Abstract: The invention discloses a preparation method of pH/reduction responsive polyamino acid zwitterionic nanoparticles, which belongs to the technical field of polymer synthesis and biomedical materials. In the invention aliphatic amines are used to initiate ring-opening polymerization of ?-benzyl-L-glutamate-N-carboxylic anhydride, and the obtained poly(?-benzyl-L-glutamate) reacts with L-lysine to form azwitterionic polymer. The zwitterionic polymer is crosslinked by cysteamine, producing pH/reduction responsive polyamino acid zwitterionic nanoparticles after purification. The nanoparticles are pH responsive and resistant to non-specific protein adsorption. Because cysteamine contains disulfide bonds, the nanoparticles have sensitive reductive responsiveness and can load anticancer drugs for controlled release at the target site of cancer.

Abstract: A computer program product provides efficient multiple aggregation distinct processing. The computer program product including a computer readable storage medium having program instructions embodied therewith. The program instructions are executable by a processor to cause the processor to convert a query with multiple aggregation distincts into a two-stage group-by process using a nest operator. The two-stage group-by process including further program instructions to cause the processor to: perform a first stage group-by process including the nest operator taking a single input row, and concatenating a grouping key with a measure value for each aggregation distinct that forms multiple inputs to a single group-by table, and perform a second stage group-by process including the nest operator bringing together entries for each original group.

Abstract: Hybrid amphiphilic star copolymer nano micelles are prepared in the invention. Cage shaped octa(?-aminopropyl) silsesquioxanes is selected as the inorganic part, and L-glutamic benzyl ester—five membered ring anhydride is ring-opening polymerized by the initiation of amino groups on the surface of cage shaped octa(?-aminopropyl) silsesquioxanes, producing copolymers with cage shaped octa(?-aminopropyl) silsesquioxanes as nucleus and poly (L-glutamic-benzyl ester) as arms. The copolymers reacts with monomethoxy poly (ethylene glycol) carboxylic acid by condensation. Finally, the benzyl groups in the side chains of poly (L-glutamic acid-benzyl ester) are converted into hydrazine groups by acylhydrazination to obtain hybrid amphiphilic star copolymer nano micelles. The micelles can load doxorubicin, they are safe to human body and have good application prospects.

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

Abstract: Disclosed is a preparation method for charge reversal and reversibly crosslinked redox-sensitive nanomicelles, falling within the technical field of biomedical materials. The method comprises: synthesizing thiocinamide from lipoic acid and ethylenediamine under an N,N?-carbonyl diimidazole catalyst; and polymerizing thiocinamide, polyethylene glycol diglycidyl ether and lysine through a nucleophilic addition mechanism to prepare a poly(lysine-co-polyethylene glycol diglycidyl ether-co-thiocinamide) terpolymer. The micelle is endowed with excellent anti-protein nonspecific adsorption and enhanced cell uptake property through a self-assembly and protonation/deprotonation action; and a disulfide bond in lipoyl may form a linear polydisulfide structure under the action of 1,4-dithiothreitol, so that a micelle core is crosslinked, and a crosslinked structure is destroyed in the cell under a redox condition, and controlled release of a drug can be achieved.

Abstract: To manage memory in a multi-processing system, a memory budget is assigned to each of a number of agents within the multi-processing system. A portion of memory is allocated to each the agents within the memory budget. Metrics are collected for each agent during processing of data by the agents; the metrics include an amount of data processed and an amount of memory used for each agent. Memory efficiency is determined for each agent based on the collected metrics and another memory budget is determined based on the memory efficiency. The portion of the memory is reallocated to the agents within the other memory budget in response to data stored in the memory relative to the assigned memory budget meeting a criterion.

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

Abstract: Embodiments include a method, system, and computer program product for encoding data while it is being processed as part of a query is provided. The method includes receiving a query request and determining a set of values associated with data to be encoded for completing the query request. The method also includes encoding those values such that any subsequent processing operations can be performed on the encoded values to complete the requested query. After performing the subsequent processing operations to complete the requested query, each value is decoded back to its original value.

Abstract: Provided are a reducible degradable hyperbranched-polymer nanomicelle and a method for preparation thereof and an application thereof. Cystamine and polyethylene glycol diglycidyl ether are polymerized by means of a nucleophilic addition mechanism; in one step, a hyperbranched polymer alternatingly arising from cystamine and polyethylene glycol structural units is synthesized and obtained; then, a hyperbranched nanomicelle is formed by means of self-assembly during the process of dialysis. The hyperbranched-polymer chain segments contain both tertiary aminos and disulfide bond structural units and have pH- and reduction responsiveness, and the hyperbranched three-dimensional cavity structure imparts a drug-carrying ability to the nanomicelle.

Abstract: A method and system for true product word recognition using a computing device. The method includes: obtaining title words from titles of products; determining word vectors based on a word matrix, where the word matrix is constructed based on a number of cooccurrence of each of the title words and all the other title words; determining title vectors based on a title matrix, where the title matrix is constructed based on the number of cooccurrence of each of the title words and all the other title words, and the title words in each of the titles; calculating scores for the title words in corresponding one of the titles based on the corresponding word vector and title vector; and recognizing true product words of the corresponding one of the titles based on the scores.

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

Abstract: A method, a system, and a computer program product are provided. A filter is created for each portion of a data set. The filter indicates which one or more characteristics are present among each of the portions. Each of the one or more characteristics comprises one or more groups defined by the data grouping operation. The filters for the portions of the data sets are transferred to one or more filter processors and combined within the one or more filter processors to indicate characteristics of data residing across multiple processing elements to produce a result for a data grouping operation, utilizing transfers based on a combined filter result. In various embodiments, the filter may be a Bloom filter.

Abstract: A method for preparing a chitosan complex film comprises: (1) reacting polyvinyl alcohol-124 with butanedioic anhydride to obtain a modified polyvinyl alcohol; (2) formulating the modified polyvinyl alcohol-124 into a 0.4 wt % aqueous solution, then adding the aqueous solution containing 0.4 wt % of modified polyvinyl alcohol-124 dropwise into an acetic acid solution at a concentration of 0.4 wt % chitosan to obtain a mixed solution; (3) adjusting the pH value of the mixed solution with a 0.01 wt % NaOH solution to pH 5.5, and removing surface bubbles after standing for one hour to obtain a casting solution; (4) pouring the casting solution into a culture dish, placing the culture dish into an oven at 60° C. and drying to a constant weight to obtain the chitosan complex film. The materials used in the method are inexpensive, and the reaction is not complicated, so the cost of the product is not high.

Abstract: A method, a system, and a computer program product are provided. A filter is created for each portion of a data set. The filter indicates which one or more characteristics are present among each of the portions. Each of the one or more characteristics comprises one or more groups defined by the data grouping operation. The filters for the portions of the data sets are transferred to one or more filter processors and combined within the one or more filter processors to indicate characteristics of data residing across multiple processing elements to produce a result for a data grouping operation, utilizing transfers based on a combined filter result. In various embodiments, the filter may be a Bloom filter.

Abstract: The present invention provides a novel pretreating agent to improve the effect of ink-jet printing on polyester fabric and its application, and this invention belongs to the field of digital ink-jet printing. Stirring the dispersing agent, which includes many procedures of wetting agent and deionized water in a stirrer, adding nano-porous oxide dispersoid. Furthermore, keep stirring for 30 min and put the mixture in a sand mill to grinded for 2 h, then nano-porous oxide dispersoid is eventually got. The nano-porous oxide dispersoid work as pretreating agent, which used in the polyester fabric, is treated like pretreating agent during the padding process. By applying this technique into double-sided permeation ink-jet printing and direct-injection ink-jet printing, its pattern's definition, color depth and color saturation could be remarkable enhanced.

Abstract: Disclosed is a method for preparing self-dispersing nano carbon black based on a thiol-ene click reaction. A sol-gel technique is used to graft a coupling agent containing a carbon-carbon double bond onto the surface of the carbon black, and a functional molecular chain is grafted onto the surface of the carbon black by a thiol-ene click reaction with a mercapto compound. The self-dispersing nano carbon black is obtained after centrifugation, washing and drying. The method is simple and easy to operate, has a high grafting rate, and can prepare self-dispersing nano carbon black adaptable to different systems by selecting mercapto compounds with different functional groups.

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

Abstract: A light reflective film, a processing method and a photovoltaic cell module. The vertex height of a prism and/or the bottom width of the prism change periodically to form a polyhedral structure, and the adjacent faces can present a mirror structure, so that the entire prism can reflect both morning and afternoon sunlight, which leads to improved reflection efficiency throughout the work period. In the prior art, the reflective surface of the straight triangular prism has a constant angle with respect to the axis of the working plane of a photovoltaic cell module, therefore, it only has high reflection efficiency for the sunlight at a certain time; the granular reflective micro-structure, such as a triangular pyramid, can be aligned with the sunlight on two sides thereof to reflect the sunlight in the morning and afternoon, but there are many blank areas between the granules.

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

Abstract: Embodiments described herein provide a solution for optimizing a generating of query search results. A filtering search term (e.g., a search term that is used in a query to perform filtering aggregations of the query search results) is identified. A filtering bitmap that has a plurality of mapped locations corresponding to data values for the filtering search term is created. As a data value in the filtering search term is encountered during a scan of the query search results, the corresponding mapped location is updated. Each mapped location in the filtering bitmap is read to determine whether the value corresponding to the mapped location satisfies the filtering aggregation. The filtering aggregation can then be performed (e.g., prior to any grouping aggregation) by removing any of the query search results determined, based on the filtering bitmap, as having data values for which the filtering aggregation is not satisfied.