Patents by Inventor Lei Fang

Lei Fang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220248737
    Abstract: An oyster peptide with an effect of improving sexual function and a preparation method thereof are provided, the oyster peptide at least includes peptide segments RI, IR and VR in its composition. Based on a mass of the oyster peptide, a content of the RI is ?3.60 mg/100 g, a content of the IR is ?7.60 mg/100 g, and a content of the VR is ?6.50 mg/100 g.
    Type: Application
    Filed: April 25, 2022
    Publication date: August 11, 2022
    Inventors: MUYI CAI, Ruizeng GU, Haixin ZHANG, WENYING LIU, YING WEI, LEI FANG, XINGCHANG PAN, ZHE DONG, LU LU, MING ZHOU, YUCHEN WANG, KONG LING, YUAN BI
  • Patent number: 11401331
    Abstract: Provided are fusion molecule having a PD-L1 inhibitor fused to a human IL-7 protein or fragment thereof through a peptide linker. The disclosed fusion molecules exhibited synergistic anti-tumor effects.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: August 2, 2022
    Assignee: I-Mab Biopharma US Limited
    Inventors: Lei Fang, Feifei Cui, Haijuan Gu, Zhengyi Wang, Bingshi Guo, Jingwu Zang
  • Publication number: 20220212147
    Abstract: Methods for preparation of a carbon membrane include providing a solution comprising a diacetyl biphenyl monomer and an alkylsulfonic acid. The solution is treated under such conditions that an aldol condensation reaction occurs so as to produce a porous polymer network. The porous polymer network is treated under such conditions that a Scholl reaction occurs.
    Type: Application
    Filed: May 10, 2020
    Publication date: July 7, 2022
    Inventors: Lei Fang, Sai Che, Chenxu Wang, Mohammed Al-Hashimi, Sarbajit Banerjee
  • Patent number: 11374688
    Abstract: The present disclosure provides a data transmission method and a data transmission device for an intelligent driving vehicle, and a device. The method includes: acquiring data to be transmitted; encoding the data to be transmitted to generate encoded data; generating a check digit according to the data to be transmitted; adding the encoded data to a data packet, wherein a trailer of the data packet comprises the check digit; and transmitting the data packet.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: June 28, 2022
    Assignee: Apollo Intelligent Driving Technology (Beijing) Co., Ltd.
    Inventors: Yifeng Shi, Xing Hu, Haisong Wang, Lei Fang, Ji Tao
  • Patent number: 11368827
    Abstract: Provided are a communication system and a communication method of an autonomous vehicle. The system includes: a plurality of application modules, and an in-vehicle terminal. The in-vehicle terminal includes: an external communication module configured to communicate with another autonomous vehicle or a server in a message mode, and an internal communication module configured to communicate with the plurality of application modules in a service mode.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: June 21, 2022
    Assignee: APOLLO INTELLIGENT DRIVING TECHNOLOGY (BEIJING) CO., LTD.
    Inventors: Yifeng Shi, Xing Hu, Haisong Wang, Lei Fang, Ji Tao
  • Publication number: 20220119531
    Abstract: Provided are anti-PD-L1 antibodies or fragments thereof. The antibodies or fragments thereof specifically bind to the immunoglobulin C domain of the PD-L1 protein. In various example, the antibodies or fragments thereof include a VH CDR1 of SEQ ID NO: 1, a VH CDR2 of SEQ ID NO: 116, a VH CDR3 of SEQ ID NO: 117, a VL CDR1 of SEQ ID NO: 4, a VL CDR2 of SEQ ID NO: 5, and a VL CDR3 of SEQ ID NO: 6, or variants of each thereof. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and infectious diseases are also provided.
    Type: Application
    Filed: December 28, 2021
    Publication date: April 21, 2022
    Inventors: Lei Fang, Yongqiang Wang, Zhengyi Wang, Bingshi Guo, Jingwu Zang
  • Publication number: 20220112258
    Abstract: Provided are polypeptides having an antigen-binding unit targeting a tumor antigen and an IL-7 protein or fragment thereof, fused to a Fc fragment. The disclosed polypeptides can be used for treating cancer.
    Type: Application
    Filed: July 27, 2020
    Publication date: April 14, 2022
    Inventors: Feifei Cui, Lei Fang, Yuanyuan Yang, Zhengyi Wang, Bingshi Guo
  • Patent number: 11261259
    Abstract: Provided are bispecific and multi-specific antibodies that target both claudin 18.2 (CLDN18.2) and 4-1BB. These antibodies, in the absence of CLDN18.2-expressing cells, can bind to 4-1BB but are unable to activate 4-1BB signaling. In the presence of CLDN18.2-expressing cells, however, these antibodies can trigger CLDN18.2-dependent 4-1BB signaling, leading to potent immune response to the CLDN18.2-expressing tumor cells.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: March 1, 2022
    Assignees: I-Mab Biopharma US Limited, ABL Bio Inc.
    Inventors: Wenqing Jiang, Lei Fang, Zhengyi Wang, Bingshi Guo, Eunyoung Park, Eunsil Sung, Byungje Sung
  • Publication number: 20220056136
    Abstract: The present disclosure provides an anti-PD-L1/anti-4-1BB bispecific antibody capable to effectively block the interactions between PD-L1 and its receptor PD-1 and between 4-1BB and its ligand. The bispecific antibody may have high binding affinity to both of a PD-L1 protein and a 4-1BB protein.
    Type: Application
    Filed: February 15, 2019
    Publication date: February 24, 2022
    Applicants: ABL BIO INC., I-MAB BIOPHARMA CO., LTD
    Inventors: Eunyoung PARK, Yangsoon LEE, Hyejin CHUNG, Eunsil SUNG, Jiseon YOO, Minji PARK, Yong-Gyu SON, Hyoju CHOI, Eunjung KIM, Jaeho JUNG, Weon-Kyoo YOU, Sang Hoon LEE, Lei FANG, Wenqing JIANG
  • Patent number: 11220546
    Abstract: Provided are anti-PD-L1 antibodies or fragments thereof. The antibodies or fragments thereof specifically bind to the immunoglobulin C domain of the PD-L1 protein. In various example, the antibodies or fragments thereof include a VH CDR1 of SEQ ID NO: 1, a VH CDR2 of SEQ ID NO: 116, a VH CDR3 of SEQ ID NO: 117, a VL CDR1 of SEQ ID NO: 4, a VL CDR2 of SEQ ID NO: 5, and a VL CDR3 of SEQ ID NO: 6, or variants of each thereof. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and infectious diseases are also provided.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: January 11, 2022
    Assignee: I-Mab Biopharma US Limited
    Inventors: Lei Fang, Yongqiang Wang, Zhengyi Wang, Bingshi Guo, Jingwu Zang
  • Patent number: 11221129
    Abstract: A dimming track lamp has a detachable assembly housing with a power supply track, a control circuit board electrically connected with the power supply track, a lamp body arranged on the assembly housing, a printed circuit board arranged in the lamp body, a light source on the printed circuit board and an optical element arranged in the light output direction of the light source. The control circuit board has a power supply module which is electrically connected with the power supply track, a signal input module, a signal processing module for analyzing and calculating the input signal and generating a control signal, and a signal output module for outputting the control signal to the printed circuit board. The light source has a warm light source and a cold light source, the control signal is used to control the light output of the warm light source and the cold light source.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: January 11, 2022
    Assignee: Self Electronics Co., Ltd.
    Inventors: Lei Fang, Jianfeng Yu, Zuping He, Jianguo Dong, Kai Xu, Jun Yang
  • Patent number: 11217091
    Abstract: Provided is a smart roadside unit, including: a high-bright camera assembly configured to capture a high-bright image; a low-bright camera assembly configured to capture a low-bright image, in which the high-bright camera assembly and the low-bright camera assembly have a substantially same shooting view; and a controller configured to extract vehicle information from the high-bright image and the low-bright image.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: January 4, 2022
    Assignee: Apollo Intelligent Driving Technology (Beijing) Co., Ltd.
    Inventors: Lei Fang, Haisong Wang, Xing Hu, Sheng Tao
  • Patent number: 11214685
    Abstract: A curable organopolysiloxane composition is provided. The curable organopolysiloxane composition comprises: (A) a diorganopolysiloxane having at least two silicon-bonded alkenyl groups per molecule; (B) an organopolysiloxane resin; (C) a mixture of (C1) a diorganopolysiloxane endblocked with silicon-atom bonded hydrogen atoms at both molecular terminals and (C2) an organohydrogenpolysiloxane having at least three silicon-bonded hydrogen atoms per molecule; (D) a polyether having at least one aliphatic unsaturated group per molecule; and (E) a hydrosilylation catalyst.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: January 4, 2022
    Assignee: DOW SILICONES CORPORATION
    Inventors: Lei Fang, Qi Chen, Qiang Huang, Yi Zhao
  • Patent number: 11210938
    Abstract: The present disclosure proposes an intelligent road side unit and a regulation method thereof. The intelligent road side unit comprises: traffic lights; a first camera configured to acquire a first image and having a first focal length; a second camera configured to acquire a second image and having a second focal length, the first focal length being greater than the second focal length; and a controller, configured to acquire anticipated arriving traffic flow information according to the first image, to acquire current traffic flow information according to the second image, and to control the traffic lights according to the anticipated arriving traffic flow information and the current traffic flow information.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: December 28, 2021
    Assignee: BAIDU ONLINE NETWORK TECHNOLOGY (BEIJING) CO., LTD.
    Inventors: Lei Fang, Haisong Wang, Xing Hu, Sheng Tao
  • Patent number: 11208486
    Abstract: Provided are full human anti-PD-L1 antibodies or fragments thereof. In various examples, the antibodies or fragments thereof include a VH CDR1, a VH CDR2, a VH CDR3, a VL CDR1, a VL CDR2, and a VL CDR3 which are selected from sequence groups of SEQ ID NO: 35-42, SEQ ID NO: 43-51, SEQ ID NO: 52-66, SEQ ID NO: 67-79, SEQ ID NO:80-88 and SEQ ID NO: 89-102, respectively, or variants of each thereof. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and infectious diseases are also provided.
    Type: Grant
    Filed: April 26, 2020
    Date of Patent: December 28, 2021
    Assignee: I-Mab Biopharma US Limited
    Inventors: Lei Fang, Yuanyuan Yang, Zhengyi Wang, Bingshi Guo, Feifei Cui
  • Patent number: D939577
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: December 28, 2021
    Assignee: BEIJING KONGMING TECHNOLOGY CO., LTD.
    Inventors: Jinyao Zhou, Lei Fang, Heli Song, Libin Chen, Meng Yuan, Lu Yu
  • Patent number: D939579
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: December 28, 2021
    Assignee: BEIJING KONGMING TECHNOLOGY CO., LTD.
    Inventors: Jinyao Zhou, Lei Fang, Heli Song, Libin Chen, Meng Yuan, Lu Yu
  • Patent number: D940199
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: January 4, 2022
    Assignee: BEIJING KONGMING TECHNOLOGY CO., LTD.
    Inventors: Jinyao Zhou, Lei Fang, Heli Song, Meng Yuan, Lu Yu, Libin Chen
  • Patent number: D940201
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: January 4, 2022
    Assignee: BEIJING KONGMING TECHNOLOGY CO., LTD.
    Inventors: Yunling Feng, Lei Fang, Lu Yu
  • Patent number: D954724
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: June 14, 2022
    Assignee: BEIJING KONGMING TECHNOLOGY CO., LTD.
    Inventors: Lei Fang, Lu Yu, Libin Chen