Abstract: Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over conventional bioadhesive hydrogels in terms of biocompatibility. In addition, the in situ-forming bioadhesive hydrogel has excellent biocompatibility and mechanical strength and has excellent tissue adhesiveness thanks to modification with/without dopa derivatives. The hydrogel finds a variety of applications in the biomedical field, including bioadhesives or hemostats, implant substances for tissue regeneration and augmentation, carriers for delivering biologically active materials or drugs, etc.

Abstract: Disclosed is a multi-layered structure for drug reservoir, comprising a first micelle layer for crosslinking and adhesion, comprising a drug, a multi-arm polymer, a phenol derivative, and a dopa derivative and having a one or two-layered structure; a second micelle layer for crosslinking, being stacked on the first micelle layer, comprising a drug, a multi-arm polymer, and a phenol derivative, and having a one or two-layered structure; and a physiologically active material layer, being stacked on the second micelle layer, comprising a physiologically active material, a water-soluble polymer, and a phenol derivative, and having a one or two-layered structure.

Abstract: Disclosed are in situ-forming injectable hydrogel and medical uses thereof. In the in situ-forming injectable hydrogel two or more homogeneous or heterogeneous polymers are bonded to each other by a dehydrogenation reaction between phenol or aniline moieties on adjacent polymers, wherein a polymer backbone is grafted with a phenol or aniline moiety using a linker. In contrast to conventional hydrogel, the in situ-forming injectable hydrogel is superior in terms of in vivo stability and mechanical strength thanks to the introduction of a water-soluble polymer as a linker which leads to an improvement in the reactivity of phenol or aniline moieties. Having the advantage of superior bio stability and mechanical strength, the hydrogel finds a variety of applications in the biomedical field.

Abstract: An improved therapeutic bed includes a bed frame; at least one spring holder, each extending along a first direction of the bed frame and including first channels provided at a top area of the at least one spring holder; coil springs disposed respectively in the first channels of the at least one spring holder, each of the coil springs extending along a second direction of the bed frame between two sides of the bed frame; at least one vibration shaft member disposed below the at least one coil spring holder and extending along the first direction of the bed frame; and a motor configured to generate vibration to the at least one vibration shaft member. The vibration is transferred from the at least one vibration shaft member to the coil springs through the at least one spring holder, whereby the therapeutic bed has improved durability and massaging effect.

Abstract: A method is provided for immobilizing a bioactive molecule onto a surface using polyphenol oxidase. In the presence of polyphenol oxidase, a bioactive molecule containing a phenol or catechol group can be simply in situ oxidized within a short time to dopa or dopaquinone which forms a coordinate bond with a metal or polymer substrate, thus immobilizing the bioactive molecule onto the surface with stability. Based on the surface immobilization of bioactive molecules using polyphenol oxidase, various bioactive molecules such as osteogenetic peptides and growth factors can be simply immobilized to medical metal or polymer substrate surfaces such as orthopedic or dental implants which can be then effectively used to induce rapid osteogenesis after being transplanted. Also, antithrombotic agents and/or entothelialization inducing agents may be immobilized to medical substrates for vascular systems, such as stents and artificial blood vessels, thus guaranteeing hemocompatibility to the medical substrates.

Abstract: Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over conventional bioadhesive hydrogels in terms of biocompatibility. In addition, the in situ-forming bioadhesive hydrogel has excellent biocompatibility and mechanical strength and has excellent tissue adhesiveness thanks to modification with/without dopa derivatives. The hydrogel finds a variety of applications in the biomedical field, including bioadhesives or hemostats, implant substances for tissue regeneration and augmentation, carriers for delivering biologically active materials or drugs, etc.

Abstract: Disclosed are in situ-forming injectable hydrogel and medical uses thereof. In the in situ-forming injectable hydrogel two or more homogeneous or heterogeneous polymers are bonded to each other by a dehydrogenation reaction between phenol or aniline moieties on adjacent polymers, wherein a polymer backbone is grafted with a phenol or aniline moiety using a linker. In contrast to conventional hydrogel, the in situ-forming injectable hydrogel is superior in terms of in vivo stability and mechanical strength thanks to the introduction of a water-soluble polymer as a linker which leads to an improvement in the reactivity of phenol or aniline moieties. Having the advantage of superior bio stability and mechanical strength, the hydrogel finds a variety of applications in the biomedical field.

Abstract: A user input method and device of a mobile communication terminal that includes displaying a menu screen comprising images associated with each key function and menu function necessary for terminal control, depending on a currently set operation mode; detecting a preset indicator from a video that is photographed by camera when augmented reality input mode is set, real-time synthesizing the detected indicator with the menu screen, and displaying the synthesized screen; and in a state where a predetermined one of the images and the indicator are overlapped on the synthesized screen, upon detection of a preset user motion associated with selection from the video photographed by the camera, performing an operation based on the function associated with the image.

Abstract: Disclosed is a novel connection structure of an outrigger and a perimeter column. The connection structure has a function of automatically absorbing differential column shortening which is occurred between the core wall and the perimeter column during or after the construction of a building, thereby preventing excessive stress due to the differential column shortening. In addition, the invented apparatus also functions as damper by providing additional damping to the structure to resist dynamic loading such as wind and earthquake efficiently.

Abstract: A user input method and device of a mobile communication terminal that includes displaying a menu screen comprising images associated with each key function and menu function necessary for terminal control, depending on a currently set operation mode; detecting a preset indicator from a video that is photographed by camera when augmented reality input mode is set, real-time synthesizing the detected indicator with the menu screen, and displaying the synthesized screen; and in a state where a predetermined one of the images and the indicator are overlapped on the synthesized screen, upon detection of a preset user motion associated with selection from the video photographed by the camera, performing an operation based on the function associated with the image.

Abstract: Disclosed is a biocompatible medical material and porous scaffold for use in tissue engineering, made from a biodegradable glycolide/?-caprolactone copolymer having a repeat unit of wherein x and y are integers greater than or equal to 18, the copolymer has an average molecular weight of about 10,000 daltons or more, and the molar ratio of glycolide: ?-caprolactone in the copolymer is about 4.0:6.0 to 6.0:4.0.

Abstract: A therapeutic bed mattress. In one embodiment, the bed mattress includes a mattress frame (1A), rope elements (26) are secured substantially to an upper surface of the bed frame. The rope elements are secured between at least two sides of the bed frame. At least one vibration member (16) is attached to and below the rope elements. The vibration member includes a shaft (12), a pulley (13) attached axially to one end of the shaft, and a counterweight (11) attached to the shaft. At least one motor (10) including an output shaft (12) and a motor pulley (14) axially attached to the output shaft vibrates the rope elements. At least one belt (9) is secured between the pulley of the vibration member and the motor pulley of the motor, such that when the motor is powered, the output shaft of the motor rotates the motor pulley which rotates the belt such that the pulley of the vibration member is rotated to rotate the shaft of the vibration member and the counterweight, in order to vibrate the rope elements.

Abstract: Disclosed is a biocompatible medical material and porous scaffold for use in tissue engineering, made from a biodegradable glycolide/&egr;-caprolactone copolymer. The medical material and porous scaffold have excellent mechanical properties such as flexibility and elasticity, and appropriate hydrolytic properties. Due to its superior mechanical properties including elasticity, flexibility and appropriate biodegradation time, it can be used effectively as a porous scaffold for tissue cell culture reproduction such as for artificial skin, blood vessels, dental matrix and wound coverings.

Abstract: Disclosed are surface-modified medical metallic materials and preparation thereof. The medical metallic material is prepared by coating a gold or silver thin layer onto a base metal, adsorbing a polyfunctional sulfur compound onto the gold or silver thin layer, and chemically bonding a biologically active material such as heparin or estradiol to the functional group of the sulfur compound. The biologically active material is firmly bonded to the base metal via the sulfur compound. Being significantly improved in antithrombogenicity and biocompatibility, the metallic materials are suitable for use in various implants, including stents, artificial cardiac valves and catheters.

Abstract: The present invention relates to polyethyleneglycol/polylactide(or polyglycolide or polycaprolactone)/polyethyleneglycol triblock copolymers with an enhanced reactivity, and process for their preparation. More specifically, the present invention is directed to triblock copolymers that are obtained by the process comprising the step of synthesizing a polylactide(or polyglycolide or polycaprolactone) having hydroxy groups at both ends and the step of coupling said polylactide with polyethyleneglycol having an acylhalide group of a high reactivity at one of its ends, and the process for preparing the same Since the triblock copolymer according to the present invention has an ester structure with good biocompatibility, it can be applied extensively for biomaterials used in tissue engineering, in a matrix that slowly releases drugs, etc.

Abstract: The present invention relates to polyethyleneglycol/polylactide (or polyglycolide or polycaprolactone)/polyethyleneglycol triblock copolymers with an enhanced reactivity, and process for their preparation.

Abstract: A surface-modified medical metallic material, which comprise a metallic substrate; a thin film of gold or silver coated on the surface of said substrate; a functional sulfur compound adsorbed on said thin film; and a sulfonated poly(ethylene oxide) (PEO) derivative chemically bonded to functional groups of said sulfur compound, and a method for the preparation thereof are disclosed. It is also disclosed a stent, a cardiac valve and a catheter prepared from the surface-modified metal material.

Abstract: Disclosed are surface-modified medical metallic materials and preparation thereof. The medical metallic material is prepared by coating a gold or silver thin layer onto a base metal, adsorbing a polyfunctional sulfur compound onto the gold or silver thin layer, and chemically bonding a biologically active material such as heparin or estradiol to the functional group of the sulfur compound. The biologically active material is firmly bonded to the base metal via the sulfur compound. Being significantly improved in antithrombogenicity and biocompatibility, the metallic materials are suitable for use in various implants, including stents, artificial cardiac valves and catheters.

Abstract: A terminal connecting device includes a main body of a terminal block having diaphragms and supporting strips, a terminal plate positioned at the top of the supporting strips, movable terminals supported by a spring to attach or detach lead wire positioned on the terminal plate, a restraining structure, proximate to the movable terminals, which limits the movement of the lead wire, and a terminal screw coupled with the movable terminals after being penetrated through the through hole of the lead wire and fastened at a screw hole of the terminal plate. The restraining structure restricts the lead wire from diverting or dropping, thereby preventing safety accidents such as stopping the operation of facility or electric shock. The restraining structure also allows easy penetration of the terminal screw through the through hole of the lead wire in fixing the lead wire, thereby improving productivity due to ease of fastening the terminal screw.

Abstract: The specification describes an invention of calcification resistant bioprosthetic heart valves which can be used for a long term, and have good blood compatibility and in vivo stability, and have high calcification resistance. The bioprosthetic heart valves of the invention can be prepared by binding sulfonated polyethylene oxide (PEO) derivatives covalently to the tissue. The valves have an anionic effect equal to that of chondroitin sulfate, space filling effect, and blocking effect of the carboxyl group of collagen which has been known as one factor of the calcium deposition,. In particular, the present method has better advantages in view of calcification resistance than any other conventional methods, because it suppresses thrombosis and embolism and decreases incidence of infection.