Abstract: A metal-ceramic substrate and to a method for the production thereof. The metal-ceramic substrate having at least one ceramic layer (2), which is provided on a first surface side (2a) with at least one first metallization (3) and on a second surface side (2b), opposite from the first surface side (2a), with a second metallization (4), wherein the first metallization (3) is formed by a film or layer of copper or a copper alloy and is connected to the first surface side (2a) of the ceramic layer (2) with the aid of a “direct copper bonding” process. The second metallization (4) is formed by a layer of aluminum or an aluminum alloy.

Abstract: Process for producing DCB substrates having in each case at least one ceramic layer which is essentially made up of aluminium nitride (AlN) and is provided on at least one surface side with an intermediate layer which is essentially made up of aluminium oxide and also has at least one metallization formed by a metal layer or metal foil on the intermediate layer

Abstract: A two-stroke engine has an intake arrangement including a carburetor. An intake channel divides into a mixture channel and an air channel. An intermediate flange is mounted between the carburetor and the cylinder. This flange has a carburetor connecting surface, which faces toward the carburetor, and a cylinder connecting surface which faces toward the cylinder. Referred to the flow direction in the intake channel, the air channel divides upstream of the cylinder connecting surface into two branches. The first branch has a first longitudinal center axis and the second branch has a second longitudinal center axis. The intersect points of the center axes with the connecting surfaces are mutually connected via an imaginary connecting line in the carburetor connecting surface or the cylinder connecting surface. The two connecting lines conjointly define an angle ? in the carburetor connecting surface with this angle being greater than 0°.

Abstract: The present invention relates to a method for the production and purification of a sialyltransferase polypeptide, in particular a N-Acetylgalactosamine (Gal NAc)-?-2,6-sialyltransferase I (ST6GalNAcI) polypeptide. The method comprises the steps of producing the sialyltransferase polypeptide in a Chinese Hamster Ovary (CHO) cell and purifying the polypeptide with a combination of chromatography steps. The method results in high yield of sialyltransferase polypeptide which is highly pure and active. The obtained sialyltransferase, especially ST6GalNAcI, can be employed for the glycosylation of therapeutic proteins such as G-CSF.

Abstract: A two-stroke engine has an intake arrangement including a carburetor. An intake channel divides into a mixture channel and an air channel. An intermediate flange is mounted between the carburetor and the cylinder. This flange has a carburetor connecting surface, which faces toward the carburetor, and a cylinder connecting surface which faces toward the cylinder. Referred to the flow direction in the intake channel, the air channel divides upstream of the cylinder connecting surface into two branches. The first branch has a first longitudinal center axis and the second branch has a second longitudinal center axis. The intersect points of the center axes with the connecting surfaces are mutually connected via an imaginary connecting line in the carburetor connecting surface or the cylinder connecting surface. The two connecting lines conjointly define an angle ? in the carburetor connecting surface with this angle being greater than 0°.

Abstract: The technology relates in part to multimer conjugates comprising a scaffold linked to two or more polypeptides that specifically interact with a nucleic acid containing beta-D-glucosyl-hydroxymethylcytosine or beta-D-glucosyl-hydroxymethyluracil. The scaffold can be chosen from an antibody, an antibody fragment, a multimerized binding partner that interacts with a binding partner counterpart in each of the polypeptides, a polymer, and a polyfunctional molecule. The polypeptides can be from a kinetoplastid flagellate organism and may comprise a full-length native or modified protein or a fragment thereof that specifically interacts with the beta-D-glucosyl-hydroxymethylcytosine and/or the beta-D-glucosyl-hydroxymethyluracil in the nucleic acid. The conjugates provided herein can be used to detect the presence, absence or amount of beta-D-glucosyl-hydroxymethylcytosine and/or beta-D-glucosyl-hydroxymethyluracil-containing nucleic acid in a sample.

Abstract: A handheld work apparatus has a combustion engine with an ignition unit, a unit for supplying fuel and a device to determine the rotational speed (n). The ignition unit includes a spark plug, a coil and a pole group. The pole group and the coil are moved in dependence on the rotational movement of a crankshaft of the combustion engine, whereby a ignition voltage is induced in the coil. The work apparatus has an open loop control which controls the ignition time (ZZP). A diagnostic unit for damage diagnosis is detachably connected to the work apparatus. For damage diagnosis, the diagnostic unit captures the course of the induced ignition voltage over at least one engine cycle when the combustion engine is running and damage is determined on the basis of the course of the captured voltage.

Abstract: According to the proposed method for producing biomass, the organisms or cells in a suspension kept in circulation in a photobioreactor are cultivated with introduction of light and of at least CO2 as a nutrient. For the cultivation, the suspension is introduced via at least one introduction organ in an upper region of a culturing space and its downward movement is slowed down by at least one inner element that has a horizontally extending grid, screen or net structure and that is disposed in the culturing space. The suspension is converted into a plurality of drops on this structure. The drops pass through a drop cycle, by means of which the downward movement of the suspension is slowed down and a particularly intensive exposure of the organisms or cells contained in the nutrient solution to nutrients and light introduced into the reactor is assured.

Abstract: For checking an address decoder of a data memory, from a record of addresses of the data memory, designated as base addresses, one after another each base address is selected, and the following steps are executed for the respectively selected base address: a) determining the content of the base address; and b) selecting an address having the Hamming distance 1 from the base address, designated as the Hamming address; and then: c) changing the content of the Hamming address selected in step b); and then: d) reading the base address and detecting an error of the address decoder if the content read differs from that determined in step a); and e) recovering the content of the Hamming address.

Abstract: A combustion engine (1) has a carburetor (17) for supplying an air/fuel mixture. An intake channel (16) is formed in the carburetor (17) and fuel is drawn into the intake channel because of the underpressure which forms during operation. The fuel quantity, which is drawn into the intake channel (16), is controlled at least in part by an electromagnetic fuel valve (23) which is open when no power is applied thereto. The engine (1) has a device for igniting the air/fuel mixture in the combustion chamber (3) of the engine and a stop switch (74) for switching off the ignition. Furthermore, a control unit (20) and a device (75) for energy supply are provided. A method for operating the engine (1) provides that the fuel valve (23) is held in the closed position by the control unit (20) after the stop switch (74) is actuated.

Abstract: The invention relates to a fuel-metering arrangement for the mixture-forming unit (2) of an internal combustion engine (10) in a portable handheld work apparatus. The mixture-forming unit comprises a fuel store (30), a switchable valve (40) and a fuel channel (20) which opens into an intake region of the engine (10). The valve (40) has an inflow port (41) which is connected to the fuel store (30) and an outflow port (42) which is connected to the fuel channel (20). A fuel column is mechanically moved by the switching of the valve. In order to compensate for this fuel column, the outflow port (42) is connected via a bypass channel (45) to the inflow port (41) and a flow valve (46) is mounted in the bypass channel (45). The flow valve (46) opens in flow direction (48) from the outflow port (42) to the inflow port (41) and blocks in the direction opposite thereto.

Abstract: The invention relates to an assembly for storing objects in the cabin of a vehicle, comprising at least one frame with attachment means, and at least one holding device for mounting the objects, wherein the frame has a contour that, at least in some regions, essentially corresponds to the interior contour of a storage container so that the frame can be arranged in the storage container and can be attached in the storage container with the use of the attachment means, and wherein the holding device can be removably stored in the frame. The assembly according to the invention can be placed in a pre-assembled state in the vehicle, thus reducing the time required for installation and maintenance, while at the same time making better use of the available space.

Abstract: For checking an address decoder of a data memory, from a record of addresses of the data memory, designated as base addresses, one after another each base address is selected, and the following steps are executed for the respectively selected base address: a) determining the content of the base address; and b) selecting an address having the Hamming distance 1 from the base address, designated as the Hamming address; and then: c) changing the content of the Hamming address selected in step b); and then: d) reading the base address and detecting an error of the address decoder if the content read differs from that determined in step a); and e) recovering the content of the Hamming address.

Abstract: In method and an arrangement for detecting parameters in displacement or angle sensors, in a test procedure sensor signals in a stationary sensor are evaluated, which signals are generated by scanning a plurality of code elements located side by side, perpendicular to a direction of motion, on a transducer element as a moving component; and the test procedure is performed with a transducer element that has a predetermined variation of geometrical variables of the code elements.

Abstract: A mirror for laser application and a method for manufacturing the mirror is disclosed herein. The mirror comprises several layers including a top layer used as the mirror surface. A cooling structure including a plurality of cooler layers are providing between the top layer, several intermediate layers and a bottom layer. Connections are provided for allowing a coolant to flow within the mirror. The mirror is constructed by stacking the layers on top of one another and connecting adjacent layers together by direct copper bonding or active soldering.

Abstract: The present invention provides methods and apparatus, including computer program products, for debugging a computer program running on a system that is separated from the debugging system by at least one firewall. The computer program being debugged can be a Java application. A router on each side of the firewall can be used to establish communication between the two systems. To the debugging system, it appears that the computer program is running locally.

Abstract: A mirror for laser application and a method for manufacturing the mirror is disclosed herein. The mirror comprises several layers including a top layer used as the mirror surface. A cooling structure including a plurality of cooler layers are providing between the top layer, several intermediate layers and a bottom layer. Connections are provided for allowing a coolant to flow within the mirror. The mirror is constructed by stacking the layers on top of one another and connecting adjacent layers together by direct copper bonding or active soldering.

Abstract: The invention relates to a novel ceramic substrate with at least one layer essentially of aluminum nitride which is provided on at least one surface side with an intermediate or auxiliary layer which contains aluminum oxide and which has a thickness in the range of 0.5-10 microns, and to a process for its production.

Abstract: A multiple substrate is provided having a large area individual base layer with multiple substrates, for electrical circuits formed thereon. Individual substrates are defined by score lines in the base layer, and include a fragment of the base layer and at least one metal coating is provided on at least one surface of the fragment and has areas which stabilize the multiple substrates against unwanted breaking. Several individual substrates are preformed along peripheral sides of the base layer, and at least one metal coating on each individual substrate projects over the peripheral side.

Abstract: A connector housing for an air bag connector and a method for contacting an air bag connector. A connector housing having at least two sections is provided with locking elements for a pre-lock-in position and a final lock-in position. In the pre-lock-in position, both sections of the housing are arranged apart from one another and the pre-lock-in position is localized by means of a spacer to maintain the pre-lock-in position maintain at a predetermined distance so that electric conductors can be introduced into the connector housing. The spacer ensures that the connector housing is not inadvertently pressed from the pre-lock-in position to the final lock-in position. The connector housing can be pressed together for an insulation-piercing contact in the connector housing, and locked in the final lock-in position. The connector housing is furthermore provided with a belt arrangement, with the spacer being of a one-piece design with one of the elements of the belt arrangement.