Abstract: Described is a conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. Also described are a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Abstract: Described is a conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. Also described are a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Abstract: Embodiments of the present disclosure provide a display panel and a display device. The display panel includes a substrate; a first electrode; a second electrode; an organic light-emitting functional layer; a line scanning drive circuit located in a surrounding area; a first flat layer; a fixed potential signal line located in the surrounding area, wherein the fixed potential signal line includes a first and a second conductive parts; an overlapping area is formed between an orthographic projection of the second conductive part on the substrate and an orthographic projection of the line scanning drive circuit on the substrate; the second conductive part includes a plurality of first through holes; and a conductive connection layer; and the conductive connection layer and the second conductive part at least are in direct contact in the overlapping area between the second conductive part and the line scanning drive circuit.

Abstract: This disclosure discloses a display panel and a display apparatus. The display panel includes: a substrate, wherein the substrate has a display region and a border region surrounding the display region; the border region includes a first power voltage line and a first planarization layer sequentially stacked on a side of the substrate; the border region has a first dam region surrounding the display region and a second dam region surrounding the first dam region; an orthographic projection of the first power voltage line on the substrate is within the first dam region; the first planarization layer is at least within the first dam region and the second dam region, and the first planarization layer within the first dam region at least covers a side surface of the first power voltage line; and the first planarization layer has a first groove and a second groove.

Abstract: Described is a conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. Also described are a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Abstract: A display substrate includes a base substrate, multiple sub-pixels, multiple first gate drive circuits, and at least one auxiliary structure. The base substrate includes a display region and a peripheral region located at a periphery of the display region. The multiple sub-pixels are located in the display region. The multiple first gate drive circuits and the at least one auxiliary structure are located in the peripheral region. The multiple first gate drive circuits are configured to provide first gate drive signals to the multiple sub-pixels. One auxiliary structure is disposed between adjacent first gate drive circuits.

Abstract: A hair care formulation is provided, comprising: a dermatologically acceptable vehicle; a dermatologically acceptable oil; and a deposition aid polymer, wherein the deposition aid polymer is a dextran polymer functionalized with an amine group; wherein the dextran polymer has a weight average molecular weight of 100,000 to 650,000 Daltons; and wherein the deposition aid polymer enhances deposition of the dermatologically acceptable oil from the hair care formulation onto mammalian hair.

Abstract: The present invention relates to the conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.

Abstract: Provided in the present disclosure are an IGBT device backside structure and a preparation method therefor, and an IGBT device, the IGBT device backside structure comprising a buffer layer, the buffer layer comprising a first activation efficiency buffer area corresponding to an active area of the IGBT device and a second activation efficiency buffer area corresponding to a terminal area of the IGBT device, the activation efficiency of the first activation efficiency buffer area being less than the activation efficiency of the second activation efficiency buffer area.

Abstract: The present invention relates to linkers having a group of propioloyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

Abstract: Provided herein is the conjugation of an amanita toxin compound to a cell-binding molecule with branched linkers for having better targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of an amanita molecule to a cell-binding ligand, as well as methods of using the conjugate in targets treatment of cancer, infection and autoimmune disease.

Abstract: The present disclosure provides a method for controlling a drone, a drone, and a system. The method for controlling a drone comprises: determining operating parameters of a moving platform according to field-of-view images containing the moving platform collected at any two different moments and flight parameters of the drone; calculating a time-varying tracking position of the moving platform based on the operating parameters; controlling the drone to track the moving platform according to the time-varying tracking position of the moving platform; and controlling the drone to perform a landing operation according to a relative position of the moving platform and the drone during tracking. The technical solutions according to the present disclosure have high landing accuracy, rely less on device performance and have high versatility.

Abstract: The present disclosure provides an X-ray detecting device, and a manufacturing method of an X-ray detecting panel. The present disclosure also provides an X-ray detecting panel including a main bias voltage signal line and a photodiode. A cathode of the photodiode is electrically connected to the main bias voltage signal line. The X-ray detecting panel further includes at least one auxiliary bias voltage signal line electrically connected to the main bias voltage signal line.

Abstract: A display driving module includes a gate driving circuit, a plurality of data lines and a data driving circuit. The pixel circuits in odd-numbered rows and one column are electrically connected to a data line, and the pixel circuits in even-numbered rows and the one column are electrically connected to another data line. The data driving circuit includes a data driver and a multiplexing circuit, the multiplexing circuit includes a first multiplexing sub-circuit and a second multiplexing sub-circuit. The gate driving circuit includes a plurality of levels of shift register units, and an nth-level shift register unit is electrically connected to the pixel circuits in a (2n?1)th row and a (2n)th row, and configured to apply a same gate driving signal to the pixel circuits in the (2n?1)th row and the (2n)th row, where n is a positive integer.

Abstract: The present invention relates to the conjugates of Tubulysin derivatives (anologs) and cell-binding molecules using branched (side-chain) linkers, and the resulting conjugates have better pharmacokinetic properties, and thus can more accurately target and kill abnormal cells. The invention also relates to the conjugation methods of the Tubulysin derivatives (anologs) to cell-binding molecules, and methods for synthesizing the small molecules, and methods of using the conjugates for targeted therapy for cancers, infections and autoimmune diseases. The conjugates of Tubulysin derivatives with long branched linkers demonstrated increased half-life, minimal exposure to non-targeted cells, tissues or organs in system circulation, leading to reduced off-target toxicity.

Abstract: The present invention relates to a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (a dual-linker) containing a 2,3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.

Abstract: A display substrate includes a scanning driving circuit arranged on a base substrate. The scanning driving circuit includes a plurality of shift register units and a first voltage signal line extending in a first direction. At least one shift register unit includes an output capacitor and a first transistor, a first electrode thereof is coupled to the first voltage signal line, and a second electrode thereof is coupled to an electrode plate of the output capacitor. A maximum distance between an orthogonal projection of the first electrode/second electrode of the first transistor onto the base substrate and an orthogonal projection of the first voltage signal line/the electrode plate of the output capacitor onto the base substrate is smaller than a first/second predetermined distance in a second direction, and the first direction intersects the second direction.

Abstract: A display panel and a display device are provided. The display panel includes: a sub-pixel including a pixel circuit and a light-emitting element, the light-emitting element including a first electrode; a first insulating layer, the first electrode being connected with the pixel circuit through a first via hole penetrating the first insulating layer; a pixel definition layer including an opening; the first electrode includes a main body portion and a connecting portion, the main body portion is at least partially overlapped with the opening, the connecting portion is at least partially overlapped with the first via hole, a size of the connecting portion at the first via hole in a first direction is ? to ? of a size of the main body portion in the first direction.

Abstract: The present invention relates to an optical element (1), an optical module and a vehicle. The optical element (1) comprises: a light incident section (10) for receiving light directly from a light source; a light exit section (30) having a focal plane (P); and a third section (20) that directs light from the light incident section (10) toward the light exit section (30) in a predetermined manner to generate a predetermined low beam distribution or high beam distribution, where the optical element (1) is implemented integrally.

Abstract: Disclosed are a display panel and a display device. The display panel comprises: a base substrate, a plurality of scanning lines, a first insulating layer, a plurality of data lines, an interlayer insulating layer, and an auxiliary power line. The auxiliary power line comprises: a plurality of sub-auxiliary power lines and a plurality of auxiliary conduction lines; the plurality of sub-auxiliary power lines are arranged in a first direction and extend in a second direction, and two sub-auxiliary power lines that are at least partially adjacent are electrically connected by means of at least one auxiliary conduction line; the orthographic projection of at least one of the plurality of auxiliary conduction lines on the base substrate does not overlap the orthographic projections of the scanning lines on the base substrate.