Abstract: A fluid-filled vibration damping device including a partition having a housing area, and a movable film housed in the housing area while including a central retainer held by the partition and spoke-shaped retainers extending radially outward from the central retainer. A first surface of the movable film is overlapped on a wall inner surface of the housing area. An elastic deformation zone provided circumferentially between the spoke-shaped retainers is allowed to deform in a direction away from the wall inner surface, and includes a cushion ridge projecting from a second surface of the movable film while extending radially outward from the central retainer. A height of the cushion ridge is varied in a direction of extension such that a timing of contact with an opposing wall inner surface in the housing area varies depending on an amount of deformation of the elastic deformation zone.

Abstract: A vibration isolation device with bracket includes a first attachment member and a second attachment member coupled by a main body rubber elastomer. The second attachment member has a frame shape with a through hole. The main body rubber elastomer is fastened to an upper surface side of the second attachment member. The main body rubber elastomer penetrates to a lower surface side of the second attachment member through the through hole. A holding rubber is formed integrally with the main body rubber elastomer on a lower surface of fitting portions of the second attachment member. A fixed surface is arranged on an upper surface of the fitting portions. The fixed surface is exposed by the main body rubber elastomer, directly superimposed on an inner surface of the fitting grooves, and pressed and fixed by static friction to the inner surface of the fitting grooves by the holding rubber.

Abstract: A vibration damping device including a vibration-damping device main unit inserted into a mounting space of a bracket from a lateral side and securely supported by the bracket. The bracket includes engaging pieces on respective opposed inside faces of the mounting space, and engaging action of the engaging pieces with respect to respective detent engaging faces formed on a fixture member of the vibration-damping device main unit prevents the vibration-damping device main unit from becoming dislodged from the mounting space of the bracket. Opposed walls of the mounting space are each penetrated by an aperture window, and inspection flat surfaces are separately provided to an outside surface of each engaging piece visible from an outside through the aperture window and a corresponding external side surface of the bracket that is off the aperture window. The inspection flat surfaces are parallel to each other.

Abstract: A liquid-filled vibration damping device including a main unit and a bracket, the main unit including first and second attachments connected by a rubber body, and a closure member locked to the second attachment from below with a seal member sandwiched therebetween to seal a liquid chamber. The second attachment includes a pair of metallic connectors inserted into a pair of metallic grooves of the bracket. The metal is exposed on lower faces of the connectors which are pressed against groove-inside lower faces of the grooves in metal-to-metal contact. Convex parts protruding downward are provided at far-side ends of the connectors while concave parts are provided on the grooves at locations corresponding to the convex parts. Detent engagers preventing dislodgment of the connectors inserted in the grooves are constituted in metal-to-metal contact by the convex parts entering the concave parts to be engaged.

Abstract: A vibration damping device including a main unit including first and second attachments connected by a rubber body, the second attachment including metallic first and second connectors inserted into metallic first and second grooves of a bracket. The metal is exposed on outer and lower faces of the first connector to be in metal-to-metal contact with groove-inside bottom and lower faces of the first groove. An upper urging rubber on the first connector contacts a groove-inside upper face of the first groove. The metal is exposed on a lower face of the second connector to be in metal-to-metal contact with a groove-inside lower face of the second groove. Upper and outer urging rubbers on the second connector contact groove-inside upper and bottom faces of the second groove. Detent engagers between the connectors and the grooves prevent dislodgment of the connectors from the grooves.

Abstract: A liquid-filled vibration damping device including a first and second attachment members elastically connected by a main rubber elastic body, and a liquid chamber sealed by a closure member attached to the second attachment member from below with a seal member interposed therebetween. The second attachment member and the closure member are attached to each other by connecting locks arranged in a circumferential direction. Each connecting lock includes a flexible locking piece projecting from one toward another of the second attachment member and the closure member while having a locking hole, and a locking claw formed on the other of the two members and hooked to the locking hole of the locking piece. The locking piece includes a guide groove extending linearly from the locking hole in a direction of projection to guide the locking claw into the locking hole.

Abstract: A walking support system including processing circuitry for determining a recommended route for a participant in a space where the participant can choose and walk along a route, and guiding the participant to the recommended route without restricting entry of the participant into a non-recommended route, which is a different route to the recommended route.

Abstract: A compound useful for preventing or treating dry eye and a medicament for preventing and/or treating dry eye comprising the same which does not substantially impact on the intraocular pressure are provided. A method of preventing and/or treating dry eye in a subject in need thereof, comprising administering a therapeutically effective amount of olodaterol or a salt thereof to the subject is also provided.

Abstract: A vibration damping device including a vibration-damping device main unit attached to a bracket from a lateral side by a second attachment member being fitted to opposed walls provided on widthwise opposite sides of the bracket. The bracket includes flexible latches extending from the respective opposed walls forward in a direction of attachment. The second attachment member includes outer recesses respectively opening onto surfaces overlapped with the respective opposed walls. Each latch has a slope portion sloping inward in a width direction of the bracket such that a distal end face of the latch is inserted in the corresponding outer recess. The distal end face of the latch is latched by a forward wall inner face of the outer recess, and displacement of the second attachment member relative to the bracket in a direction of dislodgment opposite to the direction of attachment is limited.

Abstract: In an anti-vibration apparatus having a bracket where an anti-vibration apparatus body in which a first mounting member and the second mounting member are connected by a body rubber elastic body is horizontally mounted to the bracket by fitting parts disposed on two sides of a width direction of the second mounting member in the anti-vibration apparatus body to fitting grooves disposed on opposite inner surfaces on two sides of a width direction of the bracket, a locking hole is provided on a deep wall part located on a deep side in a mounting direction of the second mounting member in the bracket, and a locking part is disposed at a tip portion in the mounting direction of the second mounting member to the bracket, and prevents return in a direction opposite to the mounting direction by inserting and locking the locking part to the locking hole.

Abstract: A vibration damping device including a vibration-damping device main unit inserted into a mounting space of a bracket from a lateral side and securely supported by the bracket. The bracket includes engaging pieces on respective opposed inside faces of the mounting space, and engaging action of the engaging pieces with respect to respective detent engaging faces formed on a fixture member of the vibration-damping device main unit prevents the vibration-damping device main unit from becoming dislodged from the mounting space of the bracket. Opposed walls of the mounting space are each penetrated by an aperture window, and inspection flat surfaces are separately provided to an outside surface of each engaging piece visible from an outside through the aperture window and a corresponding external side surface of the bracket that is off the aperture window. The inspection flat surfaces are parallel to each other.

Abstract: A method for producing a compound represented by formula (3) including bringing a carbon-carbon double bond reductase, a microorganism or cell having an ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture solution containing the enzyme which is obtained by culturing the microorganism or cell, and a carbonyl reductase, a microorganism or cell having an ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture solution containing the enzyme which is obtained by culturing the microorganism or cell into contact with a compound represented by formula (1) to obtain a compound represented by formula (3):

Abstract: A compound useful for preventing or treating dry eye and a medicament for preventing and/or treating dry eye comprising the same which does not substantially impact on the intraocular pressure are provided. A method of preventing and/or treating dry eye in a subject in need thereof, comprising administering a therapeutically effective amount of olodaterol or a salt thereof to the subject is also provided.

Abstract: A method for producing a compound represented by formula (3) including bringing a carbon-carbon double bond reductase, a microorganism or cell having an ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture solution containing the enzyme which is obtained by culturing the microorganism or cell, and a carbonyl reductase, a microorganism or cell having an ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture solution containing the enzyme which is obtained by culturing the microorganism or cell into contact with a compound represented by formula (1) to obtain a compound represented by formula (3):

Abstract: A vibration damping device including a vibration-damping device main unit attached to a bracket from a lateral side by a second attachment member being fitted to opposed walls provided on widthwise opposite sides of the bracket. The bracket includes flexible latches extending from the respective opposed walls forward in a direction of attachment. The second attachment member includes outer recesses respectively opening onto surfaces overlapped with the respective opposed walls. Each latch has a slope portion sloping inward in a width direction of the bracket such that a distal end face of the latch is inserted in the corresponding outer recess. The distal end face of the latch is latched by a forward wall inner face of the outer recess, and displacement of the second attachment member relative to the bracket in a direction of dislodgment opposite to the direction of attachment is limited.

Abstract: A fluid-filled vibration damping device including a partition having a housing area, and a movable film housed in the housing area while including a central retainer held by the partition and spoke-shaped retainers extending radially outward from the central retainer. A first surface of the movable film is overlapped on a wall inner surface of the housing area. An elastic deformation zone provided circumferentially between the spoke-shaped retainers is allowed to deform in a direction away from the wall inner surface, and includes a cushion ridge projecting from a second surface of the movable film while extending radially outward from the central retainer. A height of the cushion ridge is varied in a direction of extension such that a timing of contact with an opposing wall inner surface in the housing area varies depending on an amount of deformation of the elastic deformation zone.

Abstract: A vibration isolation device with bracket includes a first attachment member and a second attachment member coupled by a main body rubber elastomer. The second attachment member has a frame shape with a through hole. The main body rubber elastomer is fastened to an upper surface side of the second attachment member. The main body rubber elastomer penetrates to a lower surface side of the second attachment member through the through hole. A holding rubber is formed integrally with the main body rubber elastomer on a lower surface of fitting portions of the second attachment member. A fixed surface is arranged on an upper surface of the fitting portions. The fixed surface is exposed by the main body rubber elastomer, directly superimposed on an inner surface of the fitting grooves, and pressed and fixed by static friction to the inner surface of the fitting grooves by the holding rubber.

Abstract: In an anti-vibration apparatus having a bracket where an anti-vibration apparatus body in which a first mounting member and the second mounting member are connected by a body rubber elastic body is horizontally mounted to the bracket by fitting parts disposed on two sides of a width direction of the second mounting member in the anti-vibration apparatus body to fitting grooves disposed on opposite inner surfaces on two sides of a width direction of the bracket, a locking hole is provided on a deep wall part located on a deep side in a mounting direction of the second mounting member in the bracket, and a locking part is disposed at a tip portion in the mounting direction of the second mounting member to the bracket, and prevents return in a direction opposite to the mounting direction by inserting and locking the locking part to the locking hole.

Abstract: As a method for producing a 3-hydroxyisobutyric acid ester using a biocatalyst, a method for producing a 3-hydroxyisobutyric acid ester, including a step of allowing an alcohol or phenol to act on 3-hydroxyisobutyryl-CoA in the presence of alcohol acyltransferase to produce a 3-hydroxyisobutyric acid ester is provided.

Abstract: An exhalation measurement device includes: a chamber to retain exhalation; a reference gas generator 17 to generate a reference gas; a measurement device 12 to measure concentrations of exhalation being retained in the chamber and a specific gas within the reference gas; a gas transporter 18 including a pump 11 to selectively transport the exhalation being retained in the chamber and the reference gas generated by the reference gas generator to the measurement device; and a control circuit 50 to control an operation of the gas transporter.