Patents by Inventor Krzysztof Palczewski

Krzysztof Palczewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF TREATING DIABETIC RETINOPATHY
    Publication number: 20190255102
    Abstract: A method of treating diabetic retinopathy in a subject in need thereof includes administering to the subject a therapeutically effective amount of one or more agents that act as a trap of reactive aldehydes and/or inhibit diabetes-induced superoxide generation and capillary degeneration regulated by GPCR signaling pathways.
    Type: Application
    Filed: April 30, 2019
    Publication date: August 22, 2019
    Inventors: Krzysztof Palczewski, Timothy Kern
  • Compounds and methods of treating ocular disorders
    Patent number: 10363231
    Abstract: A method of treating an ocular disorder in a subject associated with increased all-trans-retinal in an ocular tissue includes administering to the subject a therapeutically effective amount of a primary amine compound of formula (I); and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: July 30, 2019
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventor: Krzysztof Palczewski
  • POLYSACCHARIDE THERAPEUTIC CONJUGATES
    Publication number: 20190216937
    Abstract: A composition includes a polysaccharide at least one retinoid linked to at least one monosaccharide subunit of the polysaccharide with a covalent linkage. The linkage being degradable by hydrolysis during digestion of the composition to provide controlled, delayed, and/or sustained delivery of the at least one retinoid upon enteral administration of the composition to a subject.
    Type: Application
    Filed: March 12, 2019
    Publication date: July 18, 2019
    Inventors: Songqi Gao, Krzysztof Palczewski, Zheng-Rong Lu
  • RETINAL DERIVATIVES AND METHODS FOR THE USE THEREOF FOR THE TREATMENT OF VISUAL DISORDERS
    Publication number: 20190167626
    Abstract: Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.
    Type: Application
    Filed: October 31, 2018
    Publication date: June 6, 2019
    Inventors: Krzysztof Palczewski, Matthew Batten
  • METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION
    Publication number: 20190133986
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Application
    Filed: January 4, 2019
    Publication date: May 9, 2019
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • Compositions and methods of treating diabetic retinopathy
    Patent number: 10272106
    Abstract: A method of treating diabetic retinopathy in a subject in need thereof includes administering to the subject a therapeutically effective amount of one or more agents that act as a trap of reactive aldehydes and/or inhibit diabetes-induced superoxide generation and capillary degeneration regulated by GPCR signaling pathways.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: April 30, 2019
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Krzysztof Palczewski, Timothy Kern
  • SYSTEMS PHARMACOLOGY FOR TREATING OCULAR DISORDERS
    Publication number: 20190099420
    Abstract: A method of treating an ocular disorder in a subject includes administering to the subject subtherapeutic amounts of two or more agents that inhibit and/or blocks the activation of Gs- or Gq-protein coupled receptors or Gs- or Gq-signaling cascade in ocular cells of the subject, and/or activates Gi-protein coupled receptors, which is induced or triggered by light induced all-trans-retinal generation.
    Type: Application
    Filed: November 5, 2018
    Publication date: April 4, 2019
    Inventors: Krzysztof Palczewski, Yu Chen, Akiko Maeda
  • Retinoid replacements and opsin agonists and methods for the use thereof
    Patent number: 10238610
    Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: March 26, 2019
    Assignee: University of Washington
    Inventors: Krzysztof Palczewski, David A. Saperstein
  • Polysaccharide therapeutic conjugates
    Patent number: 10226536
    Abstract: A composition includes a polysaccharide at least one retinoid linked to at least one monosaccharide subunit of the polysaccharide with a covalent linkage. The linkage being degradable by hydrolysis during digestion of the composition to provide controlled, delayed, and/or sustained delivery of the at least one retinoid upon enteral administration of the composition to a subject.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: March 12, 2019
    Assignee: Case Western Reserve University
    Inventors: Songqi Gao, Krzysztof Palczewski, Zheng-Rong Lu
  • Compounds and methods of treating ocular disorders
    Patent number: 10208049
    Abstract: A method of treating an ocular disorder in a subject associated with aberrant all-trans-retinal clearance in the retina, the method comprising administering to the subject a therapeutically effective amount of a primary amine compound of formula: wherein R1 is an aliphatic and/or aromatic compound.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: February 19, 2019
    Assignee: Case Western Reserve University
    Inventors: Krzysztof Palczewski, Akiko Maeda, Marcin Golczak
  • Systems pharmacology for treating ocular disorders
    Patent number: 10117868
    Abstract: A method of treating an ocular disorder in a subject includes administering to the subject subtherapeutic amounts of two or more agents that inhibit and/or blocks the activation of Gs- or Gq-protein coupled receptors or Gs- or Gq-signaling cascade in ocular cells of the subject, and/or activates Gi-protein coupled receptors, which is induced or triggered by light induced all-trans-retinal generation.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: November 6, 2018
    Assignee: Case Western Reserve University
    Inventors: Krzysztof Palczewski, Yu Chen, Akiko Maeda
  • Retinal derivatives and methods for the use thereof for the treatment of visual disorders
    Patent number: 10117845
    Abstract: Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: November 6, 2018
    Assignee: University of Washington
    Inventors: Krzysztof Palczewski, Matthew Batten
  • COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS
    Publication number: 20180134714
    Abstract: A method of treating an ocular disorder in a subject associated with aberrant all-trans-retinal clearance in the retina, the method comprising administering to the subject a therapeutically effective amount of a primary amine compound of formula: wherein R1 is an aliphatic and/or aromatic compound.
    Type: Application
    Filed: June 27, 2017
    Publication date: May 17, 2018
    Inventors: Krzysztof PALCZEWSKI, Akiko MAEDA, Marcin GOLCZAK
  • METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION
    Publication number: 20180098955
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Application
    Filed: December 12, 2017
    Publication date: April 12, 2018
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • SYSTEMS PHARMACOLOGY FOR TREATING OCULAR DISORDERS
    Publication number: 20180071285
    Abstract: A method of treating an ocular disorder in a subject includes administering to the subject subtherapeutic amounts of two or more agents that inhibit and/or blocks the activation of Gs- or Gq-protein coupled receptors or Gs- or Gq-signaling cascade in ocular cells of the subject, and/or activates Gi-protein coupled receptors, which is induced or triggered by light induced all-trans-retinal generation.
    Type: Application
    Filed: April 14, 2017
    Publication date: March 15, 2018
    Inventors: Krzysztof Palczewski, Yu Chen
  • Stabilized mutant opsin proteins
    Patent number: 9907762
    Abstract: Methods and compositions for stabilizing opsin protein, such as a Pro23His mutant opsin protein, in a vertebrate visual system, by administration of opsin-binding synthetic retinoids, are provided. The mutant opsin protein binds to the synthetic retinoid, which stabilizes the mutant opsin protein and/or ameliorates the effects of the mutant opsin protein on the vertebrate visual system.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: March 6, 2018
    Assignees: UNIVERSITY OF WASHINGTON, REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Krzysztof Palczewski, Shalesh Kaushal, Vladimir Kuksa, Syed M. Noorwez
  • Retinoid replacements and opsin agonists and methods for the use thereof
    Patent number: 9907761
    Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: March 6, 2018
    Assignee: University of Washington
    Inventors: Krzysztof Palczewski, David A. Saperstein
  • RETINOID REPLACEMENTS AND OPSIN AGONISTS AND METHODS FOR THE USE THEREOF
    Publication number: 20180008556
    Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
    Type: Application
    Filed: December 7, 2012
    Publication date: January 11, 2018
    Applicant: University Of Washington
    Inventors: Krzysztof Palczewski, David A. Saperstein
  • Methods for the treatment and prevention of age-related retinal dysfunction
    Patent number: 9855239
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: January 2, 2018
    Assignee: University of Washington
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS
    Publication number: 20170340581
    Abstract: A method of treating an ocular disorder in a subject associated with increased all-trans-retinal in an ocular tissue includes administering to the subject a therapeutically effective amount of a primary amine compound of formula (I); and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: November 24, 2015
    Publication date: November 30, 2017
    Inventor: Krzysztof Palczewski