Abstract: A method for hardware management of DMA transfer commands includes accessing, by a first DMA engine, a DMA transfer command and determining a first portion of a data transfer requested by the DMA transfer command. Transfer of a first portion of the data transfer by the first DMA engine is initiated based at least in part on the DMA transfer command. Similarly, a second portion of the data transfer by a second DMA engine is initiated based at least in part on the DMA transfer command. After transferring the first portion and the second portion of the data transfer, an indication is generated that signals completion of the data transfer requested by the DMA transfer command.

Abstract: Provided are a pixel circuit and a display panel thereof. The pixel circuit includes: a drive module, a data write module, an initialization module, a light emission control module and a light emission module, where the initialization module is electrically connected to a control terminal of the drive module and configured to write an initialization voltage to the control terminal of the drive module at an initialization stage, the light emission control module, the drive module and the light emission module are connected in series to form a driving branch, and the light emission control module is configured to be turned on at a light emission stage under a control of a first light emission control signal and under a control of a second light emission control signal so that the driving branch is turned on.

Abstract: The present invention relates to a bifunctional angiogenesis inhibitor, which has VEGF inhibitory activity and FGF inhibitory activity, and can inhibit VEGF and FGF dual factors-induced or high glucose-induced cell proliferation, cell migration, and/or lumen formation. The present invention also relates to the use of the bifunctional angiogenesis inhibitor in inhibiting retinal angiogenesis, such as diabetic retinopathy, age-related macular degeneration and the like.

Abstract: The present disclosure provides an array substrate, a display panel, a display device and a manufacturing method, for solving the problems in the prior art that the array substrate is larger in number of circuits, the area needed for punching is larger, and the high pixel resolution cannot be achieved easily.

Abstract: Systems, apparatuses, and methods for implementing duplicated registers for access by initiators across multiple semiconductor dies are disclosed. A system includes multiple initiators on multiple semiconductor dies of a chiplet processor. One of the semiconductor dies is the master die, and this master die has copies of registers which can be accessed by the multiple initiators on the multiple semiconductor dies. When a given initiator on a given secondary die generates a register access, the register access is routed to the master die and a particular duplicate copy of the register maintained for the given secondary die. From the point of view of software, the multiple semiconductor dies appear as a single die, and the multiple initiators appear as a single initiator. Multiple types of registers can be maintained by the master die, with a flush register being one of the register types.

Abstract: Apparatuses, systems and methods for performing efficient power management for a processing unit. A processing unit includes two partitions, each assigned to a respective power domain with operating parameters, and each with a respective direct memory access (DMA) engine. If a controller determines a task type of a received task indicates the task is to be processed by components of the second partition, then the controller assigns the task to the second partition and maintains the operational parameters of the first power domain for the components of the first partition or selects lower performance operational parameters of the first power domain. The processing unit accesses data stored in memory using a DMA engine and operational parameters of the second partition. Additionally, the second partition processes the task using the operational parameters of the second power domain.

Abstract: The present invention discloses a regenerated HIPS/PPO alloy material based on chemical and physical co-modification, which is mainly composed of the following components in parts by mass: waste HIPS 60-70, PPO 30-40, HIPS-based macromolecular chain extender 2-8, elastomer toughening agent 2-10, oxazoline chain extender 0.2-1, and chain-extension catalyst 0.1-0.4. The alloy material uses chemical modification of in-situ chain extension and compatibilization of the macromolecular chain extender to restore a molecular chain structure, improve a phase interface and increase compatibility of the alloy. Through physical modification introduced by adding the elastomer toughening agent, a combined effect of chemical modification and physical modification is exploited, with target properties improved, a regenerated plastic alloy material with an excellent comprehensive property prepared, and the waste fully utilized to achieve energy saving and emission reduction.

Abstract: The invention provides a method for forming a semiconductor structure, which comprises providing a substrate, sequentially a first groove and a second groove are formed in the substrate, the depth of the first groove is different from the depth of the second groove, a first oxide layer is formed in the first groove, a second oxide layer is formed in the second groove, an etching step is performed to remove part of the first oxide layer, a first gate structure is formed on the first oxide layer, and a second gate structure is formed on the second oxide layer.

Abstract: A method for driving a pixel circuit. The pixel circuit includes a drive transistor. The method includes: acquiring a theoretical threshold voltage of the drive transistor and actual threshold voltages of the drive transistor at a plurality of different gray levels; determining compensation data voltages of the drive transistor at the plurality of different gray levels according to the theoretical threshold voltage of the drive transistor and the actual threshold voltages of the drive transistor at the plurality of different gray levels; and driving the pixel circuit emit light according to the compensation data voltages of the drive transistor at the plurality of different gray levels.

Abstract: The invention relates to the field of biomedicine, and an anti-pertussis toxin (PT) single domain antibody and derivative protein thereof are disclosed. Specifically, a pertussis toxin-binding protein and use thereof are disclosed.

Abstract: Systems, apparatuses, and methods for implementing a primary input/output (PIO) queue for host and guest operating systems (OS's) are disclosed. A system includes a PIO queue, one or more compute units, and a control unit. The PIO queue is able to store work commands for multiple different types of OS's, including host and guest OS's. The control unit is able to dispatch multiple work commands from multiple OS's to execute concurrently on the compute unit(s). This allows for execution of work commands by different OS's without the processing device(s) having to incur the latency of a world switch.

Abstract: The display substrate includes: a substrate; a plurality of pixel units on the substrate, each pixel unit includes a plurality of sub-pixels, each sub-pixel includes a light-emitting element and a pixel drive circuit; a photosensitive circuit on the substrate; a first conductive film layer on the substrate. The pixel drive circuit includes a drive transistor, a gate electrode of the drive transistor is located on a side of a drive active layer away from the substrate, an orthographic projection of the gate electrode of the drive transistor on the substrate at least partially overlaps an orthographic projection of the drive active layer on the substrate. The first conductive film layer includes a first light-shielding portion between the substrate and the drive active layer, and an orthographic projection of the first light-shielding portion on the substrate at least partially overlaps the orthographic projection of the drive active layer on the substrate.

Abstract: Systems, apparatuses, and methods for implementing a centralized interrupt controller to aggregate interrupts generated across multiple semiconductor dies are disclosed. A system includes multiple interrupt sources on multiple semiconductor dies. A centralized interrupt controller on one of the semiconductor dies receives and aggregates interrupts from the multiple interrupt sources on the multiple semiconductor dies. This facilitates a single transmission point for forwarding the interrupts to the processor and operating system responsible for handling interrupts. Each interrupt source embeds an ID when conveying an interrupt to the interrupt controller. This allows the interrupt controller to differentiate between the interrupt sources and to identify which source generated a given interrupt. The interrupt controller conveys an indication of the source of the interrupt to the processor when forwarding the interrupt to the processor.

Abstract: There are provided new heterobifunctional agents designed to mediated formation of protein-protein dimers and promote ubiquitination of a protein of the dimer. Also provided are methods of synthesizing the agents, pharmaceutical formulations including the agents, and methods of using the agents to treat, ameliorate or cure diseases characterized by protein over-expression or malfunction.

Abstract: Provided is an anti-PD-L1 antigen binding protein, capable of binding to primate-derived PD-L1 with a KD value of 1×10?8 M or less. The antigen binding protein can block the binding of PD-1 and CD80 to PD-L1, stimulate the secretion of cytokines in immune cells, and can inhibit tumor growth and/or tumor cell proliferation. Also provided is a fusion protein, comprising human TGFBRII or a fragment thereof and the antigen binding protein. Also provided is an application of the antigen binding protein and/or the fusion protein in the prevention and treatment of tumors or cancers.

Abstract: Disclosed are a power grid-friendly control method and system for a data center cooling system. The method includes: dividing an equipment room into a plurality of pieces of subspace in advance, with a plurality of servers and a cooling device comprised in each piece of subspace; obtaining total power consumption of the servers in each piece of subspace; performing priority sorting on the total power consumption of the servers in each piece of subspace; obtaining a real-time power supply energy consumption value of a power grid; determining, whether an energy supply is sufficient; and if the energy supply is sufficient, skipping turning off the cooling device in the subspace; or if the energy supply is not sufficient, turning off a cooling device, till it is determined that the energy supply is sufficient, thus minimizing impact of turning off the cooling system on stability.

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: A display apparatus includes a cover plate and a display substrate. The cover plate includes a first base substrate, a black matrix and a support layer stacked on a side of the first base substrate, and a quantum dot layer disposed on the side of the first base substrate. The black matrix and the support layer each have a plurality of openings to form a plurality of opening regions. The quantum dot layer includes a plurality of quantum dot units. Each quantum dot unit is located in an opening region in the plurality of opening regions. The display substrate includes a second base substrate, driving circuit structures disposed on a side of the second base substrate, and light-emitting devices disposed on a side of the driving circuit structures. Each light-emitting device is coupled to a driving circuit structure in the driving circuit structures to emit light.

Abstract: Provided are keratin BD-4, an encoding nucleic acid molecule thereof, an expression vector, a host cell, and a pharmaceutical composition containing the keratin. The keratin BD-4 can be used for preparing drugs having antipyretic and analgesic, antitussive and expectorant, and antiepileptic effects.