Patents by Inventor Keiji Kubo

Keiji Kubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6420405
    Abstract: This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula wherein R1 is H or an optionally substituted hydrocarbon residue; R2 is an optionally esterified carboxyl group; R3 is a group capable of forming an anion or a group convertible thereinto; X is a covalent bond between the 2 phenyl rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n is 1 or 2; the ring A is a benzene ring having 1 or 2 optional substituents in addition to R2; and Y is a bond, —O—, —S(O)m- (wherein m is 0, 1 or 2) or —N(R4)— (wherein R4 is H or an optionally substituted alkyl group), or a pharmaceutically acceptable salt thereof in combination with a compound having diuretic activity or a compound having calcium antagonistic activity.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: July 16, 2002
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Yoshiyuki Inada, Keiji Kubo
  • Publication number: 20020045652
    Abstract: This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general fornula (I) 1
    Type: Application
    Filed: October 16, 2001
    Publication date: April 18, 2002
    Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
  • Patent number: 6348481
    Abstract: This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula wherein R1 is H or an optionally substituted hydrocarbon residue; R2 is an optionally esterified carboxyl group; R3 is a group capable of forming an anion or a group convertible thereinto; X is a covalent bond between the 2 phenyl rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n is 1 or 2; the ring A is a benzene ring having 1 or 2 optional substituents in addition to R2; and Y is a bond, —O—, —S(O)m— (wherein m is 0, 1 or 2) or —N(R4)— (wherein R4 is H or an optionally substituted alkyl group), or a pharmaceutically acceptable salt thereof in combination with a compound having diuretic activity or a compound having calcium antagonistic activity.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: February 19, 2002
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Yoshiyuki Inada, Keiji Kubo
  • Patent number: 6319938
    Abstract: Prophylactic or therapeutic drugs for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by formula (I) wherein R1 stands for H or an optionally substituted hydrocarbon residue; R2 stands for an optionally esterified carboxyl group; R3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R2; Y stands for a bond, —O—, —S(O)m—, wherein m stands for 0, 1 or 2, or —N(R4)— wherein R4 stands for H or an optionally substituted alkyl group are disclosed.
    Type: Grant
    Filed: December 20, 1999
    Date of Patent: November 20, 2001
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
  • Publication number: 20010011098
    Abstract: This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula 1
    Type: Application
    Filed: February 15, 2001
    Publication date: August 2, 2001
    Inventors: Yoshiyuki Inada, Keiji Kubo
  • Publication number: 20010004640
    Abstract: This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula 1
    Type: Application
    Filed: January 12, 2001
    Publication date: June 21, 2001
    Inventors: Yoshiyuki Inada, Keiji Kubo
  • Patent number: 6228874
    Abstract: This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula wherein R1 is H or an optionally substituted hydrocarbon residue; R2 is an optionally esterified carboxyl group; R3 is a group capable of forming an anion or a group convertible thereinto; X is a covalent bond between the 2 phenyl rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n is 1 or 2; the ring A is a benzene ring having 1 or 2 optional substituents in addition to R2; and Y is a bond, —O—, —S(O)m— (wherein m is 0, 1 or 2) or —N(R4)— (wherein R4 is H or an optionally substituted alkyl group), or a pharmaceutically acceptable salt thereof in combination with a compound having diuretic activity or a compound having calcium antagonistic activity.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: May 8, 2001
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Yoshiyuki Inada, Keiji Kubo
  • Patent number: 6040324
    Abstract: This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general formula (I) ##STR1## wherein R.sup.1 stands for H or an optionally substituted hydrocarbon residue; R.sup.2 stands for an optionally esterified carboxyl group; R.sup.3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R.sup.2 ; Y stands for a bond, --O--, --S(O).sub.m -- (wherein m stands for 0, 1 or 2), or --N(R.sup.4)-- (wherein R.sup.4 stands for H or an optionally substituted alkyl group).
    Type: Grant
    Filed: December 8, 1998
    Date of Patent: March 21, 2000
    Assignee: Takeda Chemical Industries, Inc.
    Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
  • Patent number: 5958961
    Abstract: This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula ##STR1## wherein R.sup.1 is H or an optionally substituted hydrocarbon residue; R.sup.2 is an optionally esterified carboxyl group; R.sup.3 is a group capable of forming an anion or a group convertible thereinto; X is a covalent bond between the 2 phenyl rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n is 1 or 2; the ring A is a benzene ring having 1 or 2 optional substituents in addition to R.sup.2 ; and Y is a bond, --O--, --S(O)m- (wherein m is 0, 1 or 2) or --N(R.sup.4)-- (wherein R.sup.4 is H or an optionally substituted alkyl group), or a pharmaceutically acceptable salt thereof in combination with a compound having diuretic activity or a compound having calcium antagonistic activity.
    Type: Grant
    Filed: June 26, 1997
    Date of Patent: September 28, 1999
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Yoshiyuki Inada, Keiji Kubo
  • Patent number: 5889036
    Abstract: This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general formula (I) ##STR1## wherein R.sup.1 stands for H or an optionally substituted hydrocarbon residue; R.sup.2 stands for an optionally esterified carboxyl group; R.sup.3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R.sup.2 ; Y stands for a bond, --O--, --S(O).sub.m -- (wherein m stands for 0, 1 or 2), or --N(R.sup.4)-- (wherein R.sup.4 stands for H or an optionally substituted alkyl group).
    Type: Grant
    Filed: November 6, 1997
    Date of Patent: March 30, 1999
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
  • Patent number: 5835815
    Abstract: An image forming machine includes a host computer, a printer, a copying machine, and a document supply device for conveying a document printed by the printer to an automatic document feeder of the copying machine. The host computer and a control device provided in the printer are connected together via a parallel data transfer type interface, while the host computer and control device provided in the copying machine are connected together via a serial data transfer type interface. Thus independent data are transferred from the host computer to the control device of the printer and the control device of the copying machine.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: November 10, 1998
    Assignee: Mita Industrial Co., Ltd.
    Inventors: Keiji Kubo, Kenji Yamamura, Motoyuki Fukuda, Satoshi Tanaka
  • Patent number: 5771419
    Abstract: An image forming machine including a host computer, a printer, a copying machine, and a document supply device for conveying a document printed by the printer to a document stand of an automatic document feeder of the copying machine is disclosed, the image forming machine including a first document conveying device for directly conveying the document printed by the printer to the automatic document feeder, and second document conveying device which has an intermediate tray for temporarily storing the document printed by the printer for conveying this document to the automatic document feeder after temporarily storing it in the intermediate tray.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: June 23, 1998
    Assignee: Mita Industrial Co., Ltd.
    Inventors: Keiji Kubo, Kenji Yamamura, Motoyuki Fukuda, Katsumi Fujimoto
  • Patent number: 5757509
    Abstract: An image forming machine comprising a host computer, a printer, a copying machine, and a document supply device for conveying a document printed by the printer to an automatic document feeder of the copying machine includes a data switching controller which is connected to the host computer via a parallel data transfer type interface to selectively transfer data transmitted from the host computer to the printer side and to the copying machine side. The host computer sequentially puts out to the data switching controller a copying machine control code comprising an identification code with a predetermined number of bytes, and control data with a predetermined number of bytes succeeding the identification code, and print data for the printer subsequent to the copying machine control code.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: May 26, 1998
    Assignee: Mita Industrial Co., Ltd.
    Inventor: Keiji Kubo
  • Patent number: 5721263
    Abstract: This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula ##STR1## wherein R.sup.1 is H or an optionally substituted hydrocarbon residue; R.sup.2 is an optionally esterified carboxyl group; R.sup.3 is a group capable of forming an anion or a group convertible thereinto; X is a covalent bond between the 2 phenyl rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n is 1 or 2; the ring A is a benzene ring having 1 or 2 optional substituents in addition to R.sup.2 ; and Y is a bond, --O--, --S(O)m-- (wherein m is 0, 1 or 2) or --N(R.sup.4)-- (wherein R.sup.4 is H or an optionally substituted alkyl group), or a pharmaceutically acceptable salt thereof in combination with a compound having diuretic activity or a compound having calcium antagonistic activity.
    Type: Grant
    Filed: December 7, 1994
    Date of Patent: February 24, 1998
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Yoshiyuki Inada, Keiji Kubo
  • Patent number: 5719173
    Abstract: This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general formula (I) ##STR1## wherein R.sup.1 stands for H or an optionally substituted hydrocarbon residue; R.sup.2 stands for an optionally esterified carboxyl group; R.sup.3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R.sup.2 ; Y stands for a bond, --O--, --S(O).sub.m -- (wherein m stands for 0, 1 or 2), or --N(R.sup.4)-- (wherein R.sup.4 stands for H or an optionally substituted alkyl group).
    Type: Grant
    Filed: August 14, 1996
    Date of Patent: February 17, 1998
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
  • Patent number: 5639773
    Abstract: This invention relates to an ocular hypotensive agent which comprises a compound represented by the formula: ##STR1## wherein R.sup.1 represents hydrogen or an optionally substituted hydrocarbon residue that may be bound via a hetero atom; R.sup.2 represents hydrogen or a hydrocarbon residue that may have a substituent; R.sup.3 represents a group capable of forming an anion or a group capable of changing thereto; X is a covalent bond between the 2 benzene rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n represents 1 or 2; ring A is a benzene ring having 1 or 2 optional substituents in addition to the group represented by COOR.sup.2, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 1, 1994
    Date of Patent: June 17, 1997
    Assignees: Senju Pharmaceutical Co., Ltd., Takeda Chemical Industries, Ltd.
    Inventors: Keiji Kubo, Takahiro Ogawa, Takaaki Deguchi
  • Patent number: 5500427
    Abstract: The present invention relates to a compounds represented by the following formula or salts thereof. ##STR1## The above compounds have strong angiotensin II antagonistic action, antihypertensive action and action on central nervous system, which are useful for the treatment of circulatory diseases such as hypertension, heart diseases, cerebral apoplexy, nephritis, atherosclerosis or Alzheimer's disease and senile dementia, and for agents of improving cerebral function.
    Type: Grant
    Filed: September 14, 1993
    Date of Patent: March 19, 1996
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Keiji Kubo, Yoshiyuki Inada, Takehiko Naka
  • Patent number: 5496835
    Abstract: This invention relates to a compound represented by the formula ##STR1## wherein the ring A stands for a 5-10 membered aromatic heterocyclic group optionally having, besides R.sup.1 and R.sup.2, further substituents; R.sup.1 stands for an optionally substituted hydrocarbon residue which is optionally bonded through a hetero-atom; R.sup.2 stands for a group capable of liberating proton in a living body or a group convertible thereinto; R.sup.
    Type: Grant
    Filed: December 22, 1993
    Date of Patent: March 5, 1996
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Keiji Kubo, Yoshiyuki Inada, Takehiko Naka
  • Patent number: 5246815
    Abstract: A photosensitive material for screen processing comprising a photosensitive resin composition (A) applied to a plastic film, and including a water-soluble or water-dispersible polymer or copolymer, an unsaturated compound, and a photopolymerization initiator, and a photosensitive resin composition (B) applied in a thickness of at least 0.1 .mu.m to the coated composition (A) and including a film-forming polymeric compound; and a photo-crosslinking polyvinyl alcohol partially containing photo-cross-linkable units provides a coating film which is water-developable, highly sensitive, and excellent in water and solvent resistances.
    Type: Grant
    Filed: May 20, 1992
    Date of Patent: September 21, 1993
    Assignees: Gen. Director of the Agency of Industrial Science & Technology, Daicel Chemical Industries, Ltd.
    Inventors: Kunihiro Ichimura, Keiji Kubo
  • Patent number: 4935488
    Abstract: Novel trimethylolheptanes having three highly reactive hydroxyl groups are provided. They are useful as raw materials for the production of polyesters for use in or as raw materials or modifiers for paints, inks, adhesives, coating compositions and molding resins. Uses for the trimethylolheptanes are also provided.
    Type: Grant
    Filed: April 20, 1989
    Date of Patent: June 19, 1990
    Assignee: Kurary Company, Ltd.
    Inventors: Toshihiro Omatsu, Yasuo Tokitoh, Noriaki Yoshimura, Masao Ishida, Makoto Yano, Koji Hirai, Yoichi Matsumoto, Keiji Kubo