Patents by Inventor Larry Morrison
Larry Morrison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11906523Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: GrantFiled: April 23, 2020Date of Patent: February 20, 2024Assignee: VENTANA MEDICAL SYSTEMS, INC.Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, II, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Publication number: 20240043904Abstract: Disclosed are systems and methods for labelling one or more morphological markers in a biological sample that are characteristic of one or more molecular features. In particular, system and methods are described for labelling one or more morphological markers in a biological sample with covalently deposited narrow band detectable moieties. Narrow band detectable moiety labelling of the one or more morphological markers permits higher order multiplexed assays due to conservation of available spectral bandwidth. Furthermore, as compared to conventional counterstaining methods, covalent deposition of one or more detectable moieties can provide flexibility and robustness with regard to the order in which biomarkers and morphological markers are labeled in a given staining protocol.Type: ApplicationFiled: October 4, 2023Publication date: February 8, 2024Inventors: Daniel R. BAUER, William DAY, Mark R. LEFEVER, Larry MORRISON
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Publication number: 20240011099Abstract: The present disclosure is directed to a method of staining a biological specimen (e.g. a single serial tissue section derived from a biological sample) with one or more routine and/or special statins while concomitantly labeling the same biological specimen with one or more detectable moieties without the need for stripping any stain or evaluating different images of stained serial tissue sections of a biological specimen. In some embodiments, the present disclosure is directed to a biological specimen stained with one or more conventional dyes, and where the biological specimen further includes one or more biomarkers labeled with one or more detectable moieties.Type: ApplicationFiled: July 20, 2023Publication date: January 11, 2024Inventors: Daniel R. Bauer, Mark Lefever, Larry Morrison
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Publication number: 20220178934Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: ApplicationFiled: February 23, 2022Publication date: June 9, 2022Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, II, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Publication number: 20220021823Abstract: Disclosed herein are embodiments of imaging biological specimens. An imaging system can include a microscope for directly viewing the biological specimen and a multi-spectral imaging apparatus for outputting digitally enhanced images, near-video rate imaging, and/or videos of the specimen. An imaging system can include a digital scanner that digitally processes images to produce a composite image with enhanced color contrast of features of interest.Type: ApplicationFiled: June 11, 2021Publication date: January 20, 2022Inventors: Larry Morrison, Lou Dietz
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Patent number: 11070750Abstract: Disclosed herein are embodiments of imaging biological specimens. An imaging system can include a microscope for directly viewing the biological specimen and a multi-spectral imaging apparatus for outputting digitally enhanced images, near-video rate imaging, and/or videos of the specimen. An imaging system can include a digital scanner that digitally processes images to produce a composite image with enhanced color contrast of features of interest.Type: GrantFiled: July 28, 2020Date of Patent: July 20, 2021Assignee: Ventana Medical Systems, Inc.Inventors: Larry Morrison, Lou Dietz
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Publication number: 20200358969Abstract: Disclosed herein are embodiments of imaging biological specimens. An imaging system can include a microscope for directly viewing the biological specimen and a multi-spectral imaging apparatus for outputting digitally enhanced images, near-video rate imaging, and/or videos of the specimen. An imaging system can include a digital scanner that digitally processes images to produce a composite image with enhanced color contrast of features of interest.Type: ApplicationFiled: July 28, 2020Publication date: November 12, 2020Inventors: Larry Morrison, Lou Dietz
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Publication number: 20200348215Abstract: Disclosed embodiments concern a composition comprising DAB chromogen, and/or derivative thereof, a stabilizer, and polymer capable of preventing or reducing DAB precipitation relative to a composition that does not comprise the polymer. Also disclosed herein is a method for using the disclosed composition and embodiments of a kit.Type: ApplicationFiled: July 20, 2020Publication date: November 5, 2020Inventors: Christopher Bieniarz, Brian D. Kelly, Jerome W. Kosmeder, II, Eric J. May, Larry Morrison
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Publication number: 20200333349Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: ApplicationFiled: April 23, 2020Publication date: October 22, 2020Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Publication number: 20200326345Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: ApplicationFiled: February 10, 2020Publication date: October 15, 2020Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, II, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Publication number: 20200319193Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: ApplicationFiled: April 23, 2020Publication date: October 8, 2020Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Patent number: 10778913Abstract: An imaging system that can include a microscope for directly viewing a biological specimen and a multi-spectral imaging apparatus for outputting digitally enhanced images, near-video rate imaging, and/or videos of the specimen. An imaging system that can include a digital scanner that digitally processes images to produce a composite image with enhanced color contrast of features of interest.Type: GrantFiled: September 13, 2013Date of Patent: September 15, 2020Assignee: Ventana Medical Systems, Inc.Inventors: Larry Morrison, Lou Dietz
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Patent number: 10775281Abstract: Disclosed embodiments concern a composition comprising DAB chromogen, and/or derivative thereof, a stabilizer, and polymer capable of preventing or reducing DAB precipitation relative to a composition that does not comprise the polymer. Also disclosed herein is a method for using the disclosed composition and embodiments of a kit.Type: GrantFiled: April 10, 2017Date of Patent: September 15, 2020Assignee: Ventana Medical Systems, Inc.Inventors: Christopher Bieniarz, Brian D. Kelly, Jerome W. Kosmeder, II, Eric J. May, Larry Morrison
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Publication number: 20200249238Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: ApplicationFiled: April 23, 2020Publication date: August 6, 2020Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Patent number: 10557851Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: GrantFiled: July 18, 2018Date of Patent: February 11, 2020Assignee: Ventana Medical Systems, Inc.Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, II, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Patent number: 10302645Abstract: A method to detect prostate cancer comprising contacting a sample of prostate cells from the patient with a set of detectably labeled probes under hybridization conditions and determining the presence of chromosomal abnormalities in prostate tumor tissue, PIN (intra-epithelial neoplasia), histologically benign tissue and benign prostatic hyperplasia (BPH); a method to combine immunofluorescence and FISH (IF-FISH) to facilitate the assessment of chromosomal abnormalities; a set of probes; and a kit comprising the set of probes and instructions for diagnosing prostate cancer in a patient.Type: GrantFiled: February 27, 2017Date of Patent: May 28, 2019Assignee: Abbott Molecular Inc.Inventors: Ying Zhang, Larry Morrison, Ekaterina Pestova, Irina Sokolova
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Publication number: 20190018018Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: ApplicationFiled: July 18, 2018Publication date: January 17, 2019Inventors: Nelson ALEXANDER, William Day, Jerome W. Kosmeder, II, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Publication number: 20180328932Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: ApplicationFiled: July 18, 2018Publication date: November 15, 2018Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, II, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Patent number: 10041950Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: GrantFiled: March 22, 2013Date of Patent: August 7, 2018Assignee: VENTANA MEDICAL SYSTEMS, INC.Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, II, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Publication number: 20170212019Abstract: Disclosed embodiments concern a composition comprising DAB chromogen, and/or derivative thereof, a stabilizer, and polymer capable of preventing or reducing DAB precipitation relative to a composition that does not comprise the polymer. Also disclosed herein is a method for using the disclosed composition and embodiments of a kit.Type: ApplicationFiled: April 10, 2017Publication date: July 27, 2017Inventors: Christopher Bieniarz, Brian D. Kelly, Jerome W. Kosmeder, II, Eric J. May, Larry Morrison