Patents by Inventor Krzysztof Palczewski

Krzysztof Palczewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods of treating ocular disorders
    Patent number: 8722669
    Abstract: A method of treating an ocular disorder in a subject associated with aberrant all-trans-retinal clearance in the retina, the method comprising administering to the subject a therapeutically effective amount of a primary amine compound of formula: wherein R1 is an aliphatic and/or aromatic compound.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: May 13, 2014
    Assignee: Case Western Reserve University
    Inventors: Krzysztof Palczewski, Akiko Maeda, Marcin Golczak
  • RETINAL DERIVATIVES AND METHODS FOR THE USE THEREOF FOR THE TREATMENT OF VISUAL DISORDERS
    Publication number: 20130079403
    Abstract: Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 28, 2013
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Krzysztof PALCZEWSKI, Matthew Batten
  • RETINAL DERIVATIVES AND METHODS FOR THE USE THEREOF FOR THE TREATMENT OF VISUAL DISORDERS
    Publication number: 20130072560
    Abstract: Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Krzysztof Palczewski, Matthew Batten
  • RETINAL DERIVATIVES AND METHODS FOR THE USE THEREOF FOR THE TREATMENT OF VISUAL DISORDERS
    Publication number: 20130072559
    Abstract: Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Krzysztof PALCZEWSKI, Matthew Batten
  • METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION
    Publication number: 20130072561
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxyiates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: University of Washington
    Inventors: Tadao Maeda, David SAPERSTEIN, Krzysztof PALCZEWSKI
  • RETINOID REPLACEMENTS AND OPSIN AGONISTS AND METHODS FOR THE USE THEREOF
    Publication number: 20130072568
    Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Krzysztof Palczewski, David A. Saperstein
  • RETINAL DERIVATIVES AND METHODS FOR THE USE THEREOF FOR THE TREATMENT OF VISUAL DISORDERS
    Publication number: 20130072556
    Abstract: Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Krzysztof PALCZEWSKI, Matthew Batten
  • METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION
    Publication number: 20130072558
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: University of Washington
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION
    Publication number: 20130072557
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: University of Washington
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • RETINOID REPLACEMENTS AND OPSIN AGONISTS AND METHODS FOR THE USE THEREOF
    Publication number: 20130072569
    Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Krzysztof PALCZEWSKI, David A. SAPERSTEIN
  • STABILIZED MUTANT OPSIN PROTEINS
    Publication number: 20130072443
    Abstract: Methods and compositions for stabilizing opsin protein in a vertebrate visual system are provided by administration of opsin-binding synthetic retinoids.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicants: Regents of the University of Minnesota, University of Washington
    Inventors: Krzysztof Palczewski, Shalesh Kaushal, Vladimir Kuksa, Syed M. Noorwez
  • Methods for assessing a physiological state of a mammalian retina
    Patent number: 8346345
    Abstract: In one aspect the present invention provides methods for assessing a physiological state of a mammalian retina in vivo, the methods of this aspect of the invention each include the steps of (a) irradiating a portion of a mammalian retina, in vivo, with light having a wavelength in the range of from 600 nm to 1000 nm at an intensity sufficient to stimulate two-photon-induced fluorescence in the retina; and (b) assessing a physiological state of the retina by analyzing the fluorescence.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: January 1, 2013
    Assignee: University of Washington
    Inventors: Yoshikazu Imanishi, Krzysztof Palczewski, Bryan S. Sires, Eric J. Seibel
  • Methods for treating metabolic diseases
    Patent number: 8338394
    Abstract: A pharmaceutical composition for treating a metabolic disease in a mammalian subject includes a therapeutically effective amount of all-trans-13,14-dihydroretinoid, all-trans-13,14-dihydroretinoid derivative, or agent capable of modulating the level of at least one all-trans-13,14-dihydroretinoid or all-trans-13,14-dihydroretinoid derivative in the subject.
    Type: Grant
    Filed: October 9, 2007
    Date of Patent: December 25, 2012
    Assignee: Case Western Reserve University
    Inventors: Krzysztof Palczewski, Radu A. Moise
  • RETINOID REPLACEMENTS AND OPSIN AGONISTS AND METHODS FOR THE USE THEREOF
    Publication number: 20120322891
    Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
    Type: Application
    Filed: March 14, 2012
    Publication date: December 20, 2012
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: KRZYSZTOF PALCZEWSKI, DAVID A. SAPERSTEIN
  • Methods for the treatment and prevention of age-related retinal dysfunction
    Patent number: 8324270
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Grant
    Filed: February 10, 2009
    Date of Patent: December 4, 2012
    Assignee: University of Washington
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS
    Publication number: 20120295895
    Abstract: A method of treating an ocular disorder in a subject associated with aberrant all-trans-retinal clearance in the retina, the method comprising administering to the subject a therapeutically effective amount of a primary amine compound of formula: wherein R1 is an aliphatic and/or aromatic compound.
    Type: Application
    Filed: June 8, 2012
    Publication date: November 22, 2012
    Inventors: Krzysztof Palczewski, Akiko Maeda, Marcin Golczak
  • STABILIZED MUTANT OPSIN PROTEINS
    Publication number: 20120041073
    Abstract: Methods and compositions for stabilizing opsin protein in a vertebrate visual system are provided by administration of opsin-binding synthetic retinoids.
    Type: Application
    Filed: August 24, 2011
    Publication date: February 16, 2012
    Applicants: REGENTS OF THE UNIVERSITY OF MINNESOTA, UNIVERSITY OF WASHINGTON
    Inventors: KRZYSZTOF PALCZEWSKI, SHALESH KAUSHAL, VLADIMIR KUKSA, SYED M. NOORWEZ
  • RETINAL DERIVATIVES AND METHODS FOR THE USE THEREOF FOR THE TREATMENT OF VISUAL DISORDERS
    Publication number: 20110288170
    Abstract: Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.
    Type: Application
    Filed: March 7, 2011
    Publication date: November 24, 2011
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Krzysztof Palczewski, Matthew Batten
  • Retinal derivatives and methods for the use thereof for the treatment of visual disorders
    Patent number: 7951841
    Abstract: Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: May 31, 2011
    Assignee: University of Washington
    Inventors: Krzysztof Palczewski, Matthew Batten
  • METHODS FOR ASSESSING A PHYSIOLOGICAL STATE OF A MAMMALIAN RETINA
    Publication number: 20100262016
    Abstract: In one aspect the present invention provides methods for assessing a physiological state of a mammalian retina in vivo, the methods of this aspect of the invention each include the steps of (a) irradiating a portion of a mammalian retina, in vivo, with light having a wavelength in the range of from 600 nm to 1000 nm at an intensity sufficient to stimulate two-photon-induced fluorescence in the retina; and (b) assessing a physiological state of the retina by analyzing the fluorescence.
    Type: Application
    Filed: March 11, 2010
    Publication date: October 14, 2010
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Yoshikazu Imanishi, Krzysztof Palczewski, Bryan S. Sires, Eric J. Seibel