Abstract: The present compositions and methods relate to an endo-B-mannanase cloned from Geobacillus tepidamans, polynucleotides encoding the endo-B-mannanase, and methods of use thereof. Formulations containing the endo-?-mannanase are highly suitable for use as detergents.

Abstract: The present compositions and methods relate to a thermostable carbonic anhydrases, polynucleotides encoding the carbonic anhydrase, and methods of make and/or use thereof. Formulations containing the carbonic anhydrase are suitable for use in extracting carbon dioxide.

Abstract: The present compositions and methods relate to an endo-B-mannanase cloned from a Bacillus sp., polynucleotides encoding the endo-B-mannanase, and methods of use thereof. Formulations containing the endo-?-mannanase are highly suitable for use as detergents.

Abstract: A fungal ?-amylase is provided from Aspergillus clavatus (AcAmyl). AcAmyl has an optimal pH of 4.5 and is operable at 30-75° C., allowing the enzyme to be used in combination with a glucoamylase in a saccharification reaction. This obviates the necessity of running a saccharification reaction as a batch process, where the pH and temperature must be readjusted for optimal use of the ?-amylase or glucoamylase. AcAmyl also catalyzes the saccharification of starch substrates to an oligosaccharide composition significantly enriched in DP2 and (DP1+DP2) compared to the products of saccharification catalyzed by an ?-amylase from Aspergillus kawachii. This facilitates the utilization of the oligosaccharide composition by a fermenting organism in a simultaneous saccharification and fermentation process, for example.

Abstract: Provided herein are methods of treating, preventing and/or managing cancers, which comprise administering to a patient 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof.

Abstract: A method for pipelining instructions on a PAC processor includes determining a minimum initial interval, and grouping the instructions so that the operands of dependent instructions are assigned to the same local register file. The virtual registers of the instructions that have data dependency across the first functional unit and the second functional unit are assigned to a global register file. The instructions are then modulo scheduled based on a current value of initial interval. The virtual registers of the scheduled instructions are allocated to the corresponding register files. If the allocation fails, a set of virtual registers is transferred from the first or second register file to the global register file.

Abstract: Methods of treating or managing specific cancers, including non-Hodgkin's lymphoma, by the administration of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione are disclosed. Methods of using gene and protein biomarkers as a predictor of non-Hodgkin's lymphoma response to treatment with 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione are also disclosed.

Abstract: Provided herein are the biomarkers for monitoring the treatment by quinazolinone compounds. For example, the use of SPARC, p21, and cyclin D1 mRNA levels as biomarkers to predict whether a quinazolinone compound is likely to be successful in treating certain types of cancer, such as NHL is provided. Further, the expression of these genes can be used to monitor progress of treatment effectiveness and patient compliance in cancer patients that are receiving treatment with quinazolinone compounds.

Abstract: The present disclosure is related to systems, compositions, and methods for producing a ?-hydroxy carboxylic acid and/or a ?-hydroxy carboxylic amide in enantiomeric excess (e.g., enantiomerically pure). In some specific example embodiments, a method may include contacting a substrate and/or intermediate with a cyanide, a ketoreductase, a nitrilase, and/or a nitrile hydratase. Systems, compositions, and methods, in some embodiments, may produce a ?-hydroxy carboxylic acid and/or a ?-hydroxy carboxylic amide in enantiomeric excess under convenient conditions (e.g., pH 5-9 and temperatures under 50° C.).

Abstract: The present disclosure relates to methods of rational genome mining. A method may include narrowing the number of clones that would otherwise need to be screened and/or identifying a gene with a desired catalytic activity. The disclosure also relates to a nitrile hydrolase from Bradyrhizobium japonicum USDA110 first identified by rational genome mining. In addition, the disclosure relates to nitrilase bll6402 and catalytically active variants capable of converting an ?-hydroxy nitriles, a ?-hydroxy nitrile and/or an ?,?-dinitrile to a carboxylic acid.

Abstract: A method for pipelining instructions on a PAC processor includes determining a minimum initial interval, and grouping the instructions so that the operands of dependent instructions are assigned to the same local register file. The virtual registers of the instructions that have data dependency across the first functional unit and the second functional unit are assigned to a global register file. The instructions are then modulo scheduled based on a current value of initial interval. The virtual registers of the scheduled instructions are allocated to the corresponding register files. If the allocation fails, a set of virtual registers is transferred from the first or second register file to the global register file.

Abstract: A building energy storage and conversion apparatus includes at least a control unit, an electric power conversion unit, an energy conversion unit and a thermoelectric conversion unit to regulate energy sources of the electric power conversion unit. The energy conversion unit generates cold/heat energy which is stored through a heat storage equipment (for cold/heat energy). The cold/heat energy can be released when needed. When the cold/heat energy is in a surplus state, it can be converted to electric power through the thermoelectric conversion unit or stored in the form of electric power. Thus energy resources can be converted and utilized in an optimal fashion to achieve energy self-sufficiency of a building. Moreover, energy exchange with other buildings in the neighborhood can be done to balance demand and supply.

Abstract: Provided herein are the biomarkers for monitoring the treatment by immunomodulatory compounds. The use of biomarkers such as SPARC, p21, and cyclin D1 mRNA or protein levels as biomarkers to predict whether an immunomodulatory compound is likely to be successful in treating certain types of cancer, such as NHL, is also provided. Further, the expression of these genes or proteins can be used to monitor progress of treatment effectiveness and patient compliance in cancer patients that are receiving treatment with immunomodulatory compounds.

Abstract: The present disclosure relates to compositions, systems, and methods that include a reusable biocatalyst. A reusable biocatalytic composition may include a stimulus-responsive support operable to be soluble under at least one first condition and insoluble under at least one second condition; and a biocatalyst bound to the stimulus-responsive support complex. According to some embodiments, a method for catalyzing a reaction may include contacting a first reactant with a composition comprising a stimulus-responsive support, a biocatalyst linked to the stimulus-responsive support, and a first solvent under conditions in which the stimulus-responsive support is soluble in the solvent and the reactant is converted to a product.

Abstract: A method for verifying scan precision of a laser measurement machine includes the steps of: preparing a standardized 3D profile model; determining an ideal curved surface as a conventional true value of the standardized 3D profile model; scanning the standardized 3D profile model by the laser measurement machine and obtaining point cloud data; calculating a bias between each point in the point cloud and the ideal curved surface; evaluating the veracity of the laser measurement machine by using the largest bias; and evaluating the receptiveness of the laser measurement machine.

Abstract: A method for verifying scan precision of a laser measurement machine includes the steps of: preparing a standardized BGA model; measuring Z coordinates values of each solder ball peak of the BGA model for certain times; determining a Z coordinates conventional true value of each solder ball peak; measuring X, Y coordinates values of each solder ball centre of the BGA model; determining a coplanarity conventional true value of a seating-plane; determining an optimum scanning mode; determining optimum scanning parameters under the optimum scanning mode; scanning the BGA model under the optimum scanning parameters and the optimum scanning mode; obtaining X, Y, Z coordinates values of each solder ball peak; evaluating the veracity of Z coordinates of each solder ball peak; evaluating the veracity and repetitiveness of coplanarity; and evaluating scan precision of the laser measurement machine.

Abstract: A method for verifying scan precision of a laser measurement machine includes the steps of: preparing a transparent flat, of which the flatness of each plane is regarded as a flatness conventional true value; determining an optimum scanning mode; determining optimum scanning parameters under the optimum scanning mode; scanning the transparent flat under the optimum scanning mode and the optimum scanning parameters for certain times, and obtaining measuring data; calculating a plurality of flatness values using the measuring data; calculating an average value and a standard deviation of the flatness values, and a bias between the average value and the flatness conventional true value; evaluating the repetitiveness of the laser measurement machine according to the standard deviation; and evaluating the veracity of the laser measurement machine according to the bias.

Abstract: The present disclosure relates to methods of rational genome mining. A method may include narrowing the number of clones that would otherwise need to be screened and/or identifying a gene with a desired catalytic activity. The disclosure also relates to a nitrile hydrolase from Bradyrhizobium japonicum USDA110 first identified by rational genome mining. In addition, the disclosure relates to nitrilase bll6402 and catalytically active variants capable of converting an ?-hydroxy nitriles, a ?-hydroxy nitrile and/or an ?,?-dinitrile to a carboxylic acid.

Abstract: A method for verifying scan precision of a laser measurement machine includes the steps of: preparing a transparent flat, of which the flatness of each plane is regarded as a flatness conventional true value; determining an optimum scanning mode; determining optimum scanning parameters under the optimum scanning mode; scanning the transparent flat under the optimum scanning mode and the optimum scanning parameters for certain times, and obtaining measuring data; calculating a plurality of flatness values using the measuring data; calculating an average value and a standard deviation of the flatness values, and a bias between the average value and the flatness conventional true value; evaluating the repetitiveness of the laser measurement machine according to the standard deviation; and evaluating the veracity of the laser measurement machine according to the bias.

Abstract: A method for verifying scan precision of a laser measurement machine includes the steps of: preparing a standardized 3D profile model; determining an ideal curved surface as a conventional true value of the standardized 3D profile model; scanning the standardized 3D profile model by the laser measurement machine and obtaining point cloud data; calculating a bias between each point in the point cloud and the ideal curved surface; evaluating the veracity of the laser measurement machine by using the largest bias; and evaluating the receptiveness of the laser measurement machine.