Abstract: Microchannels in hydrogels play an essential role in enabling a smart contact lens. A wearable contact lens is disclosed herein that uses microchannels and connected chambers located in poly-2-hydroxyethyl methacrylate (poly(HEMA)) hydrogel that is used in a commercial contact lens with three-dimensional (3D) printed mold. The corresponding capillary flow behaviors in these microchannels were investigated. Different capillary flow regimes were observed in these microchannels, depending on the hydration level of the hydrogel material. In particular, it was found that a peristaltic pressure could reinstate flow in a dehydrated microchannel, indicating the motion of eye-blinking may help tear flow in a microchannel-containing contact lens. Colorimetric pH and electrochemical Na+ sensing capabilities were demonstrated in these microchannels. Micro-engineered contact lenses formed using poly(HEMA) hydrogel can be used for various biomedical applications such as eye-care and wearable biosensing.

Abstract: A contact lens having dimples on a posterior surface is described as well as cast molds and injection molding inserts for manufacturing the same. The contact lens includes a posterior surface having an optic zone, a peripheral zone, and a circumferential edge, where dimples are located in the peripheral zone, and can include at least 1000 dimples.

Abstract: A method can include receiving input for a multiwell pad; selecting, based at least in part on a portion of the input, a template for the multiwell pad; generating, based at least in part on the template, well trajectories for the multiwell pad, where each of the well trajectories extends from a surface location of the multiwell pad to one or more reservoir target locations and where each of the well trajectories includes at least one curve generated using one or more dogleg severity values and one or more geometric control points that are not required to lie on one or more of the well trajectories; and outputting specifications for the generated trajectories of the multiwell pad.

Abstract: A linker molecule for targeting molecule-drug conjugate, has the structure of formula (I): A1p-D1q-Y-Lk-W-A2q-D2p (I). A conjugate has the structure of formula (III): A-((compound of formula (1))-PL t) z (III). The conjugate can be used in the manufacture of a medicament for treating a disease.

Abstract: A method for generating an output image from an input image and an input text instruction that specifies a location and a modification of an edit applied to the input image using a neural network is described. The neural network includes an image encoder, an image decoder, and an instruction attention network. The method includes receiving the input image and the input text instruction; extracting, from the input image, an input image feature that represents features of the input image using the image encoder; generating a spatial feature and a modification feature from the input text instruction using the instruction attention network; generating an edited image feature from the input image feature, the spatial feature and the modification feature; and generating the output image from the edited image feature using the image decoder.

Abstract: A flight trajectory multi-objective dynamic planning method, which belongs to the field of air traffic management, comprises: acquiring a route network structure, a flight segment length, flight level configurations of each flight segment and flow control information in an available airspace of a flight first, establishing a flight trajectory multi-objective dynamic planning model by taking a minimum fuel consumption, a shortest flight time and a minimum number of flight level changes as objectives, further designing a solving algorithm of the flight trajectory multi-objective dynamic planning model, and finally solving the model to form a plurality of strategies of flight trajectory multi-stage decision.

Abstract: A contact lens comprising one or more microchannels for transport of liquid through the lens is provided. The contact lens can be made by contacting a curable composition with a microfiber that is insoluble in the curable composition; curing the curable composition to provide a polymeric lens body with the microfiber embedded therein; and contacting the polymeric lens body with a solvent to dissolve the microfiber.

Abstract: A terminal according to an aspect of the present disclosure includes a receiving section that receives demodulation reference signal (DMRS) information relating to at least one resource of a DMRS, to which at least one DMRS a first precoder for a beam is applied and a second precoder for superposing signals for a plurality of terminals in the beam is not applied, and a control section that demodulates a physical downlink shared channel (PDSCH) to which the first precoder and the second precoder are applied, based on the DMRS and information relating to the second precoder. According to an aspect of the present disclosure, downlink throughput using the MIMO can be improved.

Abstract: A method for generating an output image from an input image and an input text instruction that specifies a location and a modification of an edit applied to the input image using a neural network is described. The neural network includes an image encoder, an image decoder, and an instruction attention network. The method includes receiving the input image and the input text instruction; extracting, from the input image, an input image feature that represents features of the input image using the image encoder; generating a spatial feature and a modification feature from the input text instruction using the instruction attention network; generating an edited image feature from the input image feature, the spatial feature and the modification feature; and generating the output image from the edited image feature using the image decoder.

Abstract: A contact lens comprising one or more microchannels for transport of liquid through the lens is provided. The contact lens can be made by contacting a curable composition with a microfiber that is insoluble in the curable composition; curing the curable composition to provide a polymeric lens body with the microfiber embedded therein; and contacting the polymeric lens body with a solvent to dissolve the microfiber.

Abstract: A hemostatic clip and an auxiliary system are disclosed. The hemostatic clip includes a first clip arm (110), a second clip arm (120), a tightening tube (140), a middle clip arm (150), an intermediate assembly (160), a traction assembly (170), a control handle (180) and at least two separators (190). The traction assembly (170) is connected to both the control handle (180) and the intermediate assembly (160), and the intermediate assembly (160) is connected to the tightening tube (140). Both the first clip arm (110) and the second clip arm (120) are proximally connected to the traction assembly (170). The middle clip arm (150) extends through the tightening tube (140) and is fixed proximally to the intermediate assembly (160). The first clip arm (110) and the second clip arm (120) are disposed on opposite sides of the middle clip arm (150).

Abstract: A flight trajectory multi-objective dynamic planning method, which belongs to the field of air traffic management, comprises: acquiring a route network structure, a flight segment length, flight level configurations of each flight segment and flow control information in an available airspace of a flight first, establishing a flight trajectory multi-objective dynamic planning model by taking a minimum fuel consumption, a shortest flight time and a minimum number of flight level changes as objectives, further designing a solving algorithm of the flight trajectory multi-objective dynamic planning model, and finally solving the model to form a plurality of strategies of flight trajectory multi-stage decision.

Abstract: A method can include receiving data for a bottom hole assembly of a drillstring and a drill plan; generating candidate trajectories using at least a portion of the data; generating drill command schedules for the candidate trajectories; ranking the candidate trajectories based at least in part on the drill command schedules; and outputting at least a top ranked candidate trajectory and its corresponding drill command schedule.

Abstract: Techniques for determining trajectories for a plurality of wells while avoiding collision between wells are presented. The techniques can include determining a zone of uncertainty for individual wells of the plurality of wells, determining a minimum separation factor for individual wells of the plurality of wells, determining a gradient of a separation factor for at least one pair of wells the plurality of pairs of wells, updating a nudge position for at least one well, and providing nudge positions for the individual wells of the plurality of wells.

Abstract: A contact lens having dimples on a posterior surface is described as well as cast molds and injection molding inserts for manufacturing the same. The contact lens includes a posterior surface having an optic zone, a peripheral zone, and a circumferential edge, where dimples are located in the peripheral zone, and can include at least 1000 dimples.

Abstract: The present invention provides a conjugate and preparation method thereof, a pharmaceutical composition comprising the conjugate and use of the pharmaceutical composition in the manufacture of a medicament for the treatment or prevention of a disease.

Abstract: A method for generating an output image from an input image and an input text instruction that specifies a location and a modification of an edit applied to the input image using a neural network is described. The neural network includes an image encoder, an image decoder, and an instruction attention network. The method includes receiving the input image and the input text instruction; extracting, from the input image, an input image feature that represents features of the input image using the image encoder; generating a spatial feature and a modification feature from the input text instruction using the instruction attention network; generating an edited image feature from the input image feature, the spatial feature and the modification feature; and generating the output image from the edited image feature using the image decoder.

Abstract: Provided in the present invention is a linker and a preparation method thereof, wherein one end of the linker may covalently link a small molecule compound and the like and the other end may specifically and covalently link a targeting substance site under the action of Sortase enzyme. The linker of the present invention can be used to prepare a targeting drug conjugate.

Abstract: The present invention provides a conjugate and preparation method thereof, a pharmaceutical composition comprising the conjugate and use of the pharmaceutical composition in the manufacture of a medicament for the treatment or prevention of a disease.

Abstract: A conjugate and preparation method therefor, comprising a medication composition comprising the conjugate and a use of the medication composition in preparing medications for the treatment or prevention of diseases.