Abstract: An apertured nonwovens having a first nonwoven layer is described. The first nonwoven layer includes cellulose-based fibers and a plurality of apertures, wherein the plurality apertures have a minimum aperture distance between two adjacent apertures which has a relative standard deviation no greater than about 40%, as measured according to the Aperture Quality Test. The apertures have an aperture size no greater than about 2.2 mm2 and have an occlusion no greater than about 9%, as measured according to the Aperture Quality Test, or the apertures have an aspect ratio no greater than about 2.5 as measured according to the Aspect Ratio Test.

Abstract: Recombinant Sorangium cellulosum for producing de-epoxidized epothilone B by fermentation, insertional inactivation of an epoK gene in an epothilone biosynthetic gene cluster in the recombinant bacteria, and a method for producing de-epoxidized epothilone B using the recombinant bacteria.

Abstract: The present disclosure provides a structure for detecting a crack and a semiconductor device. The structure for detecting a crack includes at least three metal layers, and an interconnection via layer is provided between adjacent metal layers. The structure for detecting a crack further includes multiple detection units. The detection unit includes an intermediate metal segment and at least two metal segment groups. Each of the metal segment groups includes a first metal segment and a second metal segment located in a same metal layer and spaced apart. The intermediate metal segment and each of the metal segment groups are located in different metal layers, and different metal segment groups are located in different metal layers.

Abstract: The present disclosure provides compositions and methods for efficient and effective protein delivery in vitro and in vivo. In some aspects, proteins are reversibly crosslinked to each other and/or modified with functional groups and protected from protease degradation by a polymer-based or silica-based nanoshell.

Abstract: Embodiments relate to the field of semiconductors, and provide a method for layout placement and routing, a circuit layout, an electronic device, and a storage medium. The method includes: generating a plurality of layout units (100) arranged along a preset direction (X) based on a schematic circuit diagram, each of the plurality of layout units (100) having a plurality of connection nodes (101), and two connection nodes (101) at two ends of each of the plurality of layout units (100) being defined as assessment nodes; determining any one of the plurality of layout units (100) as a target layout unit, and obtaining a positional relationship between the connection nodes (101) in rest of the plurality of layout units having same node information as the assessment nodes in the target layout unit and the assessment nodes; and performing routing to electrically connect the connection nodes (101) having the same node information.

Abstract: The application discloses a method for detecting gate line defects, a display panel and a readable storage medium. The method for detecting gate line defects includes the following operations: controlling a display panel to enter a self-checking mode upon receiving a startup signal; performing row scanning on the display panel according to a first preset frame rate, where the first preset frame rate is greater than a normal frame rate when the display panel normally operates; and upon determining that the display panel is abnormal, issuing a prompt message.

Abstract: A chip on film, a display panel, and a method of manufacturing the display panel are provided. The chip on film includes a flexible film and a driver chip. The flexible film includes at least a first group of lines and a second group of lines. M lines of the first group of lines are electrically connected to pins of the driver chip to form driver lines; and N lines of the secondgroup of lines are not electrically connected to any pin of the driver chip, serving as nominal lines. By arranging the nominal lines, a conventional bonding machine may be applied to bond the chip on film to the display substrate. Costs for modifying the bonding machine may be reduced, and application scenarios of the chip on film may be increased.

Abstract: The present disclosure provides a semiconductor device and a semiconductor layout structure. In the semiconductor device, a guard ring of a first type is arranged on at least one side of a transistor of a second type, and a guard ring of a second type is arranged on at least one side of a transistor of a first type, such that a plurality of signal lines in a first metal layer in the semiconductor layout structure may be arranged between a first power source line and a first ground line. Furthermore, in a second metal layer, a plurality of second power source lines are connected to one first power source line, and a plurality of second ground lines are connected to one first ground line.

Abstract: Embodiments relate to a data storage circuit and a control method thereof, and a storage apparatus. The data storage circuit includes a first storage array and a sense amplifier array, the first storage array is positioned on a side of the sense amplifier array, and the sense amplifier array is electrically connected to a main bit line. The first storage array includes a plurality of first sub storage arrays, each of the plurality of first sub storage arrays includes a plurality of first sub bit lines and a plurality of first selector switches, each of the plurality of first sub bit lines is electrically connected to the main bit line via one of the plurality of first selector switches, and the sense amplifier array is configured to amplify a signal of the main bit line.

Abstract: Provided is a series of homologous small molecule immune agonists and novel bifunctional immune targeting compounds having targeting and immune activation functions, which are obtained by coupling the small molecule immune agonists to targeting drugs. The resulting immune targeting compounds are beneficial for enhancing immune activation effects, and anti-tumor and other disease fighting effects of the targeting drug. The enhanced effect is produced from a synergy of immunological anti-tumor factors (such as IFN-?) and inhibition at pathogenic targeting sites.

Abstract: The present invention provides a tumor immunotherapy target and use thereof, specifically provides use of the LSECtin expressed by infiltrating tumor-associated macrophage and BTN3A3 expressed by tumor solely or in combination as a target in tumor immunotherapy, and further provides a substance capable of inhibiting the activity of LSECtin expressed by infiltrating tumor-associated macrophage, the activity of BTN3A3 expressed by tumor, or the interaction of the LSECtin with BTN3A3, including RNA molecules, fusion protein BTN3A3-Ig, and monoclonal antibody 5E08, which can be used as an active ingredient to prepare a tumor immunotherapy drug, and is suitable for industrial applications.

Abstract: An error calibration apparatus and method are provided. The method is adapted for calibrating a machine learning (ML) accelerator. The ML accelerator achieves computation by using an analog circuit. An error between an output value of one or more computing layers of a neural network and a corresponding corrected value is determined. The computation of the computing layers is achieved by the analog circuit. A calibration node is generated according to the error. The calibration node is located at the next layer of the computing layers. The calibration node is used to minimize the error. The calibration node is achieved by a digital circuit. Accordingly, error and distortion of the analog circuit could be reduced.

Abstract: A data processing circuit and a fault mitigating method are provided. The method is adapted for a memory having at least one fault bit. The memory provides a block for data storage. A difference between an output of a value of a plurality of bits input to at least one computing layer in a neural network and a correct value is determined. The bits are respectively considered the at least one fault bit. A repair condition is determined based on the difference. The repair condition includes a correspondence between a position where the fault bit is located in the block and at least one non-fault bit in the memory. A value of at least one non-fault bit of the memory replaces a value of the fault bit based on the repair condition.

Abstract: The present disclosure relates to a layout repairing method and apparatus, a computer device, and a storage medium. The method includes: obtaining an initial layout of a semiconductor integrated circuit, wherein a metal connection line is formed on the initial layout; forming a power fill grid on the initial layout, wherein the power fill grid includes a slotted hole that overlaps orthographic projection of the metal connection line on the power fill grid, and the slotted hole includes a first section overlapping the metal connection line and at least one second section staggered with the metal connection line; and increasing area of the second section if the area of the second section is less than a lower threshold, to form a repaired layout.

Abstract: An oral pharmaceutical formulation using 4, 8-dihydroxy-5, 5, 7, 9, 13-pentamethyl-16-[1-methyl-2-(2-methyl-thiazole-4-yl)-ethenyl]]-oxacyclohexadec-13-ene-2,6-dione (utidelone) as an active ingredient, suitable for oral administration. The pharmaceutical formulation is a solid formulation such as tablets and capsules, and the pharmaceutical dosage form has good stability, in vitro dissolution behavior, and bioavailability.

Abstract: A polycrystal form of Utidelone, particularly relating to a semi-hydrated crystal form (A) of Utidelone, a preparation method therefor and a use of crystal Utidelone in preparation of a pharmaceutical composition, especially the use in preparation of a pharmaceutical composition for inhibiting tumor growth and treating solid tumors of mammals, especially human. The provided crystal form is stable and resistant to high temperature and high humidity, and the preparation method is diversified and simple, and is suitable for industrialized production of new medicines.

Abstract: Provided are a display driving method and apparatus, and a display panel and an electronic device. The display driving method is applied to a display panel, and comprises: determining a first charging duration of each display point on the basis of a preset position, in a display panel, of each display point in the display panel; generating, according to the first charging duration of each display point, a display control signal corresponding to each display point; and adjusting a second charging duration of each display point according to the display control signal.

Abstract: Embodiments of the present application provide a method and an apparatus for adjusting metal wiring density. By detecting metal wiring density in each of metal density detection windows in a target layout, a region in which the metal wiring density is greater than a preset density threshold can be quickly positioned in the target layout, thereby improving the layout correction efficiency; then a power fill mesh in a target metal density detection window in which the metal wiring density is greater than the preset density threshold is cropped multiple times, until the metal wiring density in each of the metal density detection windows is less than or equal to the preset density threshold, such that sufficient power fill meshes are retained in the target layout while the metal wiring density of the target layout is less than or equal to the preset density threshold.