Abstract: The present invention relates to ceramic precursor powder compositions and chemically bonded ceramic (CBC) materials, Ca-aluminate and/or calcium silicate, and a composite biomaterial with prolonged shelf time of the precursor, suitable for orthopaedic applications with improved injectability. The present invention also relates to a method of manufacturing said cured material, bioelements, implants, or drug delivery carrier materials made by said cured material, a kit comprising the ceramic precursor powder and hydration liquid, as well as the use of said ceramic precursor powder and hydration liquid, or said cured material, for orthopaedic and dental applications.

Abstract: The present invention relates to ceramic precursor material exhibiting injectability arid properties that make the material suitable as a carrier material used in drug delivery. According to the invention this is accomplished by selecting a microstructure based on pre-reacted phases and after injection established phases, which contain anti-infective and/or anti-inflammatory drugs. The present invention also relates to a cured ceramic material and a method of manufacturing said cured material. The precursor and the cured ceramic material according to the present invention can suitably be used for filling orthopaedic cavities and other bone voids.

Abstract: Powdered material, the binder phase of which mainly consists of a cement-based system, which powdered material has the capacity following saturation with a liquid reacting with the binder phase to hydrate to a radiopaque and chemically bonded ceramic material. According to the invention, said binder phase mainly consists of CaO.Al2O3 (ss) and/or 3CaO.Al2O3 (ss). The material also contains one or more heavy atom types with a density over 5 g/cm3. The invention also relates to a method for manufacturing the powdered material and the chemically bonded ceramic material formed from the powdered material, in which said binder phase has a mol ratio Al2O3.3H2O (ss) to 3CaO.Al2O3.6H2O (ss) of a maximum of 2:1.

Abstract: Powdered material, the binder phase of which mainly consists of a cement-based system, which powdered material has the capacity following saturation with a liquid reacting with the binder phase to hydrate to a chemically bonded ceramic material, preferably for dental purposes. According to the invention the powdered material has a composition and/or structure suitable for giving the ceramic material translucence in the hydrated state. The invention also relates to the ceramic material produced by hydration of the powdered material.

Abstract: Implant coatings having improved haemocompatibility involve the use of alkaline chemically bonded ceramic systems based on Ca-aluminate as a thrombogenecity reducing coating material, especially intended for coating of devices used in the human or animal blood system.

Abstract: A two-step system for chemically bonded ceramic (CBC) materials, and especially a dental filling material or an implant material. The system includes an initial working part-system to provide for improved early-age properties and a second main system to provide for improved end-product properties including bioactivity. The systems interact chemically. The invention also relates to the powdered materials and the hydration liquid, respectively, as well as the formed ceramic material.

Abstract: The present invention pertains to injectable heat generating biocompatible ceramic compositions based on hydraulic calcium aluminate, which can be used for therapeutic treatment in vivo, such as tumour treatment, pain control, vascular treatment, drug activation etc, when curing in situ, and which form a biocompatible solid material that can be left in the body for prolonged periods of time without causing negative health effects. The present invention can also be used to restore the mechanical properties of the skeleton after cancerous diseases.

Abstract: The present invention pertains to injectable heat generating biocompatible ceramic compositions based on hydraulic calcium aluminate, which can be used for therapeutic treatment in vivo, such as tumour treatment, pain control, vascular treatment, drug activation etc, when curing in situ, and which form a biocompatible solid material that can be left in the body for prolonged periods of time without causing negative health effects. The present invention can also be used to restore the mechanical properties of the skeleton after cancerous diseases.

Abstract: The present invention relates to a coated implant for in vivo-anchoring of implants to a biological tissue or another implant, which coated implant comprises an implant having a pre-treated surface and on said pre-treated surface one or more layers of ceramic material chemically and/or mechanically bound to said pre-treated surface. Said one or more layers comprises mainly non-hydrated chemically bonded ceramic material, and each layer independently comprises a first binder phase selected from the group consisting of aluminates, silicates, phosphates, sulphates and combinations thereof. The invention further relates to method of manufacturing said coated implant, a ceramic paste and to a kit comprising said coated implant and ceramic paste. The invention is particularly suitable for dental and orthopaedic implants.

Abstract: An injectable heat generating biocompatible ceramic compositions based on hydraulic calcium aluminate, which can be used for therapeutic treatment in vivo, such as tumour treatment, pain control, vascular treatment, drug activation etc, when curing in situ, and which form a biocompatible solid material that can be left in the body for prolonged periods of time without causing negative health effects, and can also be used to restore the mechanical properties of the skeleton after cancerous diseases as well as in a medical implant, an orthopaedic implant, and a dental implant as a dental filling material.

Abstract: The present invention deals with the initial hydration reaction of highly alkaline chemically bonded ceramic systems such as Ca-aluminate and Ca-silicate, exhibiting a controlled pH development, reduced from very high levels to be in a pH range of 7-9 by the use of an internal buffer system added to the CBC type biomaterial used. The invention is especially intended for endodontic, orthopaedic applications and/or soft tissue applications and/or drug delivery carrier applications.

Abstract: The present invention generally relates to dental and orthopaedic implants, and more specifically to an implant coated with a chemically bonded ceramic, having a modified substrate surface to improve adhesion of the implant coating to the implant material, wherein the coating includes a gradient zone also containing the material of the implant device wherein the concentration of the implant device material decreases in a direction towards the surface of the coating, and a method of preparing the coated implant as a method of implanting the implant device.

Abstract: Implant device having a coating of a chemically bonded ceramic material exhibiting improved adhesion of the coating to the surface, wherein the surface of the implant underlying the coating exhibits a surface structure containing cavities having a width “a”, a depth “c”, and a distance between neighbouring cavities “b”, wherein 80<a<200; 50<b<400; and 20<c<200 ?m, and method for preparing the implant.

Abstract: A system for a chemically bonded ceramic material, comprising an aqueous hydration liquid and a powdered material, the binder phase of which essentially consisting of a cement system, which powdered material has the capacity following saturation with the hydration liquid reacting with the binder phase to hydrate to a chemically bonded ceramic material. According to the invention, the powdered material comprises a first part component for the formation of an organic phase in the ceramic material and the hydration liquid comprises a second part component for the formation of said organic phase. The invention also relates to the powdered material and the hydration liquid, respectively, the formed ceramic material, a method for the production of the material and a device for storing the powdered material and mixing it with the hydration liquid.

Abstract: A chemically bonded biomaterial element composed of an inorganic cement, exhibiting minimal dimensional changes upon hardening and long-time use, improved mechanical properties and improved translucency. An algorithm to describe the micro-structure is expressed as ? = d * ( 1 - V F ) ( V F ) where ? is the distance between filler particles of mean size d, and VF is the volume content of non-reacted cement and added filler, and where ??10 ?m. The invention also relates to a device in connection with the preparation of a chemically bonded biomaterial element according to the invention.

Abstract: Surface coating method for deposition of a chemically bonded ceramic coating on a substrate, includes the steps of preparing a curable coating slurry, depositing a coating of the slurry on at least a section of the substrate surface, and hardening the slurry. The step of preparing a curable coating slurry includes mixing calcium aluminate powder with water and at least one water-reducing-agent, such that a water-to-cement ratio in the range of 0.1 to 0.9 is achieved.

Abstract: The invention describes a low temperature method for producing multi-layered or multi-phased coatings. With the technique according to the present invention, surface coatings with controlled variations in terms of chemical composition, phase composition, porosity, surface roughness, mechanical properties, biocompatibility, etc can be achieved. The method of coating a substrate surface comprising the steps of preparing one powder mixture, or several powder mixtures having different chemical composition, wherein at least one of said powder mixtures comprise a non-hydrated hydraulic ceramic powder binder phase, pre-treating a substrate surface, to increase the adhesion between the substrate and the ceramic coating, applying one or more different layers on top of each other of the non-hydrated powder mixture on the substrate, and finally, hydrating the powder layer/layers in a curing agent containing ions of carbonates, phosphates or fluorides.

Abstract: A powdered material, the binder phase of which consisting of a cement-based system that has the capacity following saturation with a liquid reacting with the binder phase to hydrate to a chemically bonded ceramic material. According to the invention, the powdered material exists in the form of granules of powder particles, which granules exhibit a degree of compaction above 55% and a mean size of 30-250 ?m. The invention also relates to a raw compact of the powdered material and a method in connection with the manufacturing of a ceramic material from a powdered material. The invention also relates to a device for the powdered material.

Abstract: A system for a dental filling material or an implant material, alternatively a system for bonding between a tooth or a bone and a dental filling material and a implant material, respectively, which system comprises a water based hydration liquid and a powdered material, the binder phase of which powdered material essentially consisting of a calcium based cement system, which powdered material has the capacity following saturation with the liquid reacting with the binder phase to hydrate to a chemically bonded ceramic material. According to the invention, said powdered material and/or said hydration liquid comprises water soluble phosphate or a phase that has the capacity to form water soluble phosphate, whereby the system exhibits the capacity during hydration to form apatite. The invention also relates to the powdered material and the hydration liquid as such, an implant material and a method of achieving bonding.

Abstract: Ceramic precursor compositions and chemically bonded ceramic (CBC) materials, especially Ca-based, and a composite biomaterial suitable for orthopaedic applications. The CBC-system includes a binding phase (chemical cement) and additional phases with specified chemistry imparting to the biomaterial the ability of initial strength followed by interaction with the body tissue including body liquid, to form a resorbable or partly resorbable biomaterial. The ceramic precursor composition includes at least one silicate with Ca as the main cation with a resorption rate less or equal to that of the bone in-growth rate. The silicate will form the binding phase of the cured material. Implants and surface coated devices are also disclosed. The cured material exhibits a compressive strength exceeding 100 MPa.