Abstract: The present invention may be used for determining a topology of a network in the presence of network address translation. From an active client behind a translating device, communications are initiated that effect the network address translation. The communications are monitored beyond the translating device to infer partitioning of servers into equivalence sets relative to the network topology induced by the network address translation. Active clients behind the translating device may include a respective actual sending address in a message sent to a server beyond the translating device. The server beyond the translating device distinguishes between communications affected by and not affected by network address translation, which may include comparing an apparent source address of a message against an actual address provided in the message by the active client behind the translation device. The external server may also distinguish between active and passive client messages.

Abstract: The present invention is directed to substituted pyrazolo[1,5-?]pyridines and related methods for their synthesis and use.

Abstract: Methods of treatment and prevention of diseases associated with release of neutrophil elastase and IL-8 by administration of TFPI and analogs of TFPI are disclosed. Methods of determining efficacy of treatment with TFPI, patient's responsiveness to treatment with TFPI, and the ultimate determination of patient prognosis are also disclosed.

Abstract: An emboli extraction catheter and vascular filter system comprising a guidewire, a vascular filter attached near the distal end of the guidewire, and an emboli extraction catheter. The vascular filter has a smaller first diameter for insertion into the lumen of a vessel, and a second larger diameter for expanding to substantially equal the diameter of the lumen and to be placed in generally sealing relationship with the lumen. The emboli extraction catheter is a flexible catheter comprising a hub attached to the proximal end of the catheter. The hub further comprises a sideport and means for maintaining a seal on the guidewire. The emboli extraction catheter can be used to aspirate embolic particulates, so as to avoid their accidental release after they are captured in a vascular filter, and can also be used to empty full vascular filters of embolic particulates which may block distal flow.

Abstract: Methods of antagonizing MIF activity using ibudilast are described. Also described are methods of screening for MIF antagonists. These agents can be used for treating addictions, including drug and behavioral addictions, as well as for treating neuropathic pain.

Abstract: The present invention is directed to the use of 3,4,6-substituted pyridazines such as those characterized by structure I for treating conditions such as neuropathic pain among others.

Abstract: A guidewire navigable through body vessels of a human subject for delivery of a catheter or the like is provided. The guidewire includes an expandable segment movable between a collapsed state and an expanded state. If the catheter encounters resistance in a vessel and cannot be advanced further, the medical professional can move the expandable segment to the expanded state in which the expandable segment engages an inner surface of the catheter. The expandable segment locks onto the catheter, which allows the guidewire and catheter to be advanced through the vessel together as a single unit. An inflatable balloon catheter movable along the guidewire requires only a single tube and is sealed by the expandable segment of the guidewire for subsequent inflation.

Abstract: The present invention is directed to a prosthesis and method for treating, repairing, and/or replacing an abdominal aortic aneurysm. The prosthesis includes a coiled stent comprised of shape memory material having first and second anchoring zones and an intermediate zone. The prosthesis also includes graft material engaging at least a portion of the stent. During delivery of the prosthesis, the stent is in a substantially straight longitudinal configuration, and after delivery of the prosthesis the stent is returned to a coiled configuration. The diameter of the prosthesis may be adjusted by controlling the degree to which the stent is coiled.

Abstract: Compositions are described that are suitable for formulating TFPI. Solubilizers and stabilizers facilitate the preparation of pharmaceutically acceptable compositions of TFPI at various concentrations.

Abstract: The present invention is directed to the use of ibudilast for treating addictions, including drug and behavioral addictions. In particular, ibudilast is used to diminish the dopamine-mediated reward associated with addictions and to treat withdrawal syndromes after discontinuance of addictive drug use or behavior.

Abstract: Sidestream gas sampling assembly that does not substantially degrade the waveform of expired gases. The gas sampling assembly includes a sample cell portion integrated with a filter portion for separating undesired liquid condensate from respiratory gases to be monitored. The gas sampling assembly is configured to receive expired gases through a gas sampling line, filter undesired liquid condensate from the expired gases through hydrophobic fiber elements and communicate the filtered gases to a sample chamber which is in close proximity to the filter where measurements may be taken thereof e.g., optical or infrared sensing mechanisms. The gases that are substantially free of liquid condensate are then exhausted from the sample chamber.

Abstract: The system provides a control and management solution for linked gaming machines in a progressive game environment. The system can track multiple meters so that multiple progressive jackpots can be maintained for each game and/or for multiple participating business entities sharing in game revenue. Correspondingly, multiple progressive display meters can be controlled for each game machine. The system is scalable from near area progressive systems to wide area progressive systems. In the event that communication is lost with in a wide area progressive environment, one or more game machines may automatically switch to near area progressive behavior until communication is restored. The system is independent of currency and denomination limitations by employing and converting currency as units instead of particular denominations. Game machine population and participation can be remotely managed, updated, and changed from a central management location.

Abstract: A stent or other intraluminal medical device may be constructed utilizing multiple, individual, independent, self-expanding stent segments which are designed to interlock when constrained within a delivery sheath and uncouple upon deployment. The individual segments are releasably connected by a series of bridging elements and receptacles.

Abstract: A method for delivering a melanocortin-4 receptor agonist to a mammalian subject, includes administering the melanocortin-4 receptor agonist to a tissue inside the nasal cavity or sinuses of the mammalian subject. In some instances, the melanocortin-4 receptor agonist includes a guanidine functional group.

Abstract: Methods and apparatuses of registering on a camera display separate fields of view of a visible light camera module and an infrared camera module by focusing the IR camera module. The fields of view can be displayed in several display modes including 1) full screen visible, infrared and/or blended, 2) picture-in-a-picture such as partial infrared image in a full screen visible image, and 3) infrared color alarms in visible-light images.

Abstract: An infrared (IR) light camera or sensor that provides temperature alarms. The temperature alarms may be audible, vibrational, and visual to indicate when a portion of the IR image meets user-defined alarm criteria. Visual alarms may be provided by displaying on a camera display unit the portions of the IR image that meet the alarm criteria.

Abstract: A system for servicing a computer controlled machine comprising: a computer controlled machine including a device operable to perform a function, a controller controlling the operation of that device, and a data access port for transferring data and commands from the controller; and a service tool operably connected to the data access port, the service tool including a remote communications capability, a computer, and diagnostics and graphing software; and an expert observer system operably linked to the remote communications capability of the service tool and including historical machine data, machine sales information, software revisions for the controller, additional diagnostics software, and an expert observer capable of providing a mentor capability to the operator of a service tool.

Abstract: The present invention is directed to the use of ibudilast for treating neuropathic pain.

Abstract: Compositions are described that are suitable for formulating TFPI. Solubilizers and stabilizers facilitate the preparation of pharmaceutically acceptable compositions of TFPI at various concentrations.

Abstract: New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.