinfecting radiation base for working in conjunction with a storage case for an ophthalmic lens. The disinfecting radiation base provides disinfecting radiation for disinfecting a surface of the storage case. The disinfecting radiation base may also include a processor and digital memory for automated functions associated with the base.

Abstract: The present invention provides for a disinfecting radiation base for working in conjunction with a storage case for an ophthalmic lens. The disinfecting radiation base provides disinfecting radiation for disinfecting an ophthalmic lens. The disinfecting radiation base may also include a processor and digital memory for automated functions associated with the base.

Abstract: The present invention provides for a disinfecting radiation base with a germicidal bulb for providing disinfecting radiation to a storage case for an ophthalmic lens, such as a contact lens. The disinfecting radiation base provides disinfecting radiation for disinfecting a contact lens. The disinfecting radiation base may also include a processor and digital memory for automated functions associated with the base.

Abstract: The present invention for a storage case for an ophthalmic lens, wherein the storage case facilitates disinfecting of the ophthalmic lens with disinfecting radiation. Various embodiments may include an alignment device, such as a pedestal or a concave bowl to position the lens to receive disinfecting radiation. In addition, the case may include one or more disinfecting radiation windows for admitting disinfecting radiation into the storage case.

Abstract: The present invention provides for a disinfecting radiation base for working in conjunction with a storage case for an ophthalmic lens. The disinfecting radiation base provides disinfecting radiation for disinfecting an ophthalmic lens. The disinfecting radiation base may also include a processor and digital memory for automated functions associated with the base.

Abstract: Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.

Abstract: Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. Particularly disclosed are phosphonate esters. Compounds, methods of making the compounds, medicaments and method of manufacture of medicaments and therapeutic methods with applications against cancer including breast cancer, melanoma, colon cancer, leukemia and lymphoma, and other cancer cells are described.

Abstract: Compounds and related methods for synthesis, and the use of compounds for the treatment of neurodegenerative diseases are disclosed. Compounds are disclosed in connection with PARG and/or PARP inhibition. Therapeutic applications are relevant for preventing or inhibiting neurological cell death for a variety of neurodegenerative conditions including Parkinson's disease, ischemia, and stroke. Also disclosed is a high-throughput screen for identifying compounds capable of inhibiting PARG and/or PARP.

Abstract: Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. Particularly disclosed are phosphonate esters. Compounds, methods of making the compounds, medicaments and method of manufacture of medicaments and therapeutic methods with applications against cancer including breast cancer, melanoma, colon cancer, leukemia and lymphoma, and other cancer cells are described.

Abstract: Disclosed are compositions and methods capable of facilitating the detection and measurement of poly(ADP-ribose)polymerases (PARP enzymes). PARP enzyme activity can be monitored using a novel calorimetric substrate, ADP-ribose-para-nitrophenol. The substrate can be synthesized from beta nicotinamide adenine dinucleotide (?-NAD+) and para-nitrophenol. In an embodiment, a continuous assay was developed to detect and kinetically monitor activity for PARP enzymes such as PARP-1, tankyrase-1 (PARP-5), and VPARP (PARP-4). The compositions and methods are particularly useful in the screening and identification of specific PARP inhibitors.