Abstract: The invention discloses an adaptive path planning method based on neutral networks trained by the evolutional algorithms, the neutral network training method comprises input and output of the data acquired by the mobile sensors installed on the mobile robots as the neutral networks, and training and optimization of the recurrent neutral networks based on the evolutional algorithms; the path planning method refers to the application of the trained neutral networks to the path planning of the mobile robot, the invention effectively improves local quick search capability and global search capability of the algorithms by applying the evolutional algorithms to the optimization of the recurrent neutral networks, so that the robot can plan a rational path in a dense and uncertain environment.

Abstract: The present disclosure provides an intelligent roadside unit. The intelligent roadside unit includes: a radar configured to detect an obstacle within a first preset range of the intelligent roadside unit; a camera configured to capture an image of a second preset range of the intelligent roadside unit; a master processor coupled to the radar and the camera, and configured to generate a point cloud image according to information on the obstacle detected by the radar and the image detected by the camera; and a slave processor coupled to the radar and the camera, and configured to generate a point cloud image according to the information on the obstacle detected by the radar and the image detected by the camera, in which the slave processor checks the master processor, and when the original master processor breaks down, it is switched from the master processor to the slave processor.

Abstract: A combined telemetry system that can be used while drilling a wellbore consists of a multi-hop telemetry method and a single-hop telemetry method combined in parallel. The multi-hop and single-hop methods can be operated in parallel, for example, so that each telemetry method caries data concurrently from the Measuring-While-Drilling tool located in the Bottom-Hole-Assembly. The multi-hop and single-hop methods can also be operated in series, for example, so that data from the Measuring-While-Drilling tool located in the Bottom-Hole-Assembly are first carried with the single-hop telemetry method and then transferred to the multi-hop telemetry method at one or more node(s) close to the surface. Preferably, the multi-hop telemetry method can also carry data from along-string sensors. Another combined telemetry system that can be used while drilling a wellbore consists of two single-hop telemetry methods combined in parallel.

Abstract: The present disclosure relates to synthesis of porous polymer networks and applications of such materials. The present disclosure relates to a method of fabricating of a porous polymer network comprising: (a) providing: (i) a first reactant comprising a plurality of compounds comprising at least one acetyl group, said plurality of compounds comprising at least one compound type, and (ii) a second reactant comprising an alkylsulfonic acid, and (b) creating a solution of said reactants, (c) casting said solution in a form, and (d) treating said solution under such conditions so as to produce a porous polymer network.

Abstract: The present disclosure describes an intelligent roadside unit and a control method thereof, comprising: a circular camera array, including a plurality of cameras for capturing images in different road directions respectively; a circular radar array, including a plurality of radars for detecting obstacle information in different road directions respectively; and a controller configured to determine whether a vehicle is approaching according to the obstacle information detected by the radars, to turn on a camera corresponding to the radar that has detected the approaching of the vehicle to capture an image, and to control the cameras corresponding to the radars that have not detected the approaching of the vehicle to be in a standby state.

Abstract: The present disclosure provides an anti-PD-L1/anti-LAG3 bispecific antibody capable to effectively block the interactions between PD-L1 and its receptor PD-1 and between LAG3 and its ligand (e.g., a MHC class II molecule and FGL1). The bispecific antibody may have high binding affinity to both of a PD-L1 protein (e.g., a human PD-L1 protein) and a LAG3 protein (e.g., a human LAG3 protein). Also provided are antibodies and fragments that have specificity to the PD-L1 or LAG3 protein alone, or antibodies and fragments having additional specificity to one or more other antigens.

Abstract: Provided are bispecific and multi-specific antibodies that target both claudin 18.2 (CLDN18.2) and 4-1BB. These antibodies, in the absence of CLDN18.2-expressing cells, can bind to 4-1BB but are unable to activate 4-1BB signaling. In the presence of CLDN18.2-expressing cells, however, these antibodies can trigger CLDN18.2-dependent 4-1BB signaling, leading to potent immune response to the CLDN18.2-expressing tumor cells.

Abstract: Cross-linked polymer nanoparticles were designed and synthesized with cyclodextrins as the starting monomer. These nanoparticles display exemplary adsorption properties in terms of capacity and selectivity, which comes from the synthetic design. The nanoparticles are also highly robust for various practical adsorption applications. The new synthetic method of these nanoparticle materials involves the reaction of cyclodextrin monomers through an emulsion polymerization approach. The size of the nanoparticles can be tuned easily.

Abstract: According to implementations of the subject matter described herein, a solution for semantic parsing of the natural language query is provided. In this solution, a first natural language query for a first data table is received, where the first natural language query comprises words. A first set of knowledge representations associated with the first data table are obtained and the first set of knowledge representations describe, in a structured manner, knowledge required for understanding a natural language query for the first data table. The first natural language query is converted into a first sequence of symbols. A first computer-executable query corresponding to the first natural language query is generated.

Abstract: A curable organopolysiloxane composition is provided. The curable organopolysiloxane composition comprises: (A) an organopolysiloxane having at least two alkenyl groups per molecule; (B) an organosiloxane having one silicon atom-bonded hydrogen atom per molecule and free of alkenyl groups and silicon atom-bonded alkoxy groups; (C) an organosiloxane having one silicon atom-bonded hydrogen atom and at least one silicon atom-bonded alkoxy group per molecule and free of alkenyl groups; (D) an organopolysiloxane having at least two silicon atom-bonded hydrogen atoms per molecule and free of alkenyl groups and silicon atom-bonded alkoxy groups; (E) a hydrosilylation reaction catalyst; and (F) a condensation reaction catalyst. The curable organopolysiloxane composition can be cured to form a cured product. The cured product generally exhibits an excellent adhesion property against various substrates without cracking and delamination occurring after a thermal shock test.

Abstract: A method for producing a thixotropic curable silicone composition is provided. The curable silicone composition comprises: (A) a silicone base material comprising: an organopolysiloxane having at least two alkoxysilyl-containing groups per molecule and a filler other than fumed silica; (B) a hydrophobic fumed silica; (C) a carbasilatrane derivative; (D) an alkoxysilane or its partial hydrolysis and condensation product; and (E) a condensation reaction catalyst. The method comprises the following steps: (I) mixing components (A) and (B); (II) mixing component (C) with a mixture obtained by step (I); and (III) mixing components (D) and (E) with a mixture obtained by step (II) under free of moisture. The curable silicone composition obtained by the method has an excellent thixotropic property and can cure at room temperature by contact with moisture in air.

Abstract: The present disclosure provides antibodies that bind Lymphocyte Activation Gene-3 (LAG-3). Also provided are methods of stimulating an immune response, inhibiting growth of tumor cells, and treating an autoimmune, inflammatory, or viral disease.