Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.

Abstract: A method for manufacturing an electrofluidic device comprising the steps of providing a first plate with features for holding a first fluid, filling a first fluid into features on a first plate; providing a second plate and sealing a second plate onto the first plate forming stacked plates with at least one cavity between the plates, and leaving at least one fill port for a second fluid. Thereafter, the stacked plates are cooled to increase the viscosity of the first fluid so that the first fluid maintains a fixed position as a second fluid is filled into the cavity. Methods are disclosed.

Abstract: The invention is to an optionally piloted aircraft that can takeoff and land conventionally or vertically, and can convert between the two. The aircraft is immune to one or more engine failures during vertical flight through multiple engines and the use of a virtual nozzle. Aerodynamic controls are similarly redundant. Hovering flight is enabled with a novel stabilization system. Long range efficient cruise is achieved by turning off some engines in flight and sealing them into an aerodynamic fairing to achieve low drag. The resulting aircraft is capable of CTOL and VTOL, and is capable of converting between the two modes while in the air or on the ground. The aircraft can also be easily taxied on the ground in the conventional manner. Automatic controls considerably reduce the amount of training a pilot needs to fly and land the aircraft in either VTOL or CTOL mode.

Abstract: A method for the deployment of reconnaissance devices including buoy cameras and robotic devices in a target mission area of a remote location in space utilizing a maneuverable descent de-booster capsule and a buoyant vessel for the deployment is disclosed, including identifying the target area from an orbiting spacecraft; deploying the de-booster into orbit over the target area; initiating gradual descent of the de-booster in the atmosphere of the remote location in space; ejecting the buoyant vessel and its payload from the de-booster; filling the buoyant portion of the buoyant vessel with a lifting gas to cause the buoyant portion to become a large balloon; activating reconnaissance devices on the bay portion of the buoyant vessel, including video and other devices for monitoring and surveiling the target mission area; maneuvering the buoyant vessel to refine mission site selection; opening cargo bay doors at a predetermined altitude to deliver payloads including buoy cameras to the target mission area; ca

Abstract: The invention is directed to a center deck assembly for a tire building drum. The tire building drum is rotatably mounted on a central drive shaft and includes a center section. The center deck assembly is disposed in the center section of the drum and includes a hub that seats on and is secured to the central drive shaft. At least one piston extends circumferentially in the tire building drum about the hub and a plurality of segment bars are disposed about the circumference of the center deck assembly. The at least one piston is operably connected to the segment bars by a plurality of linkages, in which each of the linkages includes a scissor-lever mechanism.

Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.

Abstract: A method of forming a tire having a first and second bead on a tire building drum is disclosed. The method includes the steps of applying a green tire carcass onto the tire building drum, said tire building drum having a left and right hub, each hub having a bead pocket. The method includes the steps of placing the first and second bead onto a first and second respective bead pocket of the tire building drum and then inflating the carcass into engagement with a belt and tread package while moving at least one of the left and right hubs in the axial direction at a controlled velocity towards the other respective hub.

Abstract: A second stage tire building drum is disclosed. The second stage tire building drum comprises a first and second hub, wherein each hub is mounted on a central shaft of the second stage tire building drum. Each hub is axially movable and has a bead receiving mechanism. The bead receiving mechanism includes one or more bead segments, wherein each bead segment has a pocket.

Abstract: Fan assemblies, and in particular fan wheels and stator assemblies for fan assemblies, are disclosed. In one embodiment, the fan wheel includes a wheel back having an outer surface forming one of a curved dome-shape and a truncated cone-shape. The fan wheel may also include a plurality of fan blades radially spaced about and mounted to the outer surface of the wheel back. In one embodiment, each of the fan blades is formed from a segment of an airfoil-shaped aluminum extrusion defining at least one internal cavity. The fan blade first ends can be provided with a compound cut profile with at least one curved cut such that the first end of the blade is mounted flush to the wheel back outer surface. The stator assembly can also be provided with a plurality of stator blades formed from airfoil-shaped aluminum extrusion segments and provided with compound cut profiles.

Abstract: Methods and a system for controlling the movements of a proxy robot surrogate by utilizing electrical signals from the nervous system of a user are presented.

Abstract: A method and system for exploring a remote environment from an environment simulator at a local base is disclosed.

Abstract: A method for replicating the terrain of a remote environment by a terrain replicator with a plurality of extendable elements is disclosed.

Abstract: A system and method for processing X-ray fluorescence data in a hand-held X-ray Fluorescence (XRF) analyzer are provided. The X-ray fluorescence (XRF) analyzer includes a radiation source assembly including a first centerline axis and configured to direct an X-ray beam to impinge on a sample to be tested. The XRF analyzer also includes a radiation detector assembly including a second centerline axis configured to sense X-ray fluorescence (XRF) emitted from the sample in response to the X-ray beam. The XRF analyzer further includes a processor configured to determine a property of the sample to be tested from the emitted XRF, and a proximity sensor configured to continuously measure a distance between the XRF analyzer and the sample to be tested, the distance being at least one of displayed to a user and used by the processor to determine the property.

Abstract: The invention is directed to a center deck assembly for a tire building drum. The tire building drum is rotatably mounted on a central drive shaft and includes a center section. The center deck assembly is disposed in the center section of the drum and includes a hub that seats on and is secured to the central drive shaft. At least one piston extends circumferentially in the tire building drum about the hub and a plurality of segment bars are disposed about the circumference of the center deck assembly. The at least one piston is operably connected to the segment bars by a plurality of linkages, in which each of the linkages includes a scissor-lever mechanism.

Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.

Abstract: A shading assembly configured to have a first selectable state that is transmissive to more than 40% of solar light and reflects more than 35% of solar heat, a second selectable state that blocks more than 75% of the solar light and transmits more than 50% of the solar heat, and a third selectable state that transmits more than 50% of the solar light and more than 50% of the solar heat.

Abstract: A method for manufacturing a freestanding film having at least one population of through holes cumulatively totaling at least 1% of the film area, wherein the standard deviation of hole diameters is less than 25% and a thickness less than 25 micrometers, The film provides a carrier substrate, a photo-curable material, a release agent and deposits a photo-curable material on the substrate, selectively curing the material and leaving uncured material in the pattern of holes, dissolving away the uncured material and removing the cured material from the carrier substrate. Methods and apparatus are described.

Abstract: A system of reconnaissance for the staging of a mission in a target area of a remote location in space is disclosed, including satellite surveillance means; a plurality of radio beacon/video camera transceiver means; communication means connecting the satellite surveillance means with the plurality of radio beacon/video camera transceiver means; communication means connecting the plurality of radio beacon/video camera transceiver means with at least one base station; and analysis means to analyze video, positional and other data from the target area.

Abstract: An omnidirectional treadmill environment simulator is disclosed. The omnidirectional treadmill environment simulator includes a circular simulator stage area, a plurality of transport mechanisms that maintain an object at or near the center of a circular simulator stage area and at least one processor. The processor is configured to collect position data of the object and process the position data to control the transport mechanisms. Also included is a receiver for receiving data from a remote location and a terrain analysis computer for processing the data received from the remote location. The terrain analysis computer collects the data received from the remote location to form an accurate simulation of an upcoming condition at the remote location. The omnidirectional treadmill environment simulator includes a transmitter for transmitting the position data to a remote location.

Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.