Abstract: Triazolopyrimidines and related compounds are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various HSP90 mediated disorders, e.g., proliferative disorders. Method of synthesis and use of such compounds are also described and claimed.

Abstract: Pyrrolopyrimidines and related analogs are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents used in the treatment and prevention of various HSP90 mediated disorders, e.g., proliferative disorders. Methods of synthesis and use of such compounds are also described and claimed.

Abstract: Novel purine compounds and tautomers and pharmaceutically acceptable salts thereof are described, as are pharmaceutical compositions comprising the same, complexes comprising the same, e.g., HSP90 complexes, and methods of using the same.

Abstract: A remote communications server system enables multiple remote users simultaneous access to a network through a segmented design that distributes the processing of the connections among a combination of buses and processors. The system coordinates a plurality of independent communications links bonded together into a single channel to create a virtual connection to the network having a bandwidth greater than the individual links. The system supports a mixture of physical and multiplexed communication links and allows the intermixing of different types of links in a bonded channel. The system is scalable in that segments can be added as needed and the number of lines handled by a segment can be increased.

Abstract: A remote communications server system enables multiple remote users simultaneous access to a network. The system connects a plurality of on-line sessions across multiple communication lines to the network. A unique combination of multiple buses, multiple processors, and a segmented design creates a distributed processing communications system having high throughput without the stability problems associated with gigabit bus speeds. Furthermore, the system supports a mixture of communication links and allows the substitution of one service type for another without affecting the remaining communication links. The system is scalable in that segments can be added as needed and the number of lines handled by a segment can be increased.

Abstract: A remote communications server system enables multiple remote users simultaneous access to a network. The system connects a plurality of on-line sessions across multiple communication lines to the network. A unique combination of multiple buses, multiple processors, and a segmented design creates a distributed processing communications system having high throughput without the stability problems associated with gigabit bus speeds. Furthermore, the system supports a mixture of communication links and allows the substitution of one service type for another without affecting the remaining communication links. The system is scalable in that segments can be added as needed and the number of lines handled by a segment can be increased.

Abstract: This invention relates to an oil-in-water emulsion that is of a water-insoluble gas-forming chemical and a stabilizer. The emulsion being capable of forming microbubbles of gas upon application of ultrasonic energy. This composition allows for site specific imaging as the image enhancing microbubbles can be released upon the application of ultrasonic energy at the specific location where the image is desired.

Abstract: This invention relates to an oil-in-water emulsion that is of a water-insoluble gas-forming chemical and a stabilizer. The emulsion being capable of forming microbubbles of gas upon application of ultrasonic energy. This composition allows for site specific imaging as the image enhancing microbubbles can be released upon the application of ultrasonic energy at the specific location where the image is desired.

Abstract: A proxy server shares a plurality of modems connected to a wide area network among multiple client computers connected to a local area network. Each of the client computers on the local area network is assigned a local address while each of the plurality of modems is assigned a modem port address valid on the wide area network. In one embodiment, a processor controls address substitution allowing multiple client computers to share modems when communicating to host computers in a wide area network. The processor creates a descriptor list to keep track of the connections between the client computer and host computers on the wide area network and uses the descriptor list to determine to which client computer an incoming data packet should be sent. The processor also creates a proxied application list to determine if an outgoing data packet, received from one of the client computers, is one to be proxied through the proxy server.