Abstract: Systems and methods are provided for determining whether an optical cable matches a port on a switch device. The present disclosure can provide for a switch device which includes a cable identification tool. The cable identification tool can be configured to receive a port configuration table from a management device. The switch device can then obtain features of at least one cable attached to a port of the switch device. The switch device can then compare the obtained features with a table entry in the port configuration table to yield a comparison result. The table entry can correspond to the port to which the at least one cable is attached. Based on the comparison result, the switch device can generate one or more notifications. The notifications can indicate a match status of the at least one cable to the port.

Abstract: Disclosed herein are methods of treating a cancer characterized by expressing a mutant form of a RAS protein. Some embodiments relate to treatment of cancer by administering Plinabulin to a subject in need thereof.

Abstract: Disclosed herein are compositions and methods of preventing and/or treating or reducing immunotherapy mediated adverse events by administering plinabulin. Some embodiments relate to treatment of immunotherapy related inflammation by administering plinabulin. Some embodiments relate to treatment of psoriasis and/or inflammation by administering plinabulin.

Abstract: An actuating system for a window shade includes a fixed support shaft, a rotary drum pivotally connected with the support shaft, the rotary drum being rotatable for winding or unwinding a shading structure, and a limiting mechanism disposed inside the rotary drum and including a threaded portion provided on the support shaft, a stop portion, a limiting part, and a follower engaged with the threaded portion, the stop portion and the limiting part being respectively disposed adjacent to a first and a second end of the threaded portion, and the follower being rotationally coupled to and slidable relative to the rotary drum. The rotary drum is rotatable in a first direction to drive the follower to slide toward a first position for engagement with the limiting part, and in an opposite second direction to drive the follower to slide toward a second position for engagement with the stop portion.

Abstract: This invention provides a novel cancer treatment method in which plinabulin (t-butyl-dehydrophenylahistin or NPI-2358) and a taxane compound (such as docetaxel) are used in combination. Our study has shown that the optimum combination of injecting plinabulin after taxane compound has unexpected enhanced efficacy in large tumor populations in animal model and in NSCLC cancer patients compared to taxane compound treatment alone. In addition, this optimum combination can achieve unexpected safety effect in lowering unbearable side effects of taxane compound, including decreasing its neutropenia rates at all grades and decreasing G-CSF use in cancer patients.

Abstract: Systems and methods are provided for determining whether an optical cable matches a port on a switch device. The present disclosure can provide for a switch device which includes a cable identification tool. The cable identification tool can be configured to receive a port configuration table from a management device. The switch device can then obtain features of at least one cable attached to a port of the switch device. The switch device can then compare the obtained features with a table entry in the port configuration table to yield a comparison result. The table entry can correspond to the port to which the at least one cable is attached. Based on the comparison result, the switch device can generate one or more notifications. The notifications can indicate a match status of the at least one cable to the port.

Abstract: Disclosed herein are plinabulin and the use for reducing neutropenia. Some embodiments relate to reducing the docetaxel induced neutropenia using plinabulin.

Abstract: Disclosed herein are plinabulin polymorphs, compositions, their use and preparation as therapeutic agents. In particular, some embodiments relate to plinabulin monohydrate in a crystalline form.

Abstract: An actuating system for a window shade includes a fixed support shaft, a rotary drum pivotally connected with the support shaft and rotatable for winding or unwinding a shading structure, and a limiting mechanism at least partially disposed inside the rotary drum and including a threaded portion provided on the support shaft, a stop portion and a limiting part respectively adjacent to a first and a second end of the threaded portion, and a follower engaged with the threaded portion, the follower being rotationally coupled to the rotary drum and slidable relative to the rotary drum. The rotary drum is rotatable in a first direction to drive the follower to slide toward a first position for engagement with the limiting part, and in a second direction to drive the follower to slide toward a second position for engagement with the stop portion.

Abstract: Disclosed herein are compositions including a compound of formula (I) for treating cancer. Some embodiments relate to methods of treating cancer by co-administering a compound of formula (I) and one or more immune checkpoint inhibitor to a subject in need thereof. Some embodiments relate to methods of treating cancer by co-administering a compound of formula (I) and plinabulin to a subject in need thereof. Some embodiments relate to methods of providing co-stimulation of T-cell activation against cancer by co-administering a compound of formula (I), one or more immune checkpoint inhibitor.

Abstract: Disclosed herein are methods of treating a cancer characterized by expressing a mutant form of a RAS protein. Some embodiments relate to treatment of cancer by administering Plinabulin to a subject in need thereof.

Abstract: A panel assembly for a window shade includes a first and a second panel, and a plurality of transversal parts disposed between the first and second panels, each of the transversal parts being respectively attached to the first and second panels and including at least one cell having a hollow cell interior, wherein the first and second panels are movable relative to each other in opposite directions to pivot the transversal parts. Moreover, the panel assembly may include a plurality of flaps respectively coupled to the transversal parts, the flap of each transversal part respectively overlapping a connection region where an adjacent transversal part is attached to one of the first and second panels in a closed state of the panel assembly.

Abstract: A window shade includes a reel and an aperture control module respectively assembled with a head frame, and a panel assembly including transversal vanes respectively connected with two panels. The reel is rotatable to wind and unwind the panel assembly. The aperture control module includes a positioning arm connected with a rubbing roller, and is operable to rotate the rubbing roller relative to the positioning arm and to displace the positioning arm and the rubbing roller between two positions, the rubbing roller being displaced away from a sidewall of the head frame in a first position and pressing the panel assembly against the sidewall in a second position, the rubbing roller being further rotatable relative to the positioning arm in the second position to cause relative sliding between the two panels for switching the panel assembly from a closed state blocking light passage to an open state allowing light passage.

Abstract: A window shade includes a reel and a roller pivotally connected with a head frame at two spaced-apart positions, a clutch operatively connected with the roller and switchable between an engaged state preventing the roller from rotating in a first direction and a disengaged state for rotation of the roller in an opposite second direction, and a panel assembly including multiple transversal vanes respectively connected with a first and a second panel. The reel is rotatable to wind and unwind the panel assembly with the first panel remaining in contact with the roller. The panel assembly is switchable between an open state for light passage and a closed state blocking light passage by rotating the transversal vanes. The reel is rotatable in an unwinding direction while the roller is kept stationary by the clutch in the engaged state for switching the panel assembly from the closed to open state.

Abstract: Provided herein is synthesis of novel mass spectrometry-cleavable cross-linking agents. The novel mass spectrometry-cleavable cross-linking agents can be used in mass spectrometry, tandem mass spectrometry, and multi-stage tandem mass spectrometry to facilitate structural analysis of intra-protein interactions in proteins and inter-protein interactions in protein complexes. Also provided are methods of mapping intra-protein interactions in proteins and inter-protein interactions in protein complexes.

Abstract: Disclosed herein are methods of treating a brain tumor by administering Plinabulin. Some embodiments relate to treatment of glioblastoma multiforme by administering Plinabulin.

Abstract: Disclosed herein are methods of reducing neutropenia that is caused by chemotherapy or radiation therapy by administering plinabulin to a subject.

Abstract: Disclosed herein are plinabulin polymorphs, compositions, their use and preparation as therapeutic agents. In particular, some embodiments relate to plinabulin monohydrate in a crystalline form.

Abstract: Disclosed herein are methods of treating a cancer characterized by expressing a mutant form of a RAS protein. Some embodiments relate to treatment of cancer by administering Plinabulin to a subject in need thereof.

Abstract: The invention disclosed a compound of general formula (I), a single stereoisomer thereof, a mixture of stereoisomers thereof, and a prodrug, pharmaceutically acceptable salt and metabolite thereof, X1, X2, X3, X4, R1, R2, x, y and z being as defined in the present invention.