Abstract: The invention is directed to a process for preparing a pharmaceutical formulation containing two or more active pharmaceutical ingredients comprising: (a) contacting two or more active pharmaceutical ingredients with a supercritical fluid to form a supercritical fluid solution; and (b) separating the active ingredients from the supercritical solution to yield a powder precipitate. Preferably, the pharmaceutical formulation prepared according to the invention contains a combination of two anti-infective agents or two anticancer agents. The invention is further directed to a process for preparing a pharmaceutical formulation containing two or more active pharmaceutical ingredients comprising: (a) combining two or more active ingredients with a cosolvent to form a solution; (b) contacting the solution with a supercritical fluid; and (c) recovering the precipitate in a powder form.

Abstract: This invention relates to a refrigeration method and processes that employ a nontoxic and environmentally benign, oil-free refrigerant in a novel vapor-compression thermodynamic cycle that includes a means for enhancing cooling capacity and efficiency. A means of controlling of the process conditions and flow of the refrigerant are provided. The refrigerant in the invention in used in a transcritical cycle.

Abstract: This invention relates to a refrigeration method and processes that employ a nontoxic and environmentally benign, oil-free refrigerant in a novel vapor-compression thermodynamic cycle that includes a means for enhancing cooling capacity and efficiency. A means of controlling of the process conditions and flow of the refrigerant are provided. The refrigerant in the invention in used in a transcritical cycle.

Abstract: Present invention provides a method and device for the formation of fine particles of a desired substance and for the immediate subsequent administration to an external environment like human or animal tissues. It also provides ways to control the output and solvent, antisolvent concentrations in the particles.

Abstract: Present invention provides method and apparatus to produce fine particles of a desired substance utilizing antisolvent precipitation technique. It further provides ways to manipulate the solvent and antisolvent to obtain fine particles of desired characteristics.

Abstract: A process for preparing energetic materials by (1) dissolving a vinylidenuoride-hexafluoropropylene copolymer in a ketone that is acetone, methyl ethyl ketone, or mixtures thereof, (2) adding polytetrafluoroethylene particles and reactive metal (magnesium, aluminum, or their alloys) particles to form a slurry, (3) adding CO.sub.2 to the slurry to precipitate out the copolymer which then coats the polytetrafluoroethylene and reactive metal particles, and (4) separating the copolymer-coated particles from the ketone and CO.sub.2.