Patents by Inventor Keiji Kubo
Keiji Kubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6420405Abstract: This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula wherein R1 is H or an optionally substituted hydrocarbon residue; R2 is an optionally esterified carboxyl group; R3 is a group capable of forming an anion or a group convertible thereinto; X is a covalent bond between the 2 phenyl rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n is 1 or 2; the ring A is a benzene ring having 1 or 2 optional substituents in addition to R2; and Y is a bond, —O—, —S(O)m- (wherein m is 0, 1 or 2) or —N(R4)— (wherein R4 is H or an optionally substituted alkyl group), or a pharmaceutically acceptable salt thereof in combination with a compound having diuretic activity or a compound having calcium antagonistic activity.Type: GrantFiled: February 15, 2001Date of Patent: July 16, 2002Assignee: Takeda Chemical Industries, Ltd.Inventors: Yoshiyuki Inada, Keiji Kubo
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Publication number: 20020045652Abstract: This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general fornula (I) 1Type: ApplicationFiled: October 16, 2001Publication date: April 18, 2002Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
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Patent number: 6348481Abstract: This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula wherein R1 is H or an optionally substituted hydrocarbon residue; R2 is an optionally esterified carboxyl group; R3 is a group capable of forming an anion or a group convertible thereinto; X is a covalent bond between the 2 phenyl rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n is 1 or 2; the ring A is a benzene ring having 1 or 2 optional substituents in addition to R2; and Y is a bond, —O—, —S(O)m— (wherein m is 0, 1 or 2) or —N(R4)— (wherein R4 is H or an optionally substituted alkyl group), or a pharmaceutically acceptable salt thereof in combination with a compound having diuretic activity or a compound having calcium antagonistic activity.Type: GrantFiled: January 12, 2001Date of Patent: February 19, 2002Assignee: Takeda Chemical Industries, Ltd.Inventors: Yoshiyuki Inada, Keiji Kubo
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Patent number: 6319938Abstract: Prophylactic or therapeutic drugs for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by formula (I) wherein R1 stands for H or an optionally substituted hydrocarbon residue; R2 stands for an optionally esterified carboxyl group; R3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R2; Y stands for a bond, —O—, —S(O)m—, wherein m stands for 0, 1 or 2, or —N(R4)— wherein R4 stands for H or an optionally substituted alkyl group are disclosed.Type: GrantFiled: December 20, 1999Date of Patent: November 20, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
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Publication number: 20010011098Abstract: This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula 1Type: ApplicationFiled: February 15, 2001Publication date: August 2, 2001Inventors: Yoshiyuki Inada, Keiji Kubo
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Publication number: 20010004640Abstract: This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula 1Type: ApplicationFiled: January 12, 2001Publication date: June 21, 2001Inventors: Yoshiyuki Inada, Keiji Kubo
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Patent number: 6228874Abstract: This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula wherein R1 is H or an optionally substituted hydrocarbon residue; R2 is an optionally esterified carboxyl group; R3 is a group capable of forming an anion or a group convertible thereinto; X is a covalent bond between the 2 phenyl rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n is 1 or 2; the ring A is a benzene ring having 1 or 2 optional substituents in addition to R2; and Y is a bond, —O—, —S(O)m— (wherein m is 0, 1 or 2) or —N(R4)— (wherein R4 is H or an optionally substituted alkyl group), or a pharmaceutically acceptable salt thereof in combination with a compound having diuretic activity or a compound having calcium antagonistic activity.Type: GrantFiled: May 4, 2000Date of Patent: May 8, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Yoshiyuki Inada, Keiji Kubo
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Patent number: 6040324Abstract: This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general formula (I) ##STR1## wherein R.sup.1 stands for H or an optionally substituted hydrocarbon residue; R.sup.2 stands for an optionally esterified carboxyl group; R.sup.3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R.sup.2 ; Y stands for a bond, --O--, --S(O).sub.m -- (wherein m stands for 0, 1 or 2), or --N(R.sup.4)-- (wherein R.sup.4 stands for H or an optionally substituted alkyl group).Type: GrantFiled: December 8, 1998Date of Patent: March 21, 2000Assignee: Takeda Chemical Industries, Inc.Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
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Patent number: 5958961Abstract: This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula ##STR1## wherein R.sup.1 is H or an optionally substituted hydrocarbon residue; R.sup.2 is an optionally esterified carboxyl group; R.sup.3 is a group capable of forming an anion or a group convertible thereinto; X is a covalent bond between the 2 phenyl rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n is 1 or 2; the ring A is a benzene ring having 1 or 2 optional substituents in addition to R.sup.2 ; and Y is a bond, --O--, --S(O)m- (wherein m is 0, 1 or 2) or --N(R.sup.4)-- (wherein R.sup.4 is H or an optionally substituted alkyl group), or a pharmaceutically acceptable salt thereof in combination with a compound having diuretic activity or a compound having calcium antagonistic activity.Type: GrantFiled: June 26, 1997Date of Patent: September 28, 1999Assignee: Takeda Chemical Industries, Ltd.Inventors: Yoshiyuki Inada, Keiji Kubo
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Patent number: 5889036Abstract: This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general formula (I) ##STR1## wherein R.sup.1 stands for H or an optionally substituted hydrocarbon residue; R.sup.2 stands for an optionally esterified carboxyl group; R.sup.3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R.sup.2 ; Y stands for a bond, --O--, --S(O).sub.m -- (wherein m stands for 0, 1 or 2), or --N(R.sup.4)-- (wherein R.sup.4 stands for H or an optionally substituted alkyl group).Type: GrantFiled: November 6, 1997Date of Patent: March 30, 1999Assignee: Takeda Chemical Industries, Ltd.Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
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Patent number: 5835815Abstract: An image forming machine includes a host computer, a printer, a copying machine, and a document supply device for conveying a document printed by the printer to an automatic document feeder of the copying machine. The host computer and a control device provided in the printer are connected together via a parallel data transfer type interface, while the host computer and control device provided in the copying machine are connected together via a serial data transfer type interface. Thus independent data are transferred from the host computer to the control device of the printer and the control device of the copying machine.Type: GrantFiled: March 5, 1997Date of Patent: November 10, 1998Assignee: Mita Industrial Co., Ltd.Inventors: Keiji Kubo, Kenji Yamamura, Motoyuki Fukuda, Satoshi Tanaka
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Patent number: 5771419Abstract: An image forming machine including a host computer, a printer, a copying machine, and a document supply device for conveying a document printed by the printer to a document stand of an automatic document feeder of the copying machine is disclosed, the image forming machine including a first document conveying device for directly conveying the document printed by the printer to the automatic document feeder, and second document conveying device which has an intermediate tray for temporarily storing the document printed by the printer for conveying this document to the automatic document feeder after temporarily storing it in the intermediate tray.Type: GrantFiled: March 5, 1997Date of Patent: June 23, 1998Assignee: Mita Industrial Co., Ltd.Inventors: Keiji Kubo, Kenji Yamamura, Motoyuki Fukuda, Katsumi Fujimoto
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Patent number: 5757509Abstract: An image forming machine comprising a host computer, a printer, a copying machine, and a document supply device for conveying a document printed by the printer to an automatic document feeder of the copying machine includes a data switching controller which is connected to the host computer via a parallel data transfer type interface to selectively transfer data transmitted from the host computer to the printer side and to the copying machine side. The host computer sequentially puts out to the data switching controller a copying machine control code comprising an identification code with a predetermined number of bytes, and control data with a predetermined number of bytes succeeding the identification code, and print data for the printer subsequent to the copying machine control code.Type: GrantFiled: March 5, 1997Date of Patent: May 26, 1998Assignee: Mita Industrial Co., Ltd.Inventor: Keiji Kubo
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Patent number: 5721263Abstract: This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula ##STR1## wherein R.sup.1 is H or an optionally substituted hydrocarbon residue; R.sup.2 is an optionally esterified carboxyl group; R.sup.3 is a group capable of forming an anion or a group convertible thereinto; X is a covalent bond between the 2 phenyl rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n is 1 or 2; the ring A is a benzene ring having 1 or 2 optional substituents in addition to R.sup.2 ; and Y is a bond, --O--, --S(O)m-- (wherein m is 0, 1 or 2) or --N(R.sup.4)-- (wherein R.sup.4 is H or an optionally substituted alkyl group), or a pharmaceutically acceptable salt thereof in combination with a compound having diuretic activity or a compound having calcium antagonistic activity.Type: GrantFiled: December 7, 1994Date of Patent: February 24, 1998Assignee: Takeda Chemical Industries, Ltd.Inventors: Yoshiyuki Inada, Keiji Kubo
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Patent number: 5719173Abstract: This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general formula (I) ##STR1## wherein R.sup.1 stands for H or an optionally substituted hydrocarbon residue; R.sup.2 stands for an optionally esterified carboxyl group; R.sup.3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R.sup.2 ; Y stands for a bond, --O--, --S(O).sub.m -- (wherein m stands for 0, 1 or 2), or --N(R.sup.4)-- (wherein R.sup.4 stands for H or an optionally substituted alkyl group).Type: GrantFiled: August 14, 1996Date of Patent: February 17, 1998Assignee: Takeda Chemical Industries, Ltd.Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
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Patent number: 5639773Abstract: This invention relates to an ocular hypotensive agent which comprises a compound represented by the formula: ##STR1## wherein R.sup.1 represents hydrogen or an optionally substituted hydrocarbon residue that may be bound via a hetero atom; R.sup.2 represents hydrogen or a hydrocarbon residue that may have a substituent; R.sup.3 represents a group capable of forming an anion or a group capable of changing thereto; X is a covalent bond between the 2 benzene rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n represents 1 or 2; ring A is a benzene ring having 1 or 2 optional substituents in addition to the group represented by COOR.sup.2, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: July 1, 1994Date of Patent: June 17, 1997Assignees: Senju Pharmaceutical Co., Ltd., Takeda Chemical Industries, Ltd.Inventors: Keiji Kubo, Takahiro Ogawa, Takaaki Deguchi
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Patent number: 5500427Abstract: The present invention relates to a compounds represented by the following formula or salts thereof. ##STR1## The above compounds have strong angiotensin II antagonistic action, antihypertensive action and action on central nervous system, which are useful for the treatment of circulatory diseases such as hypertension, heart diseases, cerebral apoplexy, nephritis, atherosclerosis or Alzheimer's disease and senile dementia, and for agents of improving cerebral function.Type: GrantFiled: September 14, 1993Date of Patent: March 19, 1996Assignee: Takeda Chemical Industries, Ltd.Inventors: Keiji Kubo, Yoshiyuki Inada, Takehiko Naka
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Patent number: 5496835Abstract: This invention relates to a compound represented by the formula ##STR1## wherein the ring A stands for a 5-10 membered aromatic heterocyclic group optionally having, besides R.sup.1 and R.sup.2, further substituents; R.sup.1 stands for an optionally substituted hydrocarbon residue which is optionally bonded through a hetero-atom; R.sup.2 stands for a group capable of liberating proton in a living body or a group convertible thereinto; R.sup.Type: GrantFiled: December 22, 1993Date of Patent: March 5, 1996Assignee: Takeda Chemical Industries, Ltd.Inventors: Keiji Kubo, Yoshiyuki Inada, Takehiko Naka
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Patent number: 5246815Abstract: A photosensitive material for screen processing comprising a photosensitive resin composition (A) applied to a plastic film, and including a water-soluble or water-dispersible polymer or copolymer, an unsaturated compound, and a photopolymerization initiator, and a photosensitive resin composition (B) applied in a thickness of at least 0.1 .mu.m to the coated composition (A) and including a film-forming polymeric compound; and a photo-crosslinking polyvinyl alcohol partially containing photo-cross-linkable units provides a coating film which is water-developable, highly sensitive, and excellent in water and solvent resistances.Type: GrantFiled: May 20, 1992Date of Patent: September 21, 1993Assignees: Gen. Director of the Agency of Industrial Science & Technology, Daicel Chemical Industries, Ltd.Inventors: Kunihiro Ichimura, Keiji Kubo
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Patent number: 4935488Abstract: Novel trimethylolheptanes having three highly reactive hydroxyl groups are provided. They are useful as raw materials for the production of polyesters for use in or as raw materials or modifiers for paints, inks, adhesives, coating compositions and molding resins. Uses for the trimethylolheptanes are also provided.Type: GrantFiled: April 20, 1989Date of Patent: June 19, 1990Assignee: Kurary Company, Ltd.Inventors: Toshihiro Omatsu, Yasuo Tokitoh, Noriaki Yoshimura, Masao Ishida, Makoto Yano, Koji Hirai, Yoichi Matsumoto, Keiji Kubo