Publication number: 20220313837
Abstract: The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.
Type:
Application
Filed:
June 8, 2022
Publication date:
October 6, 2022
Applicant:
Hangzhou DAC Biotech Co., Ltd.
Inventors:
Yongxin Robert ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Huihui GUO, Xiaomai ZHOU, Hongsheng XIE, Haifeng ZHU, Yifang XU, Qianqian TONG, Junxiang JIA, Minjun CAO, Wenjun LI, Shuihong GAO, Zhixiang GUO, Lu BAI, Chen LI, Yanlei YANG, Chunyan WANG, Zhichang YE
Publication number: 20220249594
Abstract: A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, ----, R1, R2, R3, R4, R1, R6, R7, R1, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
Type:
Application
Filed:
February 18, 2020
Publication date:
August 11, 2022
Applicant:
HANGZHOU DAC BIOTECH CO., LTD
Inventors:
Robert ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Hangbo YE, Linyao ZHAO, Huihui GUO, Lu BAI, Wenjun LI, Junxiang JIA, Zhixiang GUO, Jun ZHENG, Xiaoxiao CHEN, Xiangfei KONG, Chen LIN, Yong DU, Yu ZHANG, Lei ZHOU, Xiuzhen ZHANG, Xiuhong ZHENG, Binbin CHEN, Yanlei YANG, Meng DAI, Yifang XU, Zhongliang FAN, Xiaomai ZHOU, Xingyan JIANG, Miaomiao CHEN, Lingli ZHANG, Yanhua LI