Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.

Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.

Abstract: A display device comprising a pixel, where the pixel includes: (a) a polar fluid that is at least one of colored and black, (b) a non-polar fluid that is at least one of transparent and translucent, (c) a first substrate, (d) a second substrate arranged relative to the first substrate to define a channel occupied by the polar fluid and the non-polar fluid, wherein at least one of the polar fluid and the non-polar fluid is visible through at least one of the first substrate and the second substrate, (e) a reflector having a plurality of features, comprising at least one of concavities and projections, that alter an angle of reflected light from a specular reflection to provide the appearance of at least one of a diffuse reflection and a non-metallic reflection, where the reflector includes a hydrophobic coating causing the polar fluid that is at least one of colored and black to be non-wetting to the hydrophobic coating in the presence of the non-polar fluid, the display device also including a plurality of el

Abstract: An apparatus, system, and method are disclosed for memory configuration analysis. A classification module 402 determines 1000 an overall performance of an array 706 of memory devices 500 in a computer memory 104, wherein overall performance has a substantially inverse relationship with a highest quantity of members of a subset of the array and a substantially direct relationship with an individual performance capability of the members. A counting module 404 takes a count 1110 of members of the array 706 whose individual performance capability varies 1108 in a selected direction from the overall performance of the array 706. A comparison module 406 takes a selected action such as issuing a memory configuration warning 1114 if the count crosses a predetermined threshold 1112 comprising a predetermined percentage for comparison with the count, as qualified by the individual performance capability, divided by an unqualified count of members of the array 706.

Abstract: A method and apparatus for tuning an engine by a modified pod filter or velocity stack using a tunable pod air filter with base and cap members forming a housing that is joined together by a filter membrane to define a plenum or resonance chamber within the housing that contains only air drawn in through the filter. An aperture in the base member passes air to the inlet of an engine. A tuning sleeve is sealingly engaged within the aperture and extends into the plenum to control air flow out of the plenum and into the engine. The tuning sleeve is tubular with a pattern of vents through its surface to control flow rate. The vents may be drilled, punched or otherwise cut through the sleeve to control air flow. After being vented, the sleeve is reinserted into the filter housing and the filter is installed on the engine.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2fluoroalkyl, halogen, NR6R7, optionally substituted heteroaryl (Het), or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis or osteoarthritis or neurodegenerative disorders.

Abstract: A system for controlling a human-controlled proxy robot surrogate is presented. The system includes a plurality of motion capture sensors for monitoring and capturing all movements of a human handler such that each change in joint angle, body posture or position; wherein the motion capture sensors are similar in operation to sensors utilized in motion picture animation, suitably modified to track critical handler movements in near real time. A plurality of controls attached to the proxy robot surrogate is also presented that relays the monitored and captured movements of the human handler as “follow me” data to the proxy robot surrogate in which the plurality of controls are configured such that the proxy robot surrogate emulates the movements of the human handler.

Abstract: A system and method of space exploration with a human-controlled proxy robot surrogates is disclosed. The method includes: training the human controlled proxy robot surrogates using human handlers; controlling the human-controlled proxy robot surrogates using the human handlers; and deploying a plurality of human-controlled proxy robot surrogates for extraterrestrial missions, missions on Earth, the Moon, and near-Earth locations. Each of the human-controlled proxy robot surrogates are in communication with each of the human handlers and wherein each one of the plurality of proxy robot surrogates is paired with each one of the plurality of human handlers. The human-controlled proxy robot surrogates further comprise an artificial intelligence (AI). The artificial intelligence of the disclosed method includes learned behavior.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2fluoroalkyl, halogen, NR6R7, optionally substituted heteroaryl (Het), or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis, osteoarthritis or neurodegenerative disorders.

Abstract: An approach is provided to inactivate a selected drive included in a RAID configuration. While inactive, write requests are handled by identifying data blocks to be written to each of the RAID drives. The identification also identifies a data block address corresponding to the data blocks. Data blocks destined to non-selected drives are written to the non-selected drives. The data blocks destined to the selected drive is written to a memory area outside of the RAID configuration. The data block addresses corresponding to the data blocks are also written to the memory area. After a period of time, the selected drive is reactivated. During reactivation, the data block addresses and their corresponding data blocks that were written to the memory area are read from the memory area and each of the data blocks are written to the selected drive at the corresponding data block addresses.

Abstract: Methods, systems, devices and/or apparatuses are provided that selectively reflect the infrared spectrum independent of other regions of the solar spectrum in order to actively manage solar heat gain across surfaces such as windows, skylights, roofs, siding and the like.

Abstract: A device, an electrode configuration and a sequence for activating those electrodes for the purpose of switching device states quickly with minimum flicker during bi-stable image reset. The disclosure addresses the constraints of electrofluidic technology: 1) the polar fluid can be attracted to a position with voltage, but it cannot be repelled, and 2) because the polar fluid translates, changing its area against an electrode and thereby changing the capacitance, the time to discharge the capacitor formed by area contact with a polar fluid is significantly smaller than the time to charge a capacitor, which requires translation of the fluid. Setting the grayscale is based on discharging, not charging, when possible. In addition, the use of pixel-level partial reset states reduces the appearance of flicker further by minimizing the change in pixel state during data write/update.

Abstract: A cleated sandal for use in athletic activities comprising a flexible sole and plural attachment straps for mounting the sandal on a foot or footwear of a wearer. A plurality of cleats for contacting a ground surface extend from a bottom side of the flexible sole at its toe and heel ends. The plural attachment straps include two vertical and two horizontal attachment straps each having a bottom surface and a top surface. The bottom and top surfaces of each of the attachment straps are covered with suction mesh hairs which cling to each other when overlaid; hence, allowing portions of each strap to connect to each other to form secure loops and to tighten the sandal on the foot or footwear of the wearer. The attachment straps also are additionally connected to the sole through respective aligned buckles.

Abstract: A method and apparatus are disclosed for automatic solid state drive performance recovery. A detection module detects a first SSD exceeding a fragmentation threshold. A plurality of drives comprises the first SSD and stores a data copy of data stored on the first SSD. An erase module erases a mapping table for the first SSD. The mapping table maps Logical Block Addresses LBA to physical addresses for the first SSD. A rebuild module rebuilds the data and the mapping table on the first SSD from the data copy.

Abstract: A decorative housing (11) for a mobile device (10) includes a first faceted cell (12) having a first angled electro-optic element (14) disposed therein. A second faceted cell (16) is adjacent the first cell (12) and has second angled electro-optic elements (18). A liquid (20) is in fluid communication with each faceted cell (12, 16) and moveable to a first position (22) in response to a first electric field (24) applied to one of the first and second electro-optic elements (14, 18) and moveable to a second position (26) in response to a second electric field (28) applied to the other of the first and second electro-optic elements (14, 18). An electronic modulator (30) is coupled to the first electro-optic element (14) and the second electro-optic element (18) to electronically modulate between the first electric field (24) and the second electric field (28).

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2fluoroalkyl, halogen, NR6R7, optionally substituted heteroaryl, or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis or osteoarthritis or neurodegenerative disorders.

Abstract: The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2-fluoroalkyl, halogen, NR6R7, optionally substituted heteroaryl, or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis, osteoarthritis or neurodegenerative disorders.

Abstract: A device (110, 151, 200) with a viewable surface (201) including a plurality of transparent pedestals (210) having a reflective material (406) disposed on its sides (408) make smudges forming thereon unnoticeable by taking advantage of optical characteristics including contrast and the user's visual acuity. The pedestals (210) generally have a width (412) of less than 50 microns, a height (414) equal to twice the width (412), and a spacing (416) between adjacent pedestals (210) equal to the width (412). The device (110, 151, 200) may be an electronic device, and more particularly a portable electronic device such as a cell phone.

Abstract: A device and method of making and using the same. The device includes first and second substrates that are spaced to define a fluid space. Polar and non-polar fluids occupy the fluid space. A first electrode, with a dielectric layer, is positioned on the first substrate and electrically coupled to at least one voltage source, which is configured to supply an electrical bias to the first electrode. The fluid space includes at least one fluid splitting structure that is configured to facilitate the movement of the non-polar fluid into a portion of the polar fluid. Fluid splitting structure assisted movement of the non-polar fluid splits the polar fluid.