Abstract: The present invention provides a new type of alpha-helix nucleating cross-link (“staple”) formed by olefin metathesis of a proline derivative with an alkenyl side chain and another amino acid derivative with an alkenyl side chain. The proline derivatives as described herein have been found to be strong nucleators of alpha-helix formation. The invention also provides moieties for shielding the free amide N—H's at the N-terminus of an alpha-helix, thereby further stabilizing the helix. The proline derivatives, precursors prior to cross-linking, and the cross-linked peptides are provided as well as methods of using and preparing these compounds and peptides.

Abstract: A composition containing polytetrafluoroethylene and substantially free from a compound represented by Formula (3): (H—(CF2)8—SO3)qM2 wherein M2 is H, a metal atom, NR54 (where R5s may be the same as or different from each other and are each H or an organic group having 1 to 10 carbon atoms), an imidazolium optionally having a substituent, a pyridinium optionally having a substituent, or a phosphonium optionally having a substituent, and q is 1 or 2. Also disclosed is a molded boy including the composition.

Abstract: Provided is an acrylamide compound, which is useful for the promotion of platelet production from platelet progenitor cells such as megakaryocytes in vitro and represented by general formula [I]: wherein each symbol is as defined in the description.

Abstract: An anti-vibration device is secured to a vibration source and a vibration transmission portion to inhibit transmission of vibration, and includes a first elastically deformed portion, a second elastically deformed portion and a third elastically deformed portion. The first elastically deformed portion is a plate having a thickness in a first thickness direction and vibrates in the first thickness direction to configure a path for the vibration to be transmitted from the vibration source to the vibration transmission portion. The second elastically deformed portion is a plate having a thickness in a second thickness direction intersecting the first thickness direction and vibrates in the second thickness direction to configure the path. The third elastically deformed portion is a plate having a thickness in a third thickness direction intersecting the first thickness direction and the second thickness direction and vibrates in the third thickness direction to configure the path.

Abstract: Provided is a novel heterocyclic compound having an aryl hydrocarbon receptor antagonist activity and useful for the promotion of platelet production, the compound being represented by the general formula [I]: wherein ring A, ring B, R1, R2, R3, R4, n, and X are as defined above, or a salt thereof.

Abstract: An information processing apparatus includes at least one processor, in which the processor is configured to perform diagnosis support processing on one medical image and derive a plurality of diagnosis support processing results, present selection information for allowing a user to select at least one diagnosis support processing result among the plurality of derived diagnosis support processing results, and output a diagnosis support processing result selected by the user according to the selection information.

Abstract: A variable capacity turbocharger includes a housing, a turbine impeller at least partially located in the housing, a scroll flow path located in the housing and encircling the turbine impeller, a first nozzle ring and a second nozzle ring facing each other in the housing, a nozzle flow path located between the first nozzle ring and the second nozzle ring and fluidly coupling the scroll flow path to the turbine impeller, a gap formed between the first nozzle ring and the housing, and a bearing hole located in the first nozzle ring and including an opening adjacent to the gap. The gap is located on an opposite side of the first nozzle ring to the nozzle flow path. Additionally, the gap is connected to the scroll flow path.

Abstract: The present disclosure provides a novel bridge peptide. The present disclosure provides a bridge peptide comprising a bridge moiety and a peptide moiety, wherein position ? is tertiary or quaternary when the carbon at which the bridge moiety attaches to the peptide moiety is in position ?. The present disclosure provides a novel bridge peptide, particularly a bridge peptide resulting from stably bridging a peptide that does not possess a hydrogen bond to induce or maintain a secondary structure, e.g., a peptide having a ?-strand structure.

Abstract: Primary plate springs overlap a first plate spring segment of a coupling plate spring in a first direction and respectively have a frictional contact portion which generates sliding friction relative to the first plate spring segment in response to vibrations, Secondary plate springs overlap a second plate spring segment of the coupling plate spring in a second direction and respectively have a frictional contact portion which generates sliding friction relative to the second plate spring segment in response to the vibrations while the second direction is different from the first direction. Tertiary plate springs overlap a third plate spring segment of the coupling plate spring in a third direction and respectively have a frictional contact portion which generates sliding friction relative to the third plate spring segment in response to the vibrations while the third direction is different from the first and second directions.

Abstract: An illumination apparatus includes a surface light source that emits illumination light and a micro louver film that limits components of a divergence of the illumination light that are parallel to a light emission plane of the surface light source. The illumination apparatus satisfies the following conditional expression: 20°?A?60°??(1) where A indicates, with reference to a direction for which the micro louver film limits the divergence of the illumination light, the maximum spread angle of the illumination light passing through the micro louver film.

Abstract: The present invention provides a new type of alpha-helix nucleating cross-link (“staple”) formed by olefin metathesis of a proline derivative with an alkenyl side chain and another amino acid derivative with an alkenyl side chain. The proline derivatives as described herein have been found to be strong nucleators of alpha-helix formation. The invention also provides moieties for shielding the free amide N—H's at the N-terminus of an alpha-helix, thereby further stabilizing the helix. The proline derivatives, precursors prior to cross-linking, and the cross-linked peptides are provided as well as methods of using and preparing these compounds and peptides.

Abstract: A vibration-isolating device includes: a vibration source, which generates vibrations; and at least one vibration-isolating rubber which is fixed to the vibration source. The vibration source is supported by at least one support member that is fixed to a transmission-receiving member through the at least one vibration-isolating rubber. The vibration source and the at least one vibration-isolating rubber are configured such that a difference between a maximum value and a minimum value of resonant frequencies of a structure, which includes the vibration source, the at least one vibration-isolating rubber and the at least one support member, is equal to or smaller than 10 Hz when the vibration source is vibrated in six degrees of freedom. The at least one vibration-isolating rubber includes: 100 parts by mass of silicone rubber; and larger than 0 parts by mass and equal to or smaller than 3 parts by mass of carbon nanotubes.

Abstract: A vibration isolator configured to restrict vibration generated in a vibration source from being transmitted to a vibration transmitted portion includes at least one elastic member. The vibration transmitted portion is provided with at least one support portion to support the vibration source via the at least one elastic member. The at least one elastic member is disposed between the vibration source and at least the one support portion, and is elastically deformed to suppress the transmission of vibration of the vibration source to the vibration transmitted portion from the at least one support portion. The vibration source and at least the one elastic member are configured so that resonance frequencies in plural vibration modes generated in the vibration source conform to one predetermined frequency.

Abstract: An iron golf club head comprises; a head main body including a club face provided with score lines; a weight member having a specific gravity larger than that of the head main body; and a fixing member having a specific gravity larger than that of the head main body and less than that of the weight member, and fixed to the head main body by welding so as to cover the weight member. In a forward tilting state of the club head in which the score lines are horizontal and the club face is vertical, the distance D in the perpendicular direction to the club face from the backmost position of the club head to the center of gravity of the weight member is not more than 47.3% of the maximum thickness w of the club head which is the shortest distance from the backmost position of the club head to the club face.

Abstract: An iron golf club head comprises; a head main body including a club face provided with score lines; a weight member having a specific gravity larger than that of the head main body; and a fixing member having a specific gravity larger than that of the head main body and less than that of the weight member, and fixed to the head main body by welding so as to cover the weight member. In a forward tilting state of the club head in which the score lines are horizontal and the club face is vertical, the distance D in the perpendicular direction to the club face from the backmost position of the club head to the center of gravity of the weight member is not more than 47.3% of the maximum thickness w of the club head which is the shortest distance from the backmost position of the club head to the club face.

Abstract: An iron golf club head comprises; a head main body including a club face provided with score lines; a weight member having a specific gravity larger than that of the head main body; and a fixing member having a specific gravity larger than that of the head main body and less than that of the weight member, and fixed to the head main body by welding so as to cover the weight member. In a forward tilting state of the club head in which the score lines are horizontal and the club face is vertical, the distance D in the perpendicular direction to the club face from the backmost position of the club head to the center of gravity of the weight member is not more than 47.3% of the maximum thickness W of the club head which is the shortest distance from the backmost position of the club head to the club face.

Abstract: A side air bag device is described which is disposed in a space between a vehicle body and a back seat and for which rigidity of attachment to a vehicle body member is improved. The side air bag device provided between a vehicle body and a back seat includes: a base member including a base storage configured to store an air bag and an inflator and a base attachment portion attached to the vehicle body; and a retainer member configured to hold the base storage from a vehicle back side. The retainer member extends from a portion holding the base storage while being bent along the shape of the vehicle body. The retainer member is attached to the vehicle body together with the base attachment portion while being overlapped with the base attachment portion.

Abstract: A side air bag device is described which is disposed in a space between a vehicle body and a back seat and for which rigidity of attachment to a vehicle body member is improved. The side air bag device provided between a vehicle body and a back seat includes: a base member including a base storage configured to store an air bag and an inflator and a base attachment portion attached to the vehicle body; and a retainer member configured to hold the base storage from a vehicle back side. The retainer member extends from a portion holding the base storage while being bent along the shape of the vehicle body. The retainer member is attached to the vehicle body together with the base attachment portion while being overlapped with the base attachment portion.

Abstract: An event notification method executed by a processor included in an event notification device, the event notification method includes receiving, from a requesting source of an event, an event notification request for requesting notification of the event, the event notification request including event notification condition information including a notification condition of the event and priority information indicating a priority of notification of the event; acquiring the event from a publishing source of the event; determining whether to perform synchronous delivery of the event based on the notification condition; and notifying the requesting source of the event in an order of priority identified based on the priority information, when it is determined that synchronous delivery of the event be performed.

Abstract: A coating region 6p of a crown 6 has a maximum saturation portion SR1 at which a saturation is a maximum value Cmax, a high saturation region SR2 which includes the maximum saturation portion SR1 and in which a saturation difference from the saturation Cmax is not greater than 15, and a low saturation region SR3 in which a saturation difference from the saturation Cmax is greater than 15. When a straight line that passes through a face center Fc and extends in a face-back direction is defined as a straight line C, an area of a portion of the high saturation region SR2 at a toe side with respect to the straight line C is denoted by St, and an area of a portion of the high saturation region SR2 at a heel side with respect to the straight line C is denoted by Sh, then St>Sh.