Abstract: Disclosed herein are methods of treating a brain tumor by administering Plinabulin. Some embodiments relate to treatment of glioblastoma multiforme by administering Plinabulin.

Abstract: Disclosed herein are plinabulin polymorphs, compositions, their use and preparation as therapeutic agents. In particular, some embodiments relate to plinabulin monohydrate in a crystalline form.

Abstract: A window shade includes a reel coupled to a first control module and connected with a panel assembly, a lift actuator coupled to a second control module, and a switchable coupling mechanism. The panel assembly has an open state for light passage and a closed state blocking light passage. The first control module can drive the reel in rotation for winding and unwinding the panel assembly. The second control module can drive the lift actuator in rotation for switching the panel assembly to the open or closed state. The coupling mechanism has a coupling state in which it rotationally couples the lift actuator to the first control module, and an uncoupling state in which it rotationally uncouples the lift actuator from the first control module. The coupling mechanism is in the uncoupling state while the panel assembly is closed, and in the coupling state while the panel assembly is opened.

Abstract: Disclosed herein are methods of treating a brain tumor by administering Plinabulin. Some embodiments relate to treatment of glioblastoma multiforme by administering Plinabulin.

Abstract: Disclosed herein are plinabulin polymorphs, compositions, their use and preparation as therapeutic agents. In particular, some embodiments relate to plinabulin monohydrate in a crystalline form.

Abstract: An actuating system for a window shade includes a fixed support shaft, a rotary drum pivotally connected with the support shaft, the rotary drum being rotatable for winding or unwinding a shading structure, and a limiting mechanism disposed inside the rotary drum and including a threaded portion provided on the support shaft, a stop portion, a limiting part, and a follower engaged with the threaded portion, the stop portion and the limiting part being respectively disposed adjacent to a first and a second end of the threaded portion, and the follower being rotationally coupled to and slidable relative to the rotary drum. The rotary drum is rotatable in a first direction to drive the follower to slide toward a first position for engagement with the limiting part, and in an opposite second direction to drive the follower to slide toward a second position for engagement with the stop portion.

Abstract: Disclosed herein are methods of treating a brain tumor by administering Plinabulin. Some embodiments relate to treatment of glioblastoma multiforme by administering Plinabulin.

Abstract: Disclosed herein are methods of treating a cancer characterized by expressing a mutant form of a RAS protein. Some embodiments relate to treatment of cancer by administering Plinabulin to a subject in need thereof.

Abstract: Disclosed herein are compositions comprising Plinabulin and one or more immune checkpoint inhibitor for treating cancer. Some embodiments relate to methods of treating cancer by co-administering Plinabulin and one or more immune checkpoint inhibitor to a subject in need thereof.

Abstract: A window shade includes a reel and an aperture control module respectively assembled with a head frame, and a panel assembly including transversal vanes respectively connected with two panels. The reel is rotatable to wind and unwind the panel assembly. The aperture control module includes a positioning arm connected with a rubbing roller, and is operable to rotate the rubbing roller relative to the positioning arm and to displace the positioning arm and the rubbing roller between two positions, the rubbing roller being displaced away from a sidewall of the head frame in a first position and pressing the panel assembly against the sidewall in a second position, the rubbing roller being further rotatable relative to the positioning arm in the second position to cause relative sliding between the two panels for switching the panel assembly from a closed state blocking light passage to an open state allowing light passage.

Abstract: A window shade includes a reel and a roller pivotally connected with a head frame at two spaced-apart positions, a clutch operatively connected with the roller and switchable between an engaged state preventing the roller from rotating in a first direction and a disengaged state for rotation of the roller in an opposite second direction, and a panel assembly including multiple transversal vanes respectively connected with a first and a second panel. The reel is rotatable to wind and unwind the panel assembly with the first panel remaining in contact with the roller. The panel assembly is switchable between an open state for light passage and a closed state blocking light passage by rotating the transversal vanes. The reel is rotatable in an unwinding direction while the roller is kept stationary by the clutch in the engaged state for switching the panel assembly from the closed to open state.

Abstract: Provided herein is synthesis of a novel acidic acid residue targeting sulfoxide-containing MS-cleavable homobifunctional cross-linker. The novel mass spectrometry-cleavable cross-linking agents can be used in mass spectrometry to facilitate structural analysis of intra-protein interactions in proteins and inter-protein interactions in protein complexes. Also disclosed herein are data based on the novel MS-cleavable homobifunctional cross-linker that are complimentary to amine-reactive sulfoxide-containing MS-cleavable reagents.

Abstract: An electricity storage battery is described, including an anode electrolyte solution 32 that contains a zinc redox material and an amine represented by a general formula (1) below: In the general formula (1), n is one of the integers 0 to 4, and each of R1, R2, R3 and R4 independently represents hydrogen, methyl or ethyl.

Abstract: The invention disclosed a compound of general formula (I), a single stereoisomer thereof, a mixture of stereoisomers thereof, and a prodrug, pharmaceutically acceptable salt and metabolite thereof, X1, X2, X3, X4, R1, R2, x, y and z being as defined in the present invention.

Abstract: A positive electrode electrolyte (22) and a negative electrode electrolyte (32) that are used in this energy storage battery have a pH within the range from 2 to 8 (inclusive). An ion exchange membrane, which is obtained by graft-polymerizing styrenesulfonate to a resin film base material that uses an ethylene-vinyl alcohol copolymer as a matrix, is used as a diaphragm (12) of this energy storage battery.

Abstract: Provided herein is synthesis of novel mass spectrometry-cleavable cross-linking agents. The novel mass spectrometry-cleavable cross-linking agents can be used in mass spectrometry, tandem mass spectrometry, and multi-stage tandem mass spectrometry to facilitate structural analysis of intra-protein interactions in proteins and inter-protein interactions in protein complexes. Also provided are methods of mapping intra-protein interactions in proteins and inter-protein interactions in protein complexes.

Abstract: A redox flow battery is described, mainly including a charge/discharge cell, a cathode electrolyte tank, and an anode electrolyte tank. The inside of the charge/discharge cell is divided into a cathode cell and an anode cell by a diaphragm. A collector plate and a cathode are contained in the cathode cell. An aqueous solution containing a Mn-polyethyleneimine complex is supplied from the cathode electrolyte tank to the cathode through a supply pipe. Thereby, an energy storage battery that has durability sufficient for practical applications in a wide range of fields can be provided.

Abstract: An electricity storage battery is described, including a cathode electrolyte solution that contains a manganese redox material and an amine represented by a general formula (1) below: In the general formula (1), n is one of the integers 0 to 4, and each of R1, R2, R3 and R4 independently represents hydrogen, methyl or ethyl, with the proviso that at least one of R1, R2, R3 and R4 is methyl when n is 0.

Abstract: This invention provides a novel cancer treatment method in which plinabulin (t-butyl-dehydrophenylahistin or NPI-2358) and a taxane compound (such as docetaxel) are used in combination. Our study has shown that the optimum combination of injecting plinabulin after taxane compound has unexpected enhanced efficacy in large tumor populations in animal model and in NSCLC cancer patients compared to taxane compound treatment alone. In addition, this optimum combination can achieve unexpected safety effect in lowering unbearable side effects of taxane compound, including decreasing its neutropenia rates at all grades and decreasing G-CSF use in cancer patients.

Abstract: Novel cross-linking compounds that can be used in mass spectrometry, tandem mass spectrometry, and multi-stage tandem mass spectrometry to facilitate structural analysis of proteins and protein complexes are provided and have the formula: where X is an N-hydroxy-succinimidyl or similar heterocyclic group. Also provided is a method of mapping protein-protein interactions of protein complexes using various mass spectrometry techniques.